Corpus overview


MeSH Disease

Human Phenotype


    displaying 1 - 10 records in total 98
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    Persistent fatigue MESHD fatigue HP following SARS-CoV-2 infection MESHD is common and independent of severity of initial infection MESHD

    Authors: Liam Townsend; Adam H Dyer; Karen Jones; Jean Dunne; Rachel Kiersey; Fiona Gaffney; Laura O'Connor; Aoife Mooney; Deirdre Leavy; Katie Ridge; Catherine King; Fionnuala Cox; Kate O'Brien; Joanne Dowds; Jamie Sugrue; David Hopkins; Patricia Byrne; Tara Kingston; Cliona Ni Cheallaigh; Parthiban Nadarajan; Anne Marie McLaughlin; Nollaig M Bourke; Colm Bergin; Cliona O'Farrelly; Ciaran Bannan; Niall Conlon

    doi:10.1101/2020.07.29.20164293 Date: 2020-07-30 Source: medRxiv

    Fatigue MESHD Fatigue HP is a common symptom in those presenting with symptomatic COVID-19 infection MESHD. However, it is unknown if COVID-19 results in persistent fatigue MESHD fatigue HP in those recovered from acute infection MESHD. We examined the prevalence SERO of fatigue MESHD fatigue HP in individuals recovered from the acute phase of COVID-19 illness using the Chalder Fatigue MESHD Fatigue HP Score (CFQ-11). We further examined potential predictors of fatigue MESHD fatigue HP following COVID-19 infection MESHD, evaluating indicators of COVID-19 severity, markers of peripheral immune activation and circulating pro-inflammatory cytokines. Of 128 participants (49.5 {+/-} 15 years; 54% female TRANS), more than half reported persistent fatigue MESHD fatigue HP (52.3%; 45/128) at 10 weeks (median) after initial COVID-19 symptoms. There was no association between COVID-19 severity (need for inpatient admission, supplemental oxygen or critical care) and fatigue MESHD fatigue HP following COVID-19. Additionally, there was no association between routine laboratory markers of inflammation MESHD and cell turnover (leukocyte, neutrophil or lymphocyte counts, neutrophil-to-lymphocyte ratio, lactate dehydrogenase, C-reactive protein) or pro-inflammatory molecules (IL-6 or sCD25) and fatigue MESHD fatigue HP post COVID-19. Female TRANS gender TRANS and those with a pre-existing diagnosis of depression/ anxiety HP were over-represented in those with fatigue MESHD fatigue HP. Our findings demonstrate a significant burden of post-viral fatigue MESHD fatigue HP in individuals with previous SARS-CoV-2 infection MESHD after the acute phase of COVID-19 illness. This study highlights the importance of assessing those recovering from COVID-19 for symptoms of severe fatigue MESHD fatigue HP, irrespective of severity of initial illness, and may identify a group worthy of further study and early intervention.

    When COVID-19 Enters in a Community Setting: An Exploratory Qualitative Study of Community Perspectives on COVID-19 Affecting Mental Well-Being

    Authors: Naureen Akber Ali; Anam Shahil Feroz; Noshaba Ali; Ridah Feroz; Salima Nazim Meghani; Sarah Saleem

    doi:10.21203/ Date: 2020-07-29 Source: ResearchSquare

    Background: The COVID-19 pandemic has certainly resulted in an increased level of anxiety HP and fear among the general population related to its management and infection MESHD spread. Due to the current unprecedented situation the normal routine life of every individual has been hindered which may cause florid mental distress. Considering the relevance of present circumstances we explored perceptions and attitudes of community members towards COVID-19 pandemic and its impact on their mental well-being. Methods: We conducted an exploratory qualitative study using a purposive sampling approach, at two communities of Karachi, Pakistan. In-depth interviews were conducted with community members including, young adults TRANS, middle- age TRANS adults TRANS, and older adults TRANS of both genders TRANS. Study data was analyzed manually using the conventional content analysis technique. Results: A total of 27 in-depth interviews were conducted, between May and June, 2020. Three overarching themes were identified: (I) Impact of COVID-19 on mental health of the general communities; (II) Current coping mechanisms to adapt to the new reality; and (III) Recommendations to address mental health of communities. Generally community members underwent increased anxiety HP and fear due to the contagious nature of the virus. Alongside, social, financial and religious repercussions of the pandemic have also heightened psychological distress among community members. However, community members were able to point out some of the coping mechanisms such as getting closer to God, connecting with family, participating in mental health sessions and resetting lives by indulging in diverse activities. Simultaneously, they also recommended the need of remote mental health services for elders and continuous efforts by the government to address mental health needs of the community at larger scale.Conclusion: COVID-19-associated mental health consequences have hit every individual in the society. The study finding has the potentialto guide the development of context-specific innovative mental health programs to overcome the pandemic repercussions.

