Corpus overview


Overview

MeSH Disease

Human Phenotype

Transmission

Seroprevalence
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    First Wave of COVID-19 Hospital Admissions in Denmark: A Nationwide Population-Based Cohort Study

    Authors: Jon Gitz Holler; Robert Eriksson; Tomas Østergaard Jensen; Maarten Van Wijhe; Thea Kølsen Fischer; Ole Schmeltz Søgaard; Simone Bastrup Israelsen; Rajesh Mohey; Thilde Fabricius; Frederik Jøhnk; Lothar Wiese; Stine Johnsen; Christian Søborg; Henrik Nielsen; Ole Kirk; Birgitte Lindegaard Madsen; Zitta Barrella Harboe

    doi:10.21203/rs.3.rs-66082/v1 Date: 2020-08-26 Source: ResearchSquare

    Background: Severe acute respiratory syndrome coronavirus 2 MESHD (SARS-CoV-2) and its associated disease coronavirus disease MESHD 2019 (COVID-19), is a worldwide emergency. Demographic, clinical and laboratory factors associated with mortality in Danish patients hospitalised with COVID-19 is limited.Methods: National health registries were used to identify all hospitalized patients with a COVID-19 diagnosis. We obtained demographics, Charlson Comorbidity Index (CCI), and laboratory results on admission and explored prognostic factors for death using multivariate Cox proportional hazard regression and competing risk survival analysis.Results: Among 2,431 hospitalised patients with COVID-19 between February 27th and July 8th (median age TRANS 69 years [IQR 53–80], 54.1% males TRANS), 359 (14.8%) needed admission to an intensive care unit (ICU) and 455 (18.7%) died within 30 days of follow-up. The seven-day cumulative incidence of ICU MESHD admission was lower for females TRANS (7.9%) than for males TRANS (16.7%), (p < 0.001). Age TRANS, high CCI, elevated C-reactive protein (CRP), ferritin, D-dimer, lactate dehydrogenase (LDH), urea, creatinine, lymphopenia HP lymphopenia MESHD, neutrophilia HP, and thrombocytopenia HP thrombocytopenia MESHD within 24-hours of admission were independently associated with death within the first week in the multivariate analysis. Conditional upon surviving the first week, male TRANS sex, age TRANS, high CCI, elevated CRP, LDH, creatinine, urea and neutrophil count were associated with death MESHD within 30 days. Males TRANS presented with more pronounced laboratory abnormalities on admission. Conclusions: Advanced age TRANS, male TRANS sex, comorbidity, higher levels of systemic inflammation MESHD and cell-turnover were prognostic factors for mortality. Age TRANS was the strongest predictor for death MESHD, moderate to high level of comorbidity were associated with a nearly two-fold increase in mortality. Mortality was significantly higher for males TRANS after surviving the first week.  

    Pathogenesis clue from early clinical presentation of 300 hospitalized COVID-19 patients

    Authors: Feng Yu; Xuemei Deng; Li Ni; Wei Li; Ping Yan; Mian Huang; Xiongbiao Wang

    doi:10.21203/rs.3.rs-44006/v1 Date: 2020-07-16 Source: ResearchSquare

    The global spread of COVID-19 has been lasted more than half a year. Except for the gene sequence and virus structure of SARS-CoV-2, its clinical characteristics, pathological mechanism and corresponding measures have not been fully revealed. Objective: To speculate the possible pathological mechanism from the early clinical manifestations of the patients with COVID-19. Methods: The onset symptoms TRANS, laboratory examination and CT findings on admission of 300 cases in two wards of Wuhan Third Hospital from January 28 to March 15 were analyzed retrospectively. Results: There was no difference in incidence between men and women, but women were hospitalized later after onset. Upper respiratory symptoms and sputum were seldom. The incidence of fever HP fever MESHD was 71%. Blood SERO lymphocytes count decreased significantly on admission, which was related to the severity of the disease. In the moderate type of patients, who without hypoxia MESHD, thrombocytopenia HP thrombocytopenia MESHD occurred in 12.37%, CRP rose in 64.43 %, BUN elevated in 20.62 %, creatinine rose in 17.53 %, D-dimer elevated in 74.74%, creatine kinase and α-hydroxybutyrate dehydrogenase elevated in 45.36% and 54.12% patients respectively. The early CT showed a small amount of infiltration in the subpleural, the lateral zone of the lung and thickening of the interlobular septum. About 5 days later, infiltration had been worse in a part of the patients, and the affected lung was negatively correlated with the lymphocyte count. Conclusion: There was no gender TRANS difference in patients with SARS-CoV-2 invasion. Alveolar MESHD cells and T lymphocytes maybe main targets of the virus and apoptosis maybe primary pathogenesis. The virus entering the lung maybe transmitted through lymph or blood SERO channels, rather than direct diffused in the respiratory tract. Early damage of multiple organs maybe caused by immune response. 

