Corpus overview


Overview

MeSH Disease

Human Phenotype

Pneumonia (131)

Fever (97)

Cough (75)

Severe infection (40)

Fatigue (31)


Transmission

Seroprevalence
    displaying 31 - 40 records in total 794
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    On Cancer, COVID-19 and CT Scan: A Monocentric Retrospective Study

    Authors: Francesca Martini; Andrea D'Alessio; Federico Bracchi; Daniela Di Mauro; Anna Fargnoli; Marco Motta; Cristina Giussani; Marco Meazza Prina; Giovanni Gobbin; Monica Taverna

    id:10.20944/preprints202009.0075.v1 Date: 2020-09-04 Source: Preprints.org

    Background The acknowledgment of computed tomography (CT) defined diagnosis in high prevalence SERO northern Italy may identify more patients with Coronavirus Disease MESHD-2019 (COVID 19) infection MESHD, than RT-PCR alone. Methods We retrospectively reviewed 148 chest CT scans of oncological patients who were referred to the Radiological Unit of Policlinico S. Marco from 1st of February 2020 to 30th of April 2020, during the Covid-19 outbreak in Bergamo area. Therefore, we analyzed RT-PCR tests of these 148 patients. Results Among 32 patients with diagnosis of COVID-19 infection MESHD: 17 patients were asymptomatic TRANS or had mild symptoms (53.1%), while 15 developed severe disease (46.8%). The incidence of COVID-19 infection MESHD is 22.9%, the mortality rate is 18.8%. Severe COVID-19 disease is associated with higher median age TRANS. We did not find any correlation between disease severity and sex, smoke or cardiovascular comorbidities. Remarkably, patients who were on treatment developed milder disease MESHD than cancer MESHD patients who were not on treatment. Conclusions The acceptance of CT-defined diagnosis in high prevalence SERO area like Bergamo highlighted a larger number of COVID-19 oncological population than RT-PCR alone, in particular asymptomatic TRANS and mild symptomatic patients. We observed that actively treated patients had milder disease, according to previous studies that suggested a protective role of immunosuppression.

    Association Between Inhaled Corticosteroid Use and the Severe Acute Respiratory Syndrome Coronavirus 2 Infection MESHD: A Nationwide Population-based Study in South Korea

    Authors: Sang Chul Lee; Kang Ju Son; Chang Hoon Han; Ji Ye Jung; Seon Cheol Park

    doi:10.21203/rs.3.rs-72221/v1 Date: 2020-09-04 Source: ResearchSquare

    Background Inhaled corticosteroid (ICS) use may increase the risk of respiratory infection MESHD, but its influence on the risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection MESHD is not known. This study aimed to investigate the association between ICS use and the risk of SARS-CoV-2 infection MESHD among the patients with chronic respiratory diseases MESHD.Methods The Ministry of Health and Welfare and Health Insurance Review and Assessment Service in Korea provided nationwide data of 44,968 individuals with chronic respiratory diseases MESHD tested for SARS-CoV-2 until May 15. The risks of SARS-CoV-2 infection MESHD were retrospectively analysed according to the prescription, type, and dose of ICS taken one year before SARS-CoV-2 test.Results Among 44,968 individuals tested, 931 (2.1%) were positive for SARS-CoV-2. A total of 7,019 patients (15.6%) were prescribed ICS one year prior to being tested for SARS-CoV-2. Low, medium, and high doses of ICS were prescribed in 7.5%, 1.6%, and 6.5% of total cases, respectively. Among the types of ICS, budesonide, fluticasone, beclomethasone, and ciclesonide were prescribed in 3.7%, 8.9%, 2.3%, and 0.6% of total cases, respectively. The multivariate analysis showed no significant increase in infection MESHD with ICS use (OR, 0.84; 95% CI, 0.66–1.03). Moreover, there were no associations between the risk of infection TRANS risk of infection TRANS infection MESHD, and doses or types of ICS prescribed.Conclusion Prior ICS use did not increase the risk of SARS-CoV-2 infection MESHD. Moreover, different doses or types of ICS did not affect the risk. This study supports the current guidelines to manage patients taking ICS during the SARS-CoV-2 pandemic.

