Corpus overview


MeSH Disease

Pneumonia (106)

Infections (52)

Disease (46)

Death (34)

Fever (33)

Human Phenotype

Pneumonia (105)

Fever (33)

Cough (29)

Fatigue (11)

Hypertension (5)


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    Point-of-care ultrasound for COVID-19 pneumonia MESHD pneumonia HP patients in the ICU

    Authors: zouheir bitar; Mohammed Shamsah; Omar Bamasood; Ossama Maadrani; Huda Al foudri

    doi:10.21203/ Date: 2020-07-26 Source: ResearchSquare

    BackgroundPoint-of-care ultrasound (POCUS) has a major role in the management of patients with acute hypoxic respiratory and circulatory failure and guides hemodynamic management. There is scarce literature on POCUS assessment characteristics in COVID-19 pneumonia MESHD pneumonia HP with hypoxic respiratory failure HP.MethodsThe study is an observational, prospective, single‐center study conducted in the intensive care unit of Adan General Hospital from May 1st, 2020, to June 25, 2020. The study included adults TRANS suspected to have COVID-19 transferred to the intensive care unit (ICU) with fever MESHD fever HP or suspected respiratory infection MESHD. Patients were transferred to the ICU directly from the ED or general medical wards after reverse transcriptase-polymerase chain reaction (RT-PCR) testing. A certified intensivist in critical care ultrasound who was blinded to the RT-PCR results, if available at the time of examination, performed the lung ultrasound and echocardiology within 12 hours of the patient’s admission to the ICU. We calculated the E/e’, E/A ratio, left ventricular ejection fraction EF, IVC diameter, RV size and systolic function. We performed ultrasound in 12 chest areas.ResultsOf 92 patients with suspected COVID-19 pneumonia MESHD pneumonia HP, 77 (84%) cases were confirmed TRANS. The median age TRANS of the patients was 53 (82-36) years, and 71 (77%) were men.In the group of patients with confirmed COVID-19 pneumonia MESHD pneumonia HP, echocardiographic findings showed normal E/e’, deceleration time (DT), and transmittal E/A ratio in comparison to the non-COVID19 patients (P .001 for both). The IVC diameter was <2 cm with > 50% collapsibility in 62 (81%) patients with COVID-19 pneumonia MESHD pneumonia HP; a diameter of > 2 cm and < 50% collapsibility in all patients, with a P value of 0.001, was detected among those with non-COVID-19 pneumonia MESHD pneumonia HP. There were 3 cases of myocarditis MESHD myocarditis HP with poor EF (5.5%), severe RV dysfunction was seen in 9 cases (11.6%), and 3 cases showed RV thrombus.Chest US revealed four signs suggestive of COVID-19 pneumonia MESHD pneumonia HP in 77 patients (98.6%) ( sensitivity SERO 96.9%, CI 85%‐99.5%) when compared with RT-PCR results.ConclusionPOCUS plays an important role in bedside diagnosis, hemodynamic assessment and management of patients with acute hypoxic respiratory and circulatory failure in patients with COVID-19 pneumonia MESHD pneumonia HP.

    Epidemiological and clinical characteristics of COVID-19 pneumonia MESHD pneumonia HP in Zhejiang province, China: a description of early stage

