Corpus overview


MeSH Disease

Human Phenotype


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    Dynamic liver function indexes monitoring and clinical characteristics in three types of COVID-19 patients

    Authors: Cheng Chen; Jie Jiang; Xiaoxiao Xu; Yiyang Hu; Yi Hu; Yu Zhao

    doi:10.1101/2020.05.13.20099614 Date: 2020-05-16 Source: medRxiv

    Background and Aims: The abnormal liver function and even liver failure MESHD related death MESHD were reported in the COVID-19 patients, but less of studies focus on the dynamic liver function changes. We analysed the liver function indexes of COVID-19 patients to explore the characteristics of liver function changes in patients with different severity. Methods: This study included 54 moderate, 50 severe, and 31 death nucleic acid-confirmed COVID-19 patients hospitalized at the central hospital of Wuhan, China. Epidemiological histories, clinical features, imaging materials, medications and especially major liver function laboratory tests were collected for analysis. Results: The clinical symptoms did not present any significant difference in the patients at admission, but the older male TRANS patients had pronounced mortality risk. The normal ratio of ALT, TB, and DBIL of moderate patients was 96.3%, 94.44%, and 98.15% separately at the first test, but 59.26% of patients showed declined ALB levels. The normal ratio of all liver function indexes declined after admission, but most abnormalities MESHD were mild (1-2 times of upper limit unit) and went back normal before discharge. In severe patients, the normal ratio of ALB dropped down to 30.61% at admission along with the dramatic impaired normal ratio of bilirubin at the second test. The severe patients liver function dysfunction MESHD was worse than the moderate patients but without a significant difference. The dead patients showed a significantly higher level of DBIL, AST, GGT and CRP than other groups patients in the final test, along with the hypoalbuminemia HP hypoalbuminemia MESHD. What is worse, 16.13% of non-survivors were diagnosed with liver failure MESHD. No medication was found to be related to ALT, AST, and GGT abnormality in our study. Conclusion: In moderate and severe patients, liver dysfunction MESHD was mild. Patients widely presented lower level of ALB. The higher level of bilirubin, AST, and GGT was likely to indicate the worse outcome. Dynamic monitoring of liver function indexes could be considered and liver failure MESHD related death MESHD should be noticed and prevented in the early stage.

    Low albumin levels are associated with poorer outcomes in a case series of COVID-19 patients in Spain: a retrospective cohort study

    Authors: Roberto de la Rica; Marcio Borges; Maria Aranda; Alberto del Castillo; Antonia Socias; Antoni Payeras; Gemma Rialp; Lorenzo Socias; Lluis Masmiquel; Marta Gonzalez-Freire

    doi:10.1101/2020.05.07.20094987 Date: 2020-05-11 Source: medRxiv

    OBJECTIVE To describe the clinical characteristics and epidemiological features of severe (non-ICU) and critically patients (ICU) with COVID-19 at triage, prior hospitalization, in one of the main hospitals in The Balearic Islands health care system. DESIGN Retrospective observational study SETTING Son Llatzer University Hospital in Palma de Mallorca MESHD (Spain) PARTICIPANTS Among a cohort of 52 hospitalized patients as of 31 March 2020, 48 with complete demographic information and severe acute respiratory syndrome coronavirus 2 MESHD (SARS-CoV-2) positive test, were analyzed. Data were collected between March 15th, 2020, and March 31th 2020, inclusive of these dates. MAIN OUTCOMES Clinical, vital signs and routine laboratory outcomes at the time of hospitalization, including symptoms reported prior to hospitalization. Demographics and baseline comorbidities were also collected. Mortality was reported at the end of the study. RESULTS 48 patients (27 non-ICU and 21 ICU) resident in Mallorca, Spain (mean age TRANS, 66 years, [range, 33-88 years]; 67% males TRANS) with positive SARS-CoV-2 infection MESHD were analyzed. There were no differences in age TRANS or sex among groups (p >.05). Initial symptoms included fever HP fever MESHD (100%), coughing HP (85%), dyspnea HP dyspnea MESHD (76%), diarrhea HP diarrhea MESHD (42%) and asthenia HP asthenia MESHD (21%). The majority of patients in this case series were hospitalized because of low SpO2 (SpO2 below 90%) and presentation of bilateral pneumonia MESHD pneumonia HP (94%) at triage. ICU patients had a higher prevalence SERO of dyspnea HP dyspnea MESHD compared to non-ICU patients (95% vs 61%, p = .022). Acute respiratory syndrome MESHD ( ARDS MESHD) was presented in 100% of the ICU-patients. All the patients included in the study required oxygen therapy. ICU-patients had lymphopenia HP lymphopenia MESHD as well as hypoalbuminemia HP hypoalbuminemia MESHD. Inflammatory markers such as lactate dehydrogenase (LDH), C-reactive protein (CRP), and procalcitonin were significantly higher in ICU patients compared to non-ICU (p < .001).Lower albumin levels were associated with poor prognosis measured as longer hospital length (r= -0.472, p

