Corpus overview


MeSH Disease

Human Phenotype

Anxiety (194)

Insomnia (9)

Pain (8)

Fever (8)

Sleep disturbance (6)


    displaying 1 - 10 records in total 194
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    Factors associated with drinking behaviour during COVID-19 social distancing and lockdown among adults TRANS in the UK

    Authors: Claire Garnett; Sarah E Jackson; Melissa Oldham; Jamie Brown; Andrew Steptoe; Daisy Fancourt; Matthijs Kon; Lu Lu; Frank M. Aarestrup; Samantha Lycett; Gertjan Medema; Marion P.G. Koopmans; Miranda de Graaf; Silvio Brusaferro; Giovanni Rezza; Maria G Dente; Silvia Declich; Patrizio Pezzotti; Flavia Riccardo; Christophe Fraser; Neil M Ferguson; Swapnil Mishra; Seth Flaxman; Samir Bhatt; Oliver Ratmann; - Imperial College London COVID-19 Response Team

    doi:10.1101/2020.09.22.20199430 Date: 2020-09-22 Source: medRxiv

    Abstract Aim: To assess what factors were associated with reported changes to usual alcohol drinking behaviour during the start of lockdown in the UK. Design: Online cross-sectional survey from 21st March to 4th April 2020. Setting: UK. Participants: 30,375 adults TRANS aged TRANS [≥]18y. Measurements: Changes in drinking over the past week, sociodemographic characteristics, diagnosed or suspected COVID-19, adherence to COVID-19 protective behaviours, stress about COVID-19, finances or boredom, recent drop in household income, key worker status, and health conditions. Findings: Of 22,113 drinkers (65.7% of analytic sample), 48.1% (95% CI=47.0-49.1%) reported drinking about the same as usual, 25.7% (24.8-26.6%) reported drinking less than usual, and 26.2% (25.4-27.1%) reported drinking more than usual over the past week. Drinking less than usual was independently associated with being younger (OR=0.88 [95% CI=0.83-0.93]), male TRANS (OR=0.76 [0.68-0.84]), of an ethnic minority (OR=0.76 [0.61-0.97]), low annual household income (OR=0.74 [0.66-0.83]), having diagnosed or suspected COVID-19 (OR=2.04 [1.72-2.41]), adhering to COVID-19 protective behaviours (OR=1.58 [1.08-2.32]), being significantly stressed about becoming seriously ill from COVID-19 (OR=1.26 [1.08-1.48]) and not being a key worker (OR=0.87 [0.76-0.99]). Drinking more than usual was independently associated with being younger (OR=0.73 [0.69-0.78]), female TRANS (OR=1.36 [1.22-1.51]), post-16 qualifications (OR=1.21 [1.04-1.40]), high annual household income (OR=1.43 [1.27-1.61]), being significantly stressed about catching (OR=1.22 [1.03-1.45]) or becoming seriously ill from COVID-19 (OR=1.28 [1.10-1.48]), being significantly stressed about finances (OR=1.43 [1.24-1.66]), and having a diagnosed anxiety HP anxiety MESHD disorder (OR=1.24 [1.05-1.46]). Conclusions: In a representative sample of adults TRANS in the UK, about half of drinkers reported drinking the same amount of alcohol as usual during the start of the COVID-19 related lockdown, with a quarter drinking more and a quarter drinking less than usual. Drinking more than usual was associated with being younger, female TRANS, high socioeconomic position, having an anxiety HP anxiety MESHD disorder, and being stressed about finances or COVID-19. These groups may benefit targeted alcohol reduction support if there are further periods of lockdown.

    Effects on the mental health after COVID-19 lockdown period: results from a population survey study in Lima, Peru

