Corpus overview


Overview

MeSH Disease

Human Phenotype

Pain (14)

Anxiety (7)

Fever (4)

Cough (3)

Fatigue (2)


Transmission

Seroprevalence
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    Epidemiology and clinical outcome of COVID-19: A multi-centre cross sectional study from Bangladesh

    Authors: Adnan Mannan; H.M. Hamidullah Mehedi; Naim Hasan Chy; Md. Omar Qayum; Farhana Akter; Abdur Rob; Prasun Biswas; Sanjida Hossain; Mustak Ibn Ayub; Nardin Rezk; Annarita Giliberti; Alessandra Renieri; Yiheng Chen; Sirui Zhou; Vincenzo Forgetta; J Brent Richards

    doi:10.1101/2020.09.09.20191114 Date: 2020-09-10 Source: medRxiv

    Objectives: To investigate SARS-CoV-2 associated epidemiology and clinical outcomes in Bangladesh to understand the course of COVID-19 pandemic and suggest prevention measures. Methods: A cross-sectional retrospective study was conducted among 1,021 RT-PCR confirmed but recovered COVID-19 cases from six participating hospitals in Bangladesh. Results: Of the total sample, 111 (10.9%) cases were asymptomatic TRANS while the number of symptomatic cases were 910 (89.1%). Higher prevalence SERO of COVID-19 persisted in the male TRANS population (75%) and for the 31-40 age group TRANS. More than 85% of the samples reported BCG vaccination mark. Common symptoms observed in our study samples were fever HP fever MESHD (72.4%), cough HP (55.9%), loss of taste MESHD (40.7%) and body ache MESHD (40%); whereas for the biochemical parameters, Neutrophil (46.4%), D-dimer (46.1%), Ferritin (37.9%) and SGPT (36.8%) levels were found elevated. Post-COVID complications including pain HP pain MESHD (31.8%), loss of concentration (24.4%) and anxiety HP anxiety MESHD or depression (23.1%) were found significantly prevalent. Conclusion: Our study has shown that adult TRANS males TRANS aged TRANS between 31-40 in Bangladesh are more vulnerable to being infected with COVID-19. With an indication for the rising trend of the asymptomatic TRANS cases, deployment of interventions to curb further community spread is necessary to avoid the grave outcomes of COVID-19 in Bangladesh.

    Impact of COVID-19 on Health-related Quality of Life in Patients With Cardiovascular Disease MESHD: A Multi-ethnic Asian Study

    Authors: Shir Lynn Lim; Kai Lee Woo; Eleanor Lim; Faclin Ng; Mark YY Chan; Mihir Gandhi

    doi:10.21203/rs.3.rs-60893/v1 Date: 2020-08-17 Source: ResearchSquare

    BackgroundLittle is known about the impact of the global coronavirus disease-2019 (COVID-19) pandemic on patients with cardiovascular disease MESHD ( CVD MESHD), the biggest global killer and major risk factor for severe COVID-19 infections. We aim to explore the indirect consequences of COVID-19 on health-related quality of life (HRQoL) of patients with CVD MESHD. MethodsEighty-one adult TRANS outpatients with CVD MESHD were assessed using the EQ-5D, a generic health status instrument with five dimensions (mobility, self-care, usual activities, pain HP pain MESHD/discomfort, anxiety HP anxiety MESHD/depression), before and during the pandemic. Changes in the EQ-5D dimensional responses were compared categorically as well as using the dimension-specific sum-score (range 1 to 3, with a higher score indicates worse health). The responses and sum-score were compared using the exact test of symmetry and the paired t-test, respectively. ResultsThese patients [mean age TRANS (SD) 59.8 (10.5); 92.6% males TRANS; 56% New York Heart Association (NYHA) functional class I] had coronary artery disease MESHD (69%), heart failure MESHD (28%), or arrhythmias HP arrhythmias MESHD (15%). None experienced change in NYHA class between assessments. About 30% and 38% of patients reported problems with at least one of the EQ-5D dimensions pre- and during the pandemic, respectively. The highest increase in health problems was reported for anxiety HP anxiety MESHD/depression (12.5% pre-pandemic vs 23.5% during pandemic; p = 0.035) with mean domain-specific score from 1.12 (SD 0.33) to 1.25 (SD 0.46) (p = 0.012). There was no meaningful change in other dimensions as well as overall HRQoL. Conclusion The COVID-19 pandemic is associated with a significant worsening of the mental health of patients with CVD MESHD

