Corpus overview


MeSH Disease

COVID-19 (1387)

Death (215)

Hypertension (187)

Fever (180)

Diabetes Mellitus (167)


gender (1443)

age categories (1443)

Transmission (170)

fomite (121)

asymptotic cases (104)

    displaying 1 - 10 records in total 1443
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    Use of dialysis, tracheostomy, and extracorporeal membrane oxygenation among 240,392 patients hospitalized with COVID-19 MESHD in the United States

    Authors: Edward Burn; Anthony G. Sena; Albert Prats-Uribe; Matthew Spotnitz; Scott DuVall; Kristine E. Lynch; Michael E. Matheny; Fredrik Nyberg; Waheed-Ul-Rahman Ahmed; Osaid Alser; Heba Alghoul; Thamir Alshammari; Lin Zhang; Paula Casajust; Carlos Areia; Karishma Shah; Christian Reich; Clair Blacketer; Alan Andryc; Stephen Fortin; Karthik Natarajan; Mengchun Gong; Asieh Golozar; Daniel Morales; Peter Rijnbeek; Vignesh Subbian; Elena Roel; Martina Recalde; Jennifer C.E. Lane; David Vizcaya; Jose D. Posada; Nigam H. Shah; Jitendra Jonnagaddala; Lana Yin Hui Lai; Francesc Xavier Aviles-Jurado; George Hripcsak; Marc A. Suchard; Otavio T. Ranzani; Patrick Ryan; Daniel Prieto-Alhambra; Kristin Kostka; Talita Duarte-Salles

    doi:10.1101/2020.11.25.20229088 Date: 2020-11-27 Source: medRxiv

    Objective To estimate the proportion of patients hospitalized with COVID-19 MESHD who undergo dialysis, tracheostomy, and extracorporeal membrane oxygenation (ECMO). Design A network cohort study. Setting Six databases from the United States containing routinely-collected patient data: HealthVerity, Premier, IQVIA Open Claims, Optum EHR, Optum SES, and VA-OMOP. Patients Patients hospitalized with a clinical diagnosis or a positive test result for COVID-19 MESHD. Interventions Dialysis, tracheostomy, and ECMO. Measurements and Main Results 240,392 patients hospitalized with COVID-19 MESHD were included (22,887 from HealthVerity, 139,971 from IQVIA Open Claims, 29,061 from Optum EHR, 4,336 from OPTUM SES, 36,019 from Premier, and 8,118 from VA-OMOP). Across the six databases, 9,703 (4.04% [95% CI: 3.96% to 4.11%]) patients received dialysis, 1,681 (0.70% [0.67% to 0.73%]) had a tracheostomy, and 398 (0.17% [95% CI: 0.15% to 0.18%]) patients underwent ECMO over the 30 days following hospitalization. Use of ECMO was generally concentrated among patients who were younger, male TRANS, and with fewer comorbidities except for obesity MESHD. Tracheostomy was used for a similar proportion of patients regardless of age TRANS, sex, or comorbidity. While dialysis was used for a similar proportion among younger and older patients, it was more frequent among male TRANS patients and among those with chronic kidney disease MESHD. Conclusion Use of dialysis among those hospitalized with COVID-19 MESHD is high at around 4%. Although less than one percent of patients undergo tracheostomy and ECMO, the absolute numbers of patients who have undergone these interventions is substantial and can be expected to continue grow given the continuing spread of the COVID-19 MESHD.

    The Anxiety MESHD and Pain of Fibromyalgia MESHD Patients during the COVID-19 Pandemic MESHD

    Authors: Anna Y. Kharko; Kirralise J. Hansford; Paul L. Furlong; Stephen D. Hall; Matthew E. Roser; Matthew McCarroll; Pushker Raj; Patricia Lloyd; Preetha Iyengar; Fern Johnson-Clarke; John Davies-Cole; LaQuandra Nesbitt; Lin Zhang; Paula Casajust; Carlos Areia; Karishma Shah; Christian Reich; Clair Blacketer; Alan Andryc; Stephen Fortin; Karthik Natarajan; Mengchun Gong; Asieh Golozar; Daniel Morales; Peter Rijnbeek; Vignesh Subbian; Elena Roel; Martina Recalde; Jennifer C.E. Lane; David Vizcaya; Jose D. Posada; Nigam H. Shah; Jitendra Jonnagaddala; Lana Yin Hui Lai; Francesc Xavier Aviles-Jurado; George Hripcsak; Marc A. Suchard; Otavio T. Ranzani; Patrick Ryan; Daniel Prieto-Alhambra; Kristin Kostka; Talita Duarte-Salles