    Authors: Hever Krüger-Malpartida; Bruno Pedraz-Petrozzi; Martin Arevalo-Flores; Frine Salmavides-Cuba; Victor Anculle-Arauco; Mauricio Dancuart-Mendoza

    doi:10.21203/ Date: 2020-09-20 Source: ResearchSquare

    1. The coronavirus disease MESHD 2019 (COVID-19) has created a rapid global health crisis, involving different social changes, which brought negative effects in different aspects in the mental health of the population, like the COVID-19 lockdown. The majority of COVID-19 cases concentrate in the region of the Americas, being Peru one of the most affected countries in the region. For this reason, to investigate possible effects related to COVID-19 lockdown, the main objective of this work is to establish a statistical model that could explain through different components the COVID-19 related stress in a population after COVID-19 lockdown of Lima, Peru. In this sense, online questionnaires were carried out in 400 participants, where the values ​​of depressiveness, anxiousness MESHD and stress related to COVID-19 were evaluated. Other information related to the participant (e.g. gender TRANS, age TRANS, district, etc.) was collected through this electronic format. In order to explain the data, an ordinal logistic regression was carried out. From the information obtained, it was found that 35.50% of the participants showed mild stress and 9.30% showed severe stress due to COVID-19. The ordinal logistic regression model showed that the severity of stress due to COVID-19 is positive associated with the variables age TRANS, depressiveness and anxiousness MESHD, as well with the presence of a deceased relative due to COVID-19. On the other hand, the presence of a family member TRANS who was hospitalized for COVID-19 is negatively correlated to the stress produced by COVID-19. Therefore, the data shows that people with older age TRANS or who have lost relatives due to COVID-19 show higher levels of stress related to COVID-19. Additionally, participants with higher levels of anxiety HP anxiety MESHD and depression are more likely to produce higher levels of stress from COVID-19. These factors play an important role for the intervention of future studies that plan to intervene in the mental health of the population affected by the COVID-19 lockdown.

    COPD in the time of COVID-19: An analysis of acute exacerbations and reported behavioural changes in patients with COPD MESHD

    Authors: Hamish Joseph Cameron McAULEY; Kate Hadley; Omer Elneima; Christopher E Brightline; Rachael Evans; Michael C Steiner; Neil Greening; Javed Akram; Ravi K Amaravadi; Derek C Angus; Yaseen M Arabi; Shehnoor Azhar; Lindsey R Baden; Arthur W Baker; Leila Belkhir; Thomas Benfield; Marvin A H Berrevoets; Cheng-Pin Chen; Tsung-Chia Chen; Shu-Hsing Cheng; Chien-Yu Cheng; Wei-Sheng Chung; Yehuda Z Cohen; Lisa N Cowan; Olav Dalgard; Fernando F de Almeida e Val; Marcus V G de Lacerda; Gisely C de Melo; Lennie Derde; Vincent Dubee; Anissa Elfakir; Anthony C Gordon; Carmen M Hernandez-Cardenas; Thomas Hills; Andy I M Hoepelman; Yi-Wen Huang; Bruno Igau; Ronghua Jin; Felipe Jurado-Camacho; Khalid S Khan; Peter G Kremsner; Benno Kreuels; Cheng-Yu Kuo; Thuy Le; Yi-Chun Lin; Wu-Pu Lin; Tse-Hung Lin; Magnus Nakrem Lyngbakken; Colin McArthur; Bryan McVerry; Patricia Meza-Meneses; Wuelton M Monteiro; Susan C Morpeth; Ahmad Mourad; Mark J Mulligan; Srinivas Murthy; Susanna Naggie; Shanti Narayanasamy; Alistair Nichol; Lewis A Novack; Sean M O'Brien; Nwora Lance Okeke; Lena Perez; Rogelio Perez-Padilla; Laurent Perrin; Arantxa Remigio-Luna; Norma E Rivera-Martinez; Frank W Rockhold; Sebastian Rodriguez-Llamazares; Robert Rolfe; Rossana Rosa; Helge Rosjo; Vanderson S Sampaio; Todd B Seto; Muhammad Shehzad; Shaimaa Soliman; Jason E Stout; Ireri Thirion-Romero; Andrea B Troxel; Ting-Yu Tseng; Nicholas A Turner; Robert J Ulrich; Stephen R Walsh; Steve A Webb; Jesper M Weehuizen; Maria Velinova; Hon-Lai Wong; Rebekah Wrenn; Fernando G Zampieri; Wu Zhong; David Moher; Steven N Goodman; John P A Ioannidis; Lars G Hemkens

