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MeSH Disease

Human Phenotype

Transmission

Seroprevalence

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    Characteristics of Ischemic Stroke HP Stroke MESHD in COVID-19: A Need for Early Detection and Management

    Authors: Dinesh V. Jillella; Nicholas J. Janocko; Fadi Nahab; Karima Benameur; James G. Greene; Wendy L. Wright; Mahmoud Obideen; Srikant Rangaraju

    doi:10.1101/2020.05.25.20111047 Date: 2020-05-26 Source: medRxiv

    Objective: In the setting of the Coronavirus Disease MESHD 2019 (COVID-19) global pandemic caused by SARS-CoV-2, a potential association of this disease with stroke HP stroke MESHD has been suggested. We aimed to describe the characteristics of patients who were admitted with COVID-19 and had an acute ischemic stroke HP ischemic stroke MESHD ( AIS MESHD). Methods: This is a case series of PCR-confirmed COVID-19 patients with ischemic stroke HP ischemic stroke MESHD admitted to an academic health system in metropolitan Atlanta (USA) between March 24th,2020, and May 5th, 2020. Demographic, clinical, and radiographic characteristics were described. Results: Of 124 ischemic stroke HP ischemic stroke MESHD stroke MESHD patients admitted during this study period, 8 (6.5%) were also diagnosed with COVID-19. The mean age TRANS of patients was 64.3 +/- 6.5 years, 5 (62.5%) male TRANS, mean time from last-normal was 4.8 days [SD 4.8], and none received acute reperfusion therapy. All 8 patients had at least one stroke HP stroke MESHD-associated co-morbidity. The predominant pattern of ischemic stroke HP ischemic stroke MESHD was embolic MESHD; 3 were explained by atrial fibrillation HP atrial fibrillation MESHD while 5 (62.5%) were cryptogenic. In contrast, cryptogenic strokes HP strokes MESHD were seen in 20 (16.1%) of 124 total stroke HP stroke MESHD admissions during this time. Conclusions: In our case series, ischemic stroke HP ischemic stroke MESHD affected COVID-19 patients with traditional stroke HP stroke MESHD risk factors with an age TRANS of stroke HP stroke MESHD presentation typically seen in non-COVID populations. We observed a predominantly embolic pattern of stroke MESHD stroke HP with a higher than expected rate of cryptogenic strokes HP strokes MESHD and with a prolonged median time to presentation and symptom recognition limiting the use of acute reperfusion treatments. These results highlight the need for increased community awareness, early identification, and management of AIS in COVID-19 patients.

    Etiologic Subtypes of Ischemic Stroke HP Ischemic Stroke MESHD in SARS-COV-2 Virus MESHD patients

    Authors: Ketevan Berekashvili; Adam A Dmytriw; Volodomyr Vulkanov; Shashank Agarwal; Amit Khaneja; David Turkel-Parella; Jeremy Liff; Jeffrey Farkas; Thambirajah Nandakumar; Ting Zhou; Jennnifer Frontera; David E Kahn; Sun Kim; Kelly A Humbert; Matthew D Sanger; Shadi Yaghi; Aaron Lord; Karthikeyan Arcot; Ambooj Tiwari

    doi:10.1101/2020.05.03.20077206 Date: 2020-05-08 Source: medRxiv

    Objective: To describe the ischemic stroke HP ischemic stroke MESHD etiopathogenesis related to COVID-19 in a cohort of NYC hospitals. Background: Extra-pulmonary involvement of COVID-19 has been reported in the hepatic, renal and hematological systems. Most neurological manifestations are non-focal but few have reported the characteristics of ischemic strokes HP ischemic strokes MESHD or investigated its pathophysiology. Methods: Over the last 6 weeks, data from four centers in New York City were collected to review the possible ischemic stroke HP ischemic stroke MESHD types seen in COVID-19 positive patients. Their presentation, demographics, other related vascular risk factors, associated laboratory and coagulation markers, as well as imaging and outcomes were collected. Results: In our study, age TRANS range of patients was 25-75 with no significant male TRANS preponderance. 70% presented for acute hospitalization due the stroke HP stroke MESHD. About a fifth did not have common risk factors for ischemic stroke HP ischemic stroke MESHD stroke MESHD like diabetes MESHD and hypertension HP hypertension MESHD. None had history of atrial fibrillation HP atrial fibrillation MESHD or smoking. 50% had poor outcome with four ending in mortality and one in a critical condition due ARDS. All had high Neutrophil/Lymphocyte ratio except one who demonstrated some neurological recovery. In 70% of our cases, D-dimer levels were collected, and all showed mild to severe elevation. None of the emergent large vessel occlusion (LVO) cases had known cardiac risk factors but two out of five were found to have cardiac abnormalities MESHD during the course of their hospitalization. All LVOs had hypercoagulable lab markers especially elevated D-dimer and/or Fibrinogen. The LVO patients were younger and sicker with a median age TRANS of 46 and mean NIHSS of 24 as opposed to non-LVOs with a median age TRANS of 62 and mean NIHSS of 6 respectively. Conclusion: COVID-19 related ischemic MESHD events can be small vessel, branch emboli MESHD or large vessel occlusions. The latter is often associated with either a hypercoagulable state or cardio-embolism MESHD. Patient outcomes were worse when multi-organ or pulmonary system failure MESHD prevailed. Keywords: COVID-19, Acute Ischemic strokes HP Ischemic strokes MESHD, Emergent Large Vessel Occlusion, Mechanical Thrombectomy MESHD

The ZB MED preprint Viewer preVIEW includes all COVID-19 related preprints from medRxiv and bioRxiv, from ChemRxiv, from ResearchSquare, from arXiv and from Preprints.org and is updated on a daily basis (7am CET/CEST).
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MeSH Disease
Human Phenotype
Transmission
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