Corpus overview


MeSH Disease

Human Phenotype


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    Acute kidney injury HP kidney injury MESHD is associated with severe and fatal outcomes in patients with Coronavirus disease MESHD 2019 (COVID-19) infection: a systematic review and meta-analysis of observational studies

    Authors: Mohammad Parohan; Sajad Yaghoubi; Mahmoud Djalali; Asal Seraji; Mohammad Hassan Javanbakht; Zahra Mousavi

    doi:10.1101/2020.08.27.20183632 Date: 2020-09-01 Source: medRxiv

    Coronavirus disease MESHD 2019 (COVID-19) is a pandemic impacting 213 countries and territories with more than 17,918,582 cases worldwide. Kidney dysfunction MESHD has been reported to occur in severe and death MESHD cases. This meta-analysis was done to summarize available studies on the association between acute kidney injury HP kidney injury MESHD and severity of COVID-19 infection MESHD. Online databases including Web of Science, PubMed/Medline, Cochrane Library, Scopus and Google Scholar were searched to detect relevant articles up to 1 July 2020, using relevant keywords. To pool data, a random- or fixed-effects model was used based on the heterogeneity between studies. In total, 50 studies with 8,180 COVID-19 confirmed cases TRANS (severe cases=1,823 and death MESHD cases=775), were included in this meta-analysis. Higher serum SERO levels of creatinine (weighted mean difference ( WMD MESHD) for disease severity=5.47 mol/L, 95% CI=2.89 to 8.05, P<0.001 and WMD for mortality=18.32 mol/L, 95% CI=12.88 to 23.75, P<0.001), blood SERO urea nitrogen (BUN) ( WMD MESHD for disease severity=1.10 mmol/L, 95% CI=0.67 to 1.54, P<0.001 and WMD for mortality=3.56 mmol/L, 95% CI=2.65 to 4.48, P<0.001) and lower levels of estimated glomerular filtration rate (eGFR) ( WMD MESHD for disease severity=-15.34 mL/min/1.73 m2, 95% CI=-18.46 to -12.22, P<0.001 and WMD for mortality=-22.74 mL/min/1.73 m2, 95% CI=-27.18 to -18.31, P<0.001) were associated with a significant increase in the severity and mortality of COVID-19 infection MESHD. Acute kidney injury HP kidney injury MESHD, as assessed by kidney biomarkers ( serum SERO creatinine, BUN and eGFR), was associated with severe outcome and death MESHD from COVID-19 infection MESHD.

    Nutritional Risk Screening Tools for Elderly TRANS Patients with COVID-19: A Systematic Review

    Authors: David Franciole de Oliveira Silva; Severina Carla Vieira Cunha Lima; Karine Cavalcanti Mauricio Sena-Evangelista; Dirce Marchioni; Ricardo Ney Cobucci; Fábia Barbosa de Andrade

    id:10.20944/preprints202008.0382.v1 Date: 2020-08-18 Source:

    Coronavirus disease MESHD 2019 (COVID-19) is associated with high risk of malnutrition HP malnutrition MESHD, primarily in elderly TRANS people; assessing nutritional risk using appropriate screening tools is critical. This systematic review identified applicable tools and assessed their measurement properties. Literature was searched in the MEDLINE, Embase, and LILACS databases. Four studies conducted in China met the eligibility criteria. Sample sizes ranged from six to 182, and participants’ ages TRANS from 65 to 87 years. Seven nutritional screening and assessment tools were used: the Nutritional Risk Screening 2002 (NRS-2002), Mini Nutritional Assessment (MNA), MNA-short form (MNA-sf), Malnutrition HP Malnutrition MESHD Universal Screening Tool (MUST), Nutritional Risk Index (NRI), Geriatric NRI (GNRI), and modified Nutrition Risk in the Critically ill MESHD (mNUTRIC) score. Nutritional risk was identified in 27.5% to 100% of participants. The NRS-2002, MNA, MNA-sf, NRI, and MUST demonstrated high sensitivity SERO; the MUST had better specificity. The MNA and MUST demonstrated better criterion validity. The MNA-sf demonstrated better predictive validity for poor appetite HP and weight loss HP weight loss MESHD; the NRS-2002 demonstrated better predictive validity for prolonged hospitalization. mNUTRIC score demonstrated good predictive validity for hospital mortality. Most instruments demonstrate high sensitivity SERO for identifying nutritional risk, but none are acknowledged as the best for nutritional screening in elderly TRANS COVID-19 patients.

