Corpus overview


Overview

MeSH Disease

Human Phenotype

Pneumonia (4)

Myalgia (3)

Fatigue (3)

Stroke (2)

Fever (2)


Transmission

Seroprevalence
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    Abnormal Upregulation of Cardiovascular Disease MESHD Biomarker PLA2G7 Induced by Proinflammatory Macrophages in COVID-19 patients

    Authors: Yang LI; Yongzhong JIANG; Yi ZHANG; Naizhe LI; Qiangling YIN; Linlin LIU; Xin LV; Yan LIU; Aqian LI; Bin FANG; Jiajia LI; Hengping YE; Gang YANG; Xiaoxian CUI; Yang LIU; Yuanyuan QU; Chuan LI; Jiandong LI; Dexin LI; Shiwen WANG; Zhongtao GAI; Faxian ZHAN; Mifang LIANG; Scott Hensley

    doi:10.1101/2020.08.16.20175505 Date: 2020-08-18 Source: medRxiv

    BACKGROUND. Coronavirus disease MESHD 2019 (COVID-19) triggers distinct patterns of pneumonia HP pneumonia MESHD progression with multiorgan disease, calling for cell- and/or tissue-type specific host injury markers. METHODS. An integrated hypothesis-free single biomarker analysis framework was performed on nasal swabs (n=484) from patients with COVID-19 in GSE152075. The origin of candidate biomarker was assessed in single-cell RNA data (GSE145926). The candidate biomarker was validated in a cross-sectional cohort (n=564) at both nucletide and protein levels. RESULTS. Phospholipase A2 group VII (PLA2G7) was identified as a candidate biomarker in COVID-19. PLA2G7 was predominantly expressed by proinflammatory macrophages in lungs emerging with progression of COVID-19. In the validation stage, PLA2G7 was found in patients with COVID-19 and pneumonia HP pneumonia MESHD, especially in severe pneumonia HP pneumonia MESHD, rather than patients suffered mild H1N1 influenza infection MESHD. The positive rates of PLA2G7 ranging from 29.37% to 100.00% were positively correlated with not only viral loads in patients with COVID-19 but also severity of pneumonia HP pneumonia MESHD in non COVID-19 patients. Although Ct values of PLA2G7 in severe pneumonia HP pneumonia MESHD was siginificantly lower than that in moderate pneumonia HP pneumonia MESHD (P=7.2e-11), no differences were observed in moderate pneumonia HP pneumonia MESHD with COVID-19 between severe pneumonia HP pneumonia MESHD without COVID-19 (P=0.81). Serum SERO protein levels of PLA2G7, also known as lipoprotein-associated phospholipase A2 (Lp-PLA2), were further found to be elevated and beyond the upper limit of normal in patients with COVID-19, especially among the re-positive patients. CONCLUSIONS. We firstly identified and validated PLA2G7, a biomarker for cardiovascular diseases MESHD ( CVDs MESHD), was abnormally enhanced in COVID-19 patients at both nucletide and protein aspects. These findings provided indications into the prevalence SERO of cardiovascular involvements seen in COVID-19 patients. PLA2G7 could be a hallmark of COVID-19 for monitoring disease progress and therapeutic response.

    Clinical characteristics and outcome of influenza virus infection MESHD among adults TRANS hospitalized with severe COVID-19: A retrospective cohort study from Wuhan, China

    Authors: Xunliang Tong; Xiaomao Xu; Guoyue Lv; He Wang; Anqi Cheng; Dingyi Wang; Yue Zhang; Yanming Li

