Corpus overview


MeSH Disease

Fever (27)

Fatigue (27)

Cough (26)

Disease (17)

Coronavirus Infections (15)

Human Phenotype

Fever (27)

Fatigue (27)

Cough (26)

Pneumonia (11)

Diarrhea (7)


    displaying 1 - 10 records in total 27
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    Children TRANS with COVID-19 like symptoms in Italian Pediatric Surgeries: the dark side of the coin

    Authors: Gianfranco Trapani; Vassilios Fanos; Enrico Bertino; Giulia Maiocco; Osama Al Jamal; Michele Fiore; VIncenzo Bembo; Domenico Careddu; Lando Barberio; Luisella Zanino; Giuseppe Verlato

    doi:10.1101/2020.07.27.20149757 Date: 2020-07-29 Source: medRxiv

    BACKGROUND: Symptoms of SARS-CoV-2 infection MESHD in children TRANS are nonspecific and shared with other common acute viral illnesses ( fever MESHD fever HP, respiratory or gastrointestinal symptoms, and cutaneous signs), thus making clinical differential diagnosis tricky. In Italy, first line management of pediatric care is handed over to Primary Care Pediatricians (PCPs), who were not allowed to directly perform diagnostic tests during the recent COVID-19 outbreak. Without a confirmatory diagnosis, PCPs could only collect information on ''COVID-19 like symptoms'' rather than identify typical COVID-19 symptoms. AIM: To evaluate the prevalence SERO of COVID-19 like symptoms in outpatient children TRANS, during Italian lockdown. To provide PCPs a risk score to be used in clinical practice during the differential diagnosis process. METHODS: A survey was submitted to 50 PCPs (assisting 47,500 children TRANS) from 7 different Italian regions between the 4th of March and the 23rd of May 2020 (total and partial lockdown period). COVID-19 like symptoms in the assisted children TRANS were recorded, as well as presence of confirmed/suspected cases in children TRANS's families, which was taken as proxy of COVID-19. Multivariable logistic regression was accomplished to estimate the risk of having suspected/ confirmed cases TRANS in families, considering symptoms as potential determinants. RESULTS: 2,300 children TRANS (4.8% of overall survey population) fell HP ill with COVID-19 like symptoms, 3.1% and 1.7% during total and partial lockdown period respectively. The concurrent presence of fatigue MESHD fatigue HP, cough MESHD cough HP, and diarrhea MESHD diarrhea HP in children TRANS, in absence of sore throat/ earache MESHD and abnormal skin signs, represents the maximum risk level of having a suspected/ confirmed case TRANS of COVID-19 at home. CONCLUSIONS: The percentage of children TRANS presenting COVID-19 like symptoms at home has been remarkable also during the total lockdown period. The present study identified a pattern of symptoms which could help, in a cost-effective perspective, PCPs in daily clinical practice to define priorities in addressing children TRANS to the proper diagnostic procedure.