    A SARS-CoV-2 neutralizing antibody SERO protects from lung pathology in a COVID-19 hamster model

    Authors: Jakob Kreye; S Momsen Reincke; Hans-Christian Kornau; Elisa Sanchez-Sendin; Victor Max Corman; Hejun Liu; Meng Yuan; Nicholas C Wu; Xueyong Zhu; Chang-Chun D Lee; Jakob Trimpert; Markus Hoeltje; Kristina Dietert; Laura Stoeffler; Niels von Wardenburg; Scott van Hoof; Marie A Homeyer; Julius Hoffmann; Azza Abdelgawad; Achim D Gruber; Luca D Bertzbach; Daria Vladimirova; Lucie Y Li; Paula Charlotte Barthel; Karl Skriner; Andreas C Hocke; Stefan Hippenstiel; Martin Witzenrath; Norbert Suttorp; Florian Kurth; Christiana Franke; Matthias Endres; Dietmar Schmitz; Lara Maria Jeworowski; Anja Richter; Marie Luisa Schmidt; Tatjana Schwarz; Marcel Alexander Mueller; Christian Drosten; Daniel Wendisch; Leif E Sander; Nikolaus Osterrieder; Ian A Wilson; Harald Pruess

    doi:10.1101/2020.08.15.252320 Date: 2020-08-16 Source: bioRxiv

    The emergence of SARS-CoV-2 led to pandemic spread of coronavirus disease MESHD 2019 (COVID-19), manifesting with respiratory symptoms MESHD and multi-organ dysfunction MESHD. Detailed characterization of virus- neutralizing antibodies SERO and target epitopes is needed to understand COVID-19 pathophysiology and guide immunization strategies. Among 598 human monoclonal antibodies SERO (mAbs) from ten COVID-19 patients, we identified 40 strongly neutralizing mAbs. The most potent mAb CV07-209 neutralized authentic SARS-CoV-2 with IC50 of 3.1 ng/ml. Crystal structures of two mAbs in complex with the SARS-CoV-2 receptor-binding domain at 2.55 and 2.70 A revealed a direct block of ACE2 attachment. Interestingly, some of the near-germline SARS-CoV-2 neutralizing mAbs reacted with mammalian self-antigens. Prophylactic and therapeutic application of CV07-209 protected hamsters from SARS-CoV-2 infection MESHD, weight loss HP weight loss MESHD and lung pathology. Our results show that non-self-reactive virus-neutralizing mAbs elicited during SARS-CoV-2 infection MESHD are a promising therapeutic strategy.

    Real-Time Neural Network Scheduling of Emergency Medical Mask Production during COVID-19

    Authors: Chen-Xin Wu; Min-Hui Liao; Mumtaz Karatas; Sheng-Yong Chen; Yu-Jun Zheng

    id:2007.14055v1 Date: 2020-07-28 Source: arXiv

    During the outbreak of the novel coronavirus pneumonia MESHD pneumonia HP (COVID-19), there is a huge demand for medical masks. A mask manufacturer often receives a large amount of orders that are beyond its capability. Therefore, it is of critical importance for the manufacturer to schedule mask production tasks as efficiently as possible. However, existing scheduling methods typically require a considerable amount of computational resources and, therefore, cannot effectively cope with the surge of orders. In this paper, we propose an end-to-end neural network for scheduling real-time production tasks. The neural network takes a sequence of production tasks as inputs to predict a distribution over different schedules, employs reinforcement learning to optimize network parameters using the negative total tardiness as the reward signal, and finally produces a high-quality solution to the scheduling problem. We applied the proposed approach to schedule emergency production tasks for a medical mask manufacturer during the peak of COVID-19 in China. Computational results show that the neural network scheduler can solve problem instances with hundreds of tasks within seconds. The objective function value (i.e., the total weighted tardiness MESHD) produced by the neural network scheduler is significantly better than those of existing constructive heuristics, and is very close to those of the state-of-the-art metaheuristics whose computational time is unaffordable in practice.