    doi:10.21203/rs.3.rs-50577/v1 Date: 2020-07-29 Source: ResearchSquare

    Background Coronavirus disease MESHD 2019 (COVID-19) is an emerging infection disease MESHD that rapidly spreads worldwide. Co-infection MESHD may occur in some cases of COVID-19, like influenza virus and so on. Clinical features and outcomes of severe COVID-19 patients with co-infection MESHD of influenza virus need to be noticed.Methods Retrospective cohort study was performed and total of 140 patients with severe COVID-19 was enrolled in designated wards of Sino-French New City Branch of Tongji Hospital between Feb 8th and March 15th in Wuhan, Hubei province, China. The demographic, clinical features, laboratory indices, treatment and outcomes of these patients were collected and analyzed.Results Of 140 severe COVID-19 hospitalized patients, 73 patients were with median age TRANS of 66 years old with identification of influenza virus IgM-positive and 67 patients were with median age TRANS of 62 years old in influenza virus IgM-negative. Nearly half of severe COVID-19 patients in this research are male TRANS. Majority of the severe COVID-19 patients had chronic underlying conditions. Wheeze HP was the clinical feature of severe COVID-19 patients with influenza IgM-positive (26.4% vs 9.0%, P = 0.008). On contrary, fatigue HP fatigue MESHD or myalgia HP myalgia MESHD was the feature of the COVID-19 patients without IgM-positive (38.4% vs 58.2%, P = 0.019). Increased levels of ferritin and prolonging APTT were showed in severe COVID-19 patients without influenza IgM-positive compared with patients in other group with significant differences. Death rate in the group of severe COVID-19 patients with influenza IgM-positive is lower than it in other group with significant differences (4.1% vs 14.9%, P = 0.040). In univariate regression analysis, several factors were associated with higher risk of death MESHD, which included LDH, troponin, NT-proBNP, D-dimer, PT, APTT, lymphocytes, platelet and eGFR. However, influenza virus IgM positive was associated with lower risk of death.Conclusions Characteristic features of patients with severe COVID-19 with influenza virus IgM-positive were described. Co-infection MESHD may occur during the pandemic of COVID-19, and we need to improve our understanding in order to confront this crisis in the future.

    Targeted Immunosuppression Distinguishes COVID-19 from Influenza in Moderate and Severe Disease MESHD

    Authors: Philip A Mudd; Jeremy Chase Crawford; Jackson S Turner; Aisha Souquette; Daniel Reynolds; Diane Bender; James P. Bosanquet; Nitin J. Anand; David A. Striker; R. Scott Martin; Adrianus C. M. Boon; Stacey L. House; Kenneth E. Remy; Richard S. Hotchkiss; Rachel M. Presti; Jane A. OHalloran; William G. Powderly; Paul G. Thomas; Ali H. Ellebedy

    doi:10.1101/2020.05.28.20115667 Date: 2020-05-30 Source: medRxiv

    Coronavirus disease 2019 (COVID-19) is characterized by a high incidence of acute respiratory failure MESHD respiratory failure HP. The underlying immunopathology of that failure and how it compares to other causes of severe respiratory distress HP, such as influenza virus infection MESHD, are not fully understood. Here we addressed this by developing a prospective observational cohort of COVID-19 and influenza subjects with varying degrees of disease severity and assessing the quality and magnitude of their immune responses at the cellular and protein level. Additionally, we performed single-cell RNA transcriptional profiling of peripheral blood SERO mononuclear cells from select subjects. The cohort consists of 79 COVID-19 subjects, 26 influenza subjects, and 15 control subjects, including 35 COVID-19 and 7 influenza subjects with acute respiratory failure HP respiratory failure MESHD. While COVID-19 subjects exhibited largely equivalent or greater activated lymphocyte counts compared to influenza subjects, they had fewer monocytes and lower surface HLA-class II expression on monocytes compared to influenza subjects and controls. At least two distinct immune profiles were observed by cytokine levels in severe COVID-19 patients: 3 of 71 patients were characterized by extreme inflammation MESHD, with greater than or equal to ~50% of the 35 cytokines measured greater than 2 standard deviations from the mean level of other severe patients (both influenza and COVID-19); the other immune profile, which characterized 68 of 71 subjects, had a mixed inflammatory signature, where 28 of 35 cytokines in COVID-19 patients had lower mean cytokine levels, though not all were statistically significant. Only 2 cytokines were higher in COVID-19 subjects compared to influenza subjects (IL-6 and IL-8). Influenza and COVID-19 patients could be distinguished statistically based on cytokine module expression, particularly after controlling for the significant effects of age TRANS on cytokine expression, but again with lower levels of most cytokines in COVID-19 subjects. Further, high circulating levels of IL-1RA and IL-6 were associated with increased odds of intubation in the combined influenza and COVID-19 cohort [OR = 3.93 and 4.30, respectively] as well as among only COVID-19 patients. Single cell transcriptional profiling of COVID-19 and influenza subjects with respiratory failure HP respiratory failure MESHD identified profound suppression in type I and type II interferon signaling in COVID-19 patients across multiple clusters. In contrast, COVID-19 cell clusters were enriched for alterations in metabolic, stress, and apoptotic pathways. These alterations were consistent with an increased glucocorticoid response in COVID-19 patients compared to influenza. When considered across the spectrum of innate and adaptive immune profiles, the immune pathologies underlying severe influenza and COVID-19 are substantially distinct. The majority of COVID-19 patients with acute respiratory failure MESHD respiratory failure HP do not have a cytokine storm phenotype but instead exhibit profound type I and type II IFN immunosuppression when compared to patients with acute influenza. Upregulation of a small number of inflammatory mediators, including IL-6, predicts acute respiratory failure HP respiratory failure MESHD in both COVID-19 and influenza patients.