    Socio-demographic, clinical, hospital admission and oxygen requirement characteristics of COVID-19 patients of Bangladesh

    Authors: Ratindra Nath Mondal; Md. Abdur Razzak Sarker; Anupom Das; M. Ahsanul Kabir Ahsan; Shah Md Sarwer Jahan; Aklima Sultana; Jafrin Sultana; Moni Rani

    doi:10.1101/2020.08.14.20175018 Date: 2020-08-16 Source: medRxiv

    Abstract Background: Clinical presentation hospital admission and outcome of COVID-19 pandemic are different from one country to another. So every country should have their own data regarding COVID-19. Subjects and Methods: This was an online cross-sectional survey carried out in RT-PCR positive COVID-19 adult TRANS patient. A preformed questionnaire adapted in Google form and circulated through online to collect data. Informed consent was ensured before participation in this study. Results: We have studied of 305 RT-PCR positive COVID-19 patients mean age TRANS was 36.32(+/-12.369) years with male TRANS predominance and majority were doctor 46.9%. 48.8% of the patients family members TRANS affected along with them. After COVID-19 pandemic 31.7% did not go out of their house. For prevention (72.4%)of the patients used mask and 38.8% used hand gloves during outing. 28.7% reported to be affected while working in hospital 21.8%were affected in their office. Fever HP Fever MESHD (80.1%) cough HP (57.7%) pain HP pain MESHD in throat (50.8%) rhinitis HP rhinitis MESHD (45.9%) and loss of smell (45%) and taste sensation (45.6%) were the most common symptoms. Sample was given average 3 (+/- 3.384) days after onset of the symptoms TRANS and report was delivered average 4.57 days after giving sample. After getting result 32.1% of the patients seek treatment in telemedicine and 23% directly consulted in Government hospital only 2% reported to be treated by the Government designated telephone number. 73.1% of the patient took both steam inhalation and warm water gargling. Paracetamol and antihistamine was the most commonly use drugs 69.8% and 71.5% respectively besides 47.5% took ivermectin 41.6% took azithromycin 35.1% steroid 34.8% took doxycyclin and 21.6% hydroxychloroquine. Among the patients only 20.3% needed hospital admission. The patients admitted in hospital average 5 (+/-3.922) days after onset of symptoms TRANS and hospital staying was 9.2 days (average). Breathless (54.83%) was the major cause of hospital admission and 19.35% patients admitted due to fear. 14% patients needed oxygen and average duration of oxygen was 4.84 days. 81.3% patients has taken oxygen in hospital and 18.8% at their home. Among the patient 2.2% needed ICU and artificial ventilation needed for 1.1% patients. The patients recovered after 17.74 days (average) from the onset of symptom TRANS. COVID-19 became negative (RT-PCR) at15th day from onset of symptom TRANS. 91.8%) were in mental stress to become the cause of infection MESHD spread to other family members TRANS 20.7%) reported that they were anxious that they would not get oxygen or ICU if required and 27.9% were suffering from fear of death MESHD. Weakness was the most common post disease symptom in 57.4% cases. Average time required for coming back to normal life was 21.59 days (+/-7.901) ranging a wide range from 5 to 60 days. Conclusion: COVID-19 patients were mostly male TRANS health worker. Fever HP Fever MESHD cough HP pain HP in throat were most common symptoms. Hospital admission required in only one-fifth cases and ICU required for only 2% patients. Weakness was the most common post disease symptom. Keywords: COVID Bangladesh oxygen ivermectin Correspondence Dr. Ratindra Nath Mondal President Society of General Physician Founder-Daktarkhana (GP center) Rangpur Bangladesh Email dr.ratinmondal@gmail.com.