    doi:10.1101/2020.11.24.20188011 Date: 2020-11-27 Source: medRxiv

    Background: Early research on the impact of the COVID-19 pandemic MESHD found persistent related anxiety MESHD in the general population. We hypothesised that this anxiety MESHD will be associated with increased pain MESHD in chronic pain MESHD patients diagnosed with fibromyalgia MESHD ( FM MESHD). Methods: To study this, we carried out a 10-day online survey with 58 female TRANS participants, diagnosed with FM MESHD and no other pain MESHD condition. We identified which aspects of the COVID-19 pandemic MESHD evoked anxiety MESHD. We then asked participants to provide daily ratings of both anxiety MESHD and pain MESHD on 101-point visual analogue scales (VAS). Key participant characteristics were included as mediators in a mixed-effects analysis, where the primary outcome was pain MESHD VAS. Results: We found that participants were most often anxious about "impact on relationships", "a family member TRANS contracting COVID-19 MESHD", and "financial hardship", but on average rated "financial hardships", "access to medication", and "home loss/eviction" as evoking the strongest anxiety MESHD. Mixed-effects modelling showed that an increase in pain MESHD was significantly associated with an increase in anxiety MESHD, when taking into account individual variance and daily caffeine intake. Age TRANS and intake of some mild analgesics were also linked to stronger pain MESHD. Conclusion: Our results extend the initial findings from the literature about the effects of COVID-19 pandemic MESHD on chronic pain MESHD sufferers. We found that not only is pandemic anxiety MESHD in FM MESHD patients present, but it is associated with amplified self-assessed chronic pain MESHD.

    Characteristics, outcomes, and mortality amongst 133,589 patients with prevalent autoimmune diseases MESHD diagnosed with, and 48,418 hospitalised for COVID-19 MESHD: a multinational distributed network cohort analysis

    Authors: Eng Hooi Tan; Anthony G. Sena; Albert Prats-Uribe; Seng Chan You; Waheed-Ul-Rahman Ahmed; Kristin Kostka; Christian Reich; Scott L. Duvall; Kristine E. Lynch; Michael E. Matheny; Talita Duarte-Salles; Sergio Fernandez Bertolin; George Hripcsak; Karthik Natarajan; Thomas Falconer; Matthew Spotnitz; Anna Ostropolets; Clair Blacketer; Thamir M Alshammari; Heba Alghoul; Osaid Alser; Jennifer C.E. Lane; Dalia M Dawoud; Karishma Shah; Yue Yang; Lin Zhang; Carlos Areia; Asieh Golozar; Martina Recalde; Paula Casajust; Jitendra Jonnagaddala; Vignesh Subbian; David Vizcaya; Lana YH Lai; Fredrik Nyberg; Daniel R. Morales; Jose D. Posada; Nigam H. Shah; Mengchun Gong; Arani Vivekanantham; Aaron Abend; Evan P Minty; Marc A. Suchard; Peter Rijnbeek; Patrick B Ryan; Daniel Prieto-Alhambra

