Corpus overview


MeSH Disease

Human Phenotype


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    Population perspective comparing COVID-19 to all and common causes of death in seven European countries

    Authors: Bayanne Olabi; Jayshree Bagaria; Sunil Bhopal; Gwenetta Curry; Nazmy Villarroel; Raj Bhopal

    doi:10.1101/2020.08.07.20170225 Date: 2020-08-11 Source: medRxiv

    Background: Mortality statistics on the COVID-19 pandemic have led to widespread concern and fear. To contextualise these data, we compared mortality related to COVID-19 with all and common causes of death MESHD, stratifying by age TRANS and sex. We also calculated deaths as a proportion of the population by age TRANS and sex. Methods: COVID-19 related mortality and population statistics from seven European countries were extracted: England and Wales, Italy, Germany, Spain, France, Portugal and Netherlands. Available data spanned 14-16 weeks since the first recorded deaths in each country, except Spain, where only comparable stratified data over an 8-week time period was available. The Global Burden of Disease database provided data on all deaths and those from pneumonia HP pneumonia MESHD, cardiovascular disease MESHD combining ischaemic heart disease MESHD and stroke HP stroke MESHD, chronic obstructive pulmonary disease HP chronic obstructive pulmonary disease MESHD, cancer MESHD, road traffic accidents and dementia HP dementia MESHD. Findings: Deaths related to COVID-19, while modest overall, varied considerably by age TRANS. Deaths as a percentage of all cause deaths during the time period under study ranged from <0.01% in children TRANS in Germany, Portugal and Netherlands, to as high as 41.65% for men aged TRANS over 80 years in England and Wales. The percentage of the population who died from COVID-19 was less than 0.2% in every age group TRANS under the age TRANS of 80. In each country, over the age TRANS of 80, these proportions were: England and Wales 1.27% males TRANS, 0.87% females TRANS; Italy 0.6% males TRANS, 0.38% females TRANS; Germany 0.13% males TRANS, 0.09% females TRANS; France 0.39% males TRANS, 0.2% females TRANS; Portugal 0.2% males TRANS, 0.15% females TRANS; and Netherlands 0.6% males TRANS, 0.4% females TRANS. Interpretation: Mortality rates from COVID-19 remains low including when compared to other common causes of death MESHD and will likely decline further while control measures are maintained. These data may help people contextualise their risk and policy makers in decision-making.

    Acutely Altered Mental Status as the Main Clinical Presentation of Multiple Strokes HP Strokes MESHD in Critically Ill Patients With COVID-19.

    Authors: Carolina Díaz-Pérez; Carmen Ramos; Alberto López-Cruz; José Muñoz Olmedo; Jimena Lázaro González; Enrique de Vega-Ríos; Carmen González-Ávila; Carlos Hervás; Santiago Trillo; José Vivancos

    doi:10.21203/ Date: 2020-05-26 Source: ResearchSquare

    Background and aims: Cerebral infarction MESHD in COVID-19 patients might be associated with a hypercoagulable state related to a systemic inflammatory response. Its diagnosis might be challenging. We present two critically ill patients with COVID-19 who presented acutely altered mental status as the main manifestation of multiple strokes MESHD strokes HP.Methods:Clinical presentation and diagnostic work-up of the patients.Results:Two patients in their sixties were hospitalized with a bilateral pneumonia HP COVID-19. They developed respiratory failure HP respiratory failure MESHD and were admitted to ICU for mechanical ventilation and intense medical treatment. They were started on low-molecular-weight heparin since admission. Their laboratory results showed lymphopenia HP lymphopenia MESHD and increased levels of C-reactive protein and D-dimer. Case 1 developed hypofibrinogenemia HP and presented several cutaneous lesions with biopsy features of thrombotic vasculopathy MESHD. Case 2 was performed a CT pulmonary angiogram at ICU showing a bilateral pulmonary embolism HP pulmonary embolism MESHD. When waking up, both patients were conscious but with a remarkable global altered mental status without focal neurological deficits MESHD. A brain MRI revealed multiple acute bilateral ischemic lesions MESHD with areas of hemorrhagic MESHD transformation in both patients (Case 1: affecting the left frontal and temporal lobes MESHD and both occipital lobes; Case 2: affecting both frontal and left occipital lobes). Cardioembolic source and acquired antiphospholipid syndrome MESHD were ruled out. COVID-19-associated coagulopathy MESHD was suspected as the possible main etiology of the strokes HP strokes MESHD.Conclusion:Acutely altered mental status might be the main manifestation of multiple brain infarctions MESHD in critically ill COVID-19 patients. It should be specially considered in those with suspected COVID-19-associated coagulopathy MESHD. Full-dose anticoagulation and clinical-radiological monitoring might reduce their neurological consequences.

