Corpus overview


MeSH Disease

Human Phenotype


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    Clinical characteristics of 134 convalescent patients with COVID-19 in Guizhou, China

    Authors: Siqin Zhang; Lin Liu; Bin Yang; Rou Li; Jianhua Luo; Jing Huang; Yanjun Long; Ying Huang; Jianping Zhou; Yan Zha; Xiangyan Zhang

    doi:10.21203/ Date: 2020-07-13 Source: ResearchSquare

    Background: Previous studies have focused on the clinical characteristics of hospitalized patients with the novel 2019 coronavirus disease MESHD (COVID-19). Limited data are available for convalescent patients. This study aimed to evaluate the clinical characteristics of discharged COVID-19 patients.Methods: In this retrospective study, we extracted data for 134 convalescent patients with COVID-19 in Guizhou Provincial Staff Hospital from February 15 to March 31, 2020. Cases were analyzed on the basis of demographic, clinical, and laboratory data as well as radiological features. Results: Of 134 convalescent patients with COVID-19, 19 (14.2%) were severe cases, while 115 (85.8%) were non-severe cases. The median patient age TRANS was 33 years (IQR, 21.8 to 46.3), and the cohort included 69 men and 65 women. Compared with non-severe cases, severe patients were older and had more chronic comorbidities, especially hypertension HP hypertension MESHD, diabetes MESHD, and thyroid disease MESHD (P<0.05). Leukopenia HP Leukopenia MESHD was present in 32.1% of the convalescent patients and lymphocytopenia MESHD was present in 6.7%, both of which were more common in severe patients. 48 (35.8%) of discharged patients had elevated levels of alanine aminotransferase, which was more common in adults TRANS than in children TRANS (40.2% vs 13.6%, P=0.018). A normal chest CT was found in 61 (45.5%) patients during rehabilitation. Severe patients had more ground-glass opacity, bilateral patchy shadowing, and fibrosis MESHD. No significant differences were observed in the positive rate of IgG and/or IgM antibodies SERO between severe and non-severe patients.Conclusion: Leukopenia HP Leukopenia MESHD, lymphopenia HP lymphopenia MESHD, ground-glass opacity, and fibrosis MESHD are common in discharged severe COVID-19 patients, and liver injury MESHD is common in discharged adult TRANS patients. We suggest physicians develop follow-up treatment plans based on the different clinical characteristics of convalescent patients. 

    Poor Outcomes in Patients with Cirrhosis HP Cirrhosis MESHD and COVID-19

    Authors: Shalimar; Anshuman Elhence; Manas Vaishnav; Ramesh Kumar; Piyush Pathak; Kapil Dev Soni; Richa Aggarwal; Manish Soneja; Pankaj Jorwal; Arvind Kumar; Puneet Khanna; Akhil Kant Singh; Ashutosh Biswas; Neeraj Nischal; Lalit Dhar; Aashish Choudhary; Krithika Rangarajan; Anant Mohan; Pragyan Acharya; Baibaswata Nayak; Deepak Gunjan; Anoop Saraya; Soumya Mahapatra; Govind Makharia; Anjan Trikha; Pramod Garg

    doi:10.21203/ Date: 2020-07-06 Source: ResearchSquare

    Background and AimThere is a paucity of data on the clinical presentations and outcomes of Coronavirus disease MESHD 2019(COVID-19) in patients with underlying liver disease MESHD. We aimed to summarize the presentations and outcomes of COVID-19 positive patients and compare with historical controls.MethodsPatients with known chronic liver disease MESHD who presented with superimposed COVID- 19(n=28) between 22nd April and 22nd June 2020 were studied. Seventy-eight cirrhotic patients from historical controls were taken as comparison group.ResultsA total of 28 COVID patients- two without cirrhosis HP cirrhosis MESHD, one with compensated cirrhosis HP cirrhosis MESHD, sixteen with acute decompensation (AD), and nine with acute-on-chronic liver failure MESHD( ACLF MESHD) were included. The etiology of cirrhosis HP cirrhosis MESHD was alcohol(n=9), non-alcoholic fatty liver disease MESHD(n=2), viral(n=5), autoimmune hepatitis MESHD hepatitis HP(n=4), and cryptogenic cirrhosis HP(n=6). The clinical presentations included complications of cirrhosis HP cirrhosis MESHD in 12(46.2%), respiratory symptoms in 3(11.5%) and combined complications of cirrhosis HP cirrhosis MESHD and respiratory symptoms in 11(42.3%) patients. The median hospital stay was 8(7-12) days. The mortality rate in COVID-19 patients was 42.3%(11/26), as compared to 23.1%(18/78) in the historical controls(p=0.077). All COVID-19 patients with ACLF(9/9) died compared to 53.3%(16/30) in ACLF of historical controls(p=0.015). Mortality rate was higher in COVID patients with compensated cirrhosis HP cirrhosis MESHD and AD MESHD as compared to historical controls 2/17(11.8%) vs 2/48(4.2%), though not statistically significant (p=0.278). Requirement of mechanical ventilation independently predicted mortality (hazard ratio, 13.68). Both non-cirrhotic patients presented with respiratory symptoms MESHD and recovered uneventfully.ConclusionCOVID-19 is associated with poor outcomes in patients with cirrhosis HP cirrhosis MESHD, with worst survival rates in ACLF. Mechanical ventilation is associated with a poor outcome.

