Corpus overview


Overview

MeSH Disease

Human Phenotype

Fever (2)

Cough (2)

Rhinitis (2)

Diarrhea (1)

Vomiting (1)


Transmission

Seroprevalence

There are no seroprevalence terms in the subcorpus

    displaying 1 - 2 records in total 2
    records per page




    Clinical severity and epidemiological spectrum of coronavirus disease MESHD 2019 in children TRANS – comparison with influenza

    Authors: Maria Pokorska-Śpiewak; Ewa Talarek; Jolanta Popielska; Karolina Nowicka; Agnieszka Ołdakowska; Konrad Zawadka; Barbara Kowalik-Mikołajewska; Anna Tomasik; Anna Dobrzeniecka; Marta Lipińska; Beata Krynicka-Czech; Urszula Coupland; Aleksandra Stańska-Perka; Małgorzata Ludek; Magdalena Marczyńska

    doi:10.21203/rs.3.rs-32960/v1 Date: 2020-06-01 Source: ResearchSquare

    Data on the novel coronavirus disease MESHD 2019 (COVID-19) in children TRANS are limited, and studies from Europe are scarce. We analyzed the clinical severity and epidemiologic aspects of COVID-19 in consecutive children TRANS aged TRANS 0 – 18 years, referred with a suspicion of COVID-19 between February 1, and April 15, 2020. RT-PCR on a nasopharyngeal swab was used to confirm COVID-19. 319 children TRANS met the criteria of a suspected case. COVID-19 was diagnosed in 15/319 (4.7%) patients (8 male TRANS; mean age TRANS 10.5 years). All of them had household contact TRANS with an infected relative. Five (33.3%) patients were asymptomatic TRANS. In 9/15 (60.0%) children TRANS, the course of the disease was mild, and in 1/15 (6.7%), it was moderate, with the following symptoms: fever HP fever MESHD (46.7%), cough HP (40%), diarrhea HP diarrhea MESHD (20%), vomiting HP vomiting MESHD (13.3%), rhinitis HP rhinitis MESHD (6.7%), and shortness of breath MESHD (6.7%). In the COVID-19-negative patients, other infections were confirmed TRANS infections were confirmed MESHD, including influenza in 32/319 (10%). The clinical course of COVID-19 and influenza differed significantly based on the clinical presentation. In conclusion, the clinical course of COVID-19 in children TRANS is usually mild or asymptomatic TRANS. In children TRANS suspected of having COVID-19, other infections should not be overlooked. The main risk factor for COVID-19 in children TRANS is household contact TRANS with an infected relative.

    Feasibility of Known RNA Polymerase Inhibitors as Anti-SARS-CoV-2 Drugs

    Authors: Ujjwal Neogi; Kyle J. Hill; Anoop T. Ambikan; Xiao Heng; Thomas P. Quinn; Siddappa N. Byrareddy; Anders Sönnerborg; Stefan G. Sarafianos; Kamal Singh

    id:10.20944/preprints202004.0184.v1 Date: 2020-04-12 Source: Preprints.org

    Coronaviruses (CoVs) are positive-stranded RNA viruses that infect MESHD humans and animals. Infection by CoVs such as HCoV-229E, -NL63, -OC43 and -HKUI1 leads to the common cold, short lasting rhinitis HP rhinitis MESHD, cough HP, sore throat and fever HP fever MESHD. However, CoVs such as Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV), Middle East Respiratory Syndrome Coronavirus (MERS-CoV) MESHD, and the newest SARS-CoV-2 (the causative agent of COVID-19) lead to severe and deadly diseases MESHD with mortality rates ranging between ~1 to 35% depending on factors such as age TRANS and pre-existing conditions. Despite continuous global health threats to human, there are no approved vaccines or drugs targeting human CoVs, and the recent outbreak of COVID-19 emphasizes an urgent need for therapeutic interventions. Using computational and bioinformatics tools, here we present the feasibility of reported broad-spectrum RNA polymerase inhibitors as anti- SARS-CoV-2 drugs targeting its main RNA polymerase, suggesting that investigational and approved nucleoside RNA polymerase inhibitors have potential as anti-SARS-CoV-2 drugs. However, we note that it is also possible for SARS-CoV-2 to evolve and acquire drug resistance mutations against these nucleoside inhibitors.

The ZB MED preprint Viewer preVIEW includes all COVID-19 related preprints from medRxiv and bioRxiv, from ChemRxiv, from ResearchSquare, from arXiv and from Preprints.org and is updated on a daily basis (7am CET/CEST).
The web page can also be accessed via API.

Sources


Annotations

All
None
MeSH Disease
Human Phenotype
Transmission
Seroprevalence


Export subcorpus as...

This service is developed in the project nfdi4health task force covid-19 which is a part of nfdi4health.

nfdi4health is one of the funded consortia of the National Research Data Infrastructure programme of the DFG.