    Lung Function Decline and Other Physiological Changes in Health Workers after Working in COVID-19 Isolation Wards: An Observational Study

    Authors: Kailei Chen; Peipei Zhu; Liyuan Wang; Siting Zuo; CuiPing Wu; Ying Hu; YiSi Wang; Feng Wu; Xin Tang

    doi:10.21203/ Date: 2020-06-17 Source: ResearchSquare

    Background:Global healthcare systems have been under huge pressure since Coronavirus Disease MESHD 2019 (COVID-19) was declared a pandemic. It is critical to prevent further spread of COVID-19 and to protect health workers from infection MESHD. This study aims to figure out short-term physiological impact on health workers induced by working in isolation wards for hours with personal protective equipment (PPE), so as to provide insights on reducing physiological impact and infection risk TRANS infection risk TRANS of health workers.Methods:Health workers who had worked in COVID-19 isolation wards for at least five weeks in Wuhan, China were recruited. Parameters including lung function, heart rate, oxygen saturation and weight were respectively measured before and after they worked in isolation wards. Comparison and regression analyses were conducted. Correlations between changing levels of measured parameters (lung function and heart rate) and baseline characteristics (body mass index, age TRANS, and working duration) were also analyzed. Results: After working in isolation wards for four to nine hours, the forced vital capacity (FVC) of health workers (74.32±17.59 versus 81.28±16.35, P<0.001) as well as weight (54.79 (48.50, 61.00) versus 55.50 (48.90, 61.00) P<0.01) showed significant decrease, while HR showed significant increase (110.31±14.65 versus 103.94±16.38, P=0.04). Correlation between BMI and the decline levels of FEV1/FVC (β=2.87, P=0.02) and correlation between BMI and the decline levels of FEF25-75 % predicted (β=1.80, P<0.05) were reported.Conclusions:After working in COVID-19 isolation wards with PPE for four to nine hours, the lung function of health workers declined. The decline levels were associated with BMI. HR increase and weight loss HP weight loss MESHD were reported. In order to reduce the potential infection risk TRANS infection risk TRANS of health workers, the balance between working duration and physiological changes should be considered when making shifting schedule. 

    Diet and physical activity during the COVID-19 lockdown period (March-May 2020): results from the French NutriNet-Sante cohort study

    Authors: Melanie Deschasaux-Tanguy; Nathalie Druesne-Pecollo; Younes Esseddik; Fabien Szabo de Edelenyi; Benjamin Alles; Valentina A Andreeva; Julia Baudry; Helene Charreire; Valerie Deschamps; Manon Egnell; Leopold K Fezeu; Pilar Galan; Chantal Julia; Emmanuelle Kesse-Guyot; Paule Latino-Martel; Jean-Michel Oppert; Sandrine Peneau; Charlotte Verdot; Serge Hercberg; Mathilde Touvier

    doi:10.1101/2020.06.04.20121855 Date: 2020-06-05 Source: medRxiv

    Background: Since December 2019, the coronavirus disease MESHD (COVID-19) has massively spread, with overwhelming of health care systems and numerous deaths worldwide. To remedy this, several countries, including France, have taken strict lockdown measures, requiring the closure of all but essential places. This unprecedented disruption of daily routines has a strong potential for disrupting nutritional behaviours. Nutrition being one of the main modifiable risk factors for chronic disease risk, this may have further consequences for public health. Our objective was therefore to describe nutritional behaviours during the lockdown period and to put them in light of individual characteristics. Methods: 37,252 French adults TRANS from the web-based NutriNet-Sante cohort filled lockdown-specific questionnaires in April-May 2020 (nutritional behaviours, body weight, physical activity, 24h-dietary records). Nutritional behaviours were compared before and during lockdown using Student paired t-tests and associated to individual characteristics using multivariable logistic or linear regression models. Clusters of nutritional behaviours were derived from multiple correspondence analysis and ascending hierarchical classification. Results: During the lockdown, trends for unfavourable nutritional behaviours were observed: weight gain (for 35%; +1.8kg on average), decreased physical activity (53%), increased sedentary time (63%), increased snacking, decreased consumption of fresh food products (especially fruit and fish), increased consumption of sweets, biscuits and cakes. Yet, opposite trends were also observed: weight loss HP weight loss MESHD (for 23%, -2kg on average), increased home-made cooking (40%), increased physical activity (19%). These behavioural trends related to sociodemographic and economic position, professional situation during the lockdown (teleworking or not), initial weight status, having children TRANS at home, anxiety HP anxiety MESHD and depressive symptoms MESHD, as well as diet quality before the lockdown. Modifications of nutritional practices mainly related to routine change, food supply, emotional reasons but also to voluntary changes to adjust to the current situation. Conclusion: These results suggest that the lockdown led, in a substantial part of the population, to unhealthy nutritional behaviours that, if maintained in the long term, may increase the nutrition-related burden of disease and also impact immunity. Yet, the lockdown situation also created an opportunity for some people to improve their nutritional behaviours, with high stakes to understand the leverages to put these on a long-term footing.