    Defining the role of asymptomatic TRANS SARS-CoV-2 transmission TRANS: a living systematic review

    Authors: Xueting Qiu; Ali Ihsan Nergiz; Alberto Enrico Maraolo; Isaac I Bogoch; Nicola Low; Muge Cevik; Michelle L. Allen; Genevieve B. Melton; Anthony Charles; Christopher J. Tignanelli; - the Yale IMPACT Research Team; Charles S. Dela Cruz; Shelli F. Farhadian; Akiko Iwasaki; Albert I. Ko; Nathan D. Grubaugh; Anne L. Wyllie

    doi:10.1101/2020.09.01.20135194 Date: 2020-09-03 Source: medRxiv

    Background Reports suggest that asymptomatic TRANS individuals (those with no symptoms at all throughout the infection) with severe HP infection) with severe MESHD acute respiratory syndrome coronavirus 2 MESHD (SARS-CoV-2) are infectious, but the extent of asymptomatic TRANS transmission TRANS requires further understanding. Purpose This living review aims to critically appraise available data about secondary attack rates TRANS from people with asymptomatic TRANS and pre-symptomatic SARS-CoV-2 infection MESHD. Data sources Medline, EMBASE, China Academic Journals full-text database (CNKI), and pre-print servers were searched from 30 December 2019 to 3 July 2020 using relevant MESH terms. Study selection Studies that report on contact tracing TRANS of index cases with asymptomatic TRANS or pre-symptomatic SARS-CoV-2 infection MESHD, in either English or Chinese were included. Data extraction Two authors independently extracted data and assessed study quality and risk of bias. We calculated the secondary attack rate TRANS as the number of contacts with SARS-CoV-2, divided by the number of contacts tested. Data synthesis Of 928 studies identified, 19 were included. Secondary attack rates TRANS from asymptomatic TRANS index cases ranged from 0% to 2.8% (9 studies). Pre-symptomatic secondary attack rates TRANS ranged from 0.7% to 31.8% (10 studies). The highest secondary attack rates TRANS were found in contacts who lived in the same household as the index case. Other activities associated with transmission TRANS were group activities such as sharing meals TRANS or playing board games with the index case. Limitations We excluded some studies because the index case or number of contacts were unclear. Owing to the anticipated heterogeneity, we did not produce a summary estimate of the included studies. Conclusion Asymptomatic TRANS patients can transmit SARS-CoV-2 to others, but our findings indicate that such individuals are responsible for fewer secondary infections than people with symptoms in the same studies. Systematic review registration PROSPERO CRD42020188168 Funding: No funding was received

    Depression MESHD and Anxiety HP Anxiety MESHD Among Pregnant Mothers in the Initial Stage of the Coronavirus Disease MESHD (COVID-19) Pandemic in Southwest of Iran

    Authors: Najmeh Maharlouei; Pedram Keshavarz; Kamran B. Lankarani

    doi:10.21203/rs.3.rs-71528/v1 Date: 2020-09-03 Source: ResearchSquare

    ‌Background: Women are at higher risk for depression MESHD progression especially during pregnancy. So, we aimed to investigate depression MESHD, anxiety HP anxiety MESHD, and stress level of pregnant mothers in the initial stage of the COVID-19 infection MESHD in Southwest of Iran. Methods: This cross-sectional study conducted during March and April, 2020 in Shiraz, Iran. Pregnant mothers registered in maternity clinics affiliated to Shiraz University of Medical Sciences were included. An online self-administered checklist was used. It included socio-demographic, obstetric and medical history, and the short form of Depression Anxiety Stress MESHD Anxiety HP Stress Scales (DASS-21) for evaluation of depression MESHD, anxiety HP anxiety MESHD, and stress. P-value < 0.05 was considered significant.Results: 540 pregnant mothers answered the questionnaire. 83.5% had no comorbidity. Abnormal depression MESHD score was significantly higher in those who did not have any insurance (OR= 2.5) and in those with poor self-rated health (SRH) (OR= 27.8). Pregnant mothers with lower SRH and two or more comorbidities had higher chance of having abnormal level of anxiety HP anxiety MESHD subscale; 6.9, 3.7 times, retrospectively. Conclusion: The study revealed that that abnormal level of depression MESHD was associated with SRH and medical insurance status. Moreover, the number of comorbidities and poor SRH were significantly increased the chance of achieving abnormal anxiety MESHD anxiety HP level in pregnant mothers during the COVID-19 pandemic.

