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Human Phenotype

Transmission

Seroprevalence
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    Emergency high ligation in a suspected COVID-19 pediatric patient with incarcerated inguinal hernia MESHD inguinal hernia HP: a case report

    Authors: Munawir Makkadafi; Aditya Rifqi Fauzi; Amsyar Praja; Kemala Athollah; . Marcellus; . Gunadi

    doi:10.21203/rs.3.rs-40812/v1 Date: 2020-07-09 Source: ResearchSquare

    Background SARS-Cov-2 infects MESHD not only adults TRANS, but also children TRANS, including pediatric surgery patients with acute abdomen. Here, we report a pediatric surgery case with incarcerated inguinal hernia MESHD inguinal hernia HP and suspected COVID-19.Case presentation: A 11-month-old male TRANS was brought to our emergency department with the main complaint of recurrent yellowish-green vomiting HP vomiting MESHD that was experienced from one day before admission. High fever MESHD fever HP and shortness of breath MESHD were also reported. This patient was also suffering from moderate dehydration HP dehydration MESHD. Neither history of contact with a confirmed case TRANS of COVID-19 nor traveling TRANS from any local transmission TRANS area were found. However, a SARS-CoV-2 rapid antibody test SERO revealed a positive result. A lump in the left scrotum that persisted during admission was found. Fluid resuscitation and nasogastric tube placement for decompression was performed. Manual reduction was attempted but failed to reduce the lump. Accordingly, we decided to perform an emergency high ligation using tertiary protection regulations, i.e., full personal protective equipment (PPE) for COVID-19. Intraoperatively, we found a small intestine loop trapped in the scrotum and stuck in the inguinal canal. Postoperatively, the baby was continued to be managed as a patient with COVID-19 while waiting for the real-time reverse transcription polymerase chain reaction (RT-PCR) results.Conclusions During the COVID-19 pandemic, surgeons should always be aware of the possibility of cross- transmission TRANS from the patient, since children TRANS are also susceptible to SARS-CoV-2 infection MESHD. When and wherever possible, surgeons should perform the procedure in the quickest and most effective manner to shorten exposure time with patient and anesthetic aerosols as well as using appropriate PPE.

    Incidence, risk factors and mortality outcome in patients with acute kidney injury HP acute kidney injury MESHD in COVID-19: a single-center observational study

    Authors: Gaetano Alfano; Annachiara Ferrari; Francesco Fontana; Giacomo Mori; Riccardo Magistroni; Meschiari Marianna; Franceschini Erica; Marianna Menozzi; Gianluca Cuomo; Gabriella Orlando; Antonella Santoro; Margherita Di Gaetano; Cinzia Puzzolante; Federica Carli; Andrea Bedini; Jovana Milic; Paolo Raggi; Massimo Girardis; Cristina Mussini; Gianni Cappelli; Giovanni Guaraldi

    doi:10.1101/2020.06.24.20138230 Date: 2020-06-24 Source: medRxiv

    Background Acute kidney injury HP Acute kidney injury MESHD ( AKI MESHD) is a recently recognized complication of coronavirus disease-2019 (COVID-19). This study aims to evaluate the incidence, risk factors and case-fatality rate of AKI MESHD in patients with documented COVID-19. Methods We reviewed the health medical records of 307 consecutive patients hospitalized for symptoms of COVID-19 at the University Hospital of Modena, Italy. Results AKI MESHD was diagnosed in 69 out of 307 (22.4%) patients. The stages of AKI MESHD were stage 1 in 57.9%, stage 2 in 24.6% and stage 3 in 17.3%. Hemodialysis was performed in 7.2% of the subjects. AKI MESHD patients had a mean age TRANS of 74.7 {+/-} 9.9 years and higher serum SERO levels of the main marker of inflammation MESHD and organ involvement (lung, liver, hearth and liver) than non- AKI MESHD patients. AKI MESHD events were more frequent in subjects with severe lung comprise. Two peaks of AKI MESHD events coincided with in-hospital admission and death of the patients. Kidney injury MESHD was associate with a higher rate of urinary abnormalities MESHD including proteinuria HP proteinuria MESHD (0.448{+/-} 0.85 vs 0.18 {+/-} 0.29; P=<0.0001) and hematuria HP hematuria MESHD (P=0.032) compared to non- AKI MESHD patients. At the end of follow-up, 65.2% of the patients did not recover their renal function after AKI MESHD. Risk factors for kidney injury MESHD were age TRANS, male TRANS sex, CKD and non-renal SOFA. Adjusted Cox regression analysis revealed that AKI MESHD was independently associated with in-hospital death (hazard ratio [HR]=3.74; CI 95%, 1.34-10.46) compared to non- AKI MESHD patients. Groups of patients with AKI MESHD stage 2-3 and failure to recover kidney function were associated with the highest risk of in-hospital mortality. Lastly, long-hospitalization was positively associated with a decrease of serum creatinine HP serum SERO creatinine, likely due to muscle depletion occurred with prolonged bed rest. Conclusions AKI MESHD was a dire consequence of patients with COVID-19. Identification of patients at high-risk for AKI MESHD and prevention of kidney injury MESHD by avoiding dehydration HP dehydration MESHD and nephrotoxic MESHD agents is imperative in this vulnerable cohort of patients.

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