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MeSH Disease

Human Phenotype

Transmission

gender (1)


Seroprevalence

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    A COVID-19 patient with multiple negative results for PCR assays outside Wuhan, China: a case report

    Authors: Li-Da Chen; Hao Li; Yu-Ming Ye; Zhi Wu; Ya-Ping Huang; Wei-Liang Zhang; Li Lin

    doi:10.21203/rs.3.rs-21601/v1 Date: 2020-04-06 Source: ResearchSquare

    Background: The outbreak of coronavirus disease MESHD 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 MESHD (SARS-CoV-2) has become a public health emergency of major international concern. Real-time RT-PCR assays are recommended for diagnosis of COVID-19. Here we report a rare case of COVID-19 with multiple negative results for PCR assays outside Wuhan, China. Case presentation: A 32-year old male TRANS was admitted to our hospital because of 6 days of unexplained fever HP fever MESHD on January 29, 2020. He had come from Wuhan city 10 days before admission. 5 days before admission, no abnormality was noted in laboratory test, chest radiography, and nasopharyngeal swab test for the SARS-CoV-2 nucleic acid. The patient was treated with ibuprofen for  alleviating fever MESHD. On admission, chest computed tomography showed multiple ground- glass opacities MESHD in right lower lung field. COVID-19 was suspected. 3 times of nasopharyngeal swab specimens were collected after admission. However, none of the specimens were positive. The patient was confirmed with COVID-19 after fifth SARS-CoV-2 nucleic acid test. He was treated with lopinavir/ritonavir, recombinant human interferon alfa-2b inhalation, methylprednisolone. After 18 days of treatment, he was discharged with improved symptoms, lung lesions MESHD and negative results of nasopharyngeal swab. Conclusion: This case reminds clinician that a patient with high clinical suspicion of COVID-19 but multiple negative RT-PCR result should not be taken out of isolation. A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. Repeat swab tests are helpful in diagnosis for this kind of patients. 

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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