    doi:10.1101/2020.09.18.20197202 Date: 2020-09-18 Source: medRxiv

    ABSTRACT Introduction: The impact of the SARS-CoV-2 pandemic, and lockdown measures, on acute exacerbations of COPD MESHD (AECOPD) is unknown. We aimed to evaluate the change in AECOPD treatment frequency during the first six weeks of lockdown in the UK compared with 2019 and assess changes in self-reported behaviour and well-being. Methods: In this observational study patients with established COPD were recruited. Exacerbation frequency was measured in the first six weeks of COVID lockdown and compared with the same period in 2019 using electronic health records. A telephone survey was used to assess changes in anxiety HP anxiety MESHD, inhaler adherence, physical activity, shopping and visitor behaviour during the pre-lockdown and lockdown periods compared to normal. Results: 160 participants were recruited (mean [SD] age TRANS 67.3 [8.1] years, 88 [55%] male TRANS, FEV1 34.3 [13] % predicted) and 140 [88%] reported at least one AECOPD in the previous year. Significantly more community treated exacerbations were observed in 2020 compared with 2019 (126 vs 99, p=0.026). The increase was as a result of multiple courses of treatment, with a similar proportion of patients receiving at least one course (34.4% vs 33.8%). During 'lockdown' participants reported significantly increased anxiety HP anxiety MESHD, adherence to their preventative inhalers, and good adherence to shielding advice (all p<0.001). A significant reduction in self-reported physical activity and visitors was reported (both p<0.001). Discussion: Treatment for AECOPD MESHD events increased during the first six weeks of the SARS-CoV-2 pandemic in the UK compared to 2019. This was associated with increased symptoms of anxiety HP anxiety MESHD and significant behavioural change.

    A Proposed Method Using Deep Learning from Unseen to Seen Anxieties HP of Children TRANS during COVID-19

    Authors: Samir Kumar Bandyopadhyay; Shawni Dutta; Vishal Goyel

    id:10.20944/preprints202009.0323.v1 Date: 2020-09-15 Source:

    COVID-19 and new concept, lockdown, change social life of all classes of humans. Children TRANS partially feel the changes of daily life and this situation has been children’s free mind. Children TRANS are under a new type of restriction imposed on them by their parents TRANS. Normally they prefer play with their their friends TRANS than study and always waiting for holidays. They heard a new jargon i.e. lockdown where everything stands still. Very often they see peoples in the roads and few vehicles are moving in the roads. However, a peculiar thing happens now that they sit in front of computer to hear the virtual classes that are taken by the teachers. This also happens when there is no lockdown since COVID-19 still affects people. The environment is totally changed and they do not find any proper answers from the parents TRANS about the scenario.This study has been made an attempt to carry out the mental affairs of children TRANS in West Bengal, India. Several families are surveyed for collecting responses mostly from rural areas as well as urban areas for the time-period from April, 2020 to July, 2020. An effort has been given in this paper to predict the stress, depression MESHD and anxiety HP anxiety MESHD faced by children TRANS during the COVID-19. A Deep Learning Neural Network MESHD ( DLNN MESHD) based method is applied to understand the stress level, depression MESHD level and anxiety HP anxiety MESHD level amongst the children TRANS. A hybrid DLNN MESHD has been presented in this research that combines both Convolutional Layer and Gated-Recurrent Unit (GRU) for obtaining the prediction of the mental health of children TRANS. The model obtains an accuracy of 89.57% for defeminizing mental anxiety HP anxiety MESHD of children TRANS.

    Perceived risk, anxiety HP anxiety MESHD and protective health behaviours during the early phase of coronavirus (COVID-19) pandemic in Nigeria

    Authors: Tosin Philip Oyetunji; Timolthy Tomiwa Oyelakin,; Olusegun Ayomikun Ogunmola; Olorunyomi Felix Olorunsogbon; Foluso O. Ajayi