    doi:10.1101/2020.11.24.20236802 Date: 2020-11-27 Source: medRxiv

    Objective: Patients with autoimmune diseases MESHD were advised to shield to avoid COVID-19 MESHD, but information on their prognosis is lacking. We characterised 30-day outcomes and mortality after hospitalisation with COVID-19 MESHD among patients with prevalent autoimmune diseases MESHD, and compared outcomes after hospital admissions among similar patients with seasonal influenza. Design: Multinational network cohort study Setting: Electronic health records data from Columbia University Irving Medical Center (CUIMC) (NYC, United States [US]), Optum [US], Department of Veterans Affairs (VA) (US), Information System for Research in Primary Care-Hospitalisation Linked Data (SIDIAP-H) (Spain), and claims data from IQVIA Open Claims (US) and Health Insurance and Review Assessment (HIRA) (South Korea). Participants: All patients with prevalent autoimmune diseases MESHD, diagnosed and/or hospitalised between January and June 2020 with COVID-19 MESHD, and similar patients hospitalised with influenza in 2017-2018 were included. Main outcome measures: 30-day complications during hospitalisation and death Results: We studied 133,589 patients diagnosed and 48,418 hospitalised with COVID-19 MESHD with prevalent autoimmune diseases MESHD. The majority of participants were female TRANS (60.5% to 65.9%) and aged TRANS [≥]50 years. The most prevalent autoimmune conditions were psoriasis MESHD (3.5 to 32.5%), rheumatoid arthritis MESHD (3.9 to 18.9%), and vasculitis MESHD (3.3 to 17.6%). Amongst hospitalised patients, Type 1 diabetes MESHD was the most common autoimmune condition (4.8% to 7.5%) in US databases, rheumatoid arthritis MESHD in HIRA (18.9%), and psoriasis MESHD in SIDIAP-H (26.4%). Compared to 70,660 hospitalised with influenza, those admitted with COVID-19 MESHD had more respiratory complications including pneumonia MESHD and acute respiratory distress syndrome MESHD, and higher 30-day mortality (2.2% to 4.3% versus 6.3% to 24.6%). Conclusions: Patients with autoimmune diseases MESHD had high rates of respiratory complications and 30-day mortality following a hospitalization with COVID-19 MESHD. Compared to influenza, COVID-19 MESHD is a more severe disease, leading to more complications and higher mortality. Future studies should investigate predictors of poor outcomes in COVID-19 MESHD patients with autoimmune diseases MESHD.

    The experience of distress during the COVID-19 MESHD outbreak: a cross-country examination on the fear of COVID-19 MESHD and the sense of loneliness

    Authors: Gianluca Lo Coco; Ambra Gentile; Ksenija Bosnar; Ivana Milovanovic; Antonino Bianco; Patrik Drid; Sasa Pisot; Maria Flamm; Nahid Mostafa; Mohamed Sahl; Jinan Suliman; Elias Tayar; Hasan Ali Kasem; Meynard J. A. Agsalog; Bassam K. Akkarathodiyil; Ayat A. Alkhalaf; Mohamed Morhaf M. H. Alakshar; Abdulsalam Ali A. H. Al-Qahtani; Monther H. A. Al-Shedifat; Anas Ansari; Ahmad Ali Ataalla; Sandeep Chougule; Abhilash K. K. V. Gopinathan; Feroz J. Poolakundan; Sanjay U. Ranbhise; Saed M. A. Saefan; Mohamed M. Thaivalappil; Abubacker S. Thoyalil; Inayath M. Umar; Zaina Al Kanaani; Abdullatif Al Khal; Einas Al Kuwari; Adeel A. Butt; Peter Coyle; Andrew Jeremijenko; Anvar Hassan Kaleeckal; Ali Nizar Latif; Riyazuddin Mohammad Shaik; Hanan F. Abdul Rahim; Hadi M. Yassine; Gheyath K. Nasrallah; Mohamed G. Al Kuwari; Odette Chaghoury; Hiam Chemaitelly; Laith J Abu-Raddad

    doi:10.1101/2020.11.24.20237586 Date: 2020-11-24 Source: medRxiv

    Objectives To examine gender TRANS, age TRANS and cross-country differences in fear of COVID-19 MESHD and sense of loneliness during the lockdown, by comparing people from countries with a high rate of infections and deaths MESHD (i.e. Spain and Italy) and from countries with a mild spread of infection (i.e. Croatia, Serbia, Slovakia, Slovenia, Bosnia and Herzegovina). Methods A total of 3876 participants (63% female TRANS) completed an online survey on Everyday life practices in COVID-19 MESHD time in April 2020, including measures of fear of COVID-19 MESHD and loneliness. Results Males TRANS and females TRANS of all age groups TRANS in countries suffering from a strong impact of the COVID-19 pandemic MESHD reported higher fear of COVID-19 MESHD and sense of loneliness. In less endangered countries females TRANS and elder stated more symptoms than males TRANS and younger; in Spanish and Italian sample the pattern of differences is considerably more complex. Conclusion Future research should thoroughly examine different age TRANS and gender TRANS groups. The analysis of emotional well-being in groups at risk of mental health issues can help to lessen the long term social and economic costs due to the COVID-19 MESHD outbreak.