    Early detection of COVID-19 pandemic: evidence from Baidu Index

    Authors: Bizhi Tu; Laifu Wei; Yaya Jia; Jun Qian

    doi:10.21203/ Date: 2020-07-16 Source: ResearchSquare

    Background: New coronavirus disease MESHD 2019 (COVID-19) poses a severe threat to human life, and causes a global pandemic. The purpose of current research is to explore the onset and progress of the pandemic with a novel perspective using Baidu Index.Methods: We collected the confirmed data of COVID-19 infection MESHD between January 11, 2020, and April 22, 2020, from the Center for Systems Science and Engineering (CSSE) at Johns Hopkins University (JHU). Based on known literature, we obtained the search index values of the most common symptoms of COVID-19, including fever MESHD fever HP, cough MESHD cough HP, fatigue MESHD fatigue HP, sputum production, and shortness of breath. Spearman's correlation analysis was used to analyze the association between the Baidu index values for each COVID-19-related symptoms and the number of confirmed cases TRANS. Regional differences among 34 provinces/ regions were also analyzed. Results: Daily growth of confirmed cases TRANS and Baidu index values for each symptoms presented a robust positive correlation during the outbreak ( fever MESHD fever HP: rs=0.705, p=9.623×10-6; cough MESHD cough HP: rs=0.592, p=4.485×10-4; fatigue MESHD fatigue HP: rs=0.629, p=1.494×10-4; sputum production: rs=0.648, p=8.206×10-5; shortness of breath: rs=0.656, p=6.182×10-5). The average search-to-confirmed interval is 19.8 days in China ( fever MESHD fever HP: 22 days, cough MESHD cough HP: 19 days, fatigue MESHD fatigue HP: 20 days, sputum production: 19 days, and shortness of breath: 19 days). We discovered similar results in the top 10 provinces/regions, which had the highest cumulative cases. Conclusion: Search terms of COVID-19- related symptoms on the Baidu search engine can be used to early warn the outbreak of the epidemic. Relevant departments need to pay more attention to areas with high search index and take precautionary measures to prevent these potentially infected persons from spreading further. Baidu search engine can reflect the public's attention to the pandemic and regional epidemics of viruses. Based on changes in the Baidu index value, we can predict the arrival of the peak confirmed cases TRANS. The clinical characteristics related to COVID-19- including fever MESHD fever HP, cough MESHD cough HP, fatigue MESHD fatigue HP, shortness of breath, deserve more attention during the pandemic.

    Association of age TRANS, sex, comorbidities, and clinical symptoms with the severity and mortality of COVID-19 cases: a meta-analysis with 85 studies and 67299 cases

    Authors: Mohammad Safiqul Islam; Md. Abdul Barek; Md. Abdul Aziz; Tutun Das Aka; Md. Jakaria

    doi:10.1101/2020.05.23.20110965 Date: 2020-05-26 Source: medRxiv

    Background: A new pathogenic disease MESHD named COVID-19 became a global threat, first reported in Wuhan, China, in December 2019. The number of affected cases growing exponentially and now, more than 210 countries confirmed the cases TRANS. Objective: This meta-analysis aims to evaluate risk factors, the prevalence SERO of comorbidity, and clinical characteristics in COVID-19 death MESHD patients compared to survival patients that can be used as a reference for further research and clinical decisions. Methods: PubMed, Science Direct, SAGE were searched to collect data about demographic, clinical characteristics, and comorbidities of confirmed COVID-19 patients from January 1, 2020, to May 17, 2020. Meta-analysis was performed with the use of Review Manager 5.3 Results: Eighty-five studies were included in Meta-analysis, including a total number of 67,299 patients with SARS-CoV-2 infection MESHD. Males TRANS are severely affected or died than females TRANS (OR = 2.26, p < 0.00001; OR = 3.59, p < 0.00001) are severely affected, or died by COVID-19 and cases with age TRANS [≥]50 are at higher risk of death MESHD than age TRANS <50 years (OR=334.23). Presence of any comorbidity or comorbidities like hypertension MESHD hypertension HP, cardiovascular disease MESHD, diabetes, cerebrovascular disease MESHD, respiratory disease, kidney MESHD disease, liver MESHD disease MESHD, malignancy significantly increased the risk of death MESHD compared to survival (OR = 3.46, 3.16, 4.67, 2.45, 5.84, 2.68, 5.62, 2.81,2.16). Among the clinical characteristics such as fever MESHD fever HP, cough MESHD cough HP, myalgia MESHD myalgia HP, diarrhea MESHD diarrhea HP, abdominal pain MESHD abdominal pain HP, dyspnea MESHD dyspnea HP, fatigue MESHD fatigue HP, sputum production, chest tightness HP headache MESHD headache HP and nausea MESHD nausea or vomiting HP or vomiting MESHD, only fatigue MESHD fatigue HP (OR = 1.31, 95%) and dyspnea MESHD dyspnea HP increased the death MESHD significantly (OR= 1.31, 4.57). The rate of death MESHD of COVID-19 cases is 0.03-times lower than the rate of survival (OR = 0.03). Conclusion Our result indicates that male TRANS patients are affected severely or died, the rate of death MESHD is more in the age TRANS [≥]50 group, and the rate of death MESHD is affected by comorbidities and clinical symptoms.

