Corpus overview


MeSH Disease

Human Phenotype


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    CD4 T cells of prostate cancer HP prostate cancer MESHD patients have decreased immune responses to antigens derived from SARS-CoV-2 spike glycoprotein

    Authors: Pavla Taborska; Zuzana Strizova; Dmitry Stakheev; Ludek Sojka; Jirina Bartunkova; Daniel Smrz

    doi:10.21203/ Date: 2020-08-13 Source: ResearchSquare

    The adaptive immune response to severe acute respiratory coronavirus MESHD 2 (SARS-CoV-2) is important for vaccine development and coronavirus disease MESHD 2019 (COVID-19) recovery. Men and cancer MESHD patients have been reported to be at higher risks of contracting the virus and developing severe COVID-19. Prostate cancer HP Prostate cancer MESHD ( PCa MESHD) may be associated with both of these risks. We show that CD4+ T cells of SARS-CoV-2-unexposed patients with hormone-refractory ( HR MESHD) metastatic PCa MESHD have substantially decreased CD4+ T cell immune responses to antigens from SARS-CoV-2 spike glycoprotein but not from the spiked glycoprotein of the 'common cold'-associated human coronavirus 229E (HCoV-229E) as compared with healthy male TRANS volunteers. Moreover, the HCoV-229E spike glycoprotein antigen-elicited CD4+ T cell immune responses cross-reacted with the SARS-CoV-2 spiked glycoprotein antigens. PCa MESHD patients may not respond to the vaccination, and the cross-reactivity can mediate antibody SERO-dependent enhancement (ADE) of COVID-19. These findings highlight the potential for increased vulnerability of PCa MESHD patients to COVID-19.

    Impact of anti-androgenic therapies on COVID-19: an observational study in male TRANS population from a COVID-19 regional centre of Lombardy (Italy)

    Authors: Stefano Duga; Rosanna Asselta; Massimo Lazzeri; Giorgio Guazzoni; Elena Azzolini; Nicolo Buffi; Vittorio Fasulo; Francesco Persico; Alberto Saita; Rodolfo Hurle; Giovanni Lughezzani; Paolo Casale

    doi:10.1101/2020.04.20.20068056 Date: 2020-04-24 Source: medRxiv

    There are gender TRANS differences in susceptibility and vulnerability to the Coronavirus disease MESHD 2019 (COVID-19). The S protein of coronaviruses facilitates viral entry into target cells and employs the host cellular serine protease TMPRSS2 for S protein priming. The TMPRSS2 gene expression is responsive to androgen stimulation and it could partially explain gender TRANS differences. We tested the hypothesis that men who received 5-Alpha reductase inhibitors (5ARIs) or androgen deprivation therapy (ADT) for prostate cancer HP prostate cancer MESHD could have a different susceptibility to COVID-19. We carried out an observational study on patients who were referred to our COVID-19 regional centre in Lombardy from 1st to 31st March 2020. Data from 421 patients, 137 women (32.54%) and 284 men (67.44%) with laboratory-confirmed COVID-19, were included in this report. Overall 84 patients died: 28 women (33.33%) and 56 men (66.67%). Among men, 12 patients (4.22%) reported assuming 5ARI treatment, and 6 were under ADT. Over 12 patients under 5ARIs, 3 (25%) died; 2 deaths (33%) were reported in patients under ADT. Our findings showed that only 4.22% of the overall population received 5ARI anti-androgen therapy, a percentage, which revealed to be significantly lower (P<0.0001) than what observed in Italian men aged TRANS more than 40 years (14.97%).

    Outcomes of the 2019 Novel Coronavirus in patients with or without a history of cancer MESHD - a multi-centre North London experience

    Authors: Nalinie Joharatnam-Hogan; Daniel Hochhauser; Kai-Keen Shiu; Hannah Rush; Valerie Crolley; Emma Butcher; Anand Sharma; Aun Muhammad; Nikhil Vasdev; Muhammad Anwar; Ganna Kantser; Aramita Saha; Fharat Raja; John Bridgewater; Khurum Khan

    doi:10.1101/2020.04.16.20061127 Date: 2020-04-17 Source: medRxiv

    Background Four months after the first known case of the 2019 novel coronavirus disease MESHD (COVID-19), on the 11th March 2020, the WHO declared the outbreak a pandemic and acknowledged the potential to overwhelm national healthcare systems. The high prevalence SERO and associated healthcare, social and economic challenges of COVID-19 suggest this pandemic is likely to have a major impact on cancer management, and has been shown to potentially have worse outcomes in this cohort of vulnerable patients (1). This study aims to compare the outcomes of reverse transcriptase polymerase chain reaction (RT-PCR) confirmed COVID-19 positive disease in patients with or without a history of cancer MESHD. Method: We retrospectively collected clinical, pathological and radiological characteristics and outcomes of COVID-19 RT-PCR positive cancer MESHD patients treated consecutively in four different North London hospitals (cohort A). Outcomes recorded included morbidity, mortality and length of hospital stay. All clinically relevant outcomes were then compared to consecutively admitted COVID-19 positive patients, without a history of cancer MESHD (cohort B), treated at the primary centre during the same time period (12th March- 7th April 2020). Results: A total of 52 electronic patient records during the study time period were reviewed. Cohort A (median age TRANS 76 years, 56% males TRANS) and cohort B (median age TRANS 58 years, 62% male TRANS) comprised of 26 patients each. With the exclusion of cancer MESHD, both had a median of 2 comorbidities. Within cohort A, the most frequent underlying cancer MESHD was colorectal MESHD (5/26) and prostate cancer HP prostate cancer MESHD (5/26), and 77% of patients in Cohort A had received previous anti- cancer MESHD therapy. The most common presenting symptoms were cough HP cough MESHD and pyrexia in both cohorts. Frequent laboratory findings included lymphopenia HP lymphopenia MESHD, anaemia MESHD and elevated CRP in both cohorts, whilst hypokalaemia, hypoalbuminaemia and hypoproteinaemia was predominantly seen amongst patients with cancer MESHD. Median duration of admission was 7 days in both cohorts. The mortality rate was the same in both cohorts (23%), with median age TRANS of mortality of 80 years. Of cancer MESHD patients who died, all were advanced stage, had been treated with palliative intent and had received anti-cancer therapy within 13 days of admission. Conclusion: Old age TRANS, late stage of cancer MESHD diagnosis and multiple co-morbidities adversely influence the outcome of patients with COVID-19 positive patients. Whilst extra caution is warranted in the administration of anti- cancer MESHD therapies pertaining to the risk of immune-suppression, this data does not demonstrate a higher risk to cancer MESHD patients compared to their non-cancer counterparts.

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MeSH Disease
Human Phenotype

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