    Loneliness among older adults TRANS in the community during COVID-19 MESHD

    Authors: Rachel D Savage; Wei Wu; Joyce Li; Andrea Lawson; Susan E Bronskill; Stephanie A. Chamberlain; Jim Grieve; Andrea Gruneir; Christina Reppas-Rindlisbacher; Nathan M. Stall; Paula A Rochon; Fanlong Bu; Sarah Klingenberg; Christian Gluud; Janus Christian Jakobsen; Willem Hanekom; Bernadett I Gosnell; COMMIT-KZN Team; Emily Wong; Tulio de Oliveira; Mahomed-Yunus S Moosa; Alasdair Leslie; Henrik Kloverpris; Alex Sigal

    doi:10.1101/2020.11.23.20237289 Date: 2020-11-24 Source: medRxiv

    Objective: Physical distancing and stay-at-home measures implemented to slow transmission TRANS of novel coronavirus disease MESHD ( COVID-19 MESHD) may intensify feelings of loneliness in older adults TRANS, especially those living alone. Our aim was to characterize the extent of loneliness in a sample of older adults TRANS living in the community and assess characteristics associated with loneliness. Design: Online cross-sectional survey between May 6 and May 19, 2020 Setting: Ontario, Canada Participants: Convenience sample of the members of a national retired educators' organization. Primary outcome measures: Self-reported loneliness, including differences between women and men. Results: 4879 respondents (71.0% women; 67.4% 65-79 years) reported that in the preceding week, 43.1% felt lonely at least some of the time, including 8.3% that felt lonely always or often. Women had increased odds of loneliness compared to men, whether living alone (adjusted Odds Ratio (aOR) 1.52 [95% Confidence Interval (CI) 1.13-2.04]) or with others (2.44 [95% CI 2.04-2.92]). Increasing age group TRANS decreased the odds of loneliness (aOR 0.69 [95% CI 0.59-0.81] 65-79 years and 0.50 [95% CI 0.39-0.65] 80+ years compared to <65 years). Living alone was associated with loneliness, with a greater association in men (aOR 4.26 [95% CI 3.15-5.76]) than women (aOR 2.65 [95% CI 2.26-3.11]). Other factors associated with loneliness included: fair or poor health (aOR 1.93 [95% CI 1.54-2.41]), being a caregiver (aOR 1.18 [95% CI 1.02-1.37]), receiving care (aOR 1.47 [95% CI 1.19-1.81]), high concern for the pandemic (aOR 1.55 [95% CI 1.31-1.84]), not experiencing positive effects of pandemic distancing measures (aOR 1.94 [95% CI 1.62-2.32]), and changes to daily routine (aOR 2.81 [95% CI 1.96-4.03]). Conclusions: While many older adults TRANS reported feeling lonely during COVID-19 MESHD, several characteristics - such as being female TRANS and living alone - increased the odds of loneliness. These characteristics may help identify priorities for targeting interventions to reduce loneliness.

    Assessment of effectiveness of a COVID-adapted diagnostic pathway for colorectal cancer MESHD to mitigate the adverse impact on investigation and referrals

    Authors: Janice Miller; Yasuko Maeda; Stephanie Au; Frances Gunn; Lorna Porteous; Rebecca Pattenden; Peter MacLean; Colin L Noble; Stephen Glancy; Malcolm G Dunlop; Farhat Din; Fanlong Bu; Sarah Klingenberg; Christian Gluud; Janus Christian Jakobsen; Willem Hanekom; Bernadett I Gosnell; COMMIT-KZN Team; Emily Wong; Tulio de Oliveira; Mahomed-Yunus S Moosa; Alasdair Leslie; Henrik Kloverpris; Alex Sigal