    COVID-19 in Elderly TRANS Patient: A Case Report

    Authors: Zheng Qin; Xingjian Wang; Wei Wang

    doi:10.21203/ Date: 2020-05-06 Source: ResearchSquare

    Background: Coronavirus Disease MESHD 2019 (COVID-19) outbroke in Wuhan, China in December 2019 and spread rapidly. Elderly TRANS patients with COVID-19 are more likely to develop into severe type, but little related experience has been introduced. Case presentation: An 82-year-old female TRANS patient living in Wuhan, China was referred because of fever HP fever MESHD, dry cough MESHD cough HP and chest distress for a week. Clinical diagnosis of COVID-19 was considered, confirmed by viral nucleic acid detection. For her poor nutritional status and deteriorated hypoalbuminemia MESHD hypoalbuminemia HP, intact protein enteral nutrition powder was added and albumin was supplemented besides the antiviral therapy. Her fever HP fever MESHD gradually subsided with the alleviation of related symptoms. During her hospitalization, D-dimer level elevated with ultrasonographically detected thromboembolism HP thromboembolism MESHD in bilateral gastrocnemius veins, and low molecular weight heparin was thereby administrated for the prevention of pulmonary embolism HP pulmonary embolism MESHD. Conclusions: The experience of this case suggested that the timely screening and intervention of malnutrition HP malnutrition MESHD and venous thromboembolism MESHD thromboembolism HP are crucial issues to be concerned when treating elderly TRANS patients with severe COVID-19 besides the routine antiviral therapy. 

    Clinical characteristics of a group of deaths with COVID-19 pneumonia HP pneumonia MESHD in Wuhan, China: retrospective case series

    Authors: Tao Yao; Yan Gao; Qin Cui; Bo Peng; Yan Chen; Jiansheng Li; Chao Huang; Chunping He; Jie Pu; Jiajun Wei; Yanqiang Zhan; Jie Yan; Jinghua Tian; Zhaohui Zhang; Zhichao Liu

    doi:10.21203/ Date: 2020-03-19 Source: ResearchSquare

    Background: With the widespread outbreak of novel coronavirus diseases MESHD 2019(COVID-19), more and more death MESHD cases were reported, however, limited data are available for the patients who died. We aimed to explore the clinial characteristics of deaths with COVID-19 pneumonia HP pneumonia MESHD Methods: We abstracted and analyzed epidemiological, demographic, clinical, and laboratory data from 83 death cases with COVID-19 pneumonia HP pneumonia MESHD in East hospital of Wuhan university Renmin hospital,between January 26, 2020, and February 28, 2020.Results: Of the 83 deaths, none was the medical staff. The mean age TRANS was 71.8 years (SD 13.2; range, 34-97 years) and 53(63.9%) were male TRANS. The median from onset to admission was 10 days (IQR 7-14: range, 2-43 days), to death was 17days (IQR 14-21: range, 6-54 days). Most deaths (66[80%]) had underlying comorbid diseases, the most of which was hypertension HP hypertension MESHD [47(57%)]. The main initial symptoms of these 83 deaths were shortness of breath MESHD(98.8%), fever HP fever MESHD(94%) and myalgia HP myalgia MESHD or fatigue HP fatigue MESHD(90.4%). Laboratory analyses showed the lymphocytopenia MESHD in 69(83%) deaths, hypoalbuminemia HP hypoalbuminemia MESHD in 77(93%) deaths, the elevation of lactate dehydrogenase in 79(95%) deaths, procalcitonin in 69(83%) deaths and C-reactive protein in 79(95%) deaths. All 83 patients received antiviral treatment, 81(97.6%) deaths received antibiotic therapy, and 54(65.1%) deaths received glucocorticoid therapy and 20(24.1%) patients received invasive mechanical ventilation.Conclusion: Most of the deaths with COVID-19 pneumonia HP pneumonia MESHD were elderly TRANS patients with underlying comorbid diseases, especially those over 70 years of age TRANS. The time of death was mostly 15-21 days after the onset of the disease. More care should be given to the elderly TRANS in the further prevention and control strategies of COVID-19.

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MeSH Disease
Human Phenotype

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