    COVID-19 and Cancer: A Comparative Case Series

    Authors: seied Asadollah Mousavi; Tahereh Rostami; Azadeh kiumarsi; soroush Rad; mohammadreza Rostami; Fatemeh Motamedi; Alireza Gandomi-Mohammadabadi; Amirhossein Mirhosseini

    doi:10.21203/rs.3.rs-41710/v1 Date: 2020-07-13 Source: ResearchSquare

    BackgroundCancer patients, with an incidence of more than 18 million new cases per year, may constitute a significant portion of the COVID-19 infected population. In the pandemic situation,  these patients are considered highly vulnerable to infectious complications due to their immunocompromised state.Material & MethodsIn this retrospective case series, the documents of solid cancer MESHD patients infected by SARS-CoV-2, hospitalized in Shariati hospital (a tertiary care referral center designated for COVID-19 patients, affiliated by Tehran University of Medical Sciences) between 20 February and 20 April 2020, were evaluated. The diagnosis of COVID-19 was based on a positive real-time fluorescence reverse transcription-polymerase chain reaction (RT-PCR) for SARS-CoV-2 nucleic acids from nasal and/or pharyngeal specimens and/or features of chest CT scan highly suggestive for SARS-CoV-2.ResultsAmong 33 patients with solid cancer MESHD, 11 patients had a positive RT-PCR for SARS-CoV-2 and 22 patients had highly suggestive chest CT scan findings in favor of SARS-CoV-2 but negative RT-PCR . The mean age TRANS of the patients was 63.9 years, and 54.5% of the patients were males TRANS. Age and sex of the patients did not correlate with mortality. There was no difference in COVID-19 symptoms, lymphocytopenia MESHD, thrombocytopenia HP thrombocytopenia MESHD between survived and un-survived cancer MESHD patients. However, LDH level was significantly higher (7170±2077 vs. 932.3±324.7, P-value=0.016) and also serum SERO albumin was significantly lower in un-survived group (3.6±0.5 vs. 2.9±0.6 p-value=0.03). Among 16 patients with stage IV cancer MESHD, thirteen patients died, which was significantly higher compared to stage I-III cancer MESHD patients (81.3% vs. 18.8% P-value= <0.001).  In terms of developing complications, sepsis HP sepsis MESHD, invasive ventilation and mortality was significantly higher in patients who received cytotoxic chemotherapy within the last 14 days. There was no significant difference between the two groups of positive and negative SARS-CoV-2 RT-PCR regarding their sex, age TRANS, cancer type MESHD, mean Hemoglobin concentration, Platelet count, lymphocyte count, serum SERO albumin level, ESR and CRP titer or other laboratory findings and also in terms of clinical symptoms and coexisting.ConclusionIn this study, we showed that the mortality rate among cancer MESHD patients affected by COVID-19 was higher than general population and this rate has a significant correlation with factors such as the stage of the disease, the type of cancer MESHD, the activity of cancer MESHD and finally receiving cytotoxic chemotherapy within 14 days before diagnosis of COVID-19. We also showed that the outcome of cancer MESHD patients with positive RT-PCR for COVID-19 similar to those with negative RT-PCR with highly suggestive chest CT scan findings.

    Are Patients with Elevated Inflammatory Indications are at Higher Risk for Developing the Severe form of COVID-19?

    Authors: Mohsen Rokni; Kazem Ahmadikia; Somaye Asghari; Shahabodin Mashaei; Fahimeh Hassanali