    doi:10.1101/2020.11.23.20236778 Date: 2020-11-24 Source: medRxiv

    Objectives The Coronavirus19 ( COVID19 MESHD) pandemic continues to impose formidable challenges on healthcare services. The dramatic curtailment of endoscopy and CT colonography capacity has adversely impacted on timely diagnosis of colorectal cancer MESHD ( CRC MESHD). We describe a COVID adapted pathway rapidly implemented to mitigate risk and maximise cancer MESHD diagnosis in patients referred with symptoms of suspected CRC MESHD during the pandemic. Design The COVID adapted pathway integrated multiple quantitative faecal immunochemical tests (qFIT), to enrich for significant colorectal disease MESHD. CT with oral contrast was used to detect gross pathology. Patients reporting high risk symptoms were triaged to qFIT+CT and the remainder underwent initial qFIT. Prospective data collection comprised referral category, symptoms, blood SERO results, medical history, time to first test, qFIT and CT results. Setting Tertiary colorectal MESHD unit which manages over 500 cancer MESHD patients annually. Participants All patients referred as urgent suspicious of cancer MESHD (USOC) were included. Overall 422 patients (median age TRANS 64 years, 220 females TRANS) were triaged using this pathway. Main outcome measures Outcomes comprised cancer MESHD detection frequency. Results Compared to the same time period (1st April to 31st May) in 2017 to 2019, we observed a 43% reduction in primary care referrals with suspected CRC MESHD (1071 referrals expected reducing to 609). Overall 422 patients (median age TRANS 64 years, 220 females TRANS) were triaged using this pathway. Most (84.6%) were referred as USOC. Of the 422 patients, 202 (47.9%) were triaged to CT and qFIT, 211 (50.0%) to qFIT only, eight (1.9%) to outpatient clinic, and one to colonoscopy. Fifteen (3.6%) declined investigation and seven (1.7%) were deemed unfit. We detected 13 cancers MESHD (3.1%); similar to the mean cancer detection rate from all referrals in 2017-2019 (3.3%). Conclusions The response to the COVID19 MESHD pandemic resulted in a marked reduction in referrals and cessation of key diagnostic services. Although this COVID adapted pathway mitigated the adverse effects on diagnostic capacity, the overall reduction in expected diagnoses is very substantial. It is clear that the adverse impact of measures taken to constrain the pandemic will lead to many undetected cancers MESHD due to the decrease in referrals. Trial registration Not applicable

    Healthcare workers hospitalized due to COVID-19 MESHD have no higher risk of death MESHD than general population. Data from the Spanish SEMI- COVID-19 MESHD Registry.

    Authors: Jesus Diez-Manglano; Nataya Solis Marquinez; Andrea Alvarez Garcia; Nicolas Alcala Rivera; Irene Maderuelo Riesco; Martin Gerico Aseguinolaza; Jose Luis Beato Perez; Manuel Mendez Bailon; Ane Elbire Laburua-Iturburu Ruiz; Miriam Garcia Gomez; Carmen Martinez Cilleros; Paula Maria Pesqueira Fontan; Lucy Abella Vazquez; Julio Cesar Blazquez Encinar; Ramon Boixeda; Ricardo Gil Sanchez; Andres de la Pena Fernandez; Jose Loureiro Amigo; Joaquin Escobar Sevilla; Marcos Guzman Garcia; Maria Dolores Martin Escalante; Jeffrey Oskar Magallanes Gamboa; Angel Luis Martinez Gonzalez; Carlos Lumbreras Bermejo; Juan Miguel Anton Santos; Saed M. A. Saefan; Mohamed M. Thaivalappil; Abubacker S. Thoyalil; Inayath M. Umar; Zaina Al Kanaani; Abdullatif Al Khal; Einas Al Kuwari; Adeel A. Butt; Peter Coyle; Andrew Jeremijenko; Anvar Hassan Kaleeckal; Ali Nizar Latif; Riyazuddin Mohammad Shaik; Hanan F. Abdul Rahim; Hadi M. Yassine; Gheyath K. Nasrallah; Mohamed G. Al Kuwari; Odette Chaghoury; Hiam Chemaitelly; Laith J Abu-Raddad

