Corpus overview


MeSH Disease

Human Phenotype


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    Factors Associated with Disease Severity and Mortality among Patients with Coronavirus Disease MESHD 2019: A Systematic Review and Meta-Analysis

    Authors: Vignesh Chidambaram; Nyan Lynn Tun; Waqas Haque; Marie Gilbert Majella; Ranjith Kumar Sivakumar; Amudha Kumar; Angela Ting-Wei Hsu; Izza Ishak; Aqsha Nur; Samuel Ayeh; Emmanuella Salia; Ahsan Zil-E-Ali; Muhammad Saeed; Ayu Sarena; Bhavna Seth; Muzzammil Ahmadzada; Eman Haque; Pranita Neupane; Kuang-Heng Wang; Tzu-Miao Pu; Syed Ali; Muhammad Arshad; Lin Wang; Sheriza Baksh; Petros Karakousis; Panagis Galiatsatos

    doi:10.1101/2020.08.07.20166868 Date: 2020-08-13 Source: medRxiv

    Background: Understanding the factors associated with disease severity and mortality in Coronavirus disease MESHD (COVID19) is imperative to effectively triage patients. We performed a systematic review to determine the demographic, clinical, laboratory and radiological factors associated with severity and mortality in COVID-19. Methods: We searched PubMed, Embase and WHO database for English language articles from inception until May 8, 2020. We included Observational studies with direct comparison of clinical characteristics between a) patients who died and those who survived or b) patients with severe disease and those without severe disease. Data extraction and quality assessment were performed by two authors independently. Results: Among 15680 articles from the literature search, 109 articles were included in the analysis. The risk of mortality was higher in patients with increasing age TRANS, male TRANS gender TRANS (RR 1.45; 95%CI 1.23,1.71), dyspnea HP dyspnea MESHD (RR 2.55; 95%CI 1.88,2.46), diabetes MESHD (RR 1.59; 95%CI 1.41,1.78), hypertension HP hypertension MESHD (RR 1.90; 95%CI 1.69,2.15). Congestive heart failure HP Congestive heart failure MESHD (OR 4.76; 95%CI 1.34,16.97), hilar lymphadenopathy HP lymphadenopathy MESHD (OR 8.34; 95%CI 2.57,27.08), bilateral lung involvement (OR 4.86; 95%CI 3.19,7.39) and reticular pattern (OR 5.54; 95%CI 1.24,24.67) were associated with severe disease. Clinically relevant cut-offs for leukocytosis HP leukocytosis MESHD(>10.0 x109/L), lymphopenia HP lymphopenia MESHD(< 1.1 x109/L), elevated C-reactive protein(>100mg/L), LDH(>250U/L) and D-dimer(>1mg/L) had higher odds of severe disease and greater risk of mortality. Conclusion: Knowledge of the factors associated of disease severity and mortality identified in our study may assist in clinical decision-making and critical-care resource allocation for patients with COVID-19.

    Risk stratification of hospitalized COVID-19 patients through comparative studies of laboratory results with influenza

    Authors: Yang Mei; Samuel E Weinberg; Lihui Zhao; Chao Qi; Adam Frink; Amir Behdad; Peng Ji

    doi:10.1101/2020.05.18.20101709 Date: 2020-05-22 Source: medRxiv

    Background The outbreak of coronavirus disease MESHD 2019 (COVID-19) in December 2019 overlaps with the flu season. Methods We compared clinical and laboratory results from 719 influenza and 973 COVID-19 patients from January to April 2020. We compiled laboratory results from the first 14 days of the hospitalized patients using parameters that are most significantly different between COVID-19 and influenza and hierarchically clustered COVID-19 patients based on these data. The clinical outcomes were compared among different clusters. Results Temporal analyses of laboratory results revealed that compared to influenza, patients with COVID-19 exhibited a continued increase in the white blood SERO cell count, rapid decline of hemoglobin, more rapid increase in blood urea nitrogen HP blood SERO urea nitrogen (BUN) and D-dimer, and higher level of alanine transaminase, C-reactive protein, ferritin, and fibrinogen. Using these results, we sub-classified the COVID-19 patients into 5 clusters through a hierarchical clustering analysis. We then reviewed the medical record of these patients and risk stratified them based on the clinical outcomes. The cluster with the highest risk showed 27.8% fatality, 94% ICU admission, 94% intubation, and 28% discharge rates compared to 0%, 38%, 22%, and 88% in the lowest risk cluster, respectively. Patients in the highest risk cluster had leukocytosis HP leukocytosis MESHD including neutrophilia HP and monocytosis HP, severe anemia HP anemia MESHD, higher BUN, creatinine, D-dimer, alkaline phosphatase, bilirubin, and troponin. Conclusions There are significant differences in the clinical and laboratory courses between COVID-19 and influenza. Risk stratification in hospitalized COVID-19 patients using laboratory data could be useful to predict clinical outcomes and pathophysiology of these patients.

