Corpus overview


Overview

MeSH Disease

Human Phenotype

Transmission

Seroprevalence

There are no seroprevalence terms in the subcorpus

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    Investigation on the influencing factors of mental health of healthcare workers for aid in Hubei during the outbreak of the COVID-19

    Authors: Peng Zhou; Na Du; Dongmei Diao; Yingjie OuYang; Heshan Sameera Kankanam Pathiranage

    doi:10.21203/rs.3.rs-39313/v1 Date: 2020-07-01 Source: ResearchSquare

    Background The objective of this study is to understand the psychological health status and analyze the related factors of healthcare workers for aid in Hubei during the epidemic. 220 subjects were investigated by Self-Rating Scale of Sleep(SRSS), Generalized Anxiety HP Scale (GAD-7), and 9-item patient health questionnaire (PHQ-9).Results The average SRSS score of all subjects was significantly higher than the national norm (pā€‰<ā€‰0.001)and the influencing factors were gender TRANS, whether the patients died under the charge of nursing/treatment, the history of psychosis HP and whether their family members TRANS were infected with the COVID-19. The average GAD-7 score of all subjects was in a moderate anxiety HP level, and the main influencing factors were gender TRANS, years of work, history of psychosis HP, self-perceived health statues and whether their family members TRANS were infected with the COVID-19. The average PHQ-9 score of all subjects was in mild depression level. The primary influencing factors were whether they nursed/treated severely ill patients during aid in Hubei and whether they had a history of psychosis HP.Conclusions During the outbreak of COVID-19, the symptoms of insomnia HP and anxiety HP of the healthcare workers for aid in Hubei were prominent. Moreover, male TRANS workers, those whose patients have died during their treatment, with previous anxiety HP disorders and whose family members TRANS infected with COVID-19 were facing more serious problems. Therefore, this special group needs to be strengthened follow-up psychological support individually.

    Clozapine treatment and risk of COVID-19.

    Authors: Risha Govind; Daniela Fonesca de Freitas; Megan R Pritchard; Richard D Hayes; James H MacCabe

    doi:10.1101/2020.06.17.20133595 Date: 2020-06-20 Source: medRxiv

    Background Clozapine, an antipsychotic with unique efficacy in treatment resistant psychosis HP psychosis MESHD, is associated with increased susceptibility to infection, including pneumonia HP pneumonia MESHD. Aims To investigate associations between clozapine treatment and increased risk of COVID-19 in patients with schizophrenia HP schizophrenia MESHD-spectrum disorders who are receiving antipsychotic medications, using electronic health records data, in a geographically defined population in London. Method Using information from South London and Maudsley NHS Foundation Trust (SLAM) clinical records, via the Clinical Record Interactive Search system, we identified 6,309 individuals who had an ICD-10 diagnosis of schizophrenia HP schizophrenia MESHD-spectrum disorders and were taking antipsychotics at the time on the COVID-19 pandemic onset in the UK. People who were on clozapine treatment were compared with those on any other antipsychotic treatment for risk of contracting COVID-19 between 1 March and 18 May 2020. We tested associations between clozapine treatment and COVID-19 infection MESHD, adjusting for gender TRANS, age TRANS, ethnicity, BMI, smoking status, and SLAM service use. Results Of 6,309 patients, 102 tested positive for COVID-19. Individuals who were on clozapine had increased risk of COVID-19 compared with those who were on other antipsychotic medication (unadjusted HR = 2.62 (95% CI 1.73 - 3.96), which was attenuated after adjusting for potential confounders, including clinical contact (adjusted hazard ratio HR=1.76, 95% CI 1.14 - 2.72). Conclusions These findings provide support for the hypothesis that clozapine treatment is associated with an increased risk of COVID-19. Further research will be needed in other samples to confirm this association. Potential clinical implications are discussed.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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