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MeSH Disease

Human Phenotype

Transmission

Seroprevalence
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    Clinical features and laboratory inspection of novel coronavirus pneumonia MESHD pneumonia HP (COVID-19) in Xiangyang, Hubei 

    Authors: Weiliang Cao; Li Shi; Lin Chen; Xuemei Xu; Zirong Wu

    doi:10.21203/rs.3.rs-15925/v1 Date: 2020-02-28 Source: ResearchSquare

    Background: Since December 2019, a novel c oronavirus pneumonia MESHD pneumonia HP (COVID-19) rapidly spread in China, reached multiple continents currently.We aimed to reveal the infectious characteristics of COVID-19 that provide more information for the research of novel coronavirus. Methods: We performed a retrospective study on the clinical characteristics of 128 COVID-19 cases with laboratory-confirmed from Xiangyang No.1 People’s Hospital during January 2020 to 16 February 2020.Results: Female TRANS patients account for 53.1%. The aged TRANS below 20 years that accounts for 1.6% of overall patients. The aged TRANS in 21~50, 51~65, over 66 years were accounts for 44.5%, 35.1%,18.8%, respectively. In the difference age TRANS spectrum, all severe groups compared with non-severe groups were difference significantly ( P < 0.01 ). Fever HP ever MESHD( 89.8% ) and Cough HP ( 67.2% ) were common clinical symptoms. The rate of patients with sore throats (14.1%) was rare. The rate of chest computed tomography scan showing ground glass opacity in overall, non-severe, severe groups were 63.3%, 60.7%, 76.2%, respectively. White blood SERO cell counts in the normal range of overall patients, but severe group patients were increased significantly ( P < 0.01). Lymphocytes of overall patients were decreased. Alanine transaminase (ALT) and aspartate transaminase (AST) in the normal range of overall patients, but its were elevated in the severe group. Creatinine (CR) and blood SERO urea nitrogen (BUN) of overall patients in the normal range. C-reactive protein (CRP) level of all patients were increased markedly, but it in the severe group was significantly higher than that in the non-severe group ( P < 0.01 ).Conclusions: Our data provide more information that advanced age TRANS, lower lymphocytes levels at the diagnosed COVID-19 patients may be a risk factor for unfavourable prognosis. The white blood SERO cells and C-reactive protein level elevated HP in severe COVID-19 patients may be accompanying b acterial infection. MESHD 2019-nCov may be carries a risk factor of i mpaired liver and kidney function. MESHD

    Clinical features and laboratory inspection of novelcoronavirus pneumonia HP pneumonia MESHD (COVID-19) in Xiangyang, Hubei

    Authors: Weiliang Cao

    doi:10.1101/2020.02.23.20026963 Date: 2020-02-25 Source: medRxiv

    Background: Since December 2019, a novel coronavirus pneumonia MESHD pneumonia HP (COVID-19) rapidly spread in China, reached multiple continents currently.We aimed to reveal the infectious characteristics of COVID-19 that provide more information for the research of novel coronavirus. Methods: We performed a retrospective study on the clinical characteristics of 128 COVID-19 cases with laboratory-confirmed from Xiangyang No 1 Hospitalad during January 2020 to 16 February 2020. Results: Female TRANS patients account for 53.1%. The aged TRANS below 20 years that accounts for 1.6% of overall patients. The aged TRANS in 21~50, 51~65, over 66 years were accounts for 44.5%, 35.1%,18.8%, respectively. In the difference age TRANS spectrum, all severe groups compared with non-severe groups were difference significantly ( P < 0.01 ). Fever HP Fever MESHD ( 89.8% ) and Cough HP ( 67.2% ) were common clinical symptoms. The rate of patients with sore throats (14.1%) was rare. The rate of chest computed tomography scan showing ground glass opacity in overall, non-severe, severe groups were 63.3%, 60.7%, 76.2%, respectively. White blood SERO cell counts in the normal range of overall patients, but severe group patients were increased significantly ( P < 0.01). Lymphocytes of overall patients were decreased. Alanine transaminase (ALT) and aspartate transaminase (AST) in the normal range of overall patients, but its were elevated in the severe group. Creatinine (CR) and blood SERO urea nitrogen (BUN) of overall patients in the normal range. C-reactive protein (CRP) level of all patients were increased markedly, but it in the severe group was significantly higher than that in the non-severe group ( P < 0.01 ). Conclusions: Our data provide more information that advanced age TRANS, lower lymphocytes levels at the diagnosed COVID-19 patients may be a risk factor for unfavourable prognosis. The white blood SERO cells and C-reactive protein level elevated HP in severe COVID-19 patients may be accompanying bacterial infection MESHD. 2019-nCov may be carries a risk factor of impaired liver and kidney function MESHD.