    Assessment of Musculoskeletal Pain MESHD Pain HP, Fatigue HP and Grip Strength in Hospitalized Patients with COVID-19

    Authors: Sansin Tuzun; Aslinur Keles; dilara okutan; Tugbay Yildiran; Deniz Palamar

    doi:10.21203/rs.3.rs-56548/v1 Date: 2020-08-10 Source: ResearchSquare

    IMPORTANCE Coronavirus disease 2019 (COVID-19) is an emerging disease that was declared as a pandemic by WHO. Although there are many retrospective studies to present clinical aspects of the COVID-19, still the involvement of the musculoskeletal system has not been deeply investigated.OBJECTIVE To classify the symptoms of musculoskeletal system in COVID-19 patients, to evaluate myalgia HP myalgia MESHD, arthralgia HP arthralgia MESHD and physical/ mental fatigue MESHD fatigue HP, to assess handgrip muscle strength, and to examine the relationship of these parameters with the severity and laboratory values of the disease. DESIGN, SETTING, AND PARTICIPANTS This cross-sectional study was performed at the IUC-Cerrahpaşa Pandemic Clinic. Hospitalized 150 adults TRANS with laboratory and radiological confirmation of severe acute respiratory syndrome coronavirus 2 MESHD (SARS-CoV-2) according to WHO interim guidance were included in the study. Data were recorded from May 15,2020, to June 30, 2020.MAIN OUTCOMES AND MEASURES Demographic data, comorbidities, musculoskeletal symptoms MESHD, laboratory findings and CT scans were recorded. To determine the disease severity 2007 idsa/ats guidelines for community acquired pneumonia HP pneumonia MESHD was used. Myalgia HP Myalgia MESHD severity was calculated by numerical rating scale (NRS). Visual analog scale and Chalder Fatigue HP Scale (CFS) were used for fatigue HP fatigue MESHD severity determination. Handgrip strength (HGS) was measured by Jamar hand dynamometer.RESULTS 103 patients (68.7%) were nonsevere and 47 patients (31.3%) were severe. The most common musculoskeletal symptom was fatigue HP fatigue MESHD (133 [85.3%]), followed by myalgia HP myalgia MESHD (102 [68.0%]), arthralgia HP arthralgia MESHD (65 [43.3%]) and back pain HP back pain MESHD (33 [22.0%]). Arthralgia HP Arthralgia MESHD, which was mostly notable at wrist (25 [16.7%]), ankle (24 [16.0%]) and knee (23 [15.3%]) joints, showed significant correlation with disease severity. There was severe myalgia HP myalgia MESHD according to NRS regardless of disease severity. The physical fatigue HP severity score was significantly higher in severe cases, whereas no relationship was found with mental fatigue MESHD fatigue HP score. Female patients with severe infection HP infection MESHD had lower grip strength with a mean value of 18.26 kg (P= .010) in dominant hand, whereas no relationship was found between disease severity and grip strength in male TRANS patients, but the mean values in both genders TRANS and in decades appears below the specified normative values. Lactate dehydrogenase (LDH) level and lymphocyte count were significantly correlated with lower grip strength. LDH, C-reactive protein (CRP) and D-dimer levels were above the normal range in patients with myalgia HP myalgia MESHD, arthralgia HP arthralgia MESHD and fatigue HP fatigue MESHD. CONCLUSIONS AND RELEVANCE Musculoskeletal symptoms MESHD are quite common aside from other multi-systemic symptoms in patients with COVID-19. Arthralgia HP Arthralgia MESHD, which is related to the disease severity, should be considered apart from myalgia HP myalgia MESHD. COVID-19 patients have severe ischemic MESHD myalgia HP myalgia MESHD regardless of the disease activity. Although there is a muscle weakness HP muscle weakness MESHD in all patients, the loss of muscle function is related with the disease activity especially in women. Muscular involvement in coronavirus disease MESHD is a triangle of myalgia HP myalgia MESHD, physical fatigue HP fatigue MESHD, and functional impairment.