    Analyzing inherent biases in SARS-CoV-2 PCR and serological epidemiologic metrics

    Authors: Monia Makhoul; Farah Abou-Hijleh; Shaheen Seedat; Ghina R Mumtaz; Hiam Chemaitelly; Houssein Ayoub; Laith J Abu-Raddad; Xiaojian Liu; Wei Gao; Renli Zhang; Qiru Su; Andrew Azman; Justin Lessler; Xuan Zou; Wenfeng Gong; Brenda Clemente; Jerel Vega; Scott Roberts; Jose A. Gonzalez; Marciano Sablad; Rodrigo Yelin; Wendy Taylor; Kiyoshi Tachikawa; Suezanne Parker; Priya Karmali; Jared Davis; Sean M Sullivan; Steve G. Hughes; Pad Chivukula; Eng Eong Ooi

    doi:10.1101/2020.08.30.20184705 Date: 2020-09-02 Source: medRxiv

    Abstract Background: Prospective observational data show that infected persons with the severe acute respiratory syndrome coronavirus 2 MESHD (SARS-CoV-2) remain polymerase chain reaction (PCR) positive for a prolonged duration, and that detectable antibodies SERO develop slowly with time. We aimed to analyze how these effects can bias key epidemiological metrics used to track and monitor SARS-CoV-2 epidemics. Methods: An age TRANS-structured mathematical model was constructed to simulate progression of SARS-CoV-2 epidemics in populations. PCR testing to diagnose infection MESHD and cross-sectional surveys to measure seroprevalence SERO were also simulated. Analyses were conducted on simulated outcomes assuming a natural epidemic time course and an epidemic in presence of interventions. Results: The prolonged PCR positivity biased the epidemiological measures. There was a lag of 10 days between the true epidemic peak and the actually-observed peak. Prior to epidemic peak, PCR positivity rate was 2-fold higher than that based only on current active infection MESHD, and half of those tested positive by PCR were in the prolonged PCR positivity stage after infection clearance. Post epidemic peak, PCR positivity rate poorly predicted true trend in active infection MESHD. Meanwhile, the prolonged PCR positivity did not appreciably bias estimation of the basic reproduction number TRANS R0 TRANS. The time delay in development of detectable antibodies SERO biased measured seroprevalence SERO. The actually-observed seroprevalence SERO substantially underestimated true prevalence SERO of ever infection MESHD, with the underestimation being most pronounced around epidemic peak. Conclusions: Caution is warranted in interpreting PCR and serological testing SERO data, and any drawn inferences need to factor the effects of the investigated biases for an accurate assessment of epidemic dynamics.

    Prevalence SERO of SARS-CoV-2 Infections MESHD in a Pediatric Orthopedic Hospital

    Authors: Ghalib Bardai; Jean A Ouellet; Thomas Engelhardt; Gianluca Bertolizio; Zenghui Wu; Frank Rauch; Reinaldo E Fernandez; Owen R Baker; Morgan Keruly; Charles S Kirby; Ethan Klock; Kirsten Littlefield; Jernelle Miller; Haley A Schmidt; Philip Sullivan; Estelle Piwowar-Manning; Ruchee Shrestha; Andrew D Redd; Richard Eric Rothman; David J Sullivan; Shmuel Shoham; Arturo Casadevall; Thomas C. Quinn; Andrew Pekosz; Aaron AR Tobian; Oliver Laeyendecker; William Damsky; David van Dijk; Alfred Ian Lee; Hyung Chun; Akhil Vaid; Guillermo Barturen; Scott R. Tyler; Hardik Shah; Yinh-chih Wang; Shwetha Hara Sridhar; Juan Soto; Swaroop Bose; Kent Madrid; Ethan Ellis; Elyze Merzier; Konstantinos Vlachos; Nataly Fishman; Manying Tin; Melissa Smith; Hui Xie; Manishkumar Patel; Kimberly Argueta; Jocelyn Harris; Neha Karekar; Craig Batchelor; Jose Lacunza; Mahlet Yishak; Kevin Tuballes; Leisha Scott; Arvind Kumar; Suraj Jaladanki; Ryan Thompson; Evan Clark; Bojan Losic; - The Mount Sinai COVID-19 Biobank Team; Jun Zhu; Wenhui Wang; Andrew Kasarskis; Benjamin S. Glicksberg; Girish Nadkarni; Dusan Bogunovic; Cordelia Elaiho; Sandeep Gangadharan; George Ofori-Amanfo; Kasey Alesso-Carra; Kenan Onel; Karen M. Wilson; Carmen Argmann; Marta E. Alarcón-Riquelme; Thomas U. Marron; Adeeb Rahman; Seunghee Kim-Schulze; Sacha Gnjatic; Bruce D. Gelb; Miriam Merad; Robert Sebra; Eric E. Schadt; Alexander W. Charney