    doi:10.21203/rs.3.rs-34994/v1 Date: 2020-06-12 Source: ResearchSquare

    BackgroundSince December 2019, when SARS-CoV-2 emerged with a cluster of unknown pneumonia HP pneumonia MESHD cases in Wuhan city and rapidly spread throughout in worldwide and Iran, data have been needed on the clinical and diagnostic features of the affected Iranian patients.MethodsWe extracted data regarding 233 patients with laboratory-confirmed COVID-19 from Buali Hospital in Iran; clinical/praclinical and inflammatory indexes data were collected and analyzed. The data of laboratory examinations and chest CT findings were compared between death and non-severe patients.ResultsThe mean age TRANS of the patients was 49 years, (63%) of the patients were male TRANS. The acute respiratory distress HP respiratory distress MESHD syndrome occurred in 64 patients, including 53 who were admitted to the ICU and underwent invasive mechanical ventilation, and 28 who died. On the admission in death group, lymphopenia HP lymphopenia MESHD (79%), neutrophilia HP (79%), and thrombocytopenia HP thrombocytopenia MESHD (21%) were usually observed. Most patients had a high SII index of > 500 (68%), increased CRP level (88%). A high level of inflammatory index’s such as NLR, PLR and SII in death comparison with moderate groups were observed (P < 0.001). The most common symptoms were fever HP fever MESHD (70%) and cough HP cough MESHD (63%) on admission. Headache HP Headache MESHD was uncommon (11%). On admission, ground-glass opacity with consolidation (mixed) was the most common radiologic finding on chest CT (51%). No radiographic or CT abnormality was found in 15 of 204 patients (7%). In ConclusionThese patients often presented without fever HP fever MESHD, and some did not have abnormal radiologic findings. Elevated NLR, PLR and SII can be considered as prognostic and risk stratifying factor of severe form of disease.

    Comparison of Clinical, Para-clinical and Laboratory Findings in Survived and Deceased Patients with COVID-19: Diagnostic Role of Inflammatory Indications in Determining the Severity of Illness

    Authors: Mohsen Rokni; Kazem Ahmadikia; Somaye Asghari; Shahabodin Mashaei; Fahimeh Hassanali

    doi:10.21203/rs.3.rs-34994/v2 Date: 2020-06-12 Source: ResearchSquare

    Background: Since December 2019, when a cluster of pneumonia HP pneumonia MESHD cases due to SARS-CoV-2 initially emerged in Wuhan city and then rapidly spread throughout the world, the necessity for data concerning the clinical and paraclinical features of Iranian patients with COVID-19 was highlighted. Therefore, we aimed to compare the clinical, paraclinical and laboratory evidences of deceased patients with survival group. Methods: We extracted data regarding 233 patients with laboratory-confirmed COVID-19 from Buali Hospital in Iran; clinical/paraclinical and inflammatory indexes data were collected and analyzed. The data of laboratory examinations and chest CT findings were compared between deceased and survived patients. Results: The mean age TRANS of the patients was 49.8 years and 64% of our patients were male TRANS. The acute respiratory distress HP respiratory distress MESHD syndrome occurred in 64 patients, 52 who were admitted to the ICU, which all of them underwent invasive mechanical ventilation, and 28 who died. Lymphopenia HP Lymphopenia MESHD (79%), neutrophilia HP (79%), and thrombocytopenia HP thrombocytopenia MESHD (21%) were the most frequently observed laboratory findings of the deceased group on admission. Most patients (68%) had a high systematic immune-inflammation MESHD (SII) index of >500 and increased C-reactive protein level (88%). Levels of inflammatory indexes such as neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR) and SII were documented to be significantly elevated in the deceased group when compared with the patients who survived (P< 0.0001, P< 0.001, P< 0.0001, respectively). The most commonly presented symptoms were fever HP fever MESHD (70%) and cough HP cough MESHD (63%) on admission. Headache HP Headache MESHD was uncommon (11%). Ground-glass opacity with consolidation (mixed) was the most common radiologic finding on chest CT (51%). No radiographic or CT abnormality was found in 15 of 204 patients (7%). Conclusion: Small fraction of patients with COVID-19 may present without fever HP fever MESHD and abnormal radiologic findings. Elevated NLR, PLR and SII can be considered as prognostic and risk stratifying factor of severe form of disease.

    The Neutrophil Lymphocyte Ratio (NLR), Platelet Lymphocyte Ratio (PLR) and routine hematological parameters of COVID-19 Patient : A perspective of the Indian scenario from a frontline pilot study of 32 COVID-19 cases in a Tertiary Care Institute of North India

    Authors: Neema Tiwari; Devajit Nath; Jyotsna Madan; Savitri Singh; Prashant Bajpai; Ujjwal Madan