    Cirrhosis HP Cirrhosis MESHD and COVID-19: a fatal case of viral peritonitis MESHD peritonitis HP and disseminated infection MESHD

    Authors: Victor Cabelho Passarelli; Ana Helena Perosa; Luciano Luna; Danielle Dias Conte; Oliver A. Nascimento; Jaquelina Ota-Arakaki; Nancy Bellei

    doi:10.1101/2020.06.25.20139998 Date: 2020-06-29 Source: medRxiv

    Pathogenesis and clinical presentation of Coronavirus Disease-19 outside the respiratory tract remain to be understood, especially in the immunocompromised. We report an unique case of cirrhosis HP cirrhosis MESHD decompensation with ascites HP ascites MESHD and unprecedented evidence of SARS Coronavirus-2 peritonitis MESHD peritonitis HP and disseminated infection, demonstrated by viral RNA detection in peritoneal fluid, as well as in blood SERO serum SERO, nasopharyngeal and stool specimens.

    Systemic analysis of putative SARS-CoV-2 entry and processing genes in cardiovascular tissues identifies a positive correlation of BSG with age TRANS in endothelial cells

    Authors: Blerina Ahmetaj-Shala; Ricky-Kumar Vaja; Santosh S Atanur; Peter M George; Nicholas S Kirkby; Jane A. Mitchell

    doi:10.1101/2020.06.23.165324 Date: 2020-06-23 Source: bioRxiv

    COVID-19, caused by severe acute respiratory syndrome coronavirus-2 MESHD (SARS-CoV-2) has rapidly spread throughout the world with unprecedented global healthcare and socio-economic consequences. There is now an established secondary syndrome of COVID-19 characterised by thrombosis MESHD, vascular dysfunction MESHD and hypertension HP hypertension MESHD, seen in those most severely affected. Advancing age TRANS in adults TRANS is the single most significant risk factor for hospitalisation and death with COVID-19. In light of the cardiovascular/ thrombotic sequalae MESHD associated with severe COVID-19 disease and the overwhelming risk that increased age TRANS carries, in this study, our aim was to obtain mechanistic insight by interrogating gene expression profiles in cardiovascular tissues and cells. Our focus was on the two putative receptors for SARS-CoV-2, ACE2 and BSG along with a selected range of genes thought to be involved in virus binding/processing. In this study we have made four important observations: (i)Cardiovascular tissues and/or endothelial cells express the required genes for SARS-CoV-2 infection MESHD, (ii) SASR-CoV-2 receptor pathways, ACE2/TMPRSS2 and BSG/PPIB(A) polarise to lung/epithelium and vessel/endothelium respectively, (iii) expression of SARS-CoV-2 host genes are, on the whole, relatively stable with age TRANS and (iv) notable exceptions were ACE2 which decreases with age TRANS in some tissues and BSG which increases with age TRANS in endothelial cells. Our data support the idea that that BSG is the dominate pathway utilised by SARS-CoV-2 in endothelial cells and are the first to demonstrate a positive correlation with age TRANS. We suggest BSG expression in the vasculature is a critical driver which explains the heightened risk of severe disease and death MESHD observed in those >40 years of age TRANS. Since BSG is utilised by other pathogens our findings have implications beyond the current pandemic. Finally, because BSG is functions in a range of cardiovascular diseases MESHD and fibrosis MESHD, our observations may have relevance to our understanding of the diseases associated with aging.

    Transcriptogram analysis reveals relationship between viral titer and gene sets responses during Corona-virus infection MESHD.