    doi:10.1101/2020.11.23.20236810 Date: 2020-11-24 Source: medRxiv

    Aim: To determine whether healthcare workers (HCW) hospitalized in Spain due to COVID-19 MESHD have a worse prognosis than non-healthcare workers (NHCW). Methods: Observational cohort study based on the SEMI- COVID-19 MESHD Registry, a nationwide registry that collects sociodemographic, clinical, laboratory, and treatment data on patients hospitalised with COVID-19 MESHD in Spain. Patients aged TRANS 20-65 years were selected. A multivariate logistic regression model was performed to identify factors associated with mortality. Results: As of 22 May 2020, 4393 patients were included, of whom 419 (9.5%) were HCW. Median (interquartile range) age TRANS of HCW was 52 (15) years and 62.4% were women. Prevalence SERO of comorbidities and severe radiological findings upon admission were less frequent in HCW. There were no difference in need of respiratory support and admission to intensive care unit, but occurrence of sepsis HP sepsis MESHD and in-hospital mortality was lower in HCW (1.7% vs. 3.9%; p=0.024 and 0.7% vs. 4.8%; p<0.001 respectively). Age TRANS, male TRANS sex and comorbidity, were independently associated with higher in-hospital mortality and healthcare working with lower mortality (OR 0.219, 95%CI 0.069-0.693, p=0.01). 30-days survival was higher in HCW (0.968 vs. 0.851 p<0.001). Conclusions: Hospitalized COVID-19 MESHD HCW had fewer comorbidities and a better prognosis than NHCW. Our results suggest that professional exposure to COVID-19 MESHD in HCW does not carry more clinical severity nor mortality.

    Posttraumatic Stress Disorder MESHD and Associated Factors During the Early Stage of the COVID-19 Pandemic MESHD in Norway

    Authors: Tore Bonsaksen; Trond Heir; Inger Schou-Bredal; Øivind Ekeberg; Laila Skogstad; Tine K. Grimholt

    id:10.20944/preprints202011.0617.v1 Date: 2020-11-24 Source:

    The COVID-19 MESHD outbreak and the sudden lockdown of society in March 2020 had a large impact on people’s daily life and gave rise to concerns for the mental health in the general population. The aim of the study was to examine post- traumatic stress MESHD reactions related to the COVID-19 pandemic MESHD, the prevalence SERO of symptom-defined post- traumatic stress disorder MESHD ( PTSD MESHD), and factors associated with post- traumatic stress MESHD in the Norwegian population during the early stages of the COVID-19 MESHD outbreak. A survey was administered via social media channels, to which a sample of 4527 adults TRANS (≥18 years) responded. Symptom-defined PTSD was measured with the PTSD Checklist for the DSM-5. The items were specifically linked to the COVID-19 pandemic MESHD. We used the DSM-5 diagnostic guidelines to categorize participants as fulfilling the PTSD symptom criteria or not. Associations with PTSD MESHD were examined with single and multiple logistic regression analyses. The prevalence SERO of symptom-defined PTSD MESHD was 12.5% for men and 19.5% for women. PTSD MESHD was associated with lower age TRANS, female TRANS gender TRANS, lack of social support, and a range of pandemic-related variables such as economic concerns, expecting economic loss, having been in quarantine or isolation, being at high-risk for complications from COVID-19 MESHD infection, and having concern for family and close friends TRANS. In conclusion, posttraumatic stress MESHD reactions were common in the Norwegian population in the early stages of the COVID-19 MESHD outbreak. Concerns about finances, health, and family and friends TRANS seem to matter.

    How closely is COVID-19 MESHD related to HCoV, SARS, and MERS? : Clinical comparison of coronavirus infections MESHD and identification of risk factors influencing the COVID-19 MESHD severity using common data model (CDM)

