Corpus overview


MeSH Disease

Human Phenotype


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    Seroprevalence SERO of immunoglobulin M and G antibodies SERO against SARS-CoV-2 in ophthalmic patients

    Authors: shengjie li Sr.; yichao qiu; li tang; zhujian wang; wenjun cao; gezhi xu; xinghuai sun; Philippa C Matthews; Jienchi Dorward; Bernhard Graf; Florian Hitzenbichler; Frank Hanses; Hendrik Poeck; Marina Kreutz; Evelyn Orso; Ralph Burkhardt; Tanja Niedermair; Christoph Brochhausen; Andre Gessner; Bernd Salzberger; Matthias Mack; Christine Goffinet; Florian Kurth; Martin Witzenrath; Maria Theresa Völker; Sarah Dorothea Müller; Uwe Gerd Liebert; Naveed Ishaque; Lars Kaderali; Leif Erik Sander; Sven Laudi; Christian Drosten; Roland Eils; Christian Conrad; Ulf Landmesser; Irina Lehmann

    doi:10.1101/2020.09.22.20198465 Date: 2020-09-23 Source: medRxiv

    Using serological test SERO to estimate the prevalence SERO and infection potential of coronavirus disease MESHD 2019 in ocular diseases MESHD patients help understand the relationship between ocular diseases MESHD and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection MESHD. We conducted a cross-sectional study assaying the IgG and IgM antibodies SERO in 1331 individuals with ocular diseases MESHD by using a magnetic chemiluminescence enzyme immunoassay SERO kit, during the period from February 2020 to May 2020. In our study, the seroposivity in total ocular disease MESHD patients was 0.83% (11/1331). The patients with different ocular diseases MESHD including xerophthalmia MESHD, keratitis HP keratitis MESHD, conjunctival cyst, cataract HP cataract MESHD, glaucoma HP glaucoma MESHD, refractive error, strabismus HP and others had seroposivity of 2.94%, 12.5%, 25%, 4.41%, 2.63%, 1.6%, 2.22% and 0%, respectively. Among that, two ocular surface disease groups ( keratitis HP keratitis MESHD and conjunctival cyst) had higher seroprevalence SERO compared with others. All the participants were reverse transcription polymerase chain reaction negative for SARS-CoV-2 from throat swabs. Our study evaluated the seroprevalence SERO in patients with different ocular diseases MESHD, which will help us understand the relationship between ocular disease MESHD and SARS-CoV-2 infection MESHD. Furthermore, the serological test SERO for the presence of IgM and/or IgG antibodies SERO against SARS-CoV-2 might provide accurate estimate of the prevalence SERO of SARS-CoV-2 infection MESHD in patients with ocular diseases MESHD.

    Ocular manifestations and clinical characteristics of 534 cases of COVID-19 in China: A cross-sectional study

    Authors: Liwen Chen; Chaohua Deng; Xuhui Chen; Xian Zhang; Bo Chen; Huimin Yu; Yuanjun Qin; Ke Xiao; Hong Zhang; Xufang Sun

    doi:10.1101/2020.03.12.20034678 Date: 2020-03-16 Source: medRxiv

    Objective: The novel coronavirus disease MESHD (COVID-19) was first reported in Wuhan, China in December 2019 and is now pandemic all over the world. Previous study has reported several COVID-19 cases with conjunctivitis HP conjunctivitis MESHD. However, the complete profiling of COVID-19 related ocular symptoms and diseases MESHD are still missing. We aim to investigate the ocular manifestations and clinical characteristics of COVID-19 patients. Methods: A total of five hundred and thirty-four patients were recruited at Mobile Cabin Hospital and Tongji Hospital. We collected information on demographic characteristics, exposure history, ocular symptoms, systemic concomitant symptoms, eye drop medication, eye protections, radiologic findings, and SARS-CoV-2 detection in nasopharyngeal swabs by RT-PCR from questionnaires and electronic medical records. Results: The median age TRANS of patients was 40 and 50 years at Mobile Cabin Hospital and Tongji Hospital, respectively. Of 534 COVID-19 patients, 25 patients (4.68%) presented with conjunctival congestion and 3 patients had conjunctival congestion as the initial symptom. The average duration of conjunctival congestion was 4.9 {+/-} 2.6 days (mean [SD]), ranging from 2 to 10 days. Dry eye (112, 20.97%), blurred vision HP blurred vision MESHD (68, 12.73%), and foreign body sensation (63, 11.80%) ranked as the top three COVID-19 related ocular symptoms. Notably, a total of 332 COVID-19 patients (62%) had a hand-eye contact history. We also found that some COVID-19 patients had a history of eye disease MESHD, including conjunctivitis HP conjunctivitis MESHD (33, 6.18%), dry eye MESHD (24, 4.49%), keratitis HP keratitis MESHD (14, 2.62%), cataract HP cataract MESHD (9, 1.69%), and diabetic retinopathy MESHD retinopathy HP (5, 0.94%). In consistent with previous studies, the most common clinical symptoms were fever HP fever MESHD, cough HP cough MESHD, and fatigue HP fatigue MESHD. Patients, 60.5% in Mobile Cabin Hospital and 67.5% in Tongji Hospital, respectively were confirmed with positive SARS-CoV-2 detection. Conclusions: Conjunctival congestion was one of the COVID-19 related ocular symptoms, which may have clinical diagnostic significance. It is essential to provide eye-care equipment and strengthen education on eye protection, as dirty hand-eye contact might be a high risk factor of COVID-19. Further detailed and comprehensive ophthalmological guidance is needed for COVID-19 control.

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MeSH Disease
Human Phenotype

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