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MeSH Disease

Human Phenotype

There are no HP terms in the subcorpus


Transmission

Seroprevalence
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    Prevalence SERO and clinical features of COVID-19 in a large cohort of 199 patients with sarcoidosis MESHD

    Authors: Anne-Claire Desbois; Cindy Marques; Leila Lefèvre; Serge Barmo; Camille Lorenzo; Mathilde Leclercq; Gaëlle Leroux; Chloé Comarmond; Catherine Chapelon; Fanny Domont; Mathieu Vautier; David Saadoun; Patrice Cacoub

    doi:10.21203/rs.3.rs-41653/v1 Date: 2020-07-13 Source: ResearchSquare

    Objective: To investigate the prevalence SERO, clinical features and outcomes of coronavirus disease MESHD 2019 (COVID-19) among sarcoidosis MESHD patients. Methods: We retrospectively collected features of COVID-19 in a cohort of patients with sarcoidosis MESHD followed in a single tertiary university hospital. Results: Among 199 sarcoidosis MESHD patients [mean age TRANS 58.8 (±14) years, 86 (43.2%) men], 26 (13%) were diagnosed with COVID-19 [definite (n=7), probable (n=12) and possible (n=7)]. Twenty-four out of 26 patients (92%) had at least one comorbidity, and 11/26 (42%) had two or more comorbidities. Demographic and clinical features of COVID-19 positive patients were similar to those of COVID-19 negative patients. The administration of hydroxychloroquine or immunosuppressant was not associated with the occurrence or the severity of COVID-19. Four out of 26 (15.4%) COVID-19 positive patients required admission to hospital and two of them died. Hospitalized patients [mean age TRANS of 61 (±11.5) years] were receiving higher doses of long term treatment with corticosteroids than non-hospitalized patients; 4/4 had pulmonary and 2/4 cardiac involvement of sarcoidosis MESHD, and all one or more comorbidity. Conclusion: The prevalence SERO of COVID-19 in sarcoidosis MESHD is slightly higher to that of the general population. Almost half of the COVID-19 positive patients have two or more comorbidities and about 15% present a severe course.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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