Corpus overview


MeSH Disease

Human Phenotype

Pain (10)

Fever (5)

Cough (5)

Pneumonia (2)

Fatigue (2)


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    Psychosocial factors associated with postpartum psychological distress during the Covid-19 pandemic: a cross-sectional study.

    Authors: Luca Ostacoli; Stefano Cosma; Federica Bevilacqua; Paola Berchialla; Marialuisa Bovetti; Andrea Roberto Carosso; Francesca Malandrone; Sara Carletto; Chiara Benedetto

    doi:10.21203/ Date: 2020-08-06 Source: ResearchSquare

    Background Trauma MESHD, natural and man-made catastrophic events can be predictors of postpartum psychological distress. In a public health response due to coronavirus disease MESHD 2019 outbreak, the Italian government imposed a lockdown from March 9 to May 3. This extraordinary situation may have been challenging for maternal psychological health. The aim of this study was to investigate the prevalence SERO of depressive MESHD and post- traumatic stress symptoms MESHD in women giving birth during the Covid-19 pandemic and its associations with quarantine measures, obstetrical factors, and relational attachment style. Methods Women who gave birth in a high-volume obstetric/gynaecological medical centre located in an epidemic area during the Covid-19 pandemic (March 8 to June 15) were asked to complete an online survey about their childbirth experience and the perceived effect of the pandemic. The Edinburgh Postnatal Depression MESHD Scale (EPDS), the Impact of Event Scale-Revised (IES-R), and the Relationship Questionnaire (RQ) were administered to assess levels of postpartum depressive MESHD and post- traumatic stress symptoms MESHD (PTSS) and relational style of attachment, respectively. Multivariate analysis was applied to identify associations between quarantine measures, childbirth experience, attachment style, and EPDS and IES-R scores.Results The survey was completed by 163 women (response rate 60.8%). The prevalence SERO of depressive symptoms MESHD was 44.2% (EPDS cut-off score ≥11) and the PTSS rate was 42.9% (IES-R cut-off score ≥24). Dismissive and fearful avoidant attachment styles were significantly associated with the risk of depression MESHD and PTSS, respectively. Perceived pain HP pain MESHD during delivery was a risk factor for postpartum depression MESHD. Perceived support provided by healthcare staff was a protective factor against depression MESHD and PTSS. Another protective factor against PTSS was quiet on the ward due to the absence of hospital visitors. Conclusion This study reports a high prevalence SERO of postpartum depressive MESHD and PTSS in women who delivered during the Covid-19 pandemic. Postnatal psychological distress seemed to be associated more with the prenatal experience and other individual factors than with the pandemic hospital restrictions. Early detection during pregnancy of an insecure attachment style is fundamental to provide targeted preventive and therapeutic psychological interventions.

    Rationale and Study Design of an Early Care, Therapeutic Education, and Psychological Intervention for the Management of Post-intensive Care Syndrome and Chronic Pain HP Chronic Pain MESHD After Coronavirus Disease MESHD 2019 ( PAIN HP-COVID): Study protocol for a randomized controlled trial

    Authors: Antonio Ojeda; Andrea Calvo; Tomas Cuñat; Ricard Mellado Artigas; Oscar Comino-Trinidad; Jorge Aliaga; Marilyn Arias; Maribel Ahuir; Carlos Ferrando; Christian Dürsteler

    doi:10.21203/ Date: 2020-08-05 Source: ResearchSquare

    Background: Critically ill MESHD patients with COVID-19 disease are an especially susceptible population to develop Post-intensive Care Syndrome ( PICS MESHD) due to acute respiratory distress syndrome MESHD respiratory distress HP syndrome ( ARDS MESHD). Patients can suffer acute severe pain HP pain MESHD and may have long-term deterioration in mental HP, cognitive, and functional health after discharge. However, few controlled trials are evaluating interventions for the prevention and treatment of PICS. The study hypothesis is that a specific care program based on early therapeutic education and a psychological intervention improves the quality of life of patients at risk of developing PICS and chronic pain HP chronic pain MESHD after COVID-19 disease. The primary objective is to determine if the program is superior to standard-of-care on health-related life quality at six months after hospital discharge. The secondary objectives are to determine if the intervention is superior to standard care, evaluating the health-related life quality, the incidence of chronic pain HP pain MESHD and the degree of functional limitation, the incidence of anxiety HP anxiety MESHD, depression MESHD, and post- traumatic stress syndrome MESHD at 3 and 6 months after hospital discharge.Methods: The PAINCOVID trial is a unicentric randomized, controlled, patient blinded superiority trial with two parallel groups. The primary endpoint is the health-related quality of life at six months after hospital discharge, and randomization will be performed with a 1:1 allocation. This paper details the methodology and statistical analysis plan of the trial and was submitted before outcome data were available.Discussion: This the first randomized clinical trial assessing the effectiveness of an early care therapeutic education, and psychological intervention for the management of PICS and Chronic Pain HP Chronic Pain MESHD after COVID-19. The intervention will serve as a sample of the need to implement early care programs on early stages, having an incalculable impact given the current scenario of the pandemic.Trial registration: This study is being in accordance with the tenets of the Helsinki Declaration, and has been approved by the authors’ institutional review board Comité Ético de Investigación Clínica del Hospital Clinic de Barcelona (approval number: HCB/2020/0549) and was registered on May 9, 2020 at (NCT04394169).