    Neurological Involvement of Coronavirus Disease MESHD 2019: A Systematic Review

    Authors: Malik Ghannam; Qasem Alshaer; Mustafa Al-Chalabi; Lara Zakarna; Jetter Robertson; Georgios Manousakis

    doi:10.21203/ Date: 2020-05-23 Source: ResearchSquare

    Background: In December 2019, unexplained cases of pneumonia HP pneumonia MESHD emerged in Wuhan, China, which were found to be secondary to the novel coronavirus SARS-CoV-2. On March 11, 2020, the WHO declared the Coronavirus Disease MESHD 2019 (COVID-2019) outbreak, a pandemic. Although the most common presentations of COVID-19 are fever HP fever MESHD, cough HP cough MESHD and shortness of breath MESHD, several clinical observations indicate that COVID-19 does affect the central and peripheral nervous system.  Methods: We conducted a systematic literature search from December 01, 2019 to May 14, 2020 using multiple combinations of keywords from PubMed and Ovid Medline databases according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. We included articles with cases of COVID-19 that were evident for neurological involvement.  Results: We were able to identify 82 cases of COVID-19 with neurological complications. The mean age TRANS was 62.28 years. 37.8% of the patients were women (n = 31). 48.8% of the patients (n=40) had cerebrovascular insults, 28% (n=23) had neuromuscular disorders MESHD, 18.3% of the patients (n=15) had encephalitis HP encephalitis MESHD or encephalopathy HP encephalopathy MESHD, and 2.4% (n=2) presented with status epilepticus HP status epilepticus MESHD. Conclusions: Neurological manifestations of COVID-19 infection MESHD are not rare, especially large vessel stroke HP stroke MESHD, Guillain barre syndrome MESHD and meningoencephalitis MESHD. Moving forward, further studies are needed to clarify the prevalence SERO of the neurological complications of COVID-19, investigate their biological backgrounds, and test treatment options. Physicians should be cautious not to overlook other neurological diagnoses that can mimic COVID-19 during the pandemic.

    COVID-19 and Crosstalk With the Hallmarks of Aging

    Authors: Shabnam Salimi; John M. Hamlyn

    id:10.20944/preprints202004.0182.v2 Date: 2020-05-16 Source:

    Within the past several decades, the emergence of new viral diseases MESHD with severe health complications and mortality is evidence of an age TRANS-dependent, compromised bodily response to abrupt stress with concomitantly reduced immunity. The new severe acute respiratory syndrome coronavirus 2 MESHD, SARS-CoV-2, causes coronavirus disease MESHD 2019 (COVID-19). It has increased morbidity and mortality in persons with underlying chronic diseases MESHD and those with a compromised immune system regardless of age TRANS and in older adults TRANS who are more likely to have these conditions. While SARS-CoV-2 is highly virulent, there is variability in the severity of the disease and its complications in humans. Severe pneumonia HP pneumonia MESHD, acute respiratory distress syndrome MESHD respiratory distress HP syndrome, lung fibrosis MESHD, cardiovascular events, acute kidney injury HP acute kidney injury MESHD, stroke HP stroke MESHD, hospitalization, and mortality have been reported that result from pathogen–host interactions. Hallmarks of aging, interacting with one another, have been proposed to influence health span in older adults TRANS, possibly via mechanisms regulating the immune system. Here, we review the potential roles of the hallmarks of aging coupled with host–coronavirus interactions. Of these hallmarks, we focused on those that directly or indirectly interact with viral infections MESHD, including immunosenescence, inflammation MESHD and inflammasomes, adaptive immunosenescence, genomic instability, mitochondrial dysfunction MESHD, telomere attrition, epigenetic alterations, and impaired autophagy. These hallmarks likely contribute to the increased pathophysiological responses to SARS-CoV-2 among older adults TRANS and may play roles as an additive risk of accelerated biological aging even after recovery. We also briefly discuss the role of anti-aging drug candidates that require paramount attention in COVID-19 research.