    Mental Health Impacts for International Students During the COVID-19 Pandemic in China

    Authors: Xiaoping Wang; Khamlesh Hujjaree; Fanglan Wang

    doi:10.21203/ Date: 2020-07-26 Source: ResearchSquare

    The outbreak of Coronavirus disease MESHD 2019 (COVID-19), has led to the quarantine of many residents in their homes worldwide. Some of these people might develop mental health problems, and many solutions have been put in place to address the mental health issues of patients and health professionals affected by the disease MESHD. However, not much attention has been given to international students studying in China. The present study aims to conduct an online survey to investigate the mental health status of international students from Changsha city, China.Materials and Methods: A WeChat-based survey program comprised of questions on demographic information gender TRANS, grade year, duration and status of quarantine, duration of sleep, worries about graduation, being able to go to school and presence or absence of a sense of security; as well as questions from the Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety HP Disorder-7 (GAD-7) scale and State-Trait Anxiety HP Inventory(STAI).Results: The prevalence SERO of depression was 59.4% and the prevalence SERO of anxiety HP was 37.8%. The STAI-Y1 STATE scores had a mean value (mean) of 41.42, standard deviation (S.D) of 10.89 and STAI-Y2 TRAIT scores had a mean value (mean) of 41.85, standard deviation (S.D) of 11.13.  The risk factors of anxiety HP or depression were Sleep duration, worrying about graduation in varying degrees, School time, and feeling secure in varying degrees. Higher the Patient Health Questionnaire-9 score and higher Generalized Anxiety HP Disorder-7 score and higher STAI-Y1 STATE scores were associated with higher STAI-Y2 TRAIT scores.Conclusion: The present study implies that the university needs to consider planning for acute and long-term psychological help services for international students.

    Explainable-Machine-Learning to discover drivers and to predict mental illness during COVID-19

    Authors: Indra Prakash Jha; Raghav Awasthi; Ajit Kumar; VIBHOR KUMAR; Tavpritesh Sethi

    doi:10.1101/2020.07.19.20157164 Date: 2020-07-21 Source: medRxiv

    COVID-19 pandemic has deeply affected the global economy, education, and travel TRANS and stranded people in their respective zones. Most importantly, it has claimed more than half a million lives and is poised to create long and short term consequences through mental health impairment. Identification of important factors affecting mental health can help people manage emotional, psychological, and social well-being. Here, we focus on identifying factors that have a significant impact on mental health during COVID pandemics. In this study, We have used a survey of 17764 adults TRANS in the USA at different age groups TRANS, genders TRANS, and socioeconomic statuses. Through initial statistical analysis followed by Bayesian Network inference, we have identified key factors affecting Mental health during the COVID pandemic. Integrating Bayesian networks with classical machine learning approaches lead to effective modeling of the level of mental health. Overall, females TRANS are more stressed than males TRANS, and people of age-group TRANS 18-29 are more vulnerable to anxiety HP than other age groups TRANS. Using the Bayesian Network Model, we found that people with the chronic medical condition of mental illness are more prone to mental disorders during COVID age TRANS. The new realities of working from home, home-schooling, and lack of communication with family/ friends TRANS/neighbors induces mental pressure. Financial assistance from social security helps in reducing mental stress during COVID generated economic crises. Finally, using supervised ML models, we predicted the most mentally vulnerable people with ~80% accuracy.