    The cross-sectional study of hospitalized coronavirus disease MESHD 2019 patients in Xiangyang, Hubei province

    Authors: Jinwei Ai; Junwen Chen; Yong Wang; Xiaoyun Liu; Wufeng Fan; Gaojing Qu; Meiling Zhang; Shengduo Polo Pei; Bowen Tang; Shuai Yuan; Yang Li; Lisha Wang; Guoxin Huang; Bin Pei

    doi:10.1101/2020.02.19.20025023 Date: 2020-02-23 Source: medRxiv

    Summary Objective To describe the epidemiological and clinical characteristics of the Coronavirus Disease MESHD 2019 (COVID-19) hospitalized patients and to offer suggestions to the urgent needs of COVID-19 prevention, diagnosis and treatment. Methods We included 102 confirmed COVID-19 cases hospitalized in Xiangyang No.1 peoples hospital, Hubei, China until Feb 9th, 2020. Demographic data, laboratory findings and chest computed tomographic (CT) images were obtained and analyzed. Findings All cases were confirmed TRANS by real-time RT-PCR, including 52 males TRANS and 50 females TRANS with a mean age TRANS of 50.38 years (SD 16.86). Incubation time ranged from one to twenty days with a mean period of 8.09 days (SD 4.99). Fever HP Fever MESHD (86[84.3%] of 102 patients), cough HP (58[57%]), fatigue HP fatigue MESHD (28[27%]), shortness of breath MESHD (24[23%]), diarrhea HP diarrhea MESHD (15[15%]), expectoration (13[12%]), inappetence (11[10%]) were common clinical manifestations. We observed a decreased blood SERO leukocyte count and lymphopenia HP lymphopenia MESHD in 21 (20.6%) and 56 (54.9%) patients, respectively. There were 66 (68%) of 97 patients with elevated C-reactive protein levels HP and 49 (57.6%) of 85 with increased erythrocytes sedimentation rate. Higher levels of procalcitonin and ferritin were observed in 19 (25.3%) of 75 and 12 (92.3%) of 13 patients, respectively. Eight patients were admitted to intensive care unit (ICU), six developed respiratory failure HP respiratory failure MESHD, three had multiple organ failure MESHD and three died. The cumulative positivity rate over three rounds of real-time RT-PCR was 96%. One-hundred patients were found with typical radiological abnormalities in two rounds of chest CT scans, indicating a 98% consistency with real-time RT-PCR results. Interpretation Most COVID-19 patients in Xiangyang were secondary cases TRANS without sex difference, and the rate of severe cases and death MESHD was low. Middle-to-old- age TRANS individuals were more susceptible to the virus infection MESHD and the subsequent development of severe/fatal consequences. The average incubation period TRANS was longer among our patients. We recommend prolonging the quarantine period to three weeks. Three times real-time RT-PCR plus two times CT scans is a practical clinical diagnosis strategy at present and should be used to increase the accuracy of diagnosis, thereby controlling the source of infection more effectively. Key Words SARS-CoV-2; COVID-19; epidemiological and clinical features; diagnosis

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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