    Association between symptoms and severity of disease MESHD in hospitalised novel coronavirus (COVID-19) patients: A systemic review and meta-analysis

    Authors: Ashis Talukder; Shaharior Rahman Razu; Sheikh Alif; Muhammad Aziz Rahman; Sheikh Mohammed Shariful Islam

    doi:10.21203/ Date: 2020-05-26 Source: ResearchSquare

    Background Symptoms of the novel coronavirus disease MESHD (COVD-19) are well known, although asymptomatic TRANS cases were also reported due to this rapidly evolving viral disease MESHD. However, there has been limited research with inconsistent findings on symptoms of COVID-19 and diseases MESHD severity. We aimed to evaluate the association between symptoms and severity of disease MESHD in confirmed COVID-19 cases by performing a meta-analysis.Methods We conducted a systematic review by searching four online databases (Medline, Web of Science, EMBASE and Cochrane library) of published studies that included symptoms of COVID-19 cases and severity of the disease MESHD between 01-Jan-2020 and 20-Apr-2020. PRISMA and MOOSE guidelines were followed, and only articles published in English were selected. We performed meta-analysis using Mantel-Haenszel random-effects model. Degree of heterogeneity among studies and quality of the selected studies were evaluated.Results Out of 153 articles identified, a total of seven articles, including 3,168 participants, met the inclusion criteria and were included. The median age TRANS of the patients was 49 years, 1818 (57.38%) were males TRANS, and 574 (18.11%) reported severe conditions. Fever MESHD Fever HP was the most commonly reported symptom in the reported COVID-19 confirmed cases TRANS (87.89%, 95% CI: 83.22–81.39%), which was followed by cough MESHD cough HP, myalgia MESHD myalgia HP or fatigue MESHD fatigue HP, and less proportionally dyspnea MESHD dyspnea HP and headache MESHD headache HP. Dyspnea MESHD Dyspnea HP was the only symptom, which was associated with severity of COVID-19 (OR 2.38, 95% CI: 1.83–3.10).Conclusions Dyspnoea was found to be associated with severity of COVID-19. People with existing respiratory illnesses, such as chronic obstructive pulmonary diseases MESHD chronic obstructive pulmonary diseases HP need to be careful about the onset of such symptom TRANS and should seek medical attention.

    COVID-19 in Great Britain: epidemiological and clinical characteristics of the first few hundred (FF100) cases: a descriptive case series and case control analysis

    Authors: Nicola L Boddington; Andre Charlett; Suzanne Elgohari; Jemma L Walker; Helen Mcdonald; Chloe Byers; Laura Coughlan; Tatiana Garcia Vilaplana; Rosie Whillock; Mary Sinnathamby; Nikolaos Panagiotopoulos; Louise Letley; Pauline MacDonald; Roberto Vivancos; Obaghe Edeghere; Joseph Shingleton; Emma Bennett; Daniel J Grint; Helen Strongman; Kathryn E Mansfield; Christopher Rentsch; Caroline Minassian; Ian J Douglas; Rohini Mathur; Maria Peppa; Simon Cottrell; Jim McMenamin; Maria Zambon; Mary Ramsay; Gavin Dabrera; Vanessa Saliba; Jamie Lopez Bernal