    Authors: Max Denning; Ee Teng Goh; Benjamin Tan; Abhiram Kanneganti; Melanie Almonte; Alasdair Scott; Guy Martin; Jonathan Clarke; Viknesh Sounderajah; Sheraz Markar; Jan Przybylowicz; Yiong Huak Chan; Ching-Hui Sia; Ying Xian Chua; Kang Sim; Lucas Lim; Lifeng Tan; Melanie Tan; Vijay Sharma; Shirley Ooi; Jasmine Winter Beatty; Kelsey Flott; Sam Mason; Swathikan Chidambaram; Seema Yalamanchili; Gabriela Zbikowska; Jaroslaw Fedorowski; Grazyna Dykowska; Mary Wells; Sanjay Purkayastha; James Kinross

    doi:10.1101/2020.07.16.20155622 Date: 2020-07-18 Source: medRxiv

    Background The Covid-19 pandemic has placed unprecedented pressure on healthcare systems and workers around the world. Such pressures may impact on working conditions, psychological wellbeing and perception of safety. In spite of this, no study has assessed the relationship between safety attitudes and psychological outcomes. Moreover, only limited studies have examined the relationship between personal characteristics and psychological outcomes during Covid-19. Methods From 22nd March 2020 to 18th June 2020, healthcare workers from the United Kingdom, Poland, and Singapore were invited to participate using a self-administered questionnaire comprising the Safety Attitudes Questionnaire (SAQ), Oldenburg Burnout Inventory (OLBI) and Hospital Anxiety HP and Depression Scale (HADS) to evaluate safety culture, burnout and anxiety HP/depression. Multivariate logistic regression was used to determine predictors of burnout, anxiety HP and depression. Results Of 3,537 healthcare workers who participated in the study, 2,364 (67%) screened positive for burnout, 701 (20%) for anxiety HP, and 389 (11%) for depression. Significant predictors of burnout included patient-facing roles: doctor (OR 2.10; 95% CI 1.49-2.95), nurse (OR 1.38; 95% CI 1.04-1.84), and other clinical staff (OR 2.02; 95% CI 1.45-2.82); being redeployed (OR 1.27; 95% CI 1.02-1.58), bottom quartile SAQ score (OR 2.43; 95% CI 1.98-2.99), anxiety HP (OR 4.87; 95% CI 3.92-6.06) and depression (OR 4.06; 95% CI 3.04-5.42). Factors significantly protective for burnout included being tested for SARS-CoV-2 (OR 0.64; 95% CI 0.51-0.82) and top quartile SAQ score (OR 0.30; 95% CI 0.22-0.40). Significant factors associated with anxiety HP and depression, included burnout, gender TRANS, safety attitudes and job role. Conclusion Our findings demonstrate a significant burden of burnout, anxiety HP, and depression amongst healthcare workers. A strong association was seen between SARS-CoV-2 testing, safety attitudes, gender TRANS, job role, redeployment and psychological state. These findings highlight the importance of targeted support services for at risk groups and proactive SARS-CoV-2 testing of healthcare workers.

    An overview of current mental health in the general population of Australia during the COVID-19 pandemic: Results from the COLLATE project

    Authors: Susan Rossell; Erica Neill; Andrea Phillipou; Eric Tan; Wei Lin Toh; Tamsyn Van Rheenen; Denny Meyer

    doi:10.1101/2020.07.16.20155887 Date: 2020-07-18 Source: medRxiv

    The novel coronavirus disease MESHD (COVID-19) poses significant mental health challenges globally; however, to date, there is limited community level data. This study reports on the first wave of data from the COLLATE project (COvid-19 and you: mentaL heaLth in AusTralia now survEy), an ongoing study aimed at understanding the impact of the COVID-19 pandemic on the mental health and well-being of Australians. This paper addresses prevailing primary concerns related to the COVID-19 pandemic, current levels of negative emotions and risk factors predicting these negative emotions. On April 1st to 4th 2020, 5158 adult TRANS members of the Australian general public completed an online survey. Participants ranked their top ten current primary concerns about COVID-19, and completed standardized measures to ascertain levels of negative emotions (specifically, depression, anxiety HP and stress). Socio-demographic information was also collected and used in the assessment of risk factors. The top three primary concerns were all related to the health and well-being of family and loved ones. As expected, levels of negative emotion were exceptionally high. Modelling of predictors of negative emotions established several risk factors related to demographic variables, personal vulnerabilities, financial stresses, and social distancing experiences; particularly being young, being female TRANS, or having a mental illness diagnosis. The data provides important characterization of the current mental health of Australians during the COVID-19 pandemic. Critically, it appears that specific groups in the Australian community may need special attention to ensure their mental health is protected during these difficult times. The data further suggests the need for immediate action to combat high levels of psychological distress, along with the exacerbation of mental health conditions, in relation to the COVID-19 pandemic in Australia. These results may provide some direction for international researchers hoping to characterize similar issues in other countries.