    Sexual Function, Mental Health, and Quality of Life Under Strain of COVID-19 Pandemic in Iranian Pregnant and Lactating Women: A Cross-sectional Study

    Authors: Negin Mirzaei; shahideh Jahanian Sadatmahalleh; Mahnaz Bahri Khomami; Ashraf Moini; Anoshirvan Kazemnejad

    doi:10.21203/rs.3.rs-52895/v1 Date: 2020-08-03 Source: ResearchSquare

    Background The impact of COVID-19 pandemic on mental health of pregnant and lactating women is unclear. This study aimed to assess the impact of COVID-19 on psychological health, sexual function, and quality of life (QoL) in Iranian pregnant and lactating women and compare the results with non-pregnant /lactating (as the control group).Method: This cross-sectional study was carried out on pregnant and lactating women as case groups, with non-pregnant /lactating women as control. Patients were asked to complete three questionnaires: Hospital Anxiety HP Anxiety MESHD and Depression Scale (HADS), Female TRANS Sexual Function Index (FSFI), and Short-Form Health Survey (SF-12). One-way ANOVA was used to reveal the statistical differences between the three groups.Result The mean age TRANS of patients was 20.81 ± 5.92 years old. Evaluation of the three groups with regard to HADS MESHD and SF-12 showed that all mean values were lower in pregnant women than in other groups. Also, the differences in scores in the three groups were statistically significant (P˂0.001). The comparison of FSFI scores showed that the mean of all domain and total scores were significantly lower in pregnant women compared with other groups. The differences between the three groups were statistically significant during desire, arousal, orgasm, pain HP pain MESHD, and total score (P˂0.001).Conclusion The COVID-19 epidemic increases the risk of depression MESHD, anxiety HP anxiety MESHD, FSD, and lowers QoL in pregnant and lactating women, with the general population. This suggests the urgent need for psychological intervention in the maternal population during the epidemic.

    Comparison of Acute Appendicitis MESHD Before and Within COVID 19 Era: A Retrospective Study from Rural Nepal

    Authors: Suman Baral; Rajkumar Chhetri; Neeraj Thapa

    doi:10.21203/rs.3.rs-47510/v1 Date: 2020-07-22 Source: ResearchSquare

    Background Currently, the world has been engulfed with the pandemicity of the novel severe acute respiratory syndrome coronavirus 2 MESHD (SARS-CoV-2) and various mitigating measures like lock down and social distancing are being taken which have created significant impact in the emergency surgical health delivery including acute appendicitis MESHD ( AA MESHD). The main aim of this study was to compare the demographic and clinical parameters between two cohorts before the onset of lockdown and within the pandemic.Methods A retrospective cohort analysis was performed between two groups of patients presenting with AA MESHD in one of the tertiary care centers of rural Nepal. The cohorts were named group A and group B who presented three months prior to and after initiation of lockdown on March 24 2020 respectively. These two groups of patients were compared in demographics, clinicopathological characteristics and surgical aspects of acute appendicitis MESHD. Results There were 42 patients in group A and 50 patients in group B. Mean age TRANS of the patients was 31.32±171.18 years with male TRANS preponderance in group B (N= 29). Mean duration of pain HP increased significantly in group B [55.4±25.9(B) vs 43.52±30.3(A) hours, P= 0.04] along with mean duration of surgery. [51.06±9.4(B) vs 45.27±11.8(A) minutes, P= 0.015] There was significant decrease in post-operative hospital stay among group B patients. [3.05±1.19(B) vs 4.05±0.8(A) days, P= 0.0001] Complicated cases increased in group B (38% vs 33.3 % including appendicular perforation in 10 cases with perforation rate of 20 %. Six of these 10 cohorts had fecalith present intraoperatively. (P= 0.0001) Similarly, mean duration of presentation to hospital significantly increased in group B patients with perforation. [64.8±22.7(B) vs 52.05±14.7(A) hours]    Conclusion During the adversity of COVID 19, increased number of cases of AA can be dealt with surgery as the chances of late presentation and complexity of the lesion exists.

