Corpus overview


MeSH Disease

Fever (158)

Cough (91)

Coronavirus Infections (78)

Dyspnea (71)

Fatigue (56)

Human Phenotype

Cough (195)

Fever (174)

Fatigue (61)

Pneumonia (59)

Hypertension (48)


    displaying 151 - 160 records in total 195
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    Quantifying the clinical characteristics of coronavirus disease MESHD 2019 (COVID-19) of different age TRANS segments based on 60 patients

    Authors: Gao Weiwei; Zhang Xia; Hu Zhiliang; Chi Yun; Zheng Yi shan; Hu Chun mei; Yi Yong Xiang; Zeng Yi

    doi:10.21203/ Date: 2020-03-29 Source: ResearchSquare

    Background: Novel coronavirus disease MESHD 2019 (COVID-19) has spread around the world; therefore, more attention should be paid to the clinical features of COVID-19, with the aim of improving the diagnosis and treatment of patients. Methods: By 15 February 2020, 60 patients diagnosed with COVID-19 had been admitted to Nanjing Second Hospital. We analyzed the clinical features of different age TRANS segments infected with COVID-19 prospectively, including epidemiological, clinical, laboratory, and radiological characteristics; treatment, clinical outcomes, and prognosis of this cohort of patients. Results: The cohort comprised 29 male TRANS and 31 female TRANS patients (median age TRANS = 46.18 years old (range: 18–97). Fifty-five (91.7%) patients had a clear epidemiological contact history. The average incubation period TRANS was 7.92 days. The most common clinical manifestations were fever HP (85%) and cough HP (75%). Peripheral white blood SERO cell counts were mostly normal at admission, 7 days, and 14 days, with no differences among patients of different ages TRANS. The lymphocyte counts of all patients were in the normal range on admission, and after 7 days and 14 days of treatment; however, the lymphocyte count in > 65-year-old patients was less than that in the < 40 and 40–65-year-old groups after 7 and 14 days of treatment (P < 0.05, respectively). At admission, the CD4 T lymphocyte count was within the normal range; however, the CD4 T lymphocyte count in >65-year-old group was less than that in the < 40 and 40–65-years-old groups after 14 days of treatment. The CD4 T lymphocyte counts were 723.46 ± 243.82/ml (< 40), 640.00 ± 242.30/ml (40–65), and 399.88 ± 256.16/ml (> 65) (P =0.0075). The > 65-years-old group had higher levels of lactate dehydrogenase (269.83 ± 73.36 vs. 208.52 ± 35.67 and 243.83 ± 76.66) after 14 days (P = 0.0496). Imaging revealed more lesions in the 40–65 and > 65-year-old groups (P < 0.0001). The days after the nucleic acid detection turned negative in the three age groups TRANS were: 9.19 ± 3.93 (< 40), 10.04 ± 4.10 (40–65), and 13.57 ± 2.76 (> 65) (P = 0.0373). After antiviral treatment, together with anti-infection regimen if the patient with lung infection and continuous oxygen inhalation if the patient is hypoxic, all patients achieved total recovery and were discharged with follow-up. Conclusion: Patients with COVID-19 pneumonia HP generally had an epidemiological history. Older patients showed more extensive lesions upon admission, more severe illness, slower recovery of immune function, the longer viral nucleic acid persistence. 

    Clinical characteristics of 194 cases of COVID-19 in Huanggang and Taian, China

    Authors: Hong Zhang; Wenli Shang; Qinghua Liu; Xuejing Zhang; Maochuan Zheng; Maokui Yue