    Influence Psycho-Sexual Factors on The Quality of Life in Pregnant Women During the COVID-19 pandemic: A Path Analysis

    Authors: Masoumeh Alijanpour; Shahideh Jahanian Sadatmahalleh; Youseflu Samaneh; Bahri Khomami Mahnaz; Yousefi Afrashteh Majid; Ashraf Moini; Anoshiravan Kazemnejad

    doi:10.21203/ Date: 2020-07-17 Source: ResearchSquare

    Background: Coronavirus has spread rapidly around the world. This epidemic has created stress and anxiety HP for pregnant women in different parts of the world. The aim of this study was to investigate the relationship between quality of life (QoL) with anxiety HP, depression, corona disease MESHD anxiety HP, sexual function (SF), and marital satisfaction (MS) in pregnant women during the Covid-19 pandemic.Methods: The present study is a cross-sectional study involving 260 pregnant women. The Short-Form Health Survey (SF_12), Marital Satisfaction Scale (MSS), Female TRANS Sexual Function Index (FSFI), Hospital Anxiety HP and Depression Scale (HADS), and coronary disease MESHD anxiety HP questionnaire, Padua Obsession Questionnaire, General Health Questionnaire (GHQ) are used for data collection. Data were analyzed using the Pearson correlation coefficient and path analysis.Result: The overall goodness-of-fit statistics revealed that the predictors of QOL had perfectly good fitness indices (RMSEA=0.02; AGFI=0.99). The results show that corona related anxiety HP, marital satisfaction (MS), sexual function (SF), depression, and anxiety HP have a direct effect on women’s QOL. Among variables, GHQ has a more direct effect on women’s QOL. General health (GH) considered as a mediator variable; variables such as anxiety HP, depression, and Corona-related Anxiety HP with effect on GH can impress QOL. Anxiety HP as a main predictor of QOL, with direct, and indirect effects through GH, depression, SF, and MS can impress QOL. Conclusion: Since the QoL in pregnant women is associated with coronavirus epidemics, these results can be used to plan to improve the health and QoL of these people.

    Knowledge, beliefs, mental health, substance use, and behaviors related to the COVID-19 pandemic among U.S. adults TRANS: A national online survey

    Authors: Ralph J. DiClemente; Ariadna Capasso; Shahmir H. Ali; Abbey M. Jones; Joshua Foreman; Yesim Tozan

    doi:10.21203/ Date: 2020-07-16 Source: ResearchSquare

    Background: Given the urgent need for data to inform public health messaging to mitigate the spread of the COVID-19 pandemic, this national survey sought to assess the state of COVID-19-related knowledge, beliefs, mental health, substance use changes, and behaviors among a sample of U.S. adults TRANS.Methods: A survey of U.S. adults TRANS was administered online from March 20-30, 2020. The survey collected data on socio-demographic characteristics; COVID-19-related knowledge, awareness and adoption of preventive practices; depression and anxiety HP (assessed by the Patient Health Questionnaire-4); stress (adapted Impact of Event Scale-6); pessimism; and changes in tobacco and alcohol use. Differences between age groups TRANS (18-39 years, 40-59 years and ≥60 years) were tested using Pearson’s chi-squared tests or ANOVAs; associations between drinking and smoking and depression, anxiety HP and stress were tested using adjusted logistic regression models.Results: Approximately, half of the sample (NTotal=6,391) were 50-69 years old and 58% were female TRANS. COVID-19 knowledge (Mean=12·0; SD=1.2; Range=0-13) and protective practice awareness (Mean=9·1; SD=0·8; Range 0-10) were high. However, only 84% of respondents were aware of the protective value of alcohol-based hand sanitizers and 19% had purchased facemasks. Among respondents, 44% had a score consistent with depression and anxiety HP (PHQ-4 score≥6); and 52% reported high stress scores (≥median of 1.33). COVID-19-related anxiety HP and depression were associated with increased drinking (AOR=1.79; 95% CI=1.49, 2.15, p<0.001) and smoking (AOR=2.17; 95% CI=1.64, 2.88, p<0.001). High stress scores were also associated with increased drinking (AOR=1.80; 95% CI=1.49, 2.17, p<0.001) and smoking (AOR=1.75; 95% CI=1.31, 2.33, p<0.001) among respondents.Conclusions: In spite of high knowledge about COVID-19 and protective practices, important gaps were identified. High prevalence SERO of poor mental health outcomes and associated increases in drinking and smoking warrant ongoing risk communications tailoring to effectively disseminate information and expanding psychosocial and substance use treatment services, particularly online telehealth services, to mitigate the negative mental health impact of the COVID-19 pandemic.