    doi:10.1101/2020.05.29.20102913 Date: 2020-06-01 Source: medRxiv

    Introduction The coronavirus disease MESHD 2019(COVID-19) is caused by the virus SARS-CoV-2 and is declared as a global pandemic by the World Health Organization (WHO). Various hematological parameters alteration has been documented in the Chinese literature in SARS-Cov-2 infection MESHD. However, there is a need for research to evaluate the pattern of the hematological parameters of COVID-19 patients in the Indian population. Aims & Objectives: The objective of the study is to see the Neutrophil-Lymphocyte Ratio (NLR), Platelet Lymphocyte Ratio (PLR), and other hematological parameters alteration of COVID-19 patients along with their clinical course in the Indian scenario. Methods: A single-center prospective study of 32 patients with laboratory-confirmed COVID-19 admitted to Super Speciality Pediatric Hospital & Post Graduate Teaching Institute NOIDA, from March to April, were enrolled for the study. The demographic data, the clinical status of the patients during admission and follow up, baseline, and follow up hematological findings were recorded. Statistical analysis of the data was carried out, and relevant findings were presented. Results: Demographic characterization shows a mean age TRANS of 37.7 years, male TRANS (41.9%), female TRANS (58.1%)with the majority of patients are mildly symptomatic to asymptomatic TRANS(93%). The CBC values and NLR, PLR at baseline between the male TRANS and the female TRANS patients, are not showing any statistically significant difference as the 95% C.I. A statistically significant increment in the lab parameters is observed in follow-up visits. Conclusion: The majority of the patients are younger and have mild clinical presentation with female TRANS predominance. Pediatric cases have mild symptomology. Baseline CBC findings show mild neutrophilia HP, lymphopenia HP lymphopenia MESHD, eosinopenia, and normal to mild thrombocytopenia HP thrombocytopenia MESHD. An increase in CBC parameters, NLR was noted in follow up cases. Anemia HP Anemia MESHD was not noted in baseline CBC and in the follow-up group. A onetime PLR is not indicative of disease progression. Key words: Corona virus,COVID-19,CBC,NLR,PLR

    Clinical, Laboratory, and Radiological Features Indicative of Novel Coronavirus Disease MESHD (COVID-19) in Emergency Departments – A Multicentre Case-Control Study in Hong Kong

    Authors: Rex Pui Kin Lam; Kevin Kei Ching Hung; Eric Ho Yin Lau; Chun Tat Lui; Kin Ling Chan; Chin San Leung; Ion Wa Wong; Kin Wa Wong; Colin A. Graham; Patrick Chiu Yat Woo

    id:10.20944/preprints202005.0285.v1 Date: 2020-05-17 Source: Preprints.org

    (1) Background: It is unclear whether the reported presenting clinical features of coronavirus disease MESHD 2019 (COVID-19) are useful in identifying high-risk patients for early testing and isolation in the emergency department (ED). We aimed to compare the exposure history, clinical, laboratory, and radiographic features of ED patients who tested positive and negative for COVID-19; (2) Methods: We conducted a case-control study in seven EDs during the first five weeks of the COVID-19 outbreak in Hong Kong. Thirty-seven laboratory-confirmed COVID-19 patients were compared with 111 age TRANS- and gender TRANS-matched controls; (3) Results: There were no significant differences in patient characteristics and reported symptoms between the groups, except patient-reported fever HP fever MESHD. A positive travel TRANS history or contact history was the most significant predictor for COVID-19 infection MESHD. After adjustment for age TRANS and presumed location of acquiring the infection in Wuhan/Hubei, patient-reported fever HP fever MESHD (OR 2.6, 95% CI 1.1 to 6.3), delayed presentation (OR 5.0, 95% CI 2.0 to 12.5), having medical consultation before ED presentation (OR 7.4, 95% 2.9 to19.1), thrombocytopenia HP thrombocytopenia MESHD (OR 4.0, 95% CI 1.6 to 9.7), raised lactate dehydrogenase (OR 5.9, 95% CI 1.9 to 18.5), haziness, consolidation or ground-glass opacity on chest radiography (OR 5.6, 95% CI 2.0 to 16.0), and bilateral changes on chest radiography (OR 13.2, 95% CI 4.7 to 37.4) were associated with a higher odds of COVID-19 separately while neutrophilia HP was associated with a lower odds (OR 0.3, 95% CI 0.1-0.8); and (4) Conclusions: This study highlights several features that may be useful in identifying high-risk patients for early testing and isolation while waiting for test result. Further studies are warranted to verify the findings.

    Comparison of clinical characteristics and risk factors in hospitalized patients with SARS-CoV-2, MERS-CoV, and SARS-CoV infection MESHD