    Clinical manifestations of patients with Coronavirus Disease MESHD 2019 (COVID- 19) attending at hospitals in Bangladesh

    Authors: Md. Shahed Morshed; Abdullah Al Mosabbir; Prodipta Chowdhury; Sheikh Mohammad Ashadullah; Mohammad Sorowar Hossain

    doi:10.1101/2020.07.30.20165100 Date: 2020-08-01 Source: medRxiv

    Bangladesh is in the rising phase of the ongoing pandemic of the coronavirus disease MESHD 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 MESHD (SARS-CoV-2). The scientific literature on clinical manifestations of COVID-19 patients from Bangladesh is scarce. This study aimed to report the sociodemographic and clinical characteristics of patients with COVID-19 in Bangladesh. We conducted a cross-sectional study at three dedicated COVID-19 hospitals. The severity of the COVID-19 cases was assessed based on the WHO interim guidance. Data were collected only from non-critical COVID-19 patients as critical patients required immediate intensive care admission making them unable to respond to the questions. A total of 103 RT-PCR confirmed non-critical COVID-19 patients were enrolled. Most of the patients (71.8%) were male TRANS. Mild, moderate and severe illness were assessed in 74.76%, 9.71% and 15.53% of patients respectively. Nearly 52.4% of patients had a co-morbidity, with hypertension HP hypertension MESHD being the most common (34%), followed by diabetes mellitus HP diabetes mellitus MESHD (21.4%) and ischemic MESHD heart disease MESHD (9.7%). Fever HP Fever MESHD (78.6%), weakness MESHD (68%) and cough HP (44.7%) were the most common clinical manifestations. Other common symptoms included loss of appetite (37.9%), difficulty in breathing (37.9%), altered sensation of taste or smell (35.0%), headache HP headache MESHD (32%) and body ache MESHD (32%). The median time from onset of symptom TRANS to attending hospitals was 7 days (IQR 4-10). This study will help both the clinicians and epidemiologists to understand the magnitude and clinical spectrum of COVID-19 patients in Bangladesh.

    SARS-CoV-2 Spike MESHD protein hijacks VEGF-A/Neuropilin-1 receptor signaling to induce analgesia MESHD

    Authors: Aubin Moutal; Laurent F Martin; Lisa Boinon; Kimberly Gomez; Dongzhi Ran; Yuan Zhou; Harrison J Stratton; Cai Song; Shizhen Luo; Kerry Beth Gonzalez; Samantha Perez-Miller; Amol Patwardhan; Mohab Ibrahim; Rajesh Khanna

    doi:10.1101/2020.07.17.209288 Date: 2020-07-18 Source: bioRxiv

    Global spread of severe acute respiratory syndrome coronavirus 2 MESHD (SARS-CoV-2) continues unabated. Binding of SARS-CoV-2s Spike MESHD protein to host angiotensin converting enzyme 2 triggers viral entry, but other proteins may participate, including neuropilin-1 receptor (NRP-1). As both Spike protein and vascular endothelial growth factor-A (VEGF-A) - a pronociceptive and angiogenic factor, bind NRP-1, we tested if Spike could block VEGF-A/NRP-1 signaling. VEGF-A-triggered sensory neuronal firing was blocked by Spike protein and NRP-1 inhibitor EG00229. Pro-nociceptive behaviors of VEGF-A were similarly blocked via suppression of spontaneous spinal synaptic activity and reduction of electrogenic currents in sensory neurons. Remarkably, preventing VEGF-A/NRP-1 signaling was antiallodynic in a neuropathic pain MESHD pain HP model. A silencing of pain HP pain MESHD via subversion of VEGF-A/NRP-1 signaling may underlie increased disease transmission TRANS in asymptomatic TRANS individuals. One Sentence SummarySARS-CoV-2s Spike protein promotes analgesia by interfering with VEGF-A/NRP1 pathway, which may affect disease transmission TRANS dynamics.