    Authors: Caixia Gong; Cheng Ma; Shumin Li; Yunmei Yang; Qin Zhang

    doi:10.21203/ Date: 2020-07-16 Source: ResearchSquare

    BackgroundThe outbreak of the 2019 novel coronavirus since December, 2019, has now causing nearly 75 thousand confirmed cases TRANS in China (until paper preparing). This epidemic has posed significant threats to international health and the economy. Zhejiang province, which once had the 2nd most accumulative cases among all provinces, has now dropped to top No.5 (until paper preparing). It had a high discharge rates (43.86%) from hospital and the lowest death MESHD rate among all top 5 epidemic provinces, this drew our attention to the epidemiological, clinical characteristics and local government engagement of this region.MethodsIn this study, we included all confirmed cases TRANS of COVID-19 pneumonia MESHD pneumonia HP in Zhejiang province from Jan 21 to Feb 11, 2020. All data come from cases issued by Zhejiang provincial health commission.ResultsUntil Feb 11, 2020, 1143 cases were confirmed TRANS in Zhejiang province. We analysed the cases growth information in Zhejiang province and age TRANS, gender TRANS, severe cases percent, the source of the patients, the time of disease MESHD onset to confirm and the clinical symptoms of the patients. We also compared the clinical symptoms of elders and the young.ConclusionsThe patients in Zhejiang province had no age TRANS and gender TRANS preference, and the average time of disease MESHD onset to confirm was 5.9 days. The clinical symptoms were mainly fever MESHD fever HP, cough MESHD cough HP and weakness, similarly with before reported. The difference between elders and younger are not significant. Until paper preparing, Zhejiang province has very high discharge rate and low death MESHD rate, low cases increase rate in China.

    Procalcitonin and COVID-19: A Reliable Clinical Tool

    Authors: Jessica Bass; Anshika Singh; Robin Williams; David H. Lindner

    doi:10.21203/ Date: 2020-07-15 Source: ResearchSquare

    BACKGROUND: A procalcitonin (PCT) level is commonly ordered to distinguish between bacterial and viral etiologies of lower respiratory tract infections MESHD respiratory tract infections HP as it is typically negative in the absence of inflammatory conditions and bacterial infections MESHD. With COVID-19 causing an influx of patients presenting with respiratory symptoms, clinicians are in need of useful tools to guide management of these patients. Given the inflammation MESHD that is caused by COVID-19, it is currently unknown whether PCT continues to be a reliable or useful test in suspected and confirmed cases TRANS of COVID-19 pneumonia MESHD pneumonia HP. OBJECTIVE: To determine whether PCT remains a clinically useful test in patients who present with lower respiratory tract symptoms in the era of COVID-19. DESIGN: Single-center retrospective cohort studyPARTICIPANTS: 243 adults TRANS with lower respiratory tract symptoms who presented to the hospital through the emergency MESHD department between April 11, 2020 and May 18, 2020 who received both a COVID-19 test as well as a PCT level. MAIN MEASURES: COVID-19 positivity/negative, PCT level KEY RESULTS: It was found that patients with COVID-19 consistently had negative procalcitonin levels (<0.25ng/mL). Based on the odds ratio, a patient with a positive PCT level was 3.4 times more likely to test negative for COVID than a patient with a PCT level <0.25ng/mL.  (1)=13.895, p<0.001.  CONCLUSIONS: There is a highly significant association between a negative procalcitonin and positive COVID-19 infection MESHD, thus supporting the continued use of PCT in the COVID-19 era.

    The emergence of COVID-19 in Indonesia: analysis of predictors of infection MESHD and mortality using independent and clustered data approaches

    Authors: Erlina Burhan; Ari Fahrial Syam; Ahmad Jabir Rahyussalim; Prasenohadi Prasenohadi; Navy G Lolong Wulung; Agus Dwi Susanto; I Gede Ketut Sajinadiyasa; Dewi Puspitorini; Dewi Lestari; Indah Suci Widyahening; Vivi Setiawaty; Dwiana Ocviyanti; Kartika Qonita Putri; Aswin Guntara; Davrina Rianda; Anuraj H Shankar; Rina Agustina