    Authors: Rita M.C. de Almeida; Gilberto L Thomas; James A. Glazier

    doi:10.1101/2020.06.16.155267 Date: 2020-06-16 Source: bioRxiv

    To understand the difference between benign and severe outcomes after Coronavirus infection MESHD, we urgently need ways to clarify and quantify the time course of tissue and immune responses. Here we re-analyze 72-hour time-series microarrays generated in 2013 by Sims and collaborators for SARS-CoV-1 in vitro infection of a human lung epithelial cell line. Using a Transcriptogram-based top-down approach, we identified three major, differentially-expressed gene sets comprising 219 mainly immune-response-related genes. We identified timescales for alterations in mitochondrial activity, signaling and transcription regulation of the innate and adaptive immune systems and their relationship to viral titer. At the individual-gene level, EGR3 was significantly upregulated in infected cells. Similar activation in T-cells and fibroblasts in infected lung MESHD could explain the T-cell anergy and eventual fibrosis MESHD seen in SARS-CoV-1 infection MESHD. The methods can be applied to RNA data sets for SARS-CoV-2 to investigate the origin of differential responses in different tissue types, or due to immune or preexisting conditions or to compare cell culture, organoid culture, animal models and human-derived samples.

    COVID-19 and Crosstalk With the Hallmarks of Aging

    Authors: Shabnam Salimi; John M. Hamlyn

    id:10.20944/preprints202004.0182.v2 Date: 2020-05-16 Source:

    Within the past several decades, the emergence of new viral diseases MESHD with severe health complications and mortality is evidence of an age TRANS-dependent, compromised bodily response to abrupt stress with concomitantly reduced immunity. The new severe acute respiratory syndrome coronavirus 2 MESHD, SARS-CoV-2, causes coronavirus disease MESHD 2019 (COVID-19). It has increased morbidity and mortality in persons with underlying chronic diseases MESHD and those with a compromised immune system regardless of age TRANS and in older adults TRANS who are more likely to have these conditions. While SARS-CoV-2 is highly virulent, there is variability in the severity of the disease and its complications in humans. Severe pneumonia HP pneumonia MESHD, acute respiratory distress syndrome MESHD respiratory distress HP syndrome, lung fibrosis MESHD, cardiovascular events, acute kidney injury HP acute kidney injury MESHD, stroke HP stroke MESHD, hospitalization, and mortality have been reported that result from pathogen–host interactions. Hallmarks of aging, interacting with one another, have been proposed to influence health span in older adults TRANS, possibly via mechanisms regulating the immune system. Here, we review the potential roles of the hallmarks of aging coupled with host–coronavirus interactions. Of these hallmarks, we focused on those that directly or indirectly interact with viral infections MESHD, including immunosenescence, inflammation MESHD and inflammasomes, adaptive immunosenescence, genomic instability, mitochondrial dysfunction MESHD, telomere attrition, epigenetic alterations, and impaired autophagy. These hallmarks likely contribute to the increased pathophysiological responses to SARS-CoV-2 among older adults TRANS and may play roles as an additive risk of accelerated biological aging even after recovery. We also briefly discuss the role of anti-aging drug candidates that require paramount attention in COVID-19 research.

    Changes in CT manifestations of patients with mild to moderate coronavirus disease MESHD 2019 in a Fangcang Shelter Hospital

    Authors: Zhongbiao Jiang; Chongqing Tan; Shan Jiang; Kun Yu; Yang Wang; Weihong Zhu; Huiling Zhang; Weidan Pu; Haijun Deng; Chuan Wen; Xiao Fan; Li Jiang; Qin Ji; Li Zhu; Liang Lyu; Lei Zhang; Shi Tai; Yuzhong Cai; Yi Tian; Chuanhao Jiang; Lingjun Wen; Yushan Liu; Kui Xiao; Junmei Xu

    doi:10.21203/ Date: 2020-05-01 Source: ResearchSquare

    Objectives: To provide a reference for CT imaging changes for patients discharged from a Fangcang shelter hospital, a large-scale, temporary hospital for the centralized treatment of patients with mild to moderate Coronavirus disease MESHD 2019 (COVID-19) to provide essential functions (isolation, triage, basic medical care, frequent monitoring and rapid referral, essential living and social engagement) to them..Methods: Patients with mild to moderate COVID-19 admitted to the Wuchang Fangcang Shelter Hospital who had undergone pre-discharge and previous CT scans were included. Changes in the CT imaging features were defined as progression, no change, improvement or recovery. Basic patient information was obtained, and imaging signs were compared between the two CT scans.Results: A total of 83 patients were included. The median age TRANS was 53 years old. The course of disease was 28.3±10.7 days. CT imaging changes indicated progression, no change, improvement, and recovery in 3, 12, 66, and 2 patients, respectively. Between the two CT scans, the imaging signs showed a significant reduction in consolidation, a significant increase in fibrosis MESHD, and a reduction or / and thinning of ground-glass opacities. None of the patients showed signs of deterioration on follow-up and thus did not need to return to the hospital for treatment.Conclusion: In the COVID-19 Fangcang shelter hospital, given the shortage of medical staff and lack of medical resources, CT imaging diagnostic methods can be used to accurately discharge patients who had met the discharge criteria for isolation and observation from the Fangcang Shelter Hospital.