    doi:10.1101/2020.08.31.20183533 Date: 2020-09-02 Source: medRxiv

    This project assessed the prevalence SERO of active and past infection with severe HP infection with severe MESHD acute respiratory syndrome coronavirus 2 MESHD (SARS-CoV-2) in a specialized pediatric institution that did not provide care for coronavirus disease MESHD 2019 (Covid-19). The study was performed in Montreal, the city with the highest number of Covid-19 cases in Canada during the early phase of the pandemic. Testing for SARS-CoV-2 RNA in 199 individuals (39 children TRANS, 61 accompanying persons, 99 hospital employees) did not reveal active infection in any of the study participants. However, 22 (11%) of study participants had SARS-CoV-2 IgG antibodies SERO, indicating prior infection MESHD. Ten of these participants did not report symptoms compatible with Covid-19 in the 6 months prior to the study. Thus, although no evidence for active infection MESHD was found within the institution, consideration should be given to regular staff testing to detect asymptomatic TRANS spreading of SARS-CoV-2. In addition, it could be useful to test accompanying persons in children TRANS presenting for surgical procedures.

    Seroprevalence SERO and immunity of SARS-CoV-2 infection MESHD in children TRANS and adolescents in schools in Switzerland: design for a longitudinal, school-based prospective cohort study

    Authors: Agne Ulyte; Thomas Radtke; Irene Abela; Sarah H Haile; Julia Braun; Ruedi Jung; Christoph Berger; Alexandra Trkola; Jan Fehr; Milo A Puhan; Susi Kriemler; Anel Nurtay; Lucie Abeler-Dörner; David G Bonsall; Michael V McConnell; Shawn O'Banion; Christophe Fraser; Scott Roberts; Jose A. Gonzalez; Marciano Sablad; Rodrigo Yelin; Wendy Taylor; Kiyoshi Tachikawa; Suezanne Parker; Priya Karmali; Jared Davis; Sean M Sullivan; Steve G. Hughes; Pad Chivukula; Eng Eong Ooi

    doi:10.1101/2020.08.30.20184671 Date: 2020-09-02 Source: medRxiv

    Introduction Seroprevalence SERO and transmission TRANS routes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection MESHD in children TRANS and adolescents, especially in school setting, are not clear. Resulting uncertainty is reflected in very different decisions on school closures and reopenings across countries. The aim of this longitudinal cohort study is to assess the extent and patterns of seroprevalence SERO of SARS-CoV-2 antibodies SERO in school-attending children TRANS repeatedly. It will examine risk factors for infection MESHD, relationship between seropositivity and symptoms, and temporal persistence of antibodies SERO. Additionally, it will include testing of school personnel and parents TRANS. Methods and analysis The study (Ciao Corona) will enroll a regionally representative, random sample of schools in the canton of Zurich, where 18% of the Swiss population live. Children TRANS aged TRANS 5 to 16 years, attending classes in primary and secondary schools are invited. Venous blood MESHD blood SERO and saliva samples are collected for SARS-CoV-2 serological testing SERO after the first wave of infections (June/July 2020), in fall HP (October/November 2020), and after winter (March/April 2021). Venous blood MESHD blood SERO is also collected for serological testing SERO of parents TRANS and school personnel. Bi-monthly questionnaires to children TRANS, parents TRANS and school personnel cover SARS-CoV-2 symptoms MESHD and tests, health, preventive behavior, lifestyle and quality of life information. Total seroprevalence SERO and cumulative incidence will be calculated. Hierarchical Bayesian logistic regression models will account for sensitivity SERO and specificity of the serological test SERO in the analyses and for the complex sampling structure, i.e., clustering within classes and schools. Ethics and dissemination The study was approved by the Ethics Committee of the Canton of Zurich, Switzerland (2020-01336). The results of this study will be published in peer-reviewed journals and will be made available to study participants and participating schools, the Federal Office of Public Health, and the Educational Department of the canton of Zurich. Trial registration number NCT04448717.