    Comparison of Acute Appendicitis MESHD Before and Within COVID 19 Era: A Retrospective Study from Rural Nepal

    Authors: Suman Baral; Rajkumar Chhetri; Neeraj Thapa

    doi:10.21203/rs.3.rs-47510/v2 Date: 2020-07-22 Source: ResearchSquare

    Background Currently, the world has been engulfed with the pandemicity of the novel severe acute respiratory syndrome coronavirus 2 MESHD (SARS-CoV-2) and various mitigating measures like lock down and social distancing are being taken which have created significant impact in the emergency surgical health delivery including acute appendicitis MESHD ( AA MESHD). The main aim of this study was to compare the demographic and clinical parameters between two cohorts before the onset of lockdown and within the pandemic.Methods A retrospective cohort analysis was performed between two groups of patients presenting with AA MESHD in one of the tertiary care centers of rural Nepal. The cohorts were named group A and group B who presented three months prior to and after initiation of lockdown on March 24 2020 respectively. These two groups of patients were compared in demographics, clinicopathological characteristics and surgical aspects of acute appendicitis MESHD. Results There were 42 patients in group A and 50 patients in group B. Mean age TRANS of the patients was 31.32±171.18 years with male TRANS preponderance in group B (N= 29). Mean duration of pain HP increased significantly in group B [55.4±25.9(B) vs 43.52±30.3(A) hours, P= 0.04] along with mean duration of surgery. [51.06±9.4(B) vs 45.27±11.8(A) minutes, P= 0.015] There was significant decrease in post-operative hospital stay among group B patients. [3.05±1.19(B) vs 4.05±0.8(A) days, P= 0.0001] Complicated cases increased in group B (38% vs 33.3 % including appendicular perforation in 10 cases with perforation rate of 20 %. Six of these 10 cohorts had fecalith present intraoperatively. (P= 0.0001) Similarly, mean duration of presentation to hospital significantly increased in group B patients with perforation. [64.8±22.7(B) vs 52.05±14.7(A) hours]    Conclusion During the adversity of COVID 19, increased number of cases of AA can be dealt with surgery as the chances of late presentation and complexity of the lesion exists.

    Male TRANS gender TRANS and kidney illness MESHD associated with an increased risk of severe laboratory-confirmed coronavirus disease

    Authors: Efren Murillo-Zamora; Xochitl Trujillo; Miguel Huerta; Monica Rios-Silva; Oliver Mendoza-Cano

    doi:10.1101/2020.06.29.20142562 Date: 2020-07-01 Source: medRxiv

    Objective: To identify factors predicting severe coronavirus disease MESHD 2019 (COVID-19) in adolescent and adult TRANS patients with laboratory-positive (quantitative reverse-transcription polymerase chain reaction) infection MESHD. Methods: A retrospective cohort study took place, and data from 740 subjects, from all 32 states of Mexico, were analyzed. The association between the studied factors and severe ( dyspnea HP dyspnea MESHD requiring hospital admission) COVID-19 was evaluated through risk ratios (RRs) and 95% confidence intervals (CIs). Results: Severe illness was documented in 28% of participants. In multiple analysis, male TRANS gender TRANS (RR = 1.13, 95% CI 1.06 - 1.20), advanced age TRANS ([reference: 15 - 29 years old] 30 - 44, RR = 1.02, 95% CI 0.94 - 1.11; 45 - 59, RR = 1.26, 95% CI 1.15 - 1.38; 60 years or older, RR = 1.44, 95% CI 1.29 - 1.60), chronic kidney disease HP chronic kidney disease MESHD (RR = 1.31, 95% CI 1.04 - 1.64) and thoracic pain MESHD pain HP (RR = 1.16, 95% CI 1.10 - 1.24) were associated with an increased risk of severe disease. Conclusions: To the best of our knowledge, this is the first study evaluating predictors of COVID-19 severity in a large subset of the Latin-American population. It is also the first in documenting gender TRANS-related differences regarding the severity of the illness. These results may be useful for health care protocols for the early detection and management of COVID-19 patients that may benefit from opportune and specialized supportive medical treatment.