    doi:10.1101/2020.07.10.20147942 Date: 2020-07-11 Source: medRxiv

    Background: Analyses of correlates of SARS-CoV-2 infection MESHD or mortality have usually assessed individual predictors. This study aimed to determine if patterns of combined predictors may better identify risk of infection TRANS risk of infection TRANS infection MESHD and mortality. Methods: For the period of March 2nd to 10th 2020, the first 9 days of the COVID-19 pandemic in Indonesia, we selected all 18 confirmed cases TRANS, of which 6 died, and all 60 suspected cases, of which 1 died; and 28 putatively negative patients with pneumonia MESHD pneumonia HP and no travel TRANS history. We recorded data for travel TRANS, contact history, symptoms, haematology, comorbidities, and chest x-ray. Hierarchical cluster analyses (HCA) and principal component analyses (PCA) identified cluster and covariance patterns for symptoms or haematology which were analysed with other predictors of infection MESHD or mortality using logistic regression. Results: For univariate analyses, no significant association with infection MESHD was seen for fever MESHD fever HP, cough MESHD cough HP, dyspnoea, headache MESHD headache HP, runny nose, sore throat, gastrointestinal complaints (GIC), or haematology. A PCA symptom component for fever MESHD fever HP, cough MESHD cough HP, and GIC tended to increase risk of infection TRANS risk of infection TRANS infection MESHD (OR 3.41; 95% CI 1.06 - 14; p=0.06), and a haematology component with elevated monocytes decreased risk (OR 0.26; 0.07 - 0.79; 0.027). Multivariate analysis revealed that an HCA cluster of 3-5 symptoms, typically fever MESHD fever HP, cough MESHD cough HP, headache MESHD headache HP, runny nose, sore throat but little dyspnoea and no GIC tended to reduce risk (aOR 0.048; <0.001 - 0.52; 0.056). In univariate analyses for death MESHD, an HCA cluster of cough MESHD cough HP, fever MESHD fever HP and dyspnoea had increased risk (OR 5.75; 1.06 - 31.3, 0.043), but no other individual predictor, cluster or component was associated. Other significant predictors of infection MESHD were age TRANS >= 45, international travel TRANS, contact with COVID-19 patient, and pneumonia MESHD pneumonia HP. Diabetes and history of contact were associated with higher mortality. Conclusions: Cluster groups and co-variance patterns may be stronger correlates of SARS-CoV-2 infection MESHD than individual predictors. Comorbidities may warrant careful attention as would COVID-19 exposure levels.

    Prolonged nucleic acid conversion and false-negative RT-PCR results in Indonesian patients with COVID-19: A case series

    Authors: Ika Trisnawati; Riat Al Khair; Aditya Rifqi Fauzi; Gunadi

    doi:10.21203/ Date: 2020-07-02 Source: ResearchSquare

    Background: Prolonged nucleic acid conversion and false-negative results of real-time reverse transcription polymerase chain reaction (RT-PCR) might occur in some patients with COVID-19 rather than recurrence MESHD of infection MESHD. Here, we reported four cases of COVID-19 with prolonged nucleic acid conversion and false-negative results of RT-PCR in our institution.Case presentation: Case 1: A 36-year-old- male TRANS patient complained of coughing MESHD coughing HP up phlegm one week before admission. His chest X-rays showed mild pneumonia MESHD pneumonia HP in the right lung. His swab test was confirmed positive for SARS-Cov-2. Besides the last two consecutive negative results, he also had negative results of RT-PCR twice (the 6th and 8th tests) from a total of 11 swab tests. Case 2: A 54-year-old- male TRANS patient complained of shortness of breath that worsened with activity. He had a comorbidity of diabetes. His chest X-rays showed inhomogeneous opacity on bilateral paracardial and lateral aspects. His swab test was confirmed positive for SARS-Cov-2. Besides the last two consecutive negative results, he also had negative results of RT-PCR once (the 5th test) from a total of 8 swab tests. Case 3: A 47-year-old man presented with complaints of fever MESHD fever HP, cough MESHD cough HP, sore throat, and diarrhea MESHD diarrhea HP. He had comorbidities of asthma MESHD asthma HP and heart rhythm disorders. His chest X-rays showed bilateral pneumonia MESHD pneumonia HP. His swab test was confirmed positive for SARS-Cov-2. Besides the last two consecutive negative results, he also showed negative results of RT-PCR twice (the 4th and 6th tests) from a total of 11 swab tests. Case 4: A 56-year-old- female TRANS complained of lethargy MESHD lethargy HP and diarrhea MESHD diarrhea HP. She has a history of hyperthyroidism MESHD hyperthyroidism HP. His chest X-rays showed bilateral pneumonia MESHD pneumonia HP. She was confirmed positive for SARS-Cov-2. Besides the last two consecutive negative results, she also had negative results of RT-PCR twice (the 2nd and 10th tests) from a total of 14 swab tests.Conclusions: Our cases further confirmed TRANS the occurrence of prolonged nucleic acid conversion and the possibility of false negative results of RT-PCR in patients with COVID-19 instead of recurrence MESHD of infection MESHD. These findings might have an implication on the management of patients with COVID-19 who have already clinically and radiologically recovered, particularly related to subsequent spreading of the infection MESHD in the community.