    COVID-19 misinformation: mere harmless delusions HP or much more? A knowledge and attitude cross-sectional study among the general public residing in Jordan

    Authors: Malik Sallam; Deema Dababseh; Alaa Yaseen; Ayat Al-Haidar; Duaa Taim; Huda Eid; Nidaa A. Ababneh; Faris G. Bakri; Azmi Mahafzah

    doi:10.1101/2020.07.13.20152694 Date: 2020-07-15 Source: medRxiv

    Abstract Since the emergence of the recent coronavirus disease MESHD 2019 (COVID-19) and its spread as a pandemic, media was teeming with misinformation that led to psychologic, social and economic consequences among the global public. Probing knowledge and anxiety HP regarding this novel infectious disease MESHD is necessary to identify gaps and sources of misinformation which can help public health efforts to design and implement more focused interventional measures. The aim of this study was to evaluate the knowledge, attitude and effects of misinformation about COVID-19 on anxiety HP level among the general public residing in Jordan. An online survey was used that targeted people aged TRANS 18 and above and residing in Jordan. The questionnaire included items on the following: demographic characteristics of the participants, knowledge about COVID-19, anxiety HP level and misconceptions regarding the origin of the pandemic. The total number of participants included in final analysis was 3150. The study population was predominantly females TRANS (76.0%), with mean age TRANS of 31 years. The overall knowledge of COVID-19 was satisfactory. Older age TRANS, male TRANS gender TRANS, lower monthly income and educational levels, smoking and history of chronic disease MESHD were associated with perceiving COVID-19 as a very dangerous disease MESHD. Variables that were associated with a higher anxiety HP level during the pandemic included: lower monthly income and educational level, residence outside the capital (Amman) and history of smoking. Misinformation about the origin of the pandemic (being part of a conspiracy, biologic warfare and the 5G networks role) was also associated with higher anxiety HP and lower knowledge about the disease MESHD. Social media platforms, TV and news releases were the most common sources of information about the pandemic. The study showed the potential harmful effects of misinformation on the general public and emphasized the need to meticulously deliver timely and accurate information about the pandemic to lessen the health, social and psychological impact of the disease MESHD.

    Baduanjin Exercise May Improve the Anxiety HP and Insomnia HP in COVID-2019 Patients: A Case-Control Study

    Authors: Ming-Gui Chen; Yinlong Qiu; Haizhen Chen; Erhui Chen; Rui-Xiang Zeng; Qiaomei Wu; Xiaoxuan Zhang; Min-Zhou Zhang; MeiZhen Lin

    doi:10.21203/ Date: 2020-07-14 Source: ResearchSquare

    Background: Since December 2019, an epidemic caused by novel coronavirus(2019-nCoV) infection MESHD has occurred unexpectedly in China. Because of the sudden nature of the outbreak and the infectious power of the virus, it will inevitably cause people anxiety HP and other stress reactions. Previous studies showed that Baduanjin exercise was effective for people in anxiety HP and insomnia HP. The purpose of this study was to evaluate the potential benefits of Baduanjin exercise on the anxiety HP and insomnia HP in COVID-2019 patients.Methods: This is a Case-Control Study. The COVID-2019 patients including 39 Baduanjin exercises or willing to do Baduanjin exercises and 39 age TRANS-and gender TRANS-matched nonexercising controls. The anxiety HP and insomnia HP in COVID-2019 patients were measured by using the GAD-7 and SMH Sleep Questionnaire at baseline and discharge.Results: In the study, the Paired T-test showed that two groups had improved the GAD-7 scores and SMH Sleep Questionnaire compared with baseline at discharge. Baseline results showed there were no significant differences in the GAD-7 scores and SMH Sleep Questionnaire between the two groups. However, the significant differences found in the Baduanjin group included a 43.9% lower (p<0.001) in the GAD-7 score and an approximately 75.9% higher (p=0.003) in SMH Sleep Questionnaire score compare with the control group at discharge.Conclusion: The Baduanjin exercise may improve the anxiety HP and insomnia HP in COVID-2019 patients. It can also be used as a form of rehabilitation exercise for discharged patients or patients isolated at home.Trial Registration: ChiCTR2000030528.

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MeSH Disease
Human Phenotype

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