    Authors: Yeon Hee Kim; YeHee Ko; Soo Young Kim; Kwangsoo Kim

    doi:10.1101/2020.11.23.20237487 Date: 2020-11-24 Source: medRxiv

    South Korea was one of the epicenters for both the 2015 MERS and 2019 COVID-19 MESHD outbreaks. However, there has been a lack of published literature, especially using the EMR records, that provides a comparative summary of the prognostic factors present in the coronavirus-derived diseases patients. Therefore, in this study, we aimed to compare and evaluate the distinct clinical traits between the patients of different coronaviruses, including the lesser pathogenic HCoV strains, SARS-CoV MESHD, MERS-CoV, and SARS-CoV-2. We also conducted observed the risk factors by the COVID severity to investigate the extent of resemblance in clinical features between the disease groups and to identify unique factor that may influence the prognosis of the COVID-19 MESHD patients. Here, we utilize the common data model (CDM), which is the database that houses the EMR records transformed into the common format to be used by the multiple institutions. For the comparative analyses between the disease groups, we used independent t-test, Scheffe post-hoc test, and Games-howell post-hoc test and for the continuous variables, chi-square test and Fisher exact test. Based on the analyses, we selected the variables with p-values less than 0.05 to predict COVID-19 MESHD severity by nominal logistic regression with adjustments to age TRANS and gender TRANS. From the study, we observed diabetes MESHD, cardio and cerebrovascular diseases MESHD, cancer MESHD, pulmonary disease MESHD, gastrointestinal disease MESHD, and renal disease MESHD in all patient groups. Of all, the proportions of cancer MESHD patients were highest in all groups with no statistical significance. Most interestingly, we observed a high degree of clinical similarity between the COVID-19 MESHD and SARS patients with more than 50% of measured clinical variables to show statistical similarities between two groups. Our research reflects the great significance within the bioinformatics field that we were able to effectively utilize the integrated CDM to reflect real-world challenges in the context of coronavirus. We expect the results from our study to provide clinical insights that can serve as predicator of risk factors from the future coronavirus outbreak as well as the prospective guidelines for the clinical treatments.

    Psychosocial Health of School- aged TRANS Children TRANS during the Initial COVID-19 MESHD Safer-At-Home School Mandates in Florida: A cross-sectional study

    Authors: Sarah Lindley McKune; Daniel E Acosta; Nick Diaz; Kaitlin Brittain; Diana Joyce Beaulieu; Anthony Thomas Maurelli; Eric J. Nelson; Maryam Azimzadeh Irani; Martin Kuper; Orlando Quintero; Kent Feng; Catherine Ley; Dean Winslow; Jennifer Newberry; Karlie Edwards; Colin Hislop; Ingrid Choong; Yvonne Maldonado; Jeffrey Glenn; Ami Bhatt; Catherine Blish; Taia Wang; Chaitan Khosla; Benjamin Pinsky; Manisha Desai; Julie Parsonnet; Upinder Singh

    doi:10.1101/2020.11.20.20235812 Date: 2020-11-23 Source: medRxiv

    Background: Given the emerging literature regarding the impacts of lockdown measures on mental health, this study aims to identify risk factors in school- aged TRANS children TRANS for being at risk for psychosocial disorders MESHD during the COVID-19 MESHD Safer-at-Home School mandates in Florida Methods: A cross-sectional study was conducted in April 2020 (n=280). Bivariate analysis and logistic and muultinomial logistic regression models are used to examine socio-demographic and knowledge, attitude, and practice (KAP) predictors of anxiety HP anxiety MESHD,depression, and obsessive-compulsive disorder MESHD ( OCD MESHD). Results: Loss of household income was associated with being at risk for depression MESHD[aOR=3.130, 95% CI= (1.41-6.97)], anxiety MESHD anxiety HP [aOR=2.531, 95%CI= (1.154-5.551)], and OCD MESHD [aOR=2.90, 95%CI= (1.32-6.36)]. Being female TRANS was associated with risk for depression MESHD [aOR=1.72, 95% CI=(1.02-2.93)], anxiety MESHD anxiety HP [aOR=1.75, 95% CI=(1.04-2.97)],and OCD MESHD[aOR=1.764, 95%CI= (1.027-3.028)]. Parental practices that are protective against COVID-19 MESHD were associated with children TRANS being at risk of depression MESHD[aOR=1.55, 95% CI= (1.04-2.31)]. Being at a lower school level was risk factor for anxiety MESHD anxiety HP and OCD MESHD. Conclusions: Efforts to address mental health risk in children TRANS, as a result schools should prioritize girls, younger children TRANS, and children TRANS of families who lose income.Limiting the spread of COVID-19 MESHD through school closure may exacerbate the risk of psychosocial disorders MESHD in children TRANS, thus school administrators should move quickly totarget those at greatest risk.

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