Corpus overview


MeSH Disease

Human Phenotype

Falls (1)

Paralysis (1)

Pneumonia (1)

Fever (1)

Cough (1)


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    Epidemiological and cohort study finds no association between COVID-19 and Guillain-Barre syndrome MESHD

    Authors: Stephen Keddie; Julia Pakpoor; Christina Mousele; Menelaos Pipis; Pedro M Machado; Mark Foster; Christopher J Record; Ryan Keh; Janev Fehmi; Ross W Paterson; Viraj Bharambe; Lisa Clayton; Claire Allen; Olivia Price; Jasmine Wall; Annamaria Kiss-csenki; Dipa P Rathnasabapathi; Ruth Geraldes; Tatyana Yermakova; Josh King-Robson; Maya Zosmer; Sanjeev Rajakulendran; Ross Nortley; Charles Marshall; Edward Newman; Niranjanan Nirmalananthan; Guru Kumar; Ashwin A Pinto; James Holt; Tim Lavin; Katie Brennan; Michael Zandi; Dipa L Jayaseelan; Jane Pritchard; Robert DM Hadden; Hadi Manji; Hugh J Willison; Simon Rinaldi; Aisling S Carr; Michael P Lunn

    doi:10.1101/2020.07.24.20161471 Date: 2020-07-24 Source: medRxiv

    Background Reports of Guillain-Barre Syndrome MESHD ( GBS MESHD) have emerged during the Coronavirus Disease MESHD 2019 (COVID-19) pandemic. This epidemiological and cohort study sought to investigate any causative association between COVID-19 infection MESHD and GBS MESHD. Methods The epidemiology of GBS MESHD cases reported via the UK National Immunoglobulin Database were studied from 2016-2019 and compared to cases reported during the COVID-19 pandemic. For the cohort study, members of the British Peripheral Nerve Society reported all cases of GBS MESHD during the pandemic. The clinical features, investigation findings and outcomes of COVID-19 (definite or probable) and non-COVID-19 associated GBS MESHD cases were compared. Results The UK GBS MESHD incidence from 2016-2019 was 1.65-1.88 per 100,000 people per year. GBS MESHD and COVID-19 incidence varied between regions and did not correlate (r = 0.06, 95% CI -0.56 to 0.63, p=0.86). GBS MESHD incidence fell HP between March and May 2020 compared to the same months of 2016-2019. Forty-seven GBS MESHD cases were included in the cohort study (13 definite, 12 probable COVID-19 and 22 non-COVID-19). There were no significant differences in the pattern of weakness, time to nadir, neurophysiology, CSF findings or outcome. Intubation was more frequent in the COVID-19+ve cohort (7/13, 54% vs 5/22, 23% in COVID negative) thought to be related directly to COVID-19 pulmonary involvement. Conclusions This study finds no epidemiological or phenotypic clues of SARS-CoV-2 being causative of GBS MESHD. GBS MESHD incidence has fallen HP during the pandemic which may be the influence of lockdown measures reducing transmission TRANS of GBS MESHD inducing pathogens such as Campylobacter jejuni and respiratory viruses.

    Neurological Involvement of Coronavirus Disease MESHD 2019: A Systematic Review

    Authors: Malik Ghannam; Qasem Alshaer; Mustafa Al-Chalabi; Lara Zakarna; Jetter Robertson; Georgios Manousakis

    doi:10.21203/ Date: 2020-05-23 Source: ResearchSquare

    Background: In December 2019, unexplained cases of pneumonia HP pneumonia MESHD emerged in Wuhan, China, which were found to be secondary to the novel coronavirus SARS-CoV-2. On March 11, 2020, the WHO declared the Coronavirus Disease MESHD 2019 (COVID-2019) outbreak, a pandemic. Although the most common presentations of COVID-19 are fever HP fever MESHD, cough HP cough MESHD and shortness of breath MESHD, several clinical observations indicate that COVID-19 does affect the central and peripheral nervous system.  Methods: We conducted a systematic literature search from December 01, 2019 to May 14, 2020 using multiple combinations of keywords from PubMed and Ovid Medline databases according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. We included articles with cases of COVID-19 that were evident for neurological involvement.  Results: We were able to identify 82 cases of COVID-19 with neurological complications. The mean age TRANS was 62.28 years. 37.8% of the patients were women (n = 31). 48.8% of the patients (n=40) had cerebrovascular insults, 28% (n=23) had neuromuscular disorders MESHD, 18.3% of the patients (n=15) had encephalitis HP encephalitis MESHD or encephalopathy HP encephalopathy MESHD, and 2.4% (n=2) presented with status epilepticus HP status epilepticus MESHD. Conclusions: Neurological manifestations of COVID-19 infection MESHD are not rare, especially large vessel stroke HP stroke MESHD, Guillain barre syndrome MESHD and meningoencephalitis MESHD. Moving forward, further studies are needed to clarify the prevalence SERO of the neurological complications of COVID-19, investigate their biological backgrounds, and test treatment options. Physicians should be cautious not to overlook other neurological diagnoses that can mimic COVID-19 during the pandemic.

    Early Guillain-Barré syndrome in COronaVIrus Disease MESHD 2019 (COVID-19): a case report from an Italian COVID-Hospital

    Authors: Donatella Ottaviani; Federica Boso; Enzo Tranquillini; Ilaria Gapeni; Giovanni Pedrotti; Susanna Cozzio; Giovanni M. Guarrera; Bruno Giometto

    doi:10.21203/ Date: 2020-04-24 Source: ResearchSquare

    Guillain Barré syndrome ( GBS MESHD) is an acute polyradiculoneuropathy MESHD associated with dysimmune processes, often related to a previous infectious exposure. During Italian Severe Acute Respiratory Syndrome Coronavirus-2 MESHD outbreak, a woman presented with a rapidly progressive flaccid paralysis MESHD paralysis HP with unilateral facial neuropathy MESHD after a few days of mild respiratory symptoms. Coronavirus was detected by nasopharyngeal swab, but there was no evidence of its presence in her cerebrospinal fluid, which confirmed the typical albumin-cytological dissociation of GBS MESHD, along with consistent neurophysiological data. Despite immunoglobulin infusions and intensive supportive care, her clinical picture worsened simultaneously both from respiratory and neurological point of view, as if reflecting different aspects of the same systemic inflammatory response. Similar early complications have already been observed in patients with para-infectious GBS MESHD related to Zika virus, but pathological mechanisms have yet to be established.

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MeSH Disease
Human Phenotype

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