    doi:10.21203/ Date: 2020-03-28 Source: ResearchSquare

    Purpose We aimed to report the clinical characteristics of 194 cases coronavirus disease-19 (COVID-19) in Huanggang, Hubei and Taian, Shandong. Methods We retrospectively investigated the clinical, laboratory characteristics and CT imaging of confirmed cases TRANS of COVID-19 from Jan 22 to Feb 28, 2020 in Huanggang Central Hospital and The Second Affiliated Hospital of Shandong First Medical University. Real time PCR was used to detect the new coronavirus in respiratory samples. Immunohistochemical staining was used to detect the expressions of ACE2 in tissues. Results Among the 194 patients infected with COVID-19, 108 patients were male TRANS, with a median age TRANS of 48.3 years. The average preclinical period was 7.44 day. Except for 37 severe or critically ill MESHD patients, the rest of the 157 patients exhibited mild or moderate symptoms. 190 (97.94%) patients were confirmed during the three times nucleic acid test. The main clinical symptom of the patients were fever HP fever MESHD, sore throat and cough HP, which accounted for 146 cases (75.26%), 98 (50.52%) and 86 cases (44.33%%), respectively. 30 patients (15.46%) showed liver dysfunction MESHD. Imaging examination showed that 141 patients (72.68%) showed abnormal, 53 cases (27.32%) had no obvious abnormal density shadow in the parenchyma of both lungs. Up to now, 109 cases were discharged from the hospital, and 9 patients died. The ACE2 expression levels were up-regulated in patients of severe type and critically ill type. Conclusion Clinical symptoms, laboratory tests and CT imaging should be combined for comprehensive analysis to diagnose COVID-19. ACE2 may be the receptor of COVID-19.

    Radiological manifestations from 101 patients with 2019 Novel Coronavirus Disease MESHD (COVID-19) in Hamadan, West of Iran: Typical and atypical findings

    Authors: Farideh Gharekhanloo; Seyyed Hamid Hashemi; Fariba Keramat; Farzaneh Esna-Ashari; Mojgan Mamani; Mohammad Mahdi Majzoubi; Peyman Eini; Mahsa Gharekhanloo; Salman Khazaei

    doi:10.21203/ Date: 2020-03-27 Source: ResearchSquare

    Background Coronavirus disease MESHD 2019 (COVID-19) has spread widely throughout the world and become a pandemic disease. In this study we decided to investigate the chest computed tomography (CT) findings in COVID-19 patients in Hamadan, west of Iran.Methods This cross-sectional study was conducted on 101 patients with confirmed COVID-19 infection from February to March 2020. Demographic, clinical, laboratory and chest CT information of identified COVID-19 patients were assessed.Results Totally, 101 patients diagnosed with COVID-19 were included. The mean age TRANS of the patients was 55.21 ± 14.08 years and 54% (53.47%) of them were male TRANS. With regards to clinical manifestations, 82.18%, 72.28% and 54.46% of COVID-19 patients had dry cough MESHD cough HP, dyspnea HP dyspnea MESHD and fever HP, respectively and 44.5% had lymphopenia HP lymphopenia MESHD. The right lower lobe was the most common (69%) and severe involved lobe followed by left lower lobe, right middle lobe, and lingual; however, anterior segment of upper lobes showed least involvement with abnormality in the late course of disease. The most common pattern is ground glass opacity, but atypical patterns such as round pneumonia HP pneumonia MESHD, moderate to severe plural effusion MESHD and segmental lobar collapse consolidation was seen without evidence of mediastinal adenopathy MESHD, cavitation or nodule. Chest X ray (CXR) was not sensitive method as a first line imaging because 34.65% of them were normal.Conclusion CXR is not sensitive method as first line imaging too (34.65% normal first CXR), but Chest CT is very sensitive and nonspecific modality for diagnosis of COVID – 19. Lower lobe and posterior basal predominance involvements were seen in most cases. About 12% showed atypical chest CT features.

    Gastrointestinal tract symptoms in coronavirus disease MESHD 2019: Analysis of clinical symptoms in adult TRANS patients

    Authors: Yong Zhang

    doi:10.1101/2020.03.23.20040279 Date: 2020-03-27 Source: medRxiv

    Objective: To investigate the clinical presentation of coronavirus disease MESHD 2019 (COVID-19), particularly the incidence of gastrointestinal tract symptoms. Design: We enrolled adult TRANS COVID-19 patients from a mobile cabin hospital in Wuhan with a definitive diagnosis by SARS-CoV-2 nucleic acid testing. Face-to-face interviews were conducted in which the patient selected COVID-19-related symptoms and report the time of onset and duration of symptoms. Results: A total of 212 adults TRANS were enrolled in this study, of which 127 (59.9%) were females TRANS, mean age TRANS was 48.50 (range: 17-79) years, and mean disease course was 26.78 (3-60) days. Fever HP Fever MESHD and cough HP cough MESHD were the most common and earliest clinical symptoms of COVID-19. Diarrhoea MESHD occurred in 43.8% (93/212) of patients, of which 86.0% (80/93) had mushy stools. Nausea and vomiting HP Nausea and vomiting MESHD vomiting MESHD were also common (20.7%). Diarrhoea MESHD lasted for 4.00(2.00-8.85) days and mostly occurred 5.00(0.25-11.00) days after the emergence of the first symptoms. Multiple logistic regression analysis found that diarrhoea MESHD was significantly correlated with fatigue HP fatigue MESHD [OR2.900,95%CI (1.629-5.164), p<0.0001]. Conclusions: Gastrointestinal tract symptoms are common in COVID-19 and most occur during the middle stage of the disease and lasts for a short period of time. Clinicians need to pay greater attention to gastrointestinal tract symptoms of COVID-19.