    Laboratory Findings of COVID-19 Infection are Conflicting in Different Age Groups TRANS and Pregnant Women: A Literature Review

    Authors: Sina Vakili; Amir Savardashtaki; Sheida jamalnia; Reza Tabrizi; Mohammad Hadi Nematollahi; Morteza Jafarinia; Hamed Akbari

    doi:10.1101/2020.04.24.20078568 Date: 2020-04-29 Source: medRxiv

    Coronavirus disease MESHD 2019 (COVID-19), a new type and rapidly spread viral pneumonia HP pneumonia MESHD, is now producing an outbreak of pandemic proportions. The clinical features and laboratory results of different age groups TRANS are different due to the general susceptibility of the disease. The laboratory findings of COVID-19 in pregnant women are also conflicting. Para-clinical investigations including laboratory tests and radiologic findings play an important role in early diagnosis and treatment monitoring of severe acute respiratory syndrome MESHD and coronavirus-2 MESHD (SARS-CoV-2). The majority of previous reports on the SARS-CoV-2 laboratory results were based on data from the general population and limited information is available based on age TRANS difference and pregnancy status. This review aimed to describe the COVID-19 laboratory findings in neonates, children TRANS, adults TRANS, elderly TRANS and pregnant women altogether for the first time. The most attracting and reliable markers of COVID-19 in patients were: normal C-reactive protein (CRP) and very different and conflicting laboratory results regardless of clinical symptoms in neonates, normal or temporary elevated CRP, conflicting WBC count results and procalcitonin elevation in children TRANS, lymphopenia HP lymphopenia MESHD and elevated lactate dehydrogenase (LDH) in adult TRANS patients, lymphopenia HP lymphopenia MESHD and elevated CRP and LDH in the elderly TRANS people and high CRP, leukocytosis HP leukocytosis MESHD and elevated neutrophil ratio in pregnant women.

    Computerized tomography scan findings of a patient with severe enterocolitis HP enterocolitis MESHD associated with the coronavirus disease MESHD 2019: a case report

    Authors: Katsunari Takifuji; Hiroshi Terasawa; Masami Oka; Masaki Sahara; Tomoko Hara; Hidekazu Itoh

    doi:10.21203/ Date: 2020-04-03 Source: ResearchSquare

    Background: Currently, there is no available study about the occurrence of enterocolitis HP enterocolitis MESHD associated with the coronavirus disease MESHD 2019 (COVID-19) among adults TRANS. Case presentation: A 56-year-old man had lower abdominal pain HP abdominal pain MESHD, distension, diarrhea, and bloody HP diarrhea, and bloody MESHD stool. Moreover, the patient presented with fever HP fever MESHD and general fatigue MESHD fatigue HP. Laboratory examination did not reveal leukocytosis HP leukocytosis MESHD nor neutrophilia HP. However, the patient’s C-reactive protein level increased to 4.9 (normal range: 0.0–0.3) mg/dL. Both sputum and stool cultures had normal results. However, abdominal computed tomography (CT) scan revealed wall thickness mainly in the submucosal layer of the left part of the large intestine. Thus, real-time polymerase chain reaction test of throat swabs was performed for the diagnosis of COVID-19, and positive results were obtained. Conclusions: We report the first case of enterocolitis HP enterocolitis MESHD correlated to COVID-19, and the patient had positive abdominal CT scan findings. This imaging modality could be effective for the diagnosis of enterocolitis HP enterocolitis MESHD associated with COVID-19.

