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MeSH Disease

Human Phenotype

Transmission

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Seroprevalence
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    SARS-CoV-2 targets cortical neurons of 3D human brain organoids and shows neurodegeneration HP neurodegeneration MESHD-like effects

    Authors: Jay Gopalakrishnan; Anand Ramani; Lisa Mueller; Philipp Niklas Ostermann; Elke Gabriel; Abida Islam Pranty; Andreas Mueller-Shiffmann; Aruljothi Mariappan; Oliver Goureau; Henning Gruell; Andreas Walker; Marcel Andree; Sandra Hauka; Kai Wohlgemuth; Heymut Omran; Florian Klein; Dagmar Wieczorek; Ortwin Adams; Joerg Timm; Carsten Korth; Heiner Schaal; Torsten Houwaart; Alexander Dilthey

    doi:10.1101/2020.05.20.106575 Date: 2020-05-20 Source: bioRxiv

    COVID-19 pandemic caused by SARS-CoV-2 infection MESHD is a public health emergency. COVID-19 typically exhibits respiratory illness MESHD. Unexpectedly, emerging clinical reports indicate that neurological symptoms continue to rise, suggesting detrimental effects of SARS-CoV-2 on the central nervous system (CNS). Here, we show that a Dusseldorf isolate of SARS-CoV-2 enters 3D human brain organoids within two days of exposure. Using COVID-19 convalescent serum SERO, we identified that SARS-CoV-2 preferably targets soma of cortical neurons but not neural stem cells, the target cell type of ZIKA virus. Imaging cortical neurons of organoids reveal that SARS-CoV-2 exposure is associated with missorted Tau from axons to soma, hyperphosphorylation, and apparent neuronal death MESHD. Surprisingly, SARS-CoV-2 co-localizes specifically with Tau phosphorylated at Threonine-231 in the soma, indicative of early neurodegeneration HP neurodegeneration MESHD-like effects. Our studies, therefore, provide initial insights into the impact of SARS-CoV-2 as a neurotropic virus and emphasize that brain organoids could model CNS pathologies of COVID-19. One sentence summaryCOVID-19 modeling in human brain organoids

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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