    Psychological distress and internet-related behaviors between schoolchildren with and without overweight HP during the COVID-19 outbreak

    Authors: Chao-Ying Chen; I-Hua Chen; Kerry O’Brien; Janet D Latner; Chung-Ying Lin

    doi:10.21203/ Date: 2020-05-07 Source: ResearchSquare

    Objective: The novel coronavirus disease MESHD 2019 (COVID-19) pandemic, and its resulting social policy changes, may result in psychological distress among schoolchildren with overweight HP. This study thus aimed to (1) compare psychological distress (including fear of COVID-19 infection MESHD, stress, anxiety HP anxiety MESHD, and depression MESHD), perceived weight stigma, and problematic internet-related behaviors between schoolchildren with and without overweight HP; (2) assess whether perceived weight stigma MESHD and problematic internet-related behaviors explained psychological distress.Methods: Schoolchildren (n=1 357; mean age=10.7 years) with overweight HP (n=236) and  without overweight HP (n=1 121) completed an online survey assessing their fear of COVID-19 infection MESHD, stress, anxiety HP anxiety MESHD, depression MESHD, perceived weight stigma, problematic smartphone application use, problematic social media use, and problematic gaming.Results: Schoolchildren with overweight HP had significantly higher levels of COVID-19 infection fear, stress, depression MESHD, perceived weight stigma, and problematic social media use than those without overweight HP. Regression models showed that perceived weight stigma and problematic internet-related behaviors were significant predictors of psychological distress MESHD among schoolchildren with overweight HP.Conclusion: Strategies to manage perceived weight stigma and problematic internet-related behaviors may have a positive influence on mental health among schoolchildren with overweight HP under health-threatening circumstances, such as the current COVID-19 pandemic.

    Association of inflammatory markers with the severity of COVID-19

    Authors: Furong Zeng; Ying Guo; Mingzhu Yin; Xiang Chen; Guangtong Deng

    doi:10.1101/2020.04.14.20065680 Date: 2020-04-17 Source: medRxiv

    Background: The ongoing worldwide epidemic of Coronavirus Disease MESHD 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 MESHD (SARS-CoV-2), has posed a huge threat to global public health. However, with regard to the effects of inflammatory markers on the severity of COVID-19, studies have reported associations that vary in strength and direction. Aims: In the meta-analysis, we aimed to provide an overview of the association of inflammatory markers with severity of COVID-19. Methods: The following databases were searched: PubMed, Embase, Cochrane Library, Wanfang database and CNKI (China National Knowledge Infrastructure) database until March 20, 2020. Weighted mean difference ( WMD MESHD) and 95% confidence intervals (CIs) were pooled using random or fixed-effects models. Results: A total of 16 studies were included in our analysis comprising of 3962 patients with COVID-19. Random-effects results demonstrated that patients with COVID-19 in non-severe group had lower levels for CRP (WMD = -41.78 mg/l, 95% CI = [-52.43, -31.13], P < 0.001), PCT (WMD = -0.13 ng/ml, 95% CI = [-0.20, -0.05], P < 0.001), IL-6 (WMD = -21.32 ng/l, 95% CI = [-28.34, -14.31], P < 0.001), ESR (WMD = -8.40 mm/h, 95% CI = [-14.32, -2.48], P = 0.005), SAA (WMD = -43.35 g/ml, 95% CI = [-80.85, -5.85], P = 0.020) and serum SERO ferritin (WMD = -398.80 mg/l, 95% CI = [-625.89, -171.71], P < 0.001), compared with those in severe group. Moreover, survivors had lower level for IL-6 than non-survivors with COVID-19 (WMD = -4.80 ng/ml, 95% CI = [-5.87, -3.73], P < 0.001). These results were consistent through sensitivity SERO analysis and publication bias assessment. Conclusions: The meta-analysis highlights the association of inflammatory markers with the severity of COVID-19. Measurement of inflammatory markers might help clinicians to monitor and evaluate the severity and prognosis of COVID-19.

