Corpus overview


MeSH Disease

Human Phenotype


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    Serum SERO responses of children TRANS with Kawasaki Disease MESHD against SARS-CoV-2 proteins.

    Authors: Arthur Chang; Michael Croix; Patrick Kenney; Sarah Baron; Mark Hicar

    doi:10.1101/2020.05.24.20111732 Date: 2020-05-26 Source: medRxiv

    Recently, numerous reports have suggested association of pediatric Coronavirus Disease MESHD 2019 (COVID-19) cases and Kawasaki Disease MESHD ( KD MESHD). KD MESHD is a major cause of childhood acquired heart disease MESHD and vasculitis HP vasculitis MESHD in the pediatric population. Epidemiological patterns suggest KD MESHD is related to an infectious agent; however, the etiology remains unknown1. As past reports have considered other coronaviruses to be related to KD2,3, these reports of pediatric COVID-19 related inflammatory disorder MESHD cases leads to the hypothesis of potential cross-coronavirus reactivity that would account for the past controversial proposals of other coronaviruses and these new cases. We sought to address this hypothesis by assessing the antigen targeting of biobanked plasma SERO samples of febrile children TRANS, including those with KD MESHD, against SARS-CoV-2 proteins.

    Vasculitis HP Vasculitis MESHD-Associated Auto- antibodies SERO and Complement Levels in patients with COVID-19 Infection 

    Authors: Maryam Mobini; Roya Ghasemian; Laleh Vahedi Larijani; Maeede Mataji; Iradj Maleki

    doi:10.21203/ Date: 2020-05-21 Source: ResearchSquare

    Introduction / objectives: The cause of c oronavirus disease MESHD2019 (COVID-19) is severe acute r espiratory syndrome MESHD2 (SARS-CoV-2). There are evidences of involvement of immune system in pathogenesis of this disease. We investigated the presence of various vasculitis HP asculitis- MESHDassociated auto- antibodies SERO and complement levels in a series of patients with COVID-19 i nfection MESHDadmitted to our hospital.Methods: Forty patients with severe or critical type of COVID 19 were evaluated for symptoms, signs and laboratory tests of vasculitis HP asculitis syndromes MESHDincluding r heumatoid MESHDfactor (RF), anti-nuclear antibody SERO (ANA), anti dsDNA, c and p anti-neutrophilic cytoplasmic antibody SERO (c ANCA and p ANCA) and complement levels. Descriptive statistics methods were used to describe the clinical / laboratory findings.Results: Forty patients with severe to c ritical illness MESHDwere enrolled in the study. The mean age TRANS of the patients was 48.5 ± 9.8 years. All patients had pulmonary involvement in lung CT scan. Lymphopenia HP ymphopenia MESHDin 19 (47.5%), raised creatinine in 8(20%) and hyperbilirubinemia HP yperbilirubinemia MESHDin 19(47.5%) of patients were seen. Vasculitis HP asculitis laboratory MESHDtest results included: RF in 2 patients, ANA in 3 patients and ANCA in one patient. 17(42.5%) of patients had hypocomplementemia in one or more complement tests. Of the four patients who were expired, three had a decrease in complement.Conclusion: In 17 of patients (42.5%) we detected low complement levels. A decrease in complement levels may predict a critical state of the disease. Therefore, measuring its levels may be helpful in making earlier decisions to initiate disease-suppressing treatments, including corticosteroids and IVIG.

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MeSH Disease
Human Phenotype

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