Corpus overview


Overview

MeSH Disease

Human Phenotype

Transmission

Seroprevalence
    displaying 1 - 1 records in total 1
    records per page




    Potential involvement of monoamine oxidase activity in SARS-COV2 infection and delirium onset MESHD delirium HP onset

    Authors: Miroslava Cuperlovic-Culf; Emma L Cunningham; Anuradha Surendra; Xiaobei Pan; Steffany A.L. Bennett; Mijin Jung; Bernadette McGuiness; Anthony Peter Passmore; Danny McAuley; David Beverland; Brian D. Green

    doi:10.1101/2020.06.16.20128660 Date: 2020-06-19 Source: medRxiv

    Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a range of extra-respiratory signs and symptoms. One such manifestation is delirium HP delirium MESHD, an acute confusional state occurring in 60-70% of severe SARS-CoV-2 cases. Delirium HP Delirium MESHD is also a common clinical syndrome following planned orthopedic surgery. This investigation initially explored the underlying role of metabolism in delirium HP delirium MESHD-susceptibility in this setting. Metabolomics profiles of cerebrospinal fluid (CSF) and blood SERO taken prior to surgery found significant concentration differences of several amino acids, acylcarnitines and polyamines were observed in delirium HP-prone patients. Phenethylamine (PEA) concentrations in delirium HP delirium MESHD-prone patients was significantly lower in CSF than in blood SERO, whilst in age TRANS- and gender TRANS-matched controls the opposite was observed (adjusted p values: 1.8x10-6 (control) and 1.788x10-10 ( delirium HP delirium MESHD)). PEA is metabolised by monoamine oxidase B (MAOB), a putative enzyme target for the treatment of Alzheimers disease HP Alzheimers disease MESHD, Parkinsons disease MESHD and depression MESHD. Our computational structural comparisons of MAOB MESHD and angiotensin converting enzyme (ACE) 2 found high similarity, specifically within the SARS-CoV-2 spike protein. MAOB structural alignment to ACE2 was 51% overall, but this was over 95% in the ACE2-spike protein binding region. Thus, it is possible that the spike protein interacts with MAOB on a molecular level. A previously published metabolomic dataset of control subjects and patients with either mild or severe COVID-19 was then analysed. Major concentration differences in some metabolites attributed to altered MAO activity were detected. Therefore, our hypothesis is that the SARS-CoV-2 influences MAOB activity, which is one potential cause for the many observed neurological and platelet based complications of SARS-CoV-2 infection MESHD. Further research is required to establish what effect MAOB inhibitors might have on these pathways. There is no evidence at present to support the withholding of MAOB inhibitors.

The ZB MED preprint Viewer preVIEW includes all COVID-19 related preprints from medRxiv and bioRxiv, from ChemRxiv, from ResearchSquare, from arXiv and from Preprints.org and is updated on a daily basis (7am CET/CEST).
The web page can also be accessed via API.

Sources


Annotations

All
None
MeSH Disease
Human Phenotype
Transmission
Seroprevalence


Export subcorpus as...

This service is developed in the project nfdi4health task force covid-19 which is a part of nfdi4health.

nfdi4health is one of the funded consortia of the National Research Data Infrastructure programme of the DFG.