Corpus overview


MeSH Disease

Human Phenotype


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    Incidence, risk factors and mortality outcome in patients with acute kidney injury HP acute kidney injury MESHD in COVID-19: a single-center observational study

    Authors: Gaetano Alfano; Annachiara Ferrari; Francesco Fontana; Giacomo Mori; Riccardo Magistroni; Meschiari Marianna; Franceschini Erica; Marianna Menozzi; Gianluca Cuomo; Gabriella Orlando; Antonella Santoro; Margherita Di Gaetano; Cinzia Puzzolante; Federica Carli; Andrea Bedini; Jovana Milic; Paolo Raggi; Massimo Girardis; Cristina Mussini; Gianni Cappelli; Giovanni Guaraldi

    doi:10.1101/2020.06.24.20138230 Date: 2020-06-24 Source: medRxiv

    Background Acute kidney injury HP Acute kidney injury MESHD ( AKI MESHD) is a recently recognized complication of coronavirus disease-2019 (COVID-19). This study aims to evaluate the incidence, risk factors and case-fatality rate of AKI MESHD in patients with documented COVID-19. Methods We reviewed the health medical records of 307 consecutive patients hospitalized for symptoms of COVID-19 at the University Hospital of Modena, Italy. Results AKI MESHD was diagnosed in 69 out of 307 (22.4%) patients. The stages of AKI MESHD were stage 1 in 57.9%, stage 2 in 24.6% and stage 3 in 17.3%. Hemodialysis was performed in 7.2% of the subjects. AKI MESHD patients had a mean age TRANS of 74.7 {+/-} 9.9 years and higher serum SERO levels of the main marker of inflammation MESHD and organ involvement (lung, liver, hearth and liver) than non- AKI MESHD patients. AKI MESHD events were more frequent in subjects with severe lung comprise. Two peaks of AKI MESHD events coincided with in-hospital admission and death of the patients. Kidney injury MESHD was associate with a higher rate of urinary abnormalities MESHD including proteinuria HP proteinuria MESHD (0.448{+/-} 0.85 vs 0.18 {+/-} 0.29; P=<0.0001) and hematuria HP hematuria MESHD (P=0.032) compared to non- AKI MESHD patients. At the end of follow-up, 65.2% of the patients did not recover their renal function after AKI MESHD. Risk factors for kidney injury MESHD were age TRANS, male TRANS sex, CKD and non-renal SOFA. Adjusted Cox regression analysis revealed that AKI MESHD was independently associated with in-hospital death (hazard ratio [HR]=3.74; CI 95%, 1.34-10.46) compared to non- AKI MESHD patients. Groups of patients with AKI MESHD stage 2-3 and failure to recover kidney function were associated with the highest risk of in-hospital mortality. Lastly, long-hospitalization was positively associated with a decrease of serum creatinine HP serum SERO creatinine, likely due to muscle depletion occurred with prolonged bed rest. Conclusions AKI MESHD was a dire consequence of patients with COVID-19. Identification of patients at high-risk for AKI MESHD and prevention of kidney injury MESHD by avoiding dehydration HP dehydration MESHD and nephrotoxic MESHD agents is imperative in this vulnerable cohort of patients.

    A multi-centered, retrospective, descriptive study on 107 dead patients with COVID-19

    Authors: chong zhang; Minhao Wu; Xiaobin Zhu; meng wu; yufan zhu; kun li; zhouming deng; yuanlong xie; lin cai

    doi:10.21203/ Date: 2020-04-02 Source: ResearchSquare

    Since the emergence of Corona Virus Disease MESHD 2019 (COVID-19) in Wuhan city, Hubei Province, China, it has caused thousands of deaths MESHD. As the ongoing outbreak of COVID-19 around the world, the number of deaths will definitely continue to increase. We aimed to further describe the clinical characteristics of dead cases with COVID-19 through a large sample and multi-centered study and to find some clinical predictors for the deterioration of COVID-19 during the process.   Methods One hundred and seven patients (16 patients from Lei Shen-Shan Hospital, 54 patients from Seventh Hospital of Wuhan and 37 patients from Zhongnan Hospital of Wuhan University) with COVID-19 were enrolled in our research from Jan 22 to Feb 29, 2020. The demographic, clinical, radiological, laboratory and treatment data of all cases were analysed.   Results Of the 107 dead patients with COVID-19, 71 (66.4%) were male TRANS and 36 (33.6%) were female TRANS. The mean age TRANS of the patients was 71.2 ± 12.1 years. 82 (76.6%) of patients had chronic diseases. The mean duration from admission to death was 9 (IQR,5-14) days. Respiratory functional damage was the most common one followed by heart and kidney. Hematuria HP was found in 36(33.6%) patients. 89(83.2%) patients’ albumin levels were decreased. 68(63.6%) patients had anemia HP. concerning laboratory results, 55 (69.6%) and 56 (70.1%) patients have the elevated white blood SERO cells and elevated Neutrophils during the process; only 43 (54.4%) have the decreased Lymphocytes; The values of platelets and haemoglobin decreased in 64(81.0%) and 58 (73.4%) patients. Alanine aminotransferase and aspartate aminotransferase elevated in near half of patients, while almost 80% of patients have the decreased albumin. The elevated blood SERO urea nitrogen and cystatin C were manifested in about 70% of patients. Procalcitonin was elevated in 38 (71.7%) patients.   Conclusions In conclusion, the older men with chronic diseases are more likely to die from COVID-19. Apart from that, more attention should be pay on timely treatment, coinfections, malnutrition HP, and dysfunction of kidney and coagulation. The rising values (white blood SERO cell, blood SERO urea nitrogen, cystatin C, PCT and PT) and the decreased values (PLT, Hb and albumin) maybe meaningful for predict the poor prognosis.

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MeSH Disease
Human Phenotype

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