    doi:10.1101/2020.05.18.20086157 Date: 2020-05-22 Source: medRxiv

    Objectives: Following detection of the first virologically- confirmed cases TRANS of COVID-19 in Great Britain, an enhanced surveillance study was initiated by Public Health England to describe the clinical presentation, course of disease MESHD and identify risk factors for infection MESHD of the first few hundred cases. Methods: Information was collected on the first COVID-19 cases according to the First Few X WHO protocol. Case-control analyses of the sensitivity SERO, specificity and predictive value of symptoms and risk factors for infection MESHD were conducted. Point prevalences SERO of underlying health conditions among the UK general population were presented. Findings: The majority of FF100 cases were imported (51.4%), of which the majority had recent travel TRANS to Italy (71.4%). 24.7% were secondary cases TRANS acquired mainly through household contact TRANS (40.4%). Children TRANS had lower odds of COVID-19 infection MESHD compared with the general population. The clinical presentation of cases was dominated by cough MESHD cough HP, fever MESHD fever HP and fatigue MESHD fatigue HP. Non-linear relationships with age TRANS were observed for fever MESHD fever HP, and sensitivity SERO and specificity of symptoms varied by age TRANS. Conditions associated with higher odds of COVID-19 infection MESHD (after adjusting for age TRANS and sex) were chronic heart disease MESHD, immunosuppression and multimorbidity. Conclusion: This study presents the first epidemiological and clinical summary of COVID-19 cases in Great Britain. The FFX study design enabled systematic data collection. The study was able to characterize the risk factors for infection MESHD with population prevalence SERO estimates setting these relative risks into a public health context. It also provides important evidence for generating case definitions to support public health risk assessment, clinical triage and diagnostic algorithms.

    Clinical characteristics and health care cost among patients successfully treated for COVID-19 in Henan, China: A Descriptive Study

    Authors: Yudong Miao; Soumitra S Bhuyan; Mengzhu Liu; Jianqin Gu; Sabiha Hussain; Jian Wu; Liuyi Wang; Min Liu; Ruirui Cheng; Urmi Basu; Feng Liu; Huayu Zhang; Zhanjun Chang

    doi:10.21203/ Date: 2020-05-22 Source: ResearchSquare

    Objective: To clarify the clinical and medical expense characteristics of COVID-19. Methods: In this retrospective, single-center study, 55 cured cases with confirmed TRANS COVID-19 were analyzed for demographic, epidemiological, clinical, and radiological features and medical expense data.Results: The average age TRANS of the 54 successfully treated patients with COVID-19 was 53.2 years old (SD 19.0), including 27 men and 27 women. Off this, 31 (57.4%) patients had chronic diseases MESHD. Patients commonly had clinical manifestations of fever MESHD fever HP (45 [83.3%] patients), cough MESHD cough HP (29[54.7%] patients), expectoration (28 [51.9%] patients), fatigue MESHD fatigue HP (24[44.4%] patients) and diarrhea MESHD diarrhea HP (8[14.8%] patients) on admission. There was a 10-day interval from the onset of signs and symptoms MESHD to hospital admission. About 80% of them got recovery after a two-week treatment. The mean interval from the onset of signs and symptoms MESHD to hospital discharge was 20.5 (IQR 16-29) days. The median total medical expense of the treated patient, in general, was 2579.6 (IQR 1366.1-4837.6) U.S. dollars. Still, the median medical expense was 8904.1 (IQR 6660.1- 27143.8) U.S. dollars in patients with more than five comorbid illnesses during the treatment.Conclusion: There is a 3-week interval from the onset of signs and symptoms MESHD to cure, and most hospitalized patients get recovery within two weeks. The total medical expense of cases with more than five comorbid conditions during the treatment is higher. Quite a few COVID-19 cases with other serious diseases MESHD are likely to account for most of the total medical expenses. 

    Comparison of initial HRCT features of COVID-19 pneumonia MESHD pneumonia HP and other viral pneumonias MESHD pneumonias HP

    Authors: Yilong Huang; Yuanming Jiang; Li Wu; Wenfang Yi; Jiyao Ma; Peng Wang; Ying Xie; Zhipeng Li; Xiang Li; Minchang Hong; Jialong Zhou; Chuwei Duan; Yunhui Yang; Wei Zhao; Feng Yuan; Dan Han; Bo He