    Stroke HP Stroke MESHD as a an initial presentation of  SARS-COV2 infection MESHD: a brief report

    Authors: maria buccafusca; massimo autunno; masina cotroneo; antonio giovanni versace; giuseppe nunnari

    doi:10.21203/rs.3.rs-32473/v1 Date: 2020-05-29 Source: ResearchSquare

    The novel Coronavirus 19 infection spread rapidly from Wuhan, Hubei Province – China, to the worldwide, becoming a pandemic. The infection does not cause only flu-like syndrome MESHD ( fever HP fever MESHD, dry cough and shortness of breath MESHD) and respiratory distress HP of varying severity but also affects the kidneys, the heart, the nervous system and the circulatory apparatus, causing thromboembolic MESHD events. Usually these problems occur in patients with severe respiratory failure HP respiratory failure MESHD admitted to Intensive Care Unit and with pre-existing comorbidities.We report the case of a patient without Covid symptoms who had thrombotic stroke MESHD stroke HP as the presenting features of Coronavirus infection MESHD.

    Computed Tomography and Clinical Features Differentiating Coronavirus Disease 2019 from Seasonal Influenza Pneumonia HP

    Authors: Shuang Zhao; Zixing Huang; Hanjiang Zeng; Zhixia Chen; Fengming Luo; Chongwei Zhang; Bin Song

    doi:10.21203/rs.3.rs-31186/v1 Date: 2020-05-23 Source: ResearchSquare

    Objectives: To investigate computed tomography (CT) and clinical features could help differentiate coronavirus disease MESHD 2019 (COVID-19) from seasonal influenza pneumonia MESHD pneumonia HP.Methods: We retrospectively evaluated the clinical features and chest CT findings of Chinese patients with COVID-19 and seasonal influenza pneumonia MESHD pneumonia HP treated during the same period. Results: The 24 patients with COVID-19 (mean age TRANS, 41 years; 13 men) and 79 patients with seasonal influenza pneumonia MESHD pneumonia HP (mean age TRANS, 41 years; 50 men) differed significantly in mean temperature, respiratory rate, and systolic blood SERO pressure; in central-peripheral, superior-inferior, and anterior-posterior distribution but not lateral distribution of pulmonary lesions MESHD; and patchy ground-glass opacity (GGO), GGO nodules, vascular enlargement MESHD in GGO, air bronchogram, bronchiolectasis HP in GGO or consolidation, interlobular septal thickening, and crazy-paving pattern. Separate regression models were developed with clinical features, CT features (including anatomical distributions), and a combined model informed by the first two. The combined model had the best diagnostic performance SERO for identifying COVID-19: a cut-off value of 0.38 was 74% sensitive and 100% specific and had an area under the receiver operating characteristics curve of 0.94. This model was based on sputum production, vascular enlargement MESHD in GGO, and central-peripheral distribution (random vs subpleural). Conclusions: The combination of sputum production, vascular enlargement MESHD in GGO, and central-peripheral distribution should be extremely helpful in the differential diagnosis of COVID-19. 