    Risk Factors Associated with Clinical Outcomes in 323 COVID-19 Patients in Wuhan, China

    Authors: Ling Hu; Shaoqiu Chen; Yuanyuan Fu; Zitong Gao; Hui Long; Hong-wei Ren; Yi Zuo; Huan Li; Jie Wang; Qing-bang Xv; Wen-xiong Yu; Jia Liu; Chen Shao; Jun-jie Hao; Chuan-zhen Wang; Yao Ma; Zhanwei Wang; Richard Yanagihara; Jian-ming Wang; Youping Deng

    doi:10.1101/2020.03.25.20037721 Date: 2020-03-26 Source: medRxiv

    Background With evidence of sustained transmission TRANS in more than 190 countries, coronavirus disease MESHD 2019 (COVID-19) has been declared a global pandemic. As such, data are urgently needed about risk factors associated with clinical outcomes. Methods A retrospective chart review of 323 hospitalized patients with COVID-19 in Wuhan was conducted. Patients were classified into three disease severity groups (non-severe, severe, and critical), based on their initial clinical presentation. Clinical outcomes were designated as favorable and unfavorable, based on disease progression and response to treatments. Logistic regression models were performed to identify factors associated with clinical outcomes, and logrank test was conducted for the association with clinical progression. Results Current standard treatments did not show significant improvement on patient outcomes in the study. By univariate logistic regression model, 27 risk factors were significantly associated with clinical outcomes. Further, multivariate regression indicated that age TRANS over 65 years, smoking, critical disease status, diabetes MESHD, high hypersensitive troponin I (>0.04 pg/mL), leukocytosis HP leukocytosis MESHD (>10 x 109/L) and neutrophilia HP (>75 x 109/L) predicted unfavorable clinical outcomes. By contrast, the use of hypnotics was significantly associated with favorable outcomes. Survival analysis also confirmed that patients receiving hypnotics had significantly better survival. Conclusions To our knowledge, this is the first indication that hypnotics could be an effective ancillary treatment for COVID-19. We also found that novel risk factors, such as higher hypersensitive troponin I, predicted poor clinical outcomes. Overall, our study provides useful data to guide early clinical decision making to reduce mortality and improve clinical outcomes of COVID-19.

    Comparative Analysis of Clinical Characteristics in Children TRANS and Adults TRANS with 2019 Novel Coronavirus Infection: A Descriptive Study

    Authors: Ya-nan Han; Zhan-wei Feng; Li-na Sun; Xiao-xia Ren; Hua Wang; Yong-ming Xue; Yi Wang; Ying Fang