    doi:10.21203/ Date: 2020-05-17 Source: ResearchSquare

    Background: Multicenter retrospective comparison of the first high-resolution computed tomography (HRCT) findings of coronavirus disease MESHD 2019 (COVID-19) and other viral pneumonias MESHD pneumonias HP.Methods: We retrospectively collected clinical and imaging data from 254 cases of confirmed TRANS viral pneumonia MESHD pneumonia HP in 20 hospitals in Yunnan Province, China, from March 1, 2015, to March 15, 2020. According to the virus responsible for the pneumonia MESHD pneumonia HP, the pneumonias MESHD pneumonias HP were divided into non-COVID-19 (133 cases) and COVID-19 (121 cases). The non-COVID-19 pneumonias MESHD pneumonias HP included 3 types: cytomegalovirus (CMV) (31 cases), influenza A virus (82 cases), and influenza B virus (20 cases). The differences in the basic clinical characteristics, lesion distribution, location and imaging signs among the four viral pneumonias MESHD pneumonias HP were analyzed and compared.Results: Fever MESHD Fever HP and cough MESHD cough HP were the most common clinical symptoms of the four viral pneumonias MESHD pneumonias HP. Compared with the COVID-19 patients, the non-COVID-19 patients had higher proportions of fatigue MESHD fatigue HP, sore throat, expectorant and chest tightness HP (all p<0.000). In addition, in the CMV pneumonia MESHD pneumonia HP patients, the proportion of patients with combined acquired immunodeficiency syndrome MESHD immunodeficiency HP syndrome (AIDS) and leukopenia MESHD leukopenia HP were high (all p<0.000). Comparisons of the imaging findings of the four viral pneumonias MESHD pneumonias HP showed that pulmonary lesions of COVID-19 were more likely to occur in the peripheral and lower lobes of both lungs, while those of CMV pneumonia MESHD pneumonia HP were diffusely distributed. Compared with the non-COVID-19 pneumonias MESHD pneumonias HP, COVID-19 pneumonia MESHD pneumonia HP was more likely to present as ground-glass opacity (GGO), intralobular interstitial thickening HP, vascular thickening and halo sign (all p<0.05). In addition, in the early stage of COVID-19, extensive consolidation, fibrous stripes, subpleural lines, crazy-paving pattern, tree-in-bud HP, mediastinal lymphadenectasis, pleural thickening HP and pleural effusion MESHD pleural effusion HP were rare (all p<0.05).Conclusion: The HRCT findings of COVID-19 pneumonia MESHD pneumonia HP and other viral pneumonias MESHD pneumonias HP overlapped significantly, but many important differential imaging features could still be observed.

    Olfactory and Gustatory Dysfunctions in Patients With COVID-19 in Wuhan, China

    Authors: Li Zou; Ting Yu; Yangyang Zhang; Lijun Dai; Zhaohui Zhang; Zhentao Zhang

    doi:10.21203/ Date: 2020-05-11 Source: ResearchSquare

    Background: The coronavirus disease MESHD 2019 (COVID-19) caused by SARS-CoV-2 isspreading all over the world.The main symptoms of COVID-19 include fever MESHD fever HP, cough MESHD cough HP, fatigue MESHD fatigue HP, and myalgia MESHD myalgia HP. However, there are few reports onolfactoryand gustatory dysfunctions in patients with COVID-19.Objective: To investigate the incidence of olfactory and gustatory dysfunctions in patients with confirmed COVID-19 infection MESHD, in Wuhan, China.Methods:In this retrospective study,we collected 81 confirmed cases TRANS of COVID-19 from the Renmin Hospital of Wuhan University, from February 2020 to March 2020, and analyzed the demographic characteristics, clinical manifestations (including olfactory and gustatory dysfunctions), laboratory findings,and comorbidities.Results: A total of 81 confirmed COVID-19 patients were enrolledin this study (38 males TRANS). The most prevalent symptoms include cough MESHD cough HP, myalgia MESHD myalgia HP, and loss of appetite. On admission, 25 (30.9%) of all patients reported either olfactory dysfunction (OD) or gustatory dysfunction (GD), and 7 (8.6%) reported both OD and GD. 13.6% and 25.9% of allpatients reported OD and GD, respectively. OD and GD were not associated with disease MESHD severity. Pearson correlation analysisidentified some factors are positively correlated with OD and GD, including headache MESHD headache HP or dizziness MESHD (r = 0.342, P = 0.002), dark urine HP (r = 0.256, P = 0.021), IgM titer (r = 0.305, P = 0.01), and diabetes (r = 0.275, P = 0.013). In 81.8% of the cases with OD and 28.6% of the cases with GD, the symptomslasted for at least 1 month after discharge.3.6% of inpatients without OD developed OD after discharge.Conclusion:OD and GDare common in COVID-19.These symptoms appear early during thecourse of disease MESHD, and may last for at least 1 month.The incidence of OD and GDisrelated to neurological manifestations, diabetics, and IgM titers.