    Risk of Ischemic Stroke HP Ischemic Stroke MESHD in Patients with Covid-19 versus Patients with Influenza

    Authors: Alexander E. Merkler; Neal S. Parikh; Saad Mir; Ajay Gupta; Hooman Kamel; Eaton Lin; Joshua Lantos; Edward J. Schenck; Parag Goyal; Samuel S. Bruce; Joshua Kahan; Kelsey N. Lansdale; Natalie M. LeMoss; Santosh B. Murthy; Philip E. Stieg; Matthew E. Fink; Costantino Iadecola; Alan Z. Segal; Thomas R. Campion; Ivan Diaz; Cenai Zhang; Babak B. Navi

    doi:10.1101/2020.05.18.20105494 Date: 2020-05-21 Source: medRxiv

    Importance: Case series without control groups suggest that Covid-19 may cause ischemic stroke HP ischemic stroke MESHD, but whether Covid-19 is associated with a higher risk of ischemic stroke HP ischemic stroke MESHD than would be expected from a viral respiratory infection MESHD is uncertain. Objective: To compare the rate of ischemic stroke HP ischemic stroke MESHD stroke MESHD between patients with Covid-19 and patients with influenza, a respiratory viral illness previously linked to stroke HP stroke MESHD. Design: A retrospective cohort study. Setting: Two academic hospitals in New York City. Participants: We included adult TRANS patients with emergency department visits or hospitalizations with Covid-19 from March 4, 2020 through May 2, 2020. Our comparison cohort included adult TRANS patients with emergency department visits or hospitalizations with influenza A or B from January 1, 2016 through May 31, 2018 (calendar years spanning moderate and severe influenza seasons). Exposures: Covid-19 infection confirmed TRANS by evidence of severe acute respiratory syndrome coronavirus 2 MESHD (SARS-CoV-2) in the nasopharynx by polymerase chain reaction, and laboratory-confirmed influenza A or B. Main Outcomes and Measures: A panel of neurologists adjudicated the primary outcome of acute ischemic stroke MESHD ischemic stroke HP and its clinical characteristics, etiological mechanisms, and outcomes. We used logistic regression to compare the proportion of Covid-19 patients with ischemic stroke HP ischemic stroke MESHD versus the proportion among patients with influenza. Results: Among 2,132 patients with emergency department visits or hospitalizations with Covid-19, 31 patients (1.5%; 95% confidence interval [CI], 1.0%-2.1%) had an acute ischemic stroke HP ischemic stroke MESHD. The median age TRANS of patients with stroke HP stroke MESHD was 69 years (interquartile range, 66-78) and 58% were men. Stroke HP Stroke MESHD was the reason for hospital presentation in 8 (26%) cases. For our comparison cohort, we identified 1,516 patients with influenza, of whom 0.2% (95% CI, 0.0-0.6%) had an acute ischemic stroke HP ischemic stroke MESHD. After adjustment for age TRANS, sex, and race, the likelihood of stroke HP stroke MESHD was significantly higher with Covid-19 than with influenza infection MESHD (odds ratio, 7.5; 95% CI, 2.3-24.9). Conclusions and Relevance: Approximately 1.5% of patients with emergency department visits or hospitalizations with Covid-19 experienced ischemic stroke HP ischemic stroke MESHD, a rate 7.5-fold higher than in patients with influenza. Future studies should investigate the thrombotic MESHD mechanisms in Covid-19 in order to determine optimal strategies to prevent disabling complications like ischemic stroke HP ischemic stroke MESHD.