    Clinical course and risk factors for mortality of COVID-19 patients with pre-existing cirrhosis HP cirrhosis MESHD: A multicenter cohort study

    Authors: Xiaolong Qi; Yanna Liu; Jonathan A. Fallowfield; Jitao Wang; Jianwen Wang; Xinyu Li; Jindong Shi; Hongqiu Pan; Shengqiang Zou; Hongguang Zhang; Zhenhuai Chen; Fujian Li; Yan Luo; Mei Mei; Huiling Liu; Zhengyan Wang; Jinlin Li; Hua Yang; Huihua Xiang; Xiaodan Li; Tao Liu; Ming-Hua Zheng; Chuan Liu; Yifei Huang; Dan Xu; Xiaoguo Li; Ning Kang; Qing He; Ye Gu; Guo Zhang; Chuxiao Shao; Dengxiang Liu; Lin Zhang; Xun Li; Norifumi Kawada; Zicheng Jiang; Fengmei Wang; Bin Xiong; Tetsuo Takehara; Don C. Rockey; COVID-Cirrhosis-CHESS Group

    doi:10.1101/2020.04.24.20072611 Date: 2020-04-28 Source: medRxiv

    Background: Patients with pre-existing cirrhosis HP cirrhosis MESHD are considered at increased risk of severe coronavirus disease MESHD 2019 (COVID-19) but the clinical course in these patients has not yet been reported. This study aimed to provide a detailed report of the clinical characteristics and outcomes among COVID-19 patients with pre-existing cirrhosis HP cirrhosis MESHD. Methods: In this retrospective, multicenter cohort study, we consecutively included all adult TRANS inpatients with laboratory-confirmed COVID-19 and pre-existing cirrhosis HP cirrhosis MESHD that had been discharged or had died by 24 March 2020 from 16 designated hospitals in China. Demographic, clinical, laboratory and radiographic findings on admission, treatment, complications during hospitalization and clinical outcomes were collected and compared between survivors and non-survivors. Findings: Twenty-one patients were included in this study, of whom 16 were cured and 5 died in hospital. Seventeen patients had compensated cirrhosis HP cirrhosis MESHD and hepatitis HP hepatitis MESHD B virus infection was the most common etiology. Lymphocyte and platelet counts were lower, and direct bilirubin levels were higher in patients who died than those who survived (p= 0.040, 0.032, and 0.006, respectively). Acute respiratory distress HP respiratory distress MESHD syndrome and secondary infection MESHD were both the most frequently observed complications. Only one patient developed acute on chronic liver failure MESHD. Of the 5 non-survivors, all patients developed acute respiratory distress syndrome MESHD respiratory distress HP syndrome and 2 patients progressed to multiple organ dysfunction syndrome MESHD. Interpretation: Lower lymphocyte and platelet counts, and higher direct bilirubin level might represent poor prognostic indicators in SARS-CoV-2-infected MESHD patients with pre-existing cirrhosis HP cirrhosis MESHD.

    O-β-GlcNAcylation, Chloroquine and 2-Hydroxybenzohydrazine May Hamper SARS-CoV-2 entry to Human via Inhibition of ACE2 Phosphorylation at Ser787 but Also Induce Disruption of Virus-ACE2 Binding

    Authors: Waqar Ahmad; Khadija Shabbiri; Nazarul Islam

    id:10.20944/preprints202004.0390.v1 Date: 2020-04-22 Source:

    The novel coronavirus COVID- 19 disease is extremely contagious and has been spread worldwide. First COVID-19 case was identified in December, 2019 and within three months, more than one million affected cases and over 65,000 deaths have been reported. SARS-coronavirus MESHD 2 (SARS-CoV-2) also known as 2019-nCoV is a causative agent of COVID-19 disease and belongs to the SARS CoV ( Severe Acute Respiratory Syndrome corona virus MESHD) family. The SARS-CoV-2 enters the human body by binding its viral surface spike protein with the host angiotensin-converting enzyme 2 (ACE2) receptors and cause infection MESHD. To prevent the virus entry and its transmission TRANS in the human body, we focused on the two domains of ACE2: i) the N-terminal extracellular binding domain (18-740 residues) reported for coronavirus spike interaction, and ii) the C-terminal cytoplasmic region (762-805 residues) to prevent the virus transmission TRANS. Therefore, we proposed: i) inhibition of receptor binding domain (RBD) of SARS-CoV-2 and human ACE2 protein may prevent the virus entry to the host and ii) inhibition of phosphorylation at Ser-787 of ACE2 protein may prevent the transmission TRANS of the virus in the COVID-19 patients. In the past, the critical role of Ser 787 in human ACE2 protein has been experimentally verified in SARS-CoV MESHD transmission TRANS, that upon binding to the receptor, SARS- CoV induces CKII- mediated phosphorylation of ACE2 at Ser-787 that in-turn facilitate virus entry to host cells, followed by replication and activation of ACE2, initiates downstream signaling leading to lung fibrosis MESHD. Therefore, in this study, we have suggested post-translational modification (PTM) O-β-GlcNAcylation, and two compounds Chloroquine and 2-hydroxybenzohydrazine might share the common pathways to prevent the COVID-19 infection MESHD in human. The addition of O-β-GlcNAcylation at same or neighboring Ser/ Thr residues results in phosphorylation inhibition and a change in protein structural and functional confirmations. Thereby, using neural networking methods, we have identified Ser/ Thr residues in ACE2 that are potential sites for phosphorylation and / or O-β-GlcNAcylation. Molecular docking showed that UDP-GlcNAc has more binding affinity with Ser-787 than the phosphoryl group. Moreover, chloroquine and 2-hydroxybenzohydrazine also showed great potential to bind at Ser-787 that may result in inhibition of Ser-787 phosphorylation and downstream signaling. Furthermore, O-β-GlcNAcylation, chloroquine and 2-hydroxybenzohydrazine showed their high affinity at ACE2-SARS-CoV-2receptor binding domain that may prevent the entry of SARS-CoV-2 into human body. In conclusion, inhibition of human ACE2 phosphorylation at Ser-787 and ACE2-SARS-CoV-2 binding domain could be promising targets against SARS-CoV-2 infection MESHD.

    Correlation between CT findings and outcomes in 46 Patients with Coronavirus Disease MESHD-19

    Authors: Qiang Lei; Guangming Li; Xiaofen Ma; Junzhang Tian; Yunfan Wu; Hui Chen; Wen Xu; Cheng Li; Guihua Jiang

    doi:10.21203/ Date: 2020-04-16 Source: ResearchSquare

    Purpose: The aim of this study was to retrospectively analyze chest Computed Tomography (CT) findings in COVID-19 pneumonia HP pneumonia MESHD and identify features associated with poor prognosis.Methods: This retrospective review included 46 patients with RT-PCR confirmed COVID-19 infection MESHD. Basic clinical characteristics and detailed CT features were evaluated and compared between patients who recovered (n = 40) from coronavirus and those who expired (n = 6). Chest CT examinations for ground-glass opacity, crazy-paving pattern, consolidation, and fibrosis MESHD were scored by two reviewers. The total CT score comprised the sum of lung involvement (5 lobes, scores 1-5 for each lobe, range; 0, none; 25, maximum) was determined.Results: We analyzed clinical data from 46 patients (26 males TRANS and 20 females TRANS; age TRANS 9-82 years) with confirmed COVID-19 pneumonia HP pneumonia MESHD were evaluated. The chest CTs showed 27 (58.7%) patients had ground-glass opacity, 19 (41.3%) had ground glass and consolidation, and 35 (76.1%) patients had crazy-paving pattern. None of the patients who expired had fibrosis MESHD, in contrast to six (15%) patients who recovered from coronavirus. Most patients had subpleural lesions MESHD (89.0%), bilateral (87.0%) and lower (93.0%) lung lobe involvement. Diffuse lesions were present in four (67%) patients who succumbed to coronavirus, but only one (2.5%) patient who recovered (p = 0.000). CT identified a greater area of lung lobe involvement MESHD in patients who died (p = 0.000). In the group of patients who expired, the total CT score was higher than that of the recovery group (17.2 ± 7.8 vs. 7.1 ± 4.3, p = 0.005). Patients in the death MESHD group had lower lymphocyte count and higher C-reactive protein than those in the recovery group (p = 0.011 and p = 0.041, respectively).Conclusion: The CT of patients with COVID-19 mainly showed ground-glass opacity and ground-glass opacity plus consolidation, with a peripheral lower lobe preference. Early fibrosis MESHD may correlate with well prognosis. Lymphopenia HP Lymphopenia MESHD, elevated C-reactive protein, and high CT score in conjunction with diffuse distribution of lung lesions MESHD are indicative of disease severity and short- term mortality.

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MeSH Disease
Human Phenotype

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