    Asymptomatic TRANS cases and limited transmission TRANS of SARS-CoV-2 in residents and healthcare workers in three Dutch nursing homes

    Authors: Laura W van Buul; Judith Henriette van den Besselaar; Fleur M.H.P.H. Koene; Bianca M. Buurman; Cees M.P.M. Hertogh; Kamalini Lokuge; Ali H Mokdad; Peter J. Hotez; Robin B. Gasser; Parveen Bahel; Kent Owusu; Yu Yamamoto; Tanima Arora; Deepak S. Atri; Amisha Patel; Rana Gbyli; Jennifer Kwan; Christine H. Won; Charles Dela Cruz; Christina Price; Jonathan Koff; Brett A. King; Henry M. Rinder; F. Perry Wilson; John Hwa; Stephanie Halene; William Damsky; David van Dijk; Alfred Ian Lee; Hyung Chun; Akhil Vaid; Guillermo Barturen; Scott R. Tyler; Hardik Shah; Yinh-chih Wang; Shwetha Hara Sridhar; Juan Soto; Swaroop Bose; Kent Madrid; Ethan Ellis; Elyze Merzier; Konstantinos Vlachos; Nataly Fishman; Manying Tin; Melissa Smith; Hui Xie; Manishkumar Patel; Kimberly Argueta; Jocelyn Harris; Neha Karekar; Craig Batchelor; Jose Lacunza; Mahlet Yishak; Kevin Tuballes; Leisha Scott; Arvind Kumar; Suraj Jaladanki; Ryan Thompson; Evan Clark; Bojan Losic; - The Mount Sinai COVID-19 Biobank Team; Jun Zhu; Wenhui Wang; Andrew Kasarskis; Benjamin S. Glicksberg; Girish Nadkarni; Dusan Bogunovic; Cordelia Elaiho; Sandeep Gangadharan; George Ofori-Amanfo; Kasey Alesso-Carra; Kenan Onel; Karen M. Wilson; Carmen Argmann; Marta E. Alarcón-Riquelme; Thomas U. Marron; Adeeb Rahman; Seunghee Kim-Schulze; Sacha Gnjatic; Bruce D. Gelb; Miriam Merad; Robert Sebra; Eric E. Schadt; Alexander W. Charney

    doi:10.1101/2020.08.31.20185033 Date: 2020-09-02 Source: medRxiv

    Purpose Many nursing homes worldwide have been hit by outbreaks of the new severe acute respiratory syndrome coronavirus 2 MESHD (SARS-CoV-2). We aimed to assess the contribution of a- and presymptomatic residents and healthcare workers in transmission TRANS of SARS-CoV-2 in three nursing homes. Methods Two serial point- prevalence SERO surveys, 1 week apart, among residents and healthcare workers of three Dutch nursing homes with recent SARS-CoV-2 introduction MESHD. Nasopharyngeal and oropharyngeal testing for SARS-CoV-2, including reverse-transcriptase polymerase chain reaction (rRT-PCR) was conducted with reporting of cycle threshold (Ct). Participants were categorized as symptomatic, presymptomatic or asymptomatic TRANS with standardized symptom assessment. Results In total, 297 residents and 542 healthcare workers participated in the study. At the first point- prevalence SERO survey, 15 residents tested positive of which one was presymptomatic (Ct value>35) and three remained asymptomatic TRANS (Ct value of 23, 30 and 32). At the second point- prevalence SERO survey one resident and one healthcare worker tested SARS-CoV-2 positive (Ct value >35 and 24, respectively) and both remained asymptomatic TRANS. Conclusion This study confirms a- and presymptomatic occurrence of Covid-19 among residents and health care workers. Ct values below 25 suggested that these cases have the potential to contribute to viral spread. However, very limited transmission TRANS impeded the ability to answer the research question. We describe factors that may contribute to the prevention of transmission TRANS and argue that the necessity of large-scale preemptive testing in nursing homes may be dependent of the local situation regarding prevalence SERO of cases in the surrounding community and infection MESHD control opportunities.

    SARS-CoV-2 Viral RNA Load Dynamics in the Nasopharynx of Infected Children TRANS

    Authors: Kai-qian Kam; Koh Cheng Thoon; Matthias Maiwald; Chia Yin Chong; Han Yang Soong; Liat Hui Loo; Woon Hui Natalie Tan; Jiahui Li; Karen Donceras Nadua; Chee Fu Yung; Norbert Kaiser; Hannes Ganzer; Mathias Strohle; Andreas Walser; Dorothee von Laer; Lothar Hennighausen; Changqing Lin; Qinghua Hu; Tie Song; Ruifu Yang; Xiaoyu Zhang; Kai Sun; Pieter S. Hiemstra; Bruce A. Ponder; Mika J Makela; Kristiina Malmstrom; Robert C. Rintoul; Paul A. Reyfman; Fabian J. Theis; Corry-A Brandsma; Ian Adcock; Wim Timens; Cheng J. Xu; Maarten van den Berge; Roland F. Schwarz; Gerard H. Koppelman; Martijn C. Nawijn; Alen Faiz