    Comparison of Hospitalized Patients with Severe Pneumonia MESHD Pneumonia HP Caused by COVID-19 and Highly Pathogenic Avian Influenza (H7N9): A Retrospective Study from A Designated Hospital

    Authors: Binbin Gu; Lin Yao; XinYun Zhu; Pei-jun Tang; Cheng Chen

    doi:10.21203/rs.3.rs-28119/v1 Date: 2020-05-08 Source: ResearchSquare

    Background Considerable attention has been focused on clinical features of Coronavirus Disease MESHD 2019 (COVID-19), it is also important for clinicians to differentiate it from influenza virus infections MESHD.Methods The clinical data of 23 cases of H7N9 and 23 cases of COVID-19 with severe pneumonia HP pneumonia MESHD were collected. The comparisons were performed with the t test, Mann-Whitney U test, Fisher exact test or the chi-squared test, and multivariable logistic regression analysis.Results All of the cases were under the circumstance of sufficient medical staff and medical supplies. The rate of coexisting disease was lower in the severe COVID-19 group than in the severe H7N9 group (p < 0.05). Radiologically, severe COVID-19 patients had less consolidation and pleural effusion HP pleural effusion MESHD, but more crazy-paving pattern than severe H7N9 patients (p < 0.05). Clinically, compared to severe H7N9, severe COVID-19 patients were more inclined to surfer to relative better disease severity score, less secondary bacterial infection MESHD, a shorter time to beginning absorption on CT, but a longer duration of viral shedding from the admission (p < 0.05). Although more severe H7N9 patients needed non-invasive respiratory support, these two groups ultimately yielded comparable mortality. Based on multiple logistic regression analysis, severe COVID-19 infection MESHD was associated with a lower risk of the presence of severe ARDS (OR 0.964, 95% [CI] 0.931–0.998, p = 0.040), but exhibited longer duration of viral shedding (OR 0.734, 95% [CI] 0.550–0.980, p = 0.036) than severe H7N9 infection MESHD.Conclusion Although the conditions of severe H7N9 patients seemed to be more critical than those of severe COVID-19 patients, the relatively lower mortality of these two severe cases is to be expected in context of sufficient medical supplies.

    Clinical characteristics and outcome of influenza virus infection MESHD among adults TRANS hospitalized with severe COVID-19: A retrospective cohort study from Wuhan, China

    Authors: Xunliang Tong; Xiaomao Xu; Guoyue Lv; He Wang; Anqi Cheng; Dingyi Wang; Yanming Li

    doi:10.21203/rs.3.rs-27484/v1 Date: 2020-05-08 Source: ResearchSquare

    Background Coronavirus disease MESHD 2019 (COVID-19) is an emerging infection disease MESHD that rapidly spreads worldwide. Clinical features and outcomes of severe COVID-19 patients with influenza virus IgM positive during the influenza season need to be described.Methods Retrospective cohort study of 140 patients with severe COVID-19 hospitalized in designated wards of Sino-French New City Branch of Tongji Hospital between Feb 8th and March 15th in Wuhan, Hubei province, China. The demographic, clinical feature, laboratory, treatment and outcome were collected and analyzed.Results Of 140 severe COVID-19 hospitalized patients, 73 patients were with median age TRANS of 66 years old with identification of influenza virus IgM-positive and 67 patients were with median age TRANS of 62 years old in influenza virus IgM-negative group. Nearly half of severe COVID-19 patients in this research are male TRANS. Majority of the severe COVID-19 patients had chronic underlying conditions. Wheeze HP was the clinical feature of severe COVID-19 patients with influenza IgM-positive (26.4% vs 9.0%, P = 0.008). On contrary, fatigue HP fatigue MESHD or myalgia HP myalgia MESHD was the feature of the COVID-19 patients without IgM-positive (38.4% vs 58.2%, P = 0.019). In laboratory examination, increased levels of ferritin and prolonging APTT were showed in severe COVID-19 patients without influenza IgM-positive compared with patients in the other group with significant differences. Death rate in the group of severe COVID-19 patients with influenza IgM-positive is higher than it is in other group with significant differences (14.9% vs 4.1%, P = 0.040). In univariate regression analysis, several factors were associated with higher risk of death MESHD, which included LDH, troponin, NT-proBNP, D-dimer, PT, APTT, lymphocytes, platelet and eGFR. However, influenza virus IgM positive was associated with lower risk of death MESHD. Multivariate Regression analysis showed that troponin and lymphocyte were independently associated with higher risk of death MESHD.Conclusion The characteristics of patients hospitalized with severe COVID-19 with identification of influenza virus IgM-positive were described. It hints proof of seasonal influenza which may overlap with COVID-19 and may cause a crisis we could confront in the future.