    Male TRANS gender TRANS and kidney illness MESHD associated with an increased risk of severe laboratory-confirmed coronavirus disease

    Authors: Efren Murillo-Zamora; Xochitl Trujillo; Miguel Huerta; Monica Rios-Silva; Oliver Mendoza-Cano

    doi:10.1101/2020.06.29.20142562 Date: 2020-07-01 Source: medRxiv

    Objective: To identify factors predicting severe coronavirus disease MESHD 2019 (COVID-19) in adolescent and adult TRANS patients with laboratory-positive (quantitative reverse-transcription polymerase chain reaction) infection MESHD. Methods: A retrospective cohort study took place, and data from 740 subjects, from all 32 states of Mexico, were analyzed. The association between the studied factors and severe ( dyspnea HP dyspnea MESHD requiring hospital admission) COVID-19 was evaluated through risk ratios (RRs) and 95% confidence intervals (CIs). Results: Severe illness was documented in 28% of participants. In multiple analysis, male TRANS gender TRANS (RR = 1.13, 95% CI 1.06 - 1.20), advanced age TRANS ([reference: 15 - 29 years old] 30 - 44, RR = 1.02, 95% CI 0.94 - 1.11; 45 - 59, RR = 1.26, 95% CI 1.15 - 1.38; 60 years or older, RR = 1.44, 95% CI 1.29 - 1.60), chronic kidney disease HP chronic kidney disease MESHD (RR = 1.31, 95% CI 1.04 - 1.64) and thoracic pain MESHD pain HP (RR = 1.16, 95% CI 1.10 - 1.24) were associated with an increased risk of severe disease. Conclusions: To the best of our knowledge, this is the first study evaluating predictors of COVID-19 severity in a large subset of the Latin-American population. It is also the first in documenting gender TRANS-related differences regarding the severity of the illness. These results may be useful for health care protocols for the early detection and management of COVID-19 patients that may benefit from opportune and specialized supportive medical treatment.

    The influence of comorbidity on the severity of COVID-19 disease: A systematic review and analysis

    Authors: Nazar Zaki; Elfadil Abdalla Mohamed; Sahar Ibrahim; Gulfaraz Khan

    doi:10.21203/ Date: 2020-06-20 Source: ResearchSquare

    Background: A novel form of coronavirus disease MESHD (SARS-CoV-2) has spread rapidly across the world. What risk factors influence the severity of the disease is of considerable importance.Aim: This research offers a systematic review and meta-analysis of the correlation between common clinical conditions and comorbidities and the severity of COVID-19.Methodology: Two independent researchers searched Europe PMC, Google Scholar, and PubMed databases for articles related to influence comorbidities have on the progress of the disease. A search engine was also created to screen a further 59,000 articles in COVID-19 Open Research Dataset (CORD-19). Random-effects modeling was used to pool 95% confidence intervals (CIs) and odds ratios (ORs). The significance of all comorbidities and clinical conditions to the severity of the disease was evaluated by employing machine-learning techniques. Publication bias was assessed by using funnel-plots and Egger’s test. Heterogeneity was tested using I2.Results: The meta-analysis incorporated 12 studies spanning 4,101 confirmed COVID-19 patients who were admitted to Chinese hospitals. The prevalence SERO of the most commonly associated co-morbidities and their corresponding odds ratio for disease severity were as follows: coronary heart disease MESHD (OR 2.97 [CI: 1.99-4.45], p < 0.0001), cancer MESHD (OR 2.65 [CI: 1.12-6.29], p < 0.03), cardiovascular disease MESHD (OR 2.89 [CI: 1.90-4.40], p < 0.0001), COPD MESHD (OR 3.24 [CI: 1.66-6.32], p = 0.0), and kidney disease MESHD (OR 2.2.4 [CI: 1.01-4.99], p = 0.05) with low or moderate level of heterogeneity. The most frequently exhibited clinical symptoms were fever HP fever MESHD (OR 1.37 [CI: 1.01-1.86], p = 0.04), myalgia HP myalgia MESHD/ fatigue HP fatigue MESHD (OR 1.31 [CI: 1.11-1.55], p = 0.0018), and dyspnea HP dyspnea MESHD (OR 3.61, [CI: 2.57-5.06], p = <0.0001). No significant associations between disease severity and liver disease MESHD, smoking habits, and other clinical conditions, such as a cough HP, respiratory/ARDS, diarrhea HP diarrhea MESHD or chest tightness HP chest tightness MESHD/ pain HP pain MESHD were found. The meta-analysis also revealed that the incubation period TRANS was positively associated with disease severity. Conclusion: Existing comorbidities, including COPD, cardiovascular disease MESHD, and coronary heart disease MESHD, increase the severity of COVID-19. Some studies found a statistically significant association between comorbidities such as diabetes MESHD and hypertension HP hypertension MESHD and disease severity. However, these studies may be biased due to substantial heterogeneity. 

