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Human Phenotype

Transmission

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    Autoantibody-negative insulin-dependent Diabetes MESHD after COVID-19

    Authors: Tim Hollstein; Juliane Schulz; Andreas Glück; Dominik M Schulte; Stefan Schreiber; Stefan R Bornstein; Matthias Laudes

    doi:10.21203/rs.3.rs-39343/v1 Date: 2020-07-01 Source: ResearchSquare

    Here we report the manifestation of insulin dependent diabetes MESHD after a COVID-19 infection MESHD in the absence of typical autoantibodies for type 1 diabetes MESHD. A 19-year-old Caucasian male TRANS subject presented to our emergency department with diabetic ketoacidosis HP diabetic ketoacidosis MESHD ( DKA MESHD). C-peptide levels accounted to 0.62µg/L in the presence of blood SERO glucose concentrations of 30.6 mmol/L (552 mg/dL). The patient´s case history revealed a COVID-19 disease 6-8 weeks prior to admission. This is of interest, since COVID-19 internalization into host cells is mediated via Angiotensin-converting enzyme 2 (ACE2) [1], a transmembrane glycoprotein which amongst others is crucial for β-cell homeostasis and function [2,3,4]. Detailed laboratory testing was performed, revealing no serum SERO- antibodies SERO against islet-cells (ICA), glutamic acid decarboxylase (GAD65-AA), tyrosine phosphatase (IA-2-AA), insulin (IAA) and zinc-transport-8 (ZnT8-AA), but against COVID-19. Hence, this is a presentation of an insulin-dependent diabetes mellitus MESHD diabetes mellitus HP in the absence of markers of autoimmunity HP, which might suggest direct cytolytic effects of COVID-19 on pancreatic β-cells presumably mediated via ACE2.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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