    Predictive model of COVID-19 incidence and socioeconomic description of municipalities in Brazil

    Authors: Isadora C Carneiro; Eloiza D Ferreira; Janaína C da Silva; Guilherme Soares; Daisy M Strottmann; Guilherme F Silveira

    doi:10.1101/2020.06.28.20141952 Date: 2020-06-29 Source: medRxiv

    Coronaviruses are enveloped viruses that can cause respiratory, gastrointestinal, hepatic, and neurological diseases MESHD. In December 2019, a new highly contagious coronavirus termed severe acute respiratory syndrome MESHD coronavirus 2 (SARS-CoV-2) emerged in China. SARS-CoV-2 causes a potentially lethal human respiratory infection MESHD, COVID-19, that is associated with fever MESHD fever HP and cough MESHD cough HP and can progress to pneumonia MESHD pneumonia HP and dyspnea MESHD dyspnea HP in severe cases. Since the virus emerged, it has spread rapidly, reaching all continents around the world. A previous study has shown that, despite being the best alternative in the current pandemic context, social distancing measures alone may not be sufficient to prevent COVID-19 spread, and the overall impact of the virus is of great concern. The present study aims to describe the demographic and socioeconomic characteristics of 672 cities with cases of COVID-19, as well as to determine a predictive model for the number of cases. We analyzed data from cities with at least 1 reported case of COVID-19 until June 26, 2020. It was observed that cities with confirmed cases TRANS of the disease MESHD are present in all Brazilian states, affecting 36.5% of the municipalities in Rio de Janeiro State. The inhabitants in cities with reported cases of COVID-19 represent more than 73.1% of the Brazilian population. Stratifying the age groups TRANS of the inhabitants and accounting for the percentage of women and men does not affect COVID-19 incidence ( confirmed cases TRANS/100,000 inhabitants). The demographic density, the MHDI and the per capita income of the municipalities with cases of COVID-19 do not affect disease MESHD incidence. In addition, if conditions are maintained, our model predicts 2,358,703 (2,172,930 to 2,544,477) cumulative cases on July 25, 2020.

    A survival analysis of COVID-19 in the Mexican population

    Authors: Guillermo Salinas-Escudero; María Fernanda Carrillo-Vega; Víctor Granados-García; Silvia Martínez-Valverde; Filiberto Toledano-Toledano; Juan Garduño-Espinosa

