Corpus overview


Overview

MeSH Disease

Human Phenotype

Transmission

There are no transmission terms in the subcorpus


Seroprevalence

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    Prognostic Significance of COVID-19 Receptor ACE2 and Recommendation For Anti- Hypertensive Drug in Renal Cell Carcinoma MESHD Renal Cell Carcinoma HP

    Authors: Kihun Kim; Yeji Ko; Dai Sik Ko; Yun Hak Kim

    doi:10.21203/rs.3.rs-49602/v1 Date: 2020-07-27 Source: ResearchSquare

    Background: Owing to its worldwide spread, the coronavirus disease MESHD (COVID-19) epidemic was declared a pandemic by the World Health Organization on March 11, 2020. Angiotensin-converting enzyme 2 (ACE2) is the outer surface protein of the cell membrane that is abundantly distributed in the heart, lungs, and kidneys, and plays an important role in molecular docking of the severe acute respiratory syndrome coronavirus 2 MESHD. In this study, we aimed to analyze the difference in the survival rate according to ACE2 expressions in pan- cancer MESHD. Methods: The clinical and genomic data of pan- cancer MESHD patients were accessed from The cancer MESHD Genome Atlas. To identify the prognostic significance of ACE2, we used Kaplan-Meier with log-rank test, and the Cox proportional hazards regression to analyze prognostic significance. Results: In the Kaplan-Meier curve, clear cell renal cell carcinoma HP clear cell renal cell carcinoma MESHD ( ccRCC MESHD), uveal melanoma HP melanoma MESHD, and prostate adenocarcinoma MESHD showed statistically significant. In the Cox regression, thyroid carcinoma HP thyroid carcinoma MESHD and glioblastoma multiforme HP glioblastoma multiforme MESHD, and ccRCC MESHD showed significant results. Only ccRCC MESHD had statistically significant, and high ACE2 expression is related to good prognosis. Conclusions: It is known that ACE inhibitor, a primary antihypertensive agent, increases ACE2 expression. Based on these results, we believe that the ACE inhibitor will be important to increase the lifespan of ccRCC MESHD patients. This study is the first research to offer a recommendation on the use of anti- hypertensive MESHD drugs to ccRCC MESHD patients.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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