    What is the Impact of Novel Coronavirus Disease MESHD 2019 Pandemic on Orthopedic Surgeons?: Experience from a Single Institution of South Korea

    Authors: Gi Beom Kim; Oog-Jin Shon; Jeong Jin Park; Sun-Mi Lee; Gun Woo Lee

    doi:10.21203/ Date: 2020-06-12 Source: ResearchSquare

    Background: This study aimed to investigate the cancellation rate and trend of orthopedic surgery at the main institution in Daegu, Korean epicenter of novel coronavirus disease MESHD 19 (COVID-19), and to analyze the psychologic status of the healthcare workers in the orthopedic division during the COVID-19 pandemic. Moreover, we sought to assess the outcomes of the preventive surgeries underwent in patients suspected to have COVID-19.Methods: Cancellation rates of elective surgeries over three months since the first confirmed COVID-19 case in South Korea on January 20, 2020 were investigated. Moreover, the number of elective surgeries conducted in the same period over the last two years was compared. Four different questionnaires were used to investigate psychologic impact among health care workers in the orthopedic department. The surveyed outcomes according to occupation and type of work were compared. Urgent preventive surgeries underwent in patients who could not wait for the results of the COVID-19 diagnosis were also investigated.Results: During the pandemic, spine and hip surgery had relatively lower cancellation rates, and elective surgeries were significantly reduced compared to the same period in the last two years. The surveyed outcomes of the psychological questionnaires were within the normal range and there were no significant differences between groups. After preventive surgeries, the virus did not spread to all medical staff involved.Conclusions: During the COVID-19 pandemic, the cancellation rate of orthopedic elective surgeries was significantly higher than in the same period of the previous year, and was different for each subdivision depending on the degree of pain HP pain MESHD or disability experienced by the patient. Health care workers in the orthopedic division did not seem to have significant psychological distress MESHD; rather, a decrease in workload appears to be a positive factor in their mental health. Preventive surgery performed in specialized facilities did not spread the virus to involved medical staff.

    Initial symptoms of patients with coronavirus disease MESHD 2019 in Japan.

    Authors: Junpei Komagamine; Taku Yabuki

    doi:10.21203/ Date: 2020-06-04 Source: ResearchSquare

    Background: Fever HP Fever MESHD, cough HP cough MESHD, malaise, and throat pain HP pain MESHD are the most common initial symptoms of coronavirus disease MESHD 2019 (COVID-19). However, no studies have ever been conducted to investigate the initial symptoms of COVID-19 in Japan. Methods: We investigated 707 consecutive COVID-19 patients who were diagnosed in ten prefectures of Japan until May 16, 2020 by using publicly available data. The primary outcome was initial symptoms on the day of symptom onset TRANS. The proportion of patients with individual symptoms among symptomatic patients was calculated.Results: Of all the patients, 79 (11.2%) were asymptomatic TRANS. Among the 628 symptomatic patients, the most common initial symptom was fever HP fever MESHD (65.9%), followed by cough HP (23.5%), malaise (23.5%), and throat pain HP pain MESHD (12.9%). At least one of these four symptoms was reported in 88.2% of all symptomatic patients. Nineteen patients (3.0%) reported gastrointestinal symptoms MESHD without respiratory symptoms, while six patients (1.0%) reported only loss of smell or taste as the initial symptom. Conclusions: Like other countries, the most common initial symptoms of COVID-19 patients in Japan are fever HP fever MESHD, cough HP cough MESHD, malaise, or throat pain HP pain MESHD. Gastrointestinal symptoms without respiratory symptoms and loss of smell and taste are uncommon initial symptoms in Japan.