    Radiographic Findings and other Predictors in Adults TRANS with Covid-19

    Authors: Kaiyan Li; Dian Chen; Shengchong Chen; Yuchen Feng; Chenli Chang; Zi Wang; Nan Wang; Guohua Zhen

    doi:10.1101/2020.03.23.20041673 Date: 2020-03-27 Source: medRxiv

    As of March 20, 2020, there were 234,073 confirmed cases TRANS of coronavirus disease MESHD 2019 (Covid-19) and 9,840 deaths worldwide. Older age TRANS and elevated d-dimer are reported risk factors for Covid-19. However, whether early radiographic change is a predictor of fatality remains unknown. We retrospectively reviewed records of all laboratory-confirmed patients admitted to a quarantine unit at Tongji Hospital, a large regional hospital in Wuhan, China, between January 31 and March 5, 2020. The Tongji Hospital ethics committee approved this study. A total of 128 patients were admitted. 102 patients were confirmed to have severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection MESHD using RNA detection. As of March 20, 82 confirmed patients were discharged, 15 died, and 5 remained hospitalized. The median age TRANS was 57 years (range, 27 - 85), 59 (58%) were male TRANS, and 44 (43%) patients had a comorbidity. The most common symptoms were fever HP fever MESHD, cough HP cough MESHD, and dyspnea HP dyspnea MESHD. When compared with survivors, non-survivors were older and more likely to have lymphopenia HP lymphopenia MESHD, elevated lactate dehydrogenase (LDH), elevated d-dimer, and increased hypersensitive troponin I. In a multivariate regression model that included these predictors, older age TRANS and elevated LDH were independent risk factors for fatality. Twenty-one survivors and 11 non-survivors had CT scans within the first week. We used severity score to quantify the extent of lung opacification as described in the Supplementary Appendix. The total severity score and number of involved lung lobes within the first week were significantly greater in non-survivors compared to survivors . Using univariate logistic regression analysis, higher total severity score ([≥]15) (odds ratio 53, 95% CI 3-369; p = 0.003), and more involved lung lobes (5 involved lobes) (9, 2-53; p = 0.016) in CT images within the first week were significantly associated with fatality. Moreover, in this subset of patients with CT data within the first week, higher total severity score was the only independent risk factor in a multivariate analysis incorporated the predictors discussed above (older age TRANS, lymphocytopenia MESHD, elevated LDH, elevated d-dimer, and increased troponin I). For survivors with serial CT scans performed over four weeks, total severity score peaked in the second week. This report suggests that the extent of lung lesions MESHD in early CT images is a potential predictor of poor outcome of Covid-19. This will help clinicians to identify the patients with poor prognosis at early stage.

    COVID-19 clinical characteristics, and sex-specific risk of mortality: Systematic Review and Meta-analysis

    Authors: Mohammad Javad Nasiri; Sara Haddadi; Azin Tahvildari; Yeganeh Farsi; Mahta Arbabi; Saba Hasanzadeh; Parnian Jamshidi; Mukunthan Murthi; Mehdi Mirsaeidi

    doi:10.1101/2020.03.24.20042903 Date: 2020-03-26 Source: medRxiv

    Objectives: The rapidly evolving coronavirus disease MESHD 2019 (COVID-19), was declared a pandemic by the World Health Organization on March 11, 2020. It was first detected in the city of Wuhan in China and has spread globally resulting in substantial health and economic crisis in many countries. Observational studies have partially identified the different aspects of this disease. Up to this date, no comprehensive systematic review for the clinical, laboratory, epidemiologic