    Authors: Zhengtu Li; Xidong Wang; Guansheng Su; Zeguang Zheng; Shaoqiang Li; Yuwei Ye; Qiuxue Deng; Jinchuang Li; Xiaoyu Xiong; Xinguang Wei; Zeqiang Lin; Zichen Jie; Feng Ye

    doi:10.21203/rs.3.rs-28847/v1 Date: 2020-05-14 Source: ResearchSquare

    Herein, we compared the risk factors, clinical presentation of patients hospitalized with SARS-CoV-2, SARS-CoV MESHD, or MERS-CoV infection MESHD. Our data sources include PubMed, Embase, CNKI, and Ovid/Medline. The proportion of male TRANS patients with COVID-19 was higher than who with SARS but lower than who with MERS (p<0.001). More patients with COVID-19 had coexisting chronic medical conditions than those with SARS (p<0.001) but fewer than those with MERS (p<0.001), and the prevalence SERO of hypertension HP hypertension MESHD (17%) and smoking history (14%) was higher than in patients with SARS (p<0.001). Furthermore, the symptom of fever HP fever MESHD (53%), hemoptysis HP (1%), diarrhea HP diarrhea MESHD (4%) and vomiting HP vomiting MESHD (3%) of COVID-19 were significantly lower than that in patients with SARS or MERS. The level of ALT and AST in COVID-19 was significantly lower (p<0.001), however, thrombocytopenia HP thrombocytopenia MESHD, high LDH were common. Summary, male TRANS, smoking history and hypertension HP hypertension MESHD were the most common risk factors for hospitalization with COVID-19; and the clinical feature was less severe in COVID-19.

    Comparison of clinical characteristics and risk factors in hospitalized patients with SARS-CoV-2, MERS-CoV, and SARS-CoV infection MESHD

    Authors: Zhengtu Li; Xidong Wang; Guansheng Su; Shaoqiang Li; Yuwei Ye; Qiuxue Deng; Jinchuang Li; Xiaoyu Xiong; Xinguang Wei; Zeqiang Lin; Zichen Jie; Feng Ye

    doi:10.21203/rs.3.rs-21414/v1 Date: 2020-04-05 Source: ResearchSquare

    Herein, we compared the risk factors, clinical presentation of patients hospitalized with  SARS-CoV-2, SARS-CoV MESHD, or MERS-CoV infection MESHD. The proportion of male TRANS patients with COVID-19 was higher than who with SARS but lower than who with MERS (p<0.001). More patients with COVID-19 had coexisting chronic medical conditions than those with SARS (p<0.001) but fewer than those with MERS (p<0.001), and the prevalence SERO of hypertension HP hypertension MESHD (17%) and smoking history (14%) was higher than in patients with SARS (p<0.001). Furthermore,the symptom of fever HP fever MESHD (53%), hemoptysis HP (1%), diarrhea HP diarrhea MESHD (4%) and vomiting HP vomiting MESHD (3%) of COVID-19 were significantly lower than that in patients with SARS or MERS. The level of ALT and AST in COVID-19 was significantly lower (p<0.001), however, thrombocytopenia HP thrombocytopenia MESHD, high LDH were common. Summary, male TRANS, smoking history and hypertension HP hypertension MESHD were the most common risk factors for hospitalization with COVID-19; and the clinical feature was less severe in COVID-19.

    A case report and summary of thrombocytopenia HP thrombocytopenia MESHD caused by coronavirus disease MESHD 2019

    Authors: Yibing Zhao; Na Du; Wei Li; Dongmei Xiang; Guodong Zhou; Ruixu Li; Panyang Xu; Jiancheng Xu

    doi:10.21203/rs.3.rs-20569/v1 Date: 2020-04-01 Source: ResearchSquare

    Background: Coronavirus disease 2019 has become a major problem for the world. We reported a representative case with thrombocytopenia HP thrombocytopenia MESHD.Case report: A 44-year-old female TRANS patient sought medical attention for fatigue HP fatigue MESHD and cough HP of 1 day duration. Thirteen days before disease onset, the patient had returned from Hubei province. Her body temperature on admission was 38.6℃. Blood SERO routine test showed a white blood SERO cell count of 4.0×109/L, lymphocyte count of 1×109/L, platelet count of 118×109/L, and C-reactive protein of 6.0mg/L. Lung computed tomography (CT) scan showed: large patches of ground-glass opacities at the posterior segment of the right upper lung lobe and bilaterally at the basal segment of the lower lung lobes. Her throat swabs tested positive for novel coronavirus nucleic acid. After antiviral and symptomatic treatment were given, on day 5 of hospitalization, her symptoms of coughing HP and chest pain HP chest pain MESHD worsened after coughing HP, and she also developed hemoptysis HP hemoptysis MESHD. Repeated lung CT scans showed that the lesion area had increased. The lymphocyte count had decreased to 0.55×109/L and the platelet count had decreased to 9×109/L on day 6. After a series of multimodal therapies were carried out, the patient’s platelet and lymphocyte count gradually increased to normal.Conclusion: We reported a COVID-2019 case with significant thrombocytopenia HP thrombocytopenia MESHD, which was more significantly decreased than in normal viral infections. However, the mechanism of thrombocytopenia HP thrombocytopenia MESHD is unknown and requires further research.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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