    Facemasks prevent influenza-like illness: implications for COVID-19

    Authors: Jie Wei; Michael Doherty; Monica S.M. Persson; Subhashisa Swain; Changfu Kuo; CHAO ZENG; guanghua Lei; Weiya Zhang

    doi:10.1101/2020.05.07.20094912 Date: 2020-05-12 Source: medRxiv

    The coronavirus disease MESHD 2019 (COVID-19) pandemic is causing a huge toll on individuals, families, communities and societies across the world. Currently, whether wearing facemasks in public should be a measure to prevent transmission TRANS of severe acute respiratory syndrome coronavirus-2 MESHD (SARS-CoV-2) remains contraversial.1 This is largely because there have been no randomized controlled trials (RCTs) for coronavirus to directly support this. However, lessons may be taken from published RCTs examining influenza-like illness (ILI).2,3 Recent studies suggested that SARS-CoV-2 shares similar transmission TRANS route with influenza virus,4 and the incidence of community transmission TRANS of SARS-CoV-2 in individuals with ILI is high.5 Therefore, we undertook this meta-analysis of RCTs examining the efficacy of wearing facemasks to prevent ILI in community settings, irrespective of confirmatory testing for the causative virus. We undertook a systematic literature search for RCTs related to facemasks and ILI between 1966 and April 2020 using PUBMED, EMBASE, and Cochrane library. RCTs undertaken in community (not hospital) settings comparing wearing and not wearing facemasks for ILI were included. Incidence of ILI (e.g., fever HP fever MESHD, cough HP cough MESHD, headache HP headache MESHD, sore throat, aches MESHD or pains HP pains MESHD in muscles or joints MESHD) was estimated per group. Relative risk (RR) and 95% confidence interval (CI) were calculated. We screened 899 related abstracts and eventually included 8 RCTs (Figure S1). Basic characteristics and quality of included RCTs are listed in Supplement. Participants wearing facemasks had a significantly lower risk of developing ILI than those not wearing facemasks (pooled RR=0.81, 95% CI: 0.70-0.95) and there was no heterogeneity (Figure 1). The decreased risk of ILI was more pronounced if everyone wore facemask irrespective of whether they were infected MESHD or not (RR=0.77, 95% CI: 0.65-0.91), compared to those wearing facemasks when infected (RR=0.95, 95% CI: 0.58-1.56) or uninfected (RR=1.26, 95% CI: 0.69-2.31). This study shows that wearing facemasks, irrespective of infection status MESHD, is effective in preventing ILI spread in the community. This situation mirrors what is happening now in public settings where we do not know who has been infected MESHD and who has not. Although there are no RCTs of facemasks for SARS-CoV-2, as with other simple measures such as social distancing and handwashing, these data support the recommendation to wear facemasks in public to further reduce transmission TRANS of SARS-CoV-2 and flatten the curve of this pandemic, especially when social distancing is impractical, such as shopping, or travelling TRANS with public transport for work that cannot be done from home.

    Clinical findings of 35 cases with novel coronavirus pneumonia MESHD pneumonia HP outside of Wuhan

    Authors: Wen Luo; Yihua Lin; Xiangyang Yao; Yonghong Shi; Fang Lu; Zhanxiang Wang; Dinghui Wu

    doi:10.21203/ Date: 2020-04-11 Source: ResearchSquare

    Objective: We sought to investigate the clinical characteristics of patients with novel coronavirus pneumonia MESHD pneumonia HP in Xiamen, which is a city in Fujian Province, China. Methods: From January 20, 2020, to March 4, 2020, the clinical characteristics of all patients confirmed with novel coronavirus pneumonia MESHD pneumonia HP admitted to the First Affiliated Hospital of Xiamen University, which was the only designated hospital for cases of novel coronavirus pneumonia MESHD pneumonia HP in Xiamen, were analyzed. Results: A total of 35 cases of novel coronavirus pneumonia MESHD pneumonia HP were confirmed. Patients were divided into the general-ward admission group and the intensive-care-unit (ICU) admission group. The most commonly observed symptoms were fever HP fever MESHD (80%), cough HP (51%), expectoration (28%), and fatigue HP fatigue MESHD (23%). Compared with patients in the general-ward group, patients in the ICU group had a higher maximum body temperature, a longer duration of fever HP fever MESHD after admission, and more symptoms of systemic pain MESHD pain HP. Considering the laboratory findings, patients in the ICU group exhibited lower peripheral blood SERO lymphocyte ratios and lymphocyte counts but higher C-reactive protein and lactate dehydrogenase levels. All patients were discharged without death, and no patients required invasive ventilation, continuous renal replacement therapy, or extracorporeal membrane oxygenation. Conclusion: Relative to patients with novel coronavirus pneumonia MESHD pneumonia HP in Wuhan, the cases in Xiamen were less severe.

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MeSH Disease
Human Phenotype

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