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MeSH Disease

Human Phenotype

Transmission

Seroprevalence
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    Novel surrogate virus neutralization test reveals low serum SERO neutralizing anti-SARS-CoV-2-S antibodies SERO levels in mildly affected COVID-19 convalescents

    Authors: Berislav Bošnjak; Saskia Catherina Stein; Stefanie Willenzon; Anne Katrin Cordes; Wolfram Puppe; Günter Bernhardt; Inga Ravens; Christiane Ritter; Christian R Schultze-Florey; Nina Gödecke; Jörg Martens; Hannah Kleine-Weber; Markus Hoffmann; Anne Cossmann; Mustafa Yilmaz; Isabelle Pink; Marius M Hoeper; Georg MN Behrens; Stefan Pöhlmann; Rainer Blasczyk; Thomas F Schulz; Reinhold Förster

    doi:10.1101/2020.07.12.20151407 Date: 2020-07-14 Source: medRxiv

    Neutralizing antibodies SERO targeting the receptor-binding domain (RBD) of the SARS-CoV-2 spike (S) block severe acute respiratory syndrome coronavirus 2 MESHD (SARS-CoV-2) entry into cells using surface-expressed angiotensin-converting enzyme 2 (ACE2). We developed a surrogate neutralization test (sVNT) to assess at what degree serum SERO antibodies SERO interfere with the binding of SARS-CoV-2-S-RBD MESHD to ACE2. The sVNT revealed neutralizing anti-SARS-CoV-2-S antibodies SERO in the sera of 90% of mildly and 100% of severely affected coronavirus-disease-2019 (COVID-19) convalescent patients. Importantly, sVNT results correlated strongly to the results from pseudotyped- vesicular stomatitis MESHD stomatitis HP virus-vector-based neutralization assay and to levels of anti-SARS-CoV-2-S1 IgG and IgA antibodies SERO. Moreover, levels of neutralizing antibodies SERO also correlated to duration and severity of clinical symptoms, but not patient age TRANS or gender TRANS. These findings together with the sVNT will not only be important for evaluating the prevalence SERO of neutralizing antibodies SERO in a population but also for identifying promising plasma SERO donors for successful passive antibody SERO therapy.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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