    Clinical Characteristics, Dynamic Profile of Radiology and Laboratory Findings in Coronavirus Disease MESHD 2019

    Authors: ailing liu; Jing Zhang; Wei Qiao; Wei Zang; Yingying Zhang; Junyang Kang; Haifeng Teng

    doi:10.21203/ Date: 2020-04-27 Source: ResearchSquare

    Background Since December 2019, when coronavirus disease MESHD 2019 (Covid-19) emerged in Wuhan city and rapidly spread throughout China, more and more data from different area and different stages of disease MESHD have been needed.Methods In this retrospective, single-centre study, we included all 38 confirmed cases TRANS of Covid-19 in Weihai from Jan 24 to Feb 24, 2020. Patients were divided into group A by normal Oxygenation Index (OI), group B by abnormal OI (less than 400 mmHg).The dynamic changes in clinical laboratory parameters were tracked from day 1 to day 32 after the onset of the disease MESHD at 4-day intervals. Cases were analyzed for clinical, radiological features and laboratory data. Outcomes were followed up until Feb 24, 2020.Results 38 patients with Covid-19 were included in this study, 68.42% patients were family clustered, and 97.37% patients had a history of exposure. The mean days between exposure and onset were about 5 days. Most patients were men, mean age TRANS was 43 years, 52.6% patients had chronic diseases MESHD. Most patients had fever MESHD fever HP or cough MESHD cough HP, about a third of patients had expectoration or fatigue MESHD fatigue HP, and 5 (13.16%) patients had shortness of breath.

    Early epidemiological and clinical manifestations of COVID-19 in Japan

    Authors: Muhammad Qasim; Muhammad Yasir; Waqas Ahmad; Minami Yoshida; Muhammad Azhar; Mohammad Azam Ali; Chris Wang; Maree Gould

    doi:10.1101/2020.04.17.20070276 Date: 2020-04-24 Source: medRxiv

    Background: Severe acute respiratory syndrome MESHD coronaviruses -2 (SARS-COV2) named as COVID-19 had spread worldwide and leading to 1,210,956 confirmed cases TRANS and 67,594 deaths MESHD Methods: A data of 1192 confirmed cases TRANS and 43 deaths MESHD due to COVID-19 in Japan collected from the Ministry of Health, Labour and Welfare of Japan and analysed for different epidemiological parameters and their clinical manifestations. We used Clauset-Newman-Moore (CNM) clustering algorithm to develop web-network of confirmed cases TRANS to identified clusters of community transmission TRANS. Results: Out of 1192 confirmed cases TRANS, 90.60% were symptomatic and 9.39% were asymptomatic TRANS. The prevalence SERO of COVID19 in males TRANS was 56.29% and 43.20 % in females TRANS. The mean interval (SD) from symptom onset TRANS to diagnosis was 6-22.6 days while mean interval (SD) from contact to onset of symptoms TRANS was 5-19.5 days. People of age TRANS range 40-79 were more infected and deaths MESHD median age TRANS was 80. The main symptoms were fever MESHD fever HP, dry cough MESHD cough HP, fatigue MESHD fatigue HP and pneumonia MESHD pneumonia HP. The main infected cities were Tokyo (195/1192, 16.35%), Hokkaido (160/1192 13.42%), Aichi (150/1192, 12.58%) and Osaka (145/1192, 12.16%). Only 2.34% cases had travel TRANS history from Wuhan China and Osaka music concert was identify as main cluster for community transmission TRANS. While 556 (46.64%) cases were clinically diagnosed and 557 (46.72%) were confirmed by using RT-PCR. Conclusions: Other than, declare emergency MESHD Japan need to change their approach of diagnosing COVID-19, as asymptomatic TRANS cases prevalence SERO is high and maybe it is reason for current sudden increase of cases. Screening centre should be establish away from hospitals, which are treating positive cases.

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MeSH Disease
Human Phenotype

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