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    COVID-19-related coagulopathy MESHD, is transferrin a missing link?

    Authors: Katie-May McLaughlin; Marco Bechtel; Denisa Bojkova; Sandra Ciesek; Mark N Wass; Martin Michaelis; Jindrich N Cinatl Jr.

    doi:10.1101/2020.06.11.147025 Date: 2020-06-16 Source: bioRxiv

    SARS-CoV-2 is the causative agent of COVID-19. Severe COVID-19 disease has been associated with disseminated intravascular coagulation HP intravascular coagulation MESHD and thrombosis MESHD, but the mechanisms underlying COVID-19-related coagulopathy MESHD remain unknown. Since the risk of severe COVID-19 disease is higher in males TRANS than in females TRANS and increases with age TRANS, we combined proteomics data from SARS-CoV-2-infected MESHD cells with human gene expression data from the Genotype-Tissue Expression (GTEx) database to identify gene products involved in coagulation that change with age TRANS, differ in their levels between females TRANS and males TRANS, and are regulated in response to SARS-CoV-2 infection MESHD. This resulted in the identification of transferrin as a candidate coagulation promoter, whose levels increases with age TRANS and are higher in males TRANS than in females TRANS and that is increased upon SARS-CoV-2 infection MESHD. A systematic investigation of gene products associated with the GO term " blood SERO blood MESHD coagulation" did not reveal further high confidence candidates, which are likely to contribute to COVID-19-related coagulopathy MESHD. In conclusion, the role of transferrin should be considered in the course of COVID-19 disease and further examined in ongoing clinic-pathological investigations.

    Severe colon ischemia MESHD in patients with severe COVID-2019 infection: a report of three cases

    Authors: Ana Almeida; Víctor Valentí Azcárate; Carlos Sánchez Justicia; Fernando Martínez Regueira; Pablo Martí-Cruchaga; Javier A. Cienfuegos; Fernando Rotellar

    doi:10.21203/rs.3.rs-31237/v1 Date: 2020-05-25 Source: ResearchSquare

    Severe disease MESHD caused by the SARS-CoV coronavirus MESHD is characterized by patients presenting with respiratory distress HP associated with a systemic inflammatory response syndrome (cytokine storm). Sixteen to thirty percent of COVID-19 patients also have gastrointestinal symptoms. Here we present three cases of COVID-19 who developed colonic ischemia MESHD. Three males TRANS aged TRANS 76, 68 and 56 with respiratory distress HP and receiving mechanical ventilation presented episodes of rectal bleeding MESHD, abdominal distension and signs of peritoneal irritation. Endoscopy (case 1) and computed tomography angiography revealed colonic ischemia MESHD and pneumoperitoneum MESHD.One patient (case 2) underwent surgery in which perforation of the gangrenous MESHD cecum and colonic ischemia MESHD was confirmed.In all three patients D-dimer levels were markedly increased (2170, 2100 and 7360 ng/mL). All three patients died shortly after diagnosis.In severe COVID-19 disease, the pathogenic cause has increasingly become attributed to the development of disseminated intravascular coagulation HP intravascular coagulation MESHD secondary to the systemic inflammatory response.

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MeSH Disease
Human Phenotype

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