    Cerebrovascular complications MESHD in patients with  SARS-CoV-2 infection MESHD: Case series 

    Authors: Mauro Morassi; Daniele Bagatto; Milena Cobelli; Serena D’Agostini; Gian Luigi Gigli; Claudio Bnà; Alberto Vogrig

    doi:10.21203/ Date: 2020-04-15 Source: ResearchSquare

    Background: Italy is one of the most affected countries by the Coronavirus disease 2019 (COVID-19). The responsible pathogen is named S evere Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) MESHD. The clinical spectrum ranges from asymptomatic TRANS infection to severe HP nfection MESHDto severe pneumonia HP neumonia MESHDleading to intensive care unit admission. Evidence of c erebrovascular complications MESHDassociated with SARS-CoV-2 is limited. We herein report 6 patients who developed a cute stroke MESHD stroke HP during COVID-19 i nfection. MESHD Methods: Retrospective case series of patients diagnosed with COVID-19 using reverse-transcriptase–polymerase-chain-reaction (RT-PCR) on nasopharyngeal swabs, who developed clinical and neuroimaging evidence of a cute stroke MESHD stroke HP during S ARS-CoV-2 infection. MESHDResults: Six patients were identified (5 men); median age TRANS was 69 years (range: 57-82). Stroke HP troke MESHDsubtypes were i schemic MESHD(4, 67%) and h emorrhagic MESHD(2, 33%). All patients but 1 had pre-existing vascular risk factors. One patient developed encephalopathy HP ncephalopathy MESHDprior to stroke HP troke, MESHD characterized by focal seizures HP eizures MESHDand behavioral abnormalities HP ehavioral abnormalities. MESHD COVID-19-related pneumonia HP neumonia MESHDwas severe (i.e. requiring critical care support) in 5/6 cases (83%). Liver enzyme alteration and lactate dehydrogenase (LDH) elevation was registered in all cases. Four patients (67%) manifested a cute kidney failure MESHDprior to stroke HP troke. MESHD Four patients (67%) had abnormal coagulation tests. Outcome was poor in the majority of the patients: 4 died (67%), 1 is still in coma HP oma MESHD(20%) and the remaining 1 remains severely neurologically affected (mRS: 4).Conclusions: Acute stroke HP troke MESHDcan complicate the course of COVI-19 i nfection. MESHD In our series, stroke HP troke MESHDdeveloped mostly in patients with severe pneumonia HP neumonia MESHDand m ulti organ failure, MESHD liver enzymes and LDH were markedly increased in all cases, and the outcome was poor.

    The 2019 novel coronavirus disease MESHD with secondary ischemic stroke HP ischemic stroke MESHD: two cases report

    Authors: Bin Fu; Yun Chen; Ping Li

    doi:10.21203/ Date: 2020-04-02 Source: ResearchSquare

    Background: The 2019 novel coronavirus disease MESHD is an outbreak of respiratory illness MESHD first detected in Wuhan, China in the end of Dec, 2019. The older patients complicated with underlying diseases MESHD are reported more likely to have clinical symptoms. But its secondary lesion is rarely reported. Case presentation: We reported two cases of coronavirus infected pneumonia MESHD pneumonia HP with acute ischemic stroke MESHD ischemic stroke HP in patients at their middle- age TRANS. In both 2019 coronavirus diseases MESHD cases, neurological physical examination are normal before infection MESHD. Lymphocytopenia MESHD and high expression of cytokines and D-dimer were found from serum SERO clinical laboratory test at admission. The dysarthria HP dysarthria MESHD and limb muscle weakness HP muscle weakness MESHD are initial manifestations in one week after 2019 novel coronavirus infection MESHD. The head CT and head/neck arterial CTA showed small-vessel occlusion MESHD. The patients were diagnosed with coronavirus diseases MESHD with secondary acute ischemic stroke HP ischemic stroke MESHD. They were treated with tirofiban and followed up with daily aspirin and atorvastatin. Conclusion: The present cases suggested that secondary ischemic stroke HP ischemic stroke MESHD, which mainly manifested as small-vessel occlusion MESHD, should be considered for coronavirus disease MESHD patients with prompt diagnosis and treatment. 

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MeSH Disease
Human Phenotype

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