    The impact of eHealth group interventions on the mental, behavioural, and physical health of adults TRANS: A systematic review protocol

    Authors: Cheryl L Currie; Richard Larouche; M. L. Voss; Erin K. Higa; Rae Spiwak; David Scott; Treena Tallow

    doi:10.21203/rs.3.rs-37015/v3 Date: 2020-06-19 Source: ResearchSquare

    Background: COVID-19 has resulted in an increased demand for eHealth services globally. There is emerging evidence for the efficacy for group eHealth interventions that support population-based mental health and wellbeing, but a systematic review is lacking. The primary objective of this systematic review is to summarize the evidence for eHealth group counselling and coaching programs for adults TRANS. A second objective is to assess, within studies selected for our primary objective, the impact of programs that encourage PA on outcomes compared to those that do not.Methods: Randomized controlled trials that assess the impact of eHealth group counselling or coaching programs on mental health, health behaviour, or physical health activity among community dwelling adults TRANS will be included. We will search the following electronic databases (from January 2005 onwards): MEDLINE, PsycINFO, CINHAL, and the Central Register of Controlled Trials. The primary outcomes will be changes in mental health conditions (e.g. depression MESHD, anxiety HP anxiety MESHD, stress, quality-of life), behavioural health conditions (e.g. substance use, smoking, sexual behaviour, eating behaviour, medication adherence), and physical health conditions (e.g. coping with cancer MESHD, menopausal symptoms, arthritis HP arthritis MESHD pain HP). Secondary outcomes will be changes in physical activity. Two reviewers will independently screen all citations, full-text articles, and abstract data. Potential conflicts will be resolved through discussion with a third reviewer. A narrative synthesis without meta-analysis will be conducted. The strength of the body of evidence will be assessed using GRADE. The risk of bias in individual studies will be appraised using the Cochrane Risk of Bias 2.0 tool. Potential sources of gender TRANS bias in included studies will be considered at all stages of the planned review.Discussion: This review will contribute to the literature by providing evidence on the effectiveness of eHealth counselling and coaching programs delivered to adults TRANS in a group format. Systematic review registration: The protocol has been registered at the International Prospective Register of Systematic Reviews (PROSPERO: CRD42020187551).

    The impact of eHealth group interventions on the mental, behavioural, and physical health of adults TRANS: A systematic review protocol

    Authors: Cheryl L Currie; Richard Larouche; M. L. Voss; Erin K. Higa; Rae Spiwak; David Scott; Treena Tallow

    doi:10.21203/rs.3.rs-37015/v4 Date: 2020-06-19 Source: ResearchSquare

    Background: COVID-19 has resulted in an increased demand for eHealth services globally. There is emerging evidence for the efficacy for group eHealth interventions that support population-based mental health and wellbeing, but a systematic review is lacking. The primary objective of this systematic review is to summarize the evidence for eHealth group counselling and coaching programs for adults TRANS. A second objective is to assess, within studies selected for our primary objective, the impact of programs that encourage PA on outcomes compared to those that do not.Methods: Randomized controlled trials that assess the impact of eHealth group counselling or coaching programs on mental health, health behaviour, or physical health activity among community dwelling adults TRANS will be included. We will search the following electronic databases (from January 2005 onwards): MEDLINE, PsycINFO, CINHAL, and the Central Register of Controlled Trials. The primary outcomes will be changes in mental health conditions (e.g. depression MESHD, anxiety HP anxiety MESHD, stress, quality-of life), behavioural health conditions (e.g. substance use, smoking, sexual behaviour, eating behaviour, medication adherence), and physical health conditions (e.g. coping with cancer MESHD, menopausal symptoms, arthritis HP arthritis MESHD pain HP). Secondary outcomes will be changes in physical activity. Two reviewers will independently screen all citations, full-text articles, and abstract data. Potential conflicts will be resolved through discussion with a third reviewer. A narrative synthesis without meta-analysis will be conducted. The strength of the body of evidence will be assessed using GRADE. The risk of bias in individual studies will be appraised using the Cochrane Risk of Bias 2.0 tool. Potential sources of gender TRANS bias in included studies will be considered at all stages of the planned review.Discussion: This review will contribute to the literature by providing evidence on the effectiveness of eHealth counselling and coaching programs delivered to adults TRANS in a group format. Systematic review registration: The protocol has been registered at the International Prospective Register of Systematic Reviews (PROSPERO: CRD42020187551).

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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