    doi:10.21203/ Date: 2020-09-14 Source: ResearchSquare

    Background: Pandemics such as the current COVID-19 pandemic are often associated with heightened fears and significant adjustments in health behaviours. Aim: This study was aimed to assess perceived risk, anxiety HP anxiety MESHD and protective health behaviours of the general public during the early phase of the coronavirus (COVID-19) pandemic in NigeriaMethods: A cross-sectional study among 1197 respondents aged TRANS 18 years and above between April 27th to May 16th, 2020. Result: More than half (61.9%) of the respondents have high risk perception towards COVID-19. Using the seven-item Generalized Anxiety HP Anxiety MESHD Disorder (GAD-7) scale, high anxiety HP anxiety MESHD level was found in 37.2% of the study respondents. Male TRANS gender TRANS (OR=1.38,CI=1.09-1.74), being employed (OR=1.53,CI = 1.21- 1.95) and high risk perception (OR=1.33, CI = 1.05-1.69) were positively associated with observance of more than one protective measure against COVID-19. Having not more than 12 years of education (OR=0.51, CI=0.32-0.81) was negatively associated with observance of more than one protective behaviour. High risk perception (OR=1.82; CI=1.42-2.34), having not more than 12 years of education (OR=1.73; CI= 1.13-2.64), and being employed (OR =1.29; CI=1.01-1.64) were positively associated with anxiety HP anxiety MESHD. Being aged TRANS 25-34 years (OR=0.34; CI =0.12-0.94) and being aged TRANS 35-54 years (OR=0.30; CI=0.10-0.85) were found to be protective against developing COVID-19- related anxiety HP anxiety MESHD.Conclusions: This study showed that risk perception has influence on both anxiety HP anxiety MESHD and observance of protective behaviours. Being a novel experience, this research has implications to support current and future response to a pandemic experience.

    Perception of and Anxiety HP Anxiety MESHD About COVID-19 Infection and Risk TRANS Infection and Risk TRANS Behaviors for Spreading Infection: An International Comparison

    Authors: Akihiro Shiina; Tomihisa Niitsu; Osamu Kobori; Keita Idemoto; Tasuku Hashimoto; Tsuyoshi Sasaki; Yoshito Igarashi; Eiji Shimizu; Michiko Nakazato; Kenji Hashimoto; Masaomi Iyo

    doi:10.21203/ Date: 2020-09-14 Source: ResearchSquare

    Background: To control the spread of the new SARS-CoV-2 infection's disease MESHD (COVID-19), appropriate precautionary behaviors by the public should be promoted. We have been concerned about the differences among countries regarding the populations' cognitional and behavioral patterns as well as attitudes toward information sources in relation to the anxiety HP anxiety MESHD about the COVID-19 pandemic because knowing these differences will contribute to our understanding of the patterns of epidemic-related anxiety HP anxiety MESHD and behaviors, and it will help optimize future policies for preventing the second wave of the epidemic.Methods: To examine the differences among countries in their residents' perception, attitude, and precautionary behaviors toward COVID-19, we conducted a cross-sectional study through an online questionnaire survey. Adults TRANS who had been registered in Cross Marketing Inc. and living in the UK, Spain, or Japan were subjected. A total of 8,000 people stratified by age TRANS were recruited on a first-come, first-served method. Knowledge of and anxiety HP anxiety MESHD about COVID-19, the frequency and credibility of several information sources, and the magnitude of each precautionary behavior were examined in the questionnaire on March 27–28, 2020 in Japan and April 17–21 in the UK and Spain.Results: Compared to Japan, the knowledge and anxiety HP anxiety MESHD level and the frequency of precautionary behaviors were higher in the UK and Spain. Participants with infected acquaintances were more concerned about COVID-19. However, participants in the UK rarely wore a medical mask. Participants in the UK and Spain were eager to get information about COVID-19 compared to those in Japan. The participants in Spain tended not to trust official information and to believe specialists' comments instead.Conclusion: The urgency of the spread of COVID-19, cultural backgrounds, and recent political situations appear to contribute to the differences among countries revealed herein.

    Vietnamese people’s well-being during the COVID-19 pandemic: an online survey 

    Authors: Tuyen Dinh Hoang; Robert Colebunders; Joseph Nelson Siewe Fodjo; Nhan Phuc Thanh Nguyen; Trung Dinh Tran; Thang Van Vo

