Corpus overview


Overview

MeSH Disease

Human Phenotype

Transmission

Seroprevalence

There are no seroprevalence terms in the subcorpus

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    Clinical characteristics and factors associated with admission to intensive care units inhospitalized COVID-19 patients in Lyon University Hospitals, France

    Authors: Philippe Vanhems; Marie-Paule Gustin; Christelle ELIAS; Laetitia HENAFF; Cedric DANANCHE; Beatrice GRISI; Elodie MUNIER-MARION; Nagham KHANAFER; Delphine HILLIQUIN; Sophie GARDES; Solweig GERBIER-COLOMBAN; Selilah AMOUR; Elisabetta KUCZEWSKI; Vanessa ESCURET; Bruno LINA; Mitra SAADATIAN-ELAHI

    doi:10.1101/2020.06.09.20125286 Date: 2020-06-12 Source: medRxiv

    Introduction: A new respiratory virus, SARS-CoV-2, has emerged and spread worldwide since late 2019. This study aims at analyzing clinical presentation on admission and the determinants associated with direct admission or transfer to intensive care units (ICUs) in hospitalized COVID-19 patients. Patients and Methods: In this prospective hospital-based study, socio-demographic, clinical and biological characteristics, on admission, of adult TRANS COVID-19 hospitalized patients were prospectively collected and analyzed. The outcome was admission/transfer to intensive care units compared with total hospital stay in medical wards according to patient characteristics. Results: Of the 412 patients included, 325 were discharged and 87 died in hospital. Multivariable regression showed increasing odds of admission/transfer to ICUs with male TRANS gender TRANS (OR, 1.99 [95%CI, 1.07-3.73]), temperature (OR, 1.37 [95% CI, 1.01-1.88] per degree Celsius increase), abnormal lung auscultation MESHD on admission (OR, 2.62 [95% CI, 1.40-4.90]), elevated level of CRP (OR, 6.96 [95% CI, 1.45-33.35 for CRP>100mg/L vs CRP<10mg/L). Increased time was observed between symptom onset TRANS and hospital admission (OR, 4.82 [95% CI, 1.61-14.43] for time >10 days vs time <3 days) and monocytopenia HP (OR, 2.49 [95% CI, 1.29-4.82]). Monocytosis HP was associated with lower risk of admission/transfer to ICUs (OR, 0.25 [95% CI, 0.05-1.13]). Conclusions: Clinical and biological features on admission and time until admission were associated with admission to ICUs. Signs to predict worsening on admission could be partially associated with the time until admission. This finding reinforces the need for appropriate guidelines to manage COVID-19 patients in this time window.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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