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MeSH Disease

Human Phenotype

Transmission

Seroprevalence
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    Lung ultrasound and neonatal COVID-19 pneumonia HP pneumonia MESHD: A case report.

    Authors: Daniel Ibarra Ríos; Dina Villanueva García; Edna Patricia Vázquez Solano; Alfonso de Jesús Martínez García; María Yolotzin Valdespino-Vázquez; Addy Cecilia Helguera Repetto; Horacio Márquez González

    doi:10.21203/rs.3.rs-33182/v2 Date: 2020-06-02 Source: ResearchSquare

    Introduction: Severe Novel Coronavirus Disease MESHD 2019 (COVID-19) infection MESHD in neonates is possible but reports are scarce.  Lung ultrasound (LUS) has been reported useful for triaging, diagnosing, and monitoring of patients with COVID-19.Material and methods: We describe SARS-CoV-2 confirmed infection MESHD confirmed infection TRANS on a term newborn that developed pneumonia HP pneumonia MESHD and pulmonary hypertension MESHD hypertension HP requiring mechanical ventilation. Ultrasonographic follow up of COVID-19 pneumonia HP pneumonia MESHD and pulmonary hypertension MESHD hypertension HP was carried out. Histopathological and genetic study of the placenta was performed. Results: A 3,140-g male TRANS infant born at 40.3 weeks’ gestation developed progressive respiratory distress HP respiratory distress MESHD ( pulmonary hypertension MESHD hypertension HP) requiring mechanical ventilation. Real time PCR respiratory tract swabs for SARS COV 2 sampled on day 3 were positive for the baby and both parents TRANS. Lung ultrasound showed an irregular pleural MESHD line (shred sign), multiple confluent B-lines and bilateral ≥ 0.5 cm subpleural consolidations. Improvement of the lung and cardiac conditions were documented by ultrasound. The newborn was supported 6 days with mechanical ventilation, 3 days on CPAP and 3 days on oxygen. No antibiotics were used. The placenta showed histological findings linked to SARS-CoV-2 infection MESHD. RT-PCR from placental tissue showed amplification of viral E gene.Conclusion: Our case represents a severe presentation of COVID-19 pneumonia HP pneumonia MESHD with pulmonary hypertension MESHD hypertension HP requiring mechanical ventilation. LUS showed to be useful for diagnosis and follow up. Transversal infection was possible. 

    Lung ultrasound and neonatal COVID-19 pneumonia HP pneumonia MESHD: A case report.

    Authors: Daniel Ibarra Ríos; Dina Villanueva García; Edna Patricia Vázquez Solano; Alfonso de Jesús Martínez García; Horacio Márquez González

    doi:10.21203/rs.3.rs-33182/v1 Date: 2020-06-02 Source: ResearchSquare

    Purpose: Severe Novel Coronavirus Disease MESHD 2019 (COVID-19) infection MESHD in neonates is possible but reports are scarce.  Lung ultrasound (LUS) has been reported useful for triaging, diagnosing, and monitoring of patients with COVID-19.Material and methods: We describe SARS-CoV-2 confirmed infection MESHD confirmed infection TRANS on a term newborn that developed pneumonia HP pneumonia MESHD and pulmonary hypertension MESHD hypertension HP requiring mechanical ventilation. Ultrasonographic follow up of COVID-19 pneumonia HP pneumonia MESHD and pulmonary hypertension MESHD hypertension HP was carried out. Results: A 3,140-g male TRANS infant born at 40.3 weeks’ gestation developed progressive respiratory distress HP requiring mechanical ventilation. Real time PCR respiratory tract swabs for SARS COV 2 sampled on day 3 were positive for the baby and both parents TRANS. Lung ultrasound showed an irregular pleural MESHD line (shred sign), multiple confluent B-lines and bilateral ≥ 0.5 cm subpleural consolidations. Improvement of the lung and cardiac conditions were documented by ultrasound. Conclusion: Our case represents a severe presentation of COVID-19 pneumonia HP pneumonia MESHD with pulmonary hypertension MESHD hypertension HP requiring mechanical ventilation. LUS showed to be useful for diagnosis and follow up. 

    Cardiac Structural MESHD and Functional Characteristics in Patients with Coronavirus Disease MESHD 2019: A Serial Echocardiographic Study

    Authors: Heng Ge; Mingli Zhu; Jing Du; Yong Zhou; Wei Wang; Wei Zhang; Handong Jiang; Zhiqing Qiao; Zhichun Gu; Fenghua Li; Jun Pu Jr.

    doi:10.1101/2020.05.12.20095885 Date: 2020-05-18 Source: medRxiv

    BACKGROUND: Increasing attention has been paid to cardiac involvement MESHD in patients with coronavirus disease MESHD 2019 (COVID-19). Yet, scarce information is available regarding the morphological and functional features of cardiac impairments MESHD in these patients. METHODS: We conducted a prospective and serial echocardiographic study to investigate the structural and functional cardiac changes among COVID-19 patients admitted to the intensive care unit (ICU). From January 21 to April 8, 2020, a total of 51 ICU patients (31 critically ill and 20 severely ill) with confirmed COVID-19 were monitored by serial transthoracic echocardiography examinations. Outcomes were followed up until April 8, 2020. RESULTS: Of 51 ICU patients, 33 (64.7%) had cardiovascular comorbidities. Elevations of levels of cardiac biomarkers including high- sensitivity SERO cardiac troponin-I (hs-cTnI) and brain natriuretic peptide were observed in 62.7% and 86.3% of patients, respectively. Forty-two (82.3%) had at least one left-heart and/or right-heart echocardiographic abnormality. The overall median left ventricular ejection fraction (LVEF) was 65.0% (IQR 58.0-69.0%), with most (44,86.3%) having preserved LVEF. Sixteen patients (31.4%) had increased pulmonary artery systolic pressure, and 14 (27.5%) had right-ventricle (RV) enlargement. During the study period, 12 (23.5%) patients died. LVEF was comparable between survivors and non-survivors, while non-survivors had more often pulmonary hypertension MESHD hypertension HP (58.3% vs. 23.1%; P=0.028) and RV enlargement (58.3% vs. 17.9%, P=0.011). Kaplan-Meier analysis demonstrated similar survival curves between patients with vs. without echocardiographic left-heart abnormalities MESHD (P=0.450 by log-rank test), while right-heart abnormalities had adverse impact on mortality (P=0.012 by log-rank test). CONCLUSIONS: Typical cardiac abnormality MESHD in ICU patients with COVID-19 was right-heart dysfunction MESHD with preserved LVEF. Echocardiographic right-heart dysfunction MESHD was associated with disease severity and increased mortality in patients affected by COVID-19.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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