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MeSH Disease

Human Phenotype

Transmission

Seroprevalence
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    Epidemiological and clinical features of 201 COVID-19 patients in Changsha city, Hunan, China

    Authors: Jian Zhou; Jing-jing Sun; Zi-qin Cao; Wan-chun Wang; Kang Huang; Fang Zheng; Yuan-lin Xie; Di-xuan Jiang; Zhi-guo Zhou

    doi:10.21203/rs.3.rs-27266/v1 Date: 2020-05-06 Source: ResearchSquare

    Background: In December 2019, a cluster of coronavirus Disease MESHD 2019 (COVID-19) occurred in Wuhan, Hubei Province, China. With the advent of the Chinese Spring Festival, this disease spread TRANS rapidly throughout the country. The information about the clinical characteristics of COVID-19 patients outside of Wuhan is limited.Methods: All of the patients with confirmed COVID-19 were admitted to the First Hospital of Changsha City, the designated hospital for COVID-19 assigned by the Changsha City Government. The clinical and epidemiological characteristics, data of laboratory, radiological picture, treatment, and outcomes records of 201 COVID-19 patients were collected using electronic medical records.Results: This study population consisted of 201 hospitalized patients with laboratory-confirmed COVID-19 in Changsha by April 28, 2020. The median age TRANS of the patients was 45 years (IQR 34–59). About half (50.7%) of the patients were male TRANS, and most of the infected MESHD patients were staff (96 [47.8%]). Concerning the epidemiologic history, the number of patients linked to Wuhan was 92 (45.8%). The most common symptoms were fever HP fever MESHD (125 [62.2%]), dry cough MESHD cough HP (118 [58.7%]), fatigue HP fatigue MESHD (65 [32.3%]), and pharyngalgia (31 [15.4%]). One hundred and forty-four (71.6%) enrolled patients showed bilateral pneumonia MESHD pneumonia HP. Fifty-four (26.9%) patients showed unilateral involvement, and three (1.5%) patients showed no abnormal signs or symptoms. The laboratory findings differed significantly between the Intensive Care Unit (ICU) and non-ICU groups. Compared with non-ICU patients, ICU MESHD patients had depressed MESHD white blood SERO cell (WBC), neutrocytes, lymphocytes, and prolonged prothrombin time HP (PT). Moreover, higher plasma SERO levels of erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), procalcitonin (PCT), alanine aminotransferase (ALA), aspartate aminotransferase (AST), creatine kinase (CK), creatine kinase-MB (CK-MB), creatinine (CREA), and lactate dehydrogenase (LDH) were detected in the ICU group.Conclusions: In this single-center study of 201 COVID-19 patients in Changsha, China, 22.4% of patients were admitted to ICU. Based on our findings, we propose that the risk of cellular immune deficiency MESHD, hepatic injury MESHD, and kidney injury MESHD should be monitored. Previous reports focused on the clinical features of patients from Wuhan, China. With the global epidemic of COVID-19, we should pay more attention to the clinical and epidemiological characteristics of patients outside of Wuhan.

    Epidemiological and clinical features of 201 COVID-19 patients in Changsha, China

    Authors: Jian Zhou; Jing-jing Sun; Zi-qin Cao; Wan-chun Wang; Kang Huang; Fang Zheng; Yuan-lin Xie; Di-xuan Jiang; Zhi-guo Zhou

    doi:10.21203/rs.3.rs-17313/v1 Date: 2020-03-11 Source: ResearchSquare

    Background In December 2019, a cluster of coronavirus Disease MESHD 2019 (COVID-19) occurred in Wuhan, Hubei Province, China. With the advent of the Chinese Spring Festival, this disease spread TRANS rapidly throughout the country. The information about the clinical characteristics of COVID-19 patients outside of Wuhan is limited. Methods All of the patients with confirmed COVID-19 were admitted to the First Hospital of Changsha City, the designated hospital for COVID-19 assigned by the Changsha City Government. The clinical and epidemiological characteristics, data of laboratory, radiological picture, treatment, and outcomes records of 201 COVID-19 patients were collected using electronic medical records. Results This study population consisted of 201 hospitalized patients with laboratory-confirmed COVID-19 in Changsha by February 15, 2020. The median age TRANS of the patients was 45 years (IQR 34–59). About half (50.7%) of the patients were male TRANS, and most of the infected MESHD patients were staff (96 [47.8%]). Concerning the epidemiologic history, the number of patients linked to Wuhan was 92 (45.8%). The most common symptoms were fever HP fever MESHD (125 [62.2%]), dry cough MESHD cough HP (118 [58.7%]), fatigue HP fatigue MESHD (65 [32.3%]), and pharyngalgia (31 [15.4%]). One hundred and forty-four (71.6%) enrolled patients showed bilateral pneumonia MESHD pneumonia HP. Fifty-four (26.9%) patients showed unilateral involvement, and three (1.5%) patients showed no abnormal signs or symptoms. The laboratory findings differed significantly between the Intensive Care Unit (ICU) and non-ICU groups. Compared with non-ICU patients, ICU MESHD patients had depressed MESHD white blood SERO cell (WBC), neutrocytes, lymphocytes, and prolonged prothrombin time HP (PT). Moreover, higher plasma SERO levels of erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), procalcitonin (PCT), alanine aminotransferase (ALA), aspartate aminotransferase (AST), creatine kinase (CK), creatine kinase-MB (CK-MB), creatinine (CREA), and lactate dehydrogenase (LDH) were detected in the ICU group. Conclusions In this single-center study of 201 COVID-19 patients in Changsha, China, 22.4% of patients were admitted to ICU. Based on our findings, we propose that the risk of cellular immune deficiency MESHD, hepatic injury MESHD, and kidney injury MESHD should be monitored. Previous reports focused on the clinical features of patients from Wuhan, China. With the global epidemic of COVID-19, we should pay more attention to the clinical and epidemiological characteristics of patients outside of Wuhan.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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