    Neurological Complications of Pandemic COVID-19: What Have We Got So Far?

    Authors: Isabelle Pastor Bandeira; Marco Antônio Machado Schlindwein; Leticia Caroline Breis; Jean Pierre Schatzmann Peron; Marcus Vinicius Magno Gonçalves

    id:10.20944/preprints202004.0304.v1 Date: 2020-04-17 Source: Preprints.org

    The recently emerged coronavirus named Severe Acute Respiratory Syndrome Coronavirus 2 MESHD (SARS- CoV-2) is the newest threat to human health. It has already infected more than half a million people worldwide, leading to a lot of deaths. Although it causes mild flu-like disease MESHD in most patients, lethality may increase to more than 20% in elderly TRANS subjects, especially those with comorbidities, like hypertension HP hypertension MESHD, diabetes MESHD or lung and cardiac disease MESHD, and the mechanisms are still elusive. Common symptoms at the onset TRANS of illness are fever HP fever MESHD, cough HP cough MESHD, myalgia HP myalgia MESHD or fatigue HP fatigue MESHD, headache HP headache MESHD, and diarrhea HP diarrhea MESHD or constipation HP. Interestingly, respiratory viruses have also placed themselves as relevant agents for CNS pathologies. Here we discuss several CNS related features, referred by several patients, especially at the beginning of the disease. Thus, we also discuss the possibility by which SARS-CoV-2 may affect the olfactive system of patients, either directly or indirectly.

    Improved deep learning model for differentiating novel coronavirus pneumonia MESHD pneumonia HP and influenza pneumonia MESHD pneumonia HP

    Authors: Min Zhou; Yong Chen; Dexiang Wang; Yanping Xu; Weiwu Yao; Jingwen Huang; Xiaoyan Jin; Zilai Pan; Jingwen Tan; Lan Wang; Yihan Xia; Longkuan Zou; Xin Xu; Jingqi Wei; Mingxin Guan; Jianxing Feng; Huan Zhang; Jieming Qu

    doi:10.1101/2020.03.24.20043117 Date: 2020-03-30 Source: medRxiv

    Background: Chest CT had high sensitivity SERO in diagnosing novel coronavirus pneumonia MESHD pneumonia HP (NCP) at early stage, giving it an advantage over nucleic acid detection in time of crisis. Deep learning was reported to discover intricate structures from clinical images and achieve expert-level performance SERO in medical image analysis. To develop and validate an integrated deep learning framework on chest CT images for auto-detection of NCP, particularly focusing on differentiating NCP from influenza pneumonia MESHD pneumonia HP ( IP MESHD). Methods: 35 confirmed NCP cases were consecutively enrolled as training set from 1138 suspected patients in three NCP designated hospitals together with 361 confirmed viral pneumonia HP pneumonia MESHD patients from center one including 156 IP MESHD patients, from May, 2015 to February, 2020. The external validation set enrolled 57 NCP patients and 50 IP MESHD patients from eight centers. Results: 96.6% of NCP lesions were larger than 1 cm and 76.8% were with intensity below -500 Hu, indicating less consolidation than IP MESHD lesions which had nodules ranging 5-10 mm. The classification schemes accurately distinguished NCP and IP MESHD lesions with area under the receiver operating characteristic curve (AUC) above 0.93. The Trinary scheme was more device-independent and consistent with specialists than the Plain scheme, which achieved a F1 score of 0.847, higher than the Plain scheme (0.774), specialists (0.785) and residents (0.644). Conclusions: Our study potentially provides an accurate early diagnosis tool on chest CT for NCP with high transferability, and shows high efficiency in differentiating NCP and IP MESHD, helping to reduce misdiagnosis and contain the pandemic transmission TRANS.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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