    doi:10.21203/ Date: 2020-03-17 Source: ResearchSquare

    Background: Since December 2019, acute respiratory disease MESHD ( ARD MESHD) caused by 2019 novel coronavirus (2019-nCoV) rapidly spread throughout China. Children TRANS and adults TRANS seemed to differ in the clinical course of the disease. The purpose of the current study is to comparatively analyze the clinical characteristics of children TRANS and adult TRANS patients with 2019-nCoV infection MESHD and to explore the possible causes for the discrepant aspects.Methods: In this retrospective study, the medical records of 32 cases confirmed TRANS with 2019-nCoV ARD MESHD from Xi'an eighth hospital (Shaanxi, China) from January 31 to February 16, 2020 were reviewed.Results: In all 32 patients contained 7 children TRANS and 25 adults TRANS. All children TRANS were family cluster. For adult TRANS patients, local residents of Wuhan, recently travelled TRANS to Wuhan, patient contacted with people from Wuhan were 14 (56%), 10 (40%), 1 (4%), respectively. The median incubation period TRANS of children TRANS and adult TRANS was 5 days (range, 3 to 12) and 4 days (range, 2 to 12), respectively. Altogether 10 (40%) adult TRANS patients had underlying conditions significantly, but no children TRANS had. Fever HP Fever MESHD ( Children TRANS 71.4% vs. Adult TRANS 96%) and cough HP ( Children TRANS 71.4% vs. Adult TRANS 76%) were the most common symptoms in both groups. The third symptom observed in children TRANS was diarrhea HP diarrhea MESHD and/or vomiting HP vomiting MESHD (57.1%), for adult TRANS it was myalgia HP myalgia MESHD or fatigue HP fatigue MESHD (52%). On admission, 5 (71.4%) children TRANS patients showed pneumonia HP pneumonia MESHD roughly the same as adult TRANS patients (20, 80%), and that the two group shared a multitude of common imaging characteristics. 20% of adult TRANS with leucopoenia, but leukocytosis HP leukocytosis MESHD was significantly more frequently in children TRANS (28.6%, P=0.014). More children TRANS had elevated creatine kinase isoenzyme (57.1% vs. 4%, P=0.004). All patients were discharged after symptomatic treatment, including oxygen therapy, antiviral treatment, antibiotic treatment. Only one infant was intravenously injected low-dose glucocorticoids.Conclusions: Our results multi-dimensionally demonstrate that children TRANS with 2019-nCoV infection MESHD present a clinical picture which is often distinct from that of adults TRANS. Knowledge of these differences will be helpful for the clinical diagnosis of 2019 novel coronavirus diseases MESHD (COVID-19) and for a future discussion on age TRANS specific infection MESHD case definitions.

    Clinical course and outcome of 107 patients infected with the novel coronavirus, SARS-CoV-2, discharged from two hospitals in Wuhan, China.

    Authors: Dawei Wang; Yimei Yin; Chang Hu; Xing Liu; Xingguo Zhang; Shuliang Zhou; Mingzhi Jian; Haibo Xu; John Prowle; Bo Hu; Yirong Li; Zhi-Yong Peng

    doi:10.21203/ Date: 2020-03-04 Source: ResearchSquare

    Background In December 2019, Coronavirus Disease MESHD 2019 (COVID-19) outbreak was reported from Wuhan, China. Information on the clinical course and prognosis of COVID-19 was not thoroughly described. We described the clinical courses and prognosis in COVID-19 patients. Methods Retrospective case series of COVID-19 patients from Zhongnan Hospital of Wuhan University in Wuhan, and Xi-shui Hospital, Hubei Province, China, up to February 10, 2020. Epidemiological, demographic and clinical data were collected. Clinical course of survivors and non-survivors were compared. Risk factors for death MESHD were analyzed. Results A total of 107 discharged patients with COVID-19 were enrolled. The clinical course of COVID-19 presented as a tri-phasic pattern. Week 1 after illness onset was characterized by fever HP fever MESHD, cough HP cough MESHD, dyspnea HP dyspnea MESHD, lymphopenia HP lymphopenia MESHD and radiological multilobar pulmonary infiltrates HP. In severe cases, thrombocytopenia HP thrombocytopenia MESHD, acute kidney injury HP acute kidney injury MESHD, acute myocardial injury MESHD or adult TRANS adult MESHD respiratory distress HP syndrome were observed. During week 2, in mild cases, fever HP fever MESHD, cough HP cough MESHD and systemic symptoms began to resolve and platelet count rose to normal range, but lymphopenia HP lymphopenia MESHD persisted. In severe cases, leukocytosis HP leukocytosis MESHD, neutrophilia HP and deteriorating multi-organ dysfunction were dominant. By week 3, mild cases had clinically resolved except for lymphopenia HP lymphopenia MESHD. However, severe cases showed persistent lymphopenia HP lymphopenia MESHD, severe acute respiratory dyspnea syndrome MESHD dyspnea HP syndrome , refractory shock MESHD shock HP, anuric acute kidney injury MESHD acute kidney injury HP, coagulopathy MESHD, thrombocytopenia HP thrombocytopenia MESHD and death MESHD. Older age TRANS and male TRANS sex were independent risk factors for poor outcome of the illness. Conclusions A period of 7–13 days after illness onset is the critical stage in COVID-19 course. Age TRANS and male TRANS gender TRANS were independent risk factors for death of COVID-19.

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MeSH Disease
Human Phenotype

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