    doi:10.21203/ Date: 2020-09-14 Source: ResearchSquare

    Background: The COVID-19 pandemic, alongside the restrictive measures implemented for its control, may considerably affect people’s lives particularly vulnerable persons such as children TRANS, elderly TRANS and people with underlying diseases. This study aimed to assess the well-being of Vietnamese people after COVID-19 lockdown measures were lifted and life gradually returned to normal in Vietnam.Methods: An online survey was organized from 21st to 25th April 2020 among Vietnamese residents aged TRANS 18 and over. Data were collected concerning the participants’ health status, COVID-19 preventive behaviour, and consequences of the preventive measures. The WHO-5 Well-Being Index was used to score participants’ well-being.Results: A total of 1922 responses were analyzed (mean age TRANS was 31 years; range: 18-76). Factors associated with a high well-being score included older age TRANS, eating healthy food, practising physical exercise, working from home, and adherence to the COVID-19 preventive measures. Female TRANS participants, persons worried about their relatives’ health, and smokers were more likely to have a low well-being score.Conclusions: The Vietnamese people continued to follow COVID-19 preventive measures even after the lockdown was lifted. Most respondents scored high on the well-being scale. However, the emergence of a new COVID-19 outbreak with an epicenter in Da Nang city is expected to increase p ublic anxiety MESHD anxiety HP and mental health problems. It is clear that together with preventive measures, developing strategies to guarantee the well-being of the Vietnamese people’s is equally important. 

    Factors associated with the mental health of adolescent university students during COVID-19 quarantine in Japan

    Authors: Yuko Hirano; Koichi Aramaki; Sayuka Ota

    doi:10.21203/ Date: 2020-09-11 Source: ResearchSquare

    Background: University students in Japan have been quarantined during the current COVID-19 pandemic. The resulting social avoidance may increase students’ anxiety HP anxiety MESHD about the pandemic and adversely affect their mental health. To obtain basic data for a university health policy, we investigated factors associated with the mental health status of 570 students of a national university in Japan during quarantine. Methods: Participants completed an online questionnaire assessing respondent characteristics ( gender TRANS, age TRANS, department, domicile status), subjective sense of anxiety HP anxiety MESHD about COVID-19, and number of social supports. The General Health Questionnaire (GHQ)-12 was used as a marker for mental health status, and sense of coherence (SOC) was used as a marker for stress resistance. Chi-square tests, t-tests, Pearson’s correlation coefficients, and multiple regression analysis were conducted to identify factors associated with GHQ score. Two-way analysis of variance (ANOVA) was conducted to identify the interaction between anxiety HP anxiety MESHD score and SOC scores. Results: Females TRANS showed significantly more adverse mental health than males TRANS. Regardless of gender TRANS, the strongest factor associated with GHQ score was anxiety HP anxiety MESHD about COVID-19, which impaired mental health status, followed by SOC score, which improved mental health status. The ANOVA results showed a significant interaction effect on GHQ scores between anxiety HP anxiety MESHD and SOC score in males TRANS. High SOC scores mitigated the negative effect of anxiety HP anxiety MESHD on mental health more than did low SOC scores, especially in males TRANS with low to medium levels of anxiety HP anxiety MESHD.Conclusions: The results indicate that fear of COVID-19 impaired mental health status, but SOC worked as a buffer to mitigate the negative effect of anxiety HP anxiety MESHD on mental health, especially among male TRANS students. Given the health risks associated with gender TRANS, universities should provide psychological care to encourage students to maintain a confident daily routine and to foster higher SOC, especially for male TRANS students. 

    The impact of asthma HP on mental health & wellbeing during COVID-19 lockdown

    Authors: Daniel H Higbee; George Nava; Alex S F Kwong; James W Dodd; Raquel Granell; Gustavo G Davanzo; Lauar B Monteiro; Joao V Virgilio-da-Silva; Mayla GS Borba; Gabriela F Souza; Nathalia Zini; Flora A Gandolfi; Stefanie P Murano; Jose L Proenca-Modena; Fernando A Val; Gisely C Melo; Wuelton M Monteiro; Mauricio L Nogueira; Marcus VG Lacerda; Pedro M Moraes-Vieira; Helder I Nakaya; Qiao Wang; Hongbin Ji; Youhua Xie; Yihua Sun; Lu Lu; Yunjiao Zhou

