Corpus overview


MeSH Disease

Human Phenotype



There are no seroprevalence terms in the subcorpus

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    COVID-19: Role of the Inflammasome

    Authors: Claudio G. Gallo; Sirio Fiorino; Giovanni Posabella; Donato Antonacci; Antonio Tropeano; Emanuele Pausini; Carlotta Pausini; Tommaso Guarniero; Marco Zancanaro

    id:202007.0246/v1 Date: 2020-07-12 Source:

    Covid-19 disease is caused by SARS Cov-2 virus. Despite its high transmissibility TRANS, the CFR (Case Fatality Rate) of COVID-19 seems to be lower than the SARS (9,5%) and MERS (34,4%) ones93 , but higher than the influenza one (0-1%)94,95 . The disease is asymptomatic TRANS or paucisymptomatic in most of the patients, although in few cases it can be characterized by serious complications. The main causes of hospitalization in intensive care are represented by ALI MESHD (Acute Lung Injury), ARDS MESHD ( Acute Respiratory Distress Syndrome MESHD Respiratory Distress HP Syndrome), cardiovascular problems and coagulopathies MESHD (diffuse thrombosis MESHD, microthrombosis, embolisms MESHD, myocarditis HP myocarditis MESHD, arrhytmias, heart failure MESHD, stroke HP stroke MESHD)96-98, acute nephropathy99,100 and encephalopathies101 MESHD. The virus presence in the vascular wall can cause endotheliitis MESHD, which triggers the process of diffuse coagulation that can lead to a worsening of the systemic inflammation MESHD. The exaggerated inflammatory response seems to be connected with the development of ARDS MESHD, MOF (Multiple Organ Failure) and coagulopathies102-107.

    Insight from a noticeable difference between two families infected with COVID-19

    Authors: Shugang Cao; Yuancheng Li; Hong Yue; Chenchen Li; Mingwu Xia; Fang Liu; Juncang Wu

    doi:10.21203/ Date: 2020-04-14 Source: ResearchSquare

    The outbreak of COVID-19 shows a high potent of person-to-person transmission TRANS and thus contributes to a large spread of infection sweeping the world. The family cluster of infection MESHD has been paid much more attention. We reported two different families infected by SARS-CoV-2 in the context of family clustering, one of which is a typical family cluster of infection MESHD with the transmission chain TRANS being an asymptomatic TRANS patient in the incubation period TRANS. However, the outcome of another family was exactly the opposite, in which the index patient was the only individual infected and complicated with fatal ischemic stroke HP ischemic stroke MESHD. These two families highlight that more attention should be paid to the distinctions underlying the family cluster of infections MESHD and the possibility of COVID-19-related stroke HP stroke MESHD

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MeSH Disease
Human Phenotype

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