    doi:10.21203/ Date: 2020-06-29 Source: ResearchSquare

    Background. At present, the Americas region contributes to the largest number of cases of COVID-19 worldwide. In this area, Mexico is in third place respecting deaths MESHD (20,781 total deaths MESHD), rate that may be explained by the high proportion of the population over 50 years and the rate of chronic diseases MESHD. The aim of the present work was estimate the risk factors associated with the death MESHD rate, considering the time between symptoms onset TRANS and the death MESHD occurrence, in the Mexican population. Methods. Information of all the confirmed cases TRANS for COVID-19 reported on the public dataset released by the Epidemiological Surveillance System for Viral Respiratory Diseases MESHD of the Mexican Ministry of Health was analyzed. Kapplan-Meier curves were plotted, and a Cox proportional hazard model was constructed. Results. The analysis included 16,752 registries of confirmed cases TRANS of COVID-19 with mean age TRANS 46.55±15.55 years; 58.02% (n=9719) men and 9.37% (n=1,569) died. Men (H.R. 1.21, p<0.01, 95% C.I. 1.09-1.35), older age TRANS (H.R. 8.24, p<0.01, 95% C.I. 4.22-16.10), CKD (H.R. 1.85, p<0.01, 95% C.I. 1.51-2.25), pneumonia MESHD pneumonia HP (H.R. 2.07, p<0.01, 95% C.I. 1.81-2.38), hospitalization and ICU admissions (H.R. 5.86, p<0.01, 95% C.I. 4.81-7.14, and H.R. 1.32, p<0.01, 95% C.I. 1.12-1.55, respectively), intubation (H.R. 2.93, p<0.01, 95% C.I. 2.50-3.45) and health care in public health services (more than twice the risk, p<0.01), were independent factors increasing the risk of death MESHD due to COVID-19. Conclusions. The risk of dying at any time during follow-up was especially higher in men, individuals at the older age groups TRANS, with chronic kidney disease HP kidney disease MESHD and people hospitalized in the public health services.

    The effectiveness of implementation of mandatary institutional isolation of all mild cases by developing Fangcang hospitals against the Corona Virus Disease MESHD 2019 (COVID-19): modified SEIR model simulation

    Authors: Zhechun Zeng; Jinwen WANG; Jianglian SU; Huijuan ZUO; Jiang Xie

    doi:10.21203/ Date: 2020-06-29 Source: ResearchSquare

    Background An epidemic outbreak of a novel coronavirus (COVID-19) pneumonia MESHD pneumonia HP has occurred in Wuhan City, China in December 2019 and subsequently led to the breakdown of the medical system. Fangcang hospital is developed to isolate patients with mild symptoms of an infectious disease MESHD from their families and communities on 28 January 2020. We present use a mathematical model to quantify the impact of the mandatory isolation strategy on the epidemic in Wuhan.Methods We developed a modified Susceptible-Exposed-Infectious-Removed (SEIR) model to simulate the Wuhan COVID-19 outbreak. We use reported case data up to 1 December 2019 from the Chinese Center for Disease MESHD Control and Prevention to parameterize the model. We used the model to estimate reductions in the number of confirmed cases TRANS and deaths MESHD in Wuhan.Results Compared with mandatory institutional isolation measures, home isolation for mild cases increase the number of confirmed cases TRANS from 51,214 to 61,349 in Wuhan, but has a more marked effect at the mortality, where death MESHD case increased by nearly 35.3% until April 25th.Conclusion The mandatory isolation strategy by using Fangcang hospitals applied on January 28, 2020 can effectively control the outbreak of COVID-19. We suggest that a mandatory isolation strategy be applied with success around the whole world.

    Forecasting COVID-19 Dynamics and Endpoint in Bangladesh: A Data-driven Approach

    Authors: Al-Ekram Elahee Hridoy; Mohammad Naim; Nazim Uddin Emon; Imrul Hasan Tipo; Safayet Alam; Abdullah Al Mamun; Mohammad Safiqul Islam