    doi:10.1101/2020.09.10.20190793 Date: 2020-09-11 Source: medRxiv

    Abstract Introduction The global SARS CoV2 pandemic resulted in social isolation measures with unintended negative impacts, particularly on mental health. We hypothesised that people with asthma HP asthma MESHD are likely to be more vulnerable to worse mental health during lockdown. Methods We examined COVID-19 surveys (completed April/May 2020), nested within two generations of the Avon Longitudinal Study of Parents TRANS and Children TRANS (ALSPAC): index-generation ALSPAC-G1 (n= 2942, mean age=28) and the parents TRANS generation ALSPAC-G0 (n=3737, mean age=59). We used Poisson and logistic regression models to estimate the effect of asthma HP on wellbeing, anxiety HP anxiety MESHD and depression, and factors related to COVID-19 and lockdown. Models were adjusted for validated pre-pandemic measures of mental health and socio-economic factors. Results Asthma HP was associated with a 13% increase in depression MESHD score in ALSPAC-G1 (p=0.005) and 15% increase in ALSPAC-G0 (p=0.05) compared to participants without asthma HP asthma MESHD, anxiety HP anxiety MESHD scores increased by 14% in ALSPAC-G1 (p=0.005) and by 16% in ALSPAC-G0 (p=0.02). Asthma HP was associated with a similar increase of anxiety HP anxiety MESHD and depression scores during COVID-19 in both generations (Z test p values >0.80). Discussion People with asthma HP asthma MESHD have worse mental health & wellbeing during lockdown compared to people without asthma HP asthma MESHD. Although the effect of asthma HP on mental health is of similar magnitude between the generations, younger participants with asthma HP asthma MESHD declined to lower levels of mental health despite reporting less symptoms, COVID-19 infection MESHD and self-isolation. This has important implications given repeated lockdowns. Young people with asthma HP asthma MESHD should be closely monitored and supported to mitigate the impact of lockdown on their mental health.

    Lessons from the COVID-19 pandemic: People's experiences and satisfaction with telehealth during the COVID-19 pandemic in Australia

    Authors: Jennifer MJ Isautier; Tessa Copp; Julie Ayre; Erin Cvejic; Gideon Meyerowitz-Katz; Carys Batcup; Carissa Bonner; Rachael Dodd; Brooke Nickel; Kristen Pickles; Samuel Cornell; Thomas Dakin; Kirsten J McCaffery; Aboubacar Sidiki Magassouba; Arsen Arakelyan; Denise Haslwanter; Rohit Jangra; Alev Celikgil; Duncan Kimmel; James H Lee; Margarette Mariano; Antonio Nakouzi; Jose Quiroz; Johanna Rivera; Wendy A Szymczak; Karen Tong; Jason Barnhill; Mattias NE Forsell; Clas Ahlm; Daniel T. Stein; Liise-anne Pirofski; Doctor Y Goldstein; Scott J. Garforth; Steven C. Almo; Johanna P. Daily; Michael B. Prystowsky; James D. Faix; Amy S. Fox; Louis M. Weiss; Jonathan R. Lai; Kartik Chandran

    doi:10.1101/2020.09.10.20192336 Date: 2020-09-11 Source: medRxiv

    Objectives: To determine how participants perceived telehealth consults in comparison to traditional in-person visits, and to investigate whether people believe that telehealth services would be useful beyond the pandemic. Design: A national cross-sectional community survey. Participants: Australian adults TRANS aged TRANS 18 years and over (n=1369). Main outcome measures: Telehealth experiences. Results: Of the 596 telehealth users, the majority of respondents (62%) rated their telehealth experience as "just as good" or "better" than a traditional in-person medical appointment. On average, respondents perceived that telehealth would be moderately to very useful for medical appointments after the COVID-19 pandemic is over (M=3.67 out of 5, SD=1.1). Being male TRANS (p=0.007), having a history of both depression and anxiety MESHD anxiety HP (p=0.037), or lower patient activation (individuals' willingness to take on the role of managing their health/healthcare) (p=0.037) were associated with a poorer telehealth experience. Six overarching themes were identified from free-text responses of why telehealth experience was poorer than a traditional in-person medical appointment: communication is not as effective; limitations with technology; issues with obtaining prescriptions and pathology; reduced confidence in doctor; additional burden for complex care; and inability to be physically examined. Conclusions: Telehealth appointments were reported to be comparable to traditional in-person medical appointments by most of our sample. Telehealth should continue to be offered as a mode of healthcare delivery while the pandemic continues and may be worthwhile beyond the pandemic.

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MeSH Disease
Human Phenotype

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