    Status of and Factors Influencing the Anxiety HP Anxiety MESHD and Depression of Front-line Medical Staff Supporting Wuhan in Containing COVID-19

    Authors: ning sun; Laiyou LI; Shuangqin CHEN; Shuang YANG; Xiufen LIU

    doi:10.21203/ Date: 2020-03-27 Source: ResearchSquare

    Background: The novel coronavirus pneumonia MESHD pneumonia HP (NCP) has the novel coronavirus as its pathogen. At present, more than 30,000 medics from nationwide medical teams have supported Wuhan. However, some medical workers have been seriously infected in Wuhan and other parts of Hubei Province, with over 3,000 medical staff having been confirmed of infection TRANS infection MESHD. Therefore, it is necessary to analysis the emotional status of front-line medical staff and their influencing factors in dealing with the NCP so as to provide an objective basis for prevention and intervention measures. Methods: This research aimed to shed light on the relation between the personality characteristics of front-line medical workers and their anxiety HP anxiety MESHD and depression, to provide the basis and reference for targeted mental health education and for relevant departments to formulate relevant policies. This study adopted a convenient sampling method and examined the psychological status of 150 front-line medical workers from Zhejiang Province with questionnaire surveys using the Hamilton Anxiety HP Anxiety MESHD and Depression Scale. Results: The participants had severe anxiety HP anxiety MESHD and depression; the top three items under the category of anxiety HP anxiety MESHD were genitourinary symptoms, behavior at interview, and respiratory symptoms, whereas the top three items under depression MESHD were feelings of guilt, weight loss HP weight loss MESHD, and retardation MESHD. Among all personal data, the following factors influenced anxiety HP anxiety MESHD, in decreasing order: degree of suspicion of being infected MESHD when showing associated symptoms, degree of fear of yourself and your family being infected, and the affiliated hospital (P <0.05). The first two factors similarly influenced depression MESHD (P <0.05).      Conclusion: The front-line medical staff were found to have serious anxiety HP anxiety MESHD and depression when dealing with the outbreak of the novel coronavirus pneumonia MESHD pneumonia HP, and have enormous psychological stress MESHD in the face of the growing number of confirmed cases TRANS and current absence of special treatment. Targeted mental health promotion work must be carried out to alleviate the psychological pressure of front-line medical staff and enhance their physical and mental health so that they can better contribute to the efforts against the current epidemic.

    An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 and multiple endemic, epidemic and bat coronavirus

    Authors: Timothy P Sheahan; Amy C Sims; Shuntai Zhou; Collin Hill; Sarah R Leist; Alexandra Schaefer; Maria Agostini; Andrea Pruijssers; Ariane J Brown; Gregory Bluemling; Michael Natchus; Manohar Saindane; Alexander Kolykhalov; George Painter; Ronald Swanstrom; Kenneth Dinnon III; Rachel Graham; Jennifer Harcourt; Azaibi Tamin; Natalie J. Thornburg; Stephanie A. Montgomery; James Chappell; Mark Denison; Ralph S. Baric

    doi:10.1101/2020.03.19.997890 Date: 2020-03-20 Source: bioRxiv

    Coronaviruses (CoVs) traffic frequently between species resulting in novel disease outbreaks, most recently exemplified by the newly emerged SARS-CoV-2. Herein, we show that the ribonucleoside analog {beta}-D-N4-hydroxycytidine (NHC, EIDD-1931) has broad spectrum antiviral activity against SARS-CoV 2, MERS-CoV, SARS-CoV MESHD, and related zoonotic group 2b or 2c Bat-CoVs, as well as increased potency against a coronavirus bearing resistance mutations to another nucleoside analog inhibitor. In mice infected with SARS-CoV MESHD or MERS-CoV, both prophylactic and therapeutic administration of EIDD-2801, an orally bioavailable NHC-prodrug (b-D-N4-hydroxycytidine-5-isopropyl ester), improved pulmonary function, and reduced virus titer and body weight loss HP weight loss MESHD. Decreased MERS-CoV MESHD yields in vitro and in vivo were associated with increased transition mutation frequency in viral but not host cell RNA, supporting a mechanism of lethal mutagenesis. The potency of NHC/EIDD-2801 against multiple coronaviruses, its therapeutic efficacy, and oral bioavailability in vivo, all highlight its potential utility as an effective antiviral against SARS-CoV-2 and other future zoonotic coronaviruses.

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MeSH Disease
Human Phenotype

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