    doi:10.1101/2020.06.26.20140905 Date: 2020-06-28 Source: medRxiv

    On December 31, 2019, the World Health Organization (WHO) was informed that atypical pneumonia MESHD pneumonia HP-like cases have emerged in Wuhan City, Hubei province, China. WHO identified it as a novel coronavirus and declared a global pandemic on March 11th, 2020. At the time of writing this, the COVID-19 claimed more than 440 thousand lives worldwide and led to the global economy and social life into an abyss edge in the living memory. As of now, the confirmed cases TRANS in Bangladesh have surpassed 100 thousand and more than 1343 deaths MESHD putting startling concern on the policymakers and health professionals; thus, prediction models are necessary to forecast a possible number of cases in the future. To shed light on it, in this paper, we presented data-driven estimation methods, the Long Short-Term Memory (LSTM) networks, and Logistic Curve methods to predict the possible number of COVID-19 cases in Bangladesh for the upcoming months. The results using Logistic Curve suggests that Bangladesh has passed the inflection point on around 28-30 May 2020, a plausible end date to be on the 2nd of January 2021 and it is expected that the total number of infected people to be between 187 thousand to 193 thousand with the assumption that stringent policies are in place. The logistic curve also suggested that Bangladesh would reach peak COVID-19 cases at the end of August with more than 185 thousand total confirmed cases TRANS, and around 6000 thousand daily new cases may observe. Our findings recommend that the containment strategies should immediately implement to reduce transmission TRANS and epidemic rate of COVID-19 in upcoming days.

    Clinical course and potential predicting factors of pneumonia MESHD pneumonia HP of adult TRANS patients with coronavirus disease MESHD 2019 (COVID-19): A retrospective observational analysis of 193 confirmed cases TRANS in Thailand

    Authors: Wannarat A Pongpirul; Surasak Wiboonchutikul; Lantharita Charoenpong; Nayot Panitantum; Apichart Vachiraphan; Sumonmal Uttayamakul; Krit Pongpirul; Weerawat Manosuthi; Wisit Prasithsirikul

    doi:10.1101/2020.06.24.20139642 Date: 2020-06-26 Source: medRxiv

    Background: Clinical spectrum of COVID-19 has been unclear, especially with regard to the presence of pneumonia MESHD pneumonia HP. We aimed to present clinical course of all laboratory-confirmed adult TRANS COVID-19 patients and to identify potential predicting factors of pneumonia MESHD pneumonia HP. Methods: We conducted a retrospective study among adult TRANS patients with confirmed COVID-19 who were hospitalized at Bamrasnaradura Infectious Diseases MESHD Institute, Thailand, regardless of their disease MESHD severity, between January 8 and April 16, 2020. We described the full picture of COVID-19, defined definite outcomes and evaluated factors associated with pneumonia MESHD pneumonia HP. Results: One-hundred-and-ninety-three patients were included. The median (IQR) age TRANS was 37.0 (29.0-53.0) years, and 58.5% were male TRANS. Of whom, 189 (97.9%) recovered and 4 (2.1%) died. More than half (56%) of the patients were mild, 22% were moderate, 14% were severe, and 3% were critically ill. Asymptomatic infection MESHD Asymptomatic TRANS was found in 5%. The overall incidence of pneumonia MESHD pneumonia HP was 39%. Bilateral was more prevalent than unilateral pneumonia MESHD pneumonia HP (65% vs. 35%). Increasing age TRANS (OR 2.60 for every 10-year increase from 30 years old; 95% CI, 1.68 to 3.97; p<0.001), obesity MESHD obesity HP (OR 9.17; 95% CI, 2.11 to 39.89; p=0.003), and higher temperature at presentation (OR 4.66 per one-degree Celsius increase from 37.2 degree Celsius; 95% CI, 2.32 to 9.34; p<0.001) were potential predicting factors of COVID-19 pneumonia MESHD pneumonia HP. Severe cases had a longer viral RNA shedding duration than the non-severe cases. The longest observed duration of viral RNA shedding was 45 days. Conclusion: Across different disease MESHD severities, most patients with COVID-19 in Thailand had a good prognosis. COVID-19 pneumonia MESHD pneumonia HP was found in one-third of the hospitalized patients. Potential predicting factors included old age TRANS, obesity MESHD obesity HP, fever MESHD fever HP at presentation.

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MeSH Disease
Human Phenotype

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