Corpus overview


Overview

MeSH Disease

Human Phenotype

Transmission

Seroprevalence

There are no seroprevalence terms in the subcorpus

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    Surprising protective mechanisms against severe forms of COVID-19 infection MESHD among Common Variable Immunodeficiency HP Immunodeficiency MESHD Patients- one center experience.

    Authors: Carina Petricau; Irena Nedelea; Diana Deleanu

    doi:10.21203/rs.3.rs-57542/v1 Date: 2020-08-11 Source: ResearchSquare

    In this report we aimed to present the nonthreatening experience of patients diagnosed with Common variable immunodeficiency HP immunodeficiency MESHD ( CVID MESHD) included in the National Rare Disease Program registry and consulted at the Immunology department of the Regional Institute of Gastroenterology and Hepatology “Prof Dr. Octavian Fodor” during the Coronavirus disease 2019 (COVID-19) pandemic as well as to review the current understanding of COVID-19 immunopathology followed by possible protective mechanisms against severe infection HP infection MESHD in these highly susceptible individuals. We report clinical and laboratory results of patients in a single-center retrospective study after lockdown restrictions were partially lifted (May-June 2020) and patients were able to come into the hospital for routine check-up and immunoglobulin replacement treatment. Of the 49 patients consulted during this period, we identified only one asymptomatic TRANS patient with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection MESHD, supporting recently published data that not all immune compromised patients are at increased risk. According to recent publications the virus induces an inflammatory response leading to a cytokine storm responsible for severe complications. CVID MESHD patients seem to be protected from severe forms of this severe virus through reduced viral susceptibility, deficient B lymphocyte response, loss of Interleukin-6 (IL-6) receptor and impaired toll-like receptor pathway activation. Despite being at high risk for other infectious disease MESHD, in the context of SARS-CoV-2 induced pandemic, CVID MESHD patient’s lack of immune response is their protection against the dangerous macrophage hyper-activation resulting cytokine storm consequences. 

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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