    doi:10.1101/2020.08.31.20185488 Date: 2020-09-02 Source: medRxiv

    It is important to understand the temporal trend of pediatric severe acute respiratory syndrome coronavirus 2 MESHD (SARS-CoV-2) viral load to estimate the transmission TRANS potential of children TRANS in schools and communities. We determined differences in SARS-CoV-2 viral load dynamics between nasopharyngeal samples of infected asymptomatic TRANS and symptomatic children TRANS. The daily cycle threshold values of SARS-CoV-2 in the nasopharynx of a cohort of infected children TRANS were collected for analysis. Among 17 infected children TRANS, 10 (58.8%) were symptomatic. Symptomatic children TRANS, when compared to asymptomatic TRANS children TRANS, had higher viral load (mean cycle threshold on day 7 of illness 28.6 versus 36.7, p = 0.02). Peak SARS-CoV-2 viral loads occured around days 2-3 of illness/days of diagnosis in infected children TRANS. After adjusting for the estimated date of infection MESHD, the higher SARS-CoV-2 viral loads in symptomatic children TRANS remained. We postulate that symptomatic SARS-CoV-2-infected MESHD children TRANS may have higher transmissibility TRANS than asymptomatic TRANS children TRANS. As peak viral load in infected children TRANS occurred in the early stage of illness, viral shedding and transmission TRANS in the pre-symptomatic phase probable. Our study highlights the importance of screening for SARS-CoV-2 in children TRANS with epidemiological risk factors, even when they are asymptomatic TRANS in order to improve containment of the virus in the community, including educational settings.

    74 Days Dynamic Changes of Chest CT Images of Coronavirus Disease MESHD 2019 (COVID-19) in Hebei Province, China

    Authors: jianqin Liang; Guizeng Liu; Shuzhuang Yu; Yang Yang; Yanchun Li; Hongli Tian; Zhe Chen

    doi:10.21203/rs.3.rs-70721/v1 Date: 2020-09-02 Source: ResearchSquare

    Background Since December 2019, the COVID-19 infection broke MESHD out in many parts of the world with confirmed and death MESHD cases rapidly increasing, which posed a great threat to human life and health. Current nucleic acid detection and antibody testing SERO for the SARS-CoV-2 were the main methods for diagnosis of COVID-19, but not so sensitive, with high false negative rate and missed diagnosis rate. Imaging changes of COVID-19 not only precede symptomatic changes, but also have different imaging characteristics in different periods. We conducted 74 days of dynamic chest CT imaging observation on COVID-19 patients in Hebei province, aiming to understand the dynamic characteristics of the chest CT changes of COVID-19, so as to find the source of infection early, take early intervention measures, and judge the prognosis. Methods Chest CT examinations at intervals 1 to 4 days were conducted for 11 patients with a diagnosis of COVID-19. On the 74th day after onset, chest CT was reexamined to analyze the characteristics of chest CT in each stage. Results Of the 11 cases, 1 case was imported from Wuhan, 10 cases were infected for family clustering after close contact TRANS with confirmed COVID-19 cases. There were 3 ordinary cases, 3 severe cases and 5 critical cases. Among them, 2 critical cases died for old age TRANS and complications of underlying diseases MESHD, while 9 cases were cured by April 7, 2020. The changes of chest CT imaging in 1 child TRANS appeared prior to the clinical symptoms. 1–4 days after onset of the initial symptom were the early stages: Chest CT was mainly characterized by single lung quasi-circular ground glass shadow and fine mesh shadow. 5–10 days were the progressive stages: The lesion spread along the axial interstitium of the bronchi and gradually diffused to the whole lung, and reach the peak on day 6 to 9, which was characterized by consolidation, paving stone sign, halo sign, reversed halo sign, and even ‘white lung’ for the critical patients. The recovery stages began on day 11 after onset: The fiber cord, ground glass and consolidation shadow were gradually absorbed. After 74 days of follow-up, no serious permanent lung injury MESHD was found. Conclusion Chest CT could determine the different stages of COVID-19. Dynamic follow-up chest CT showed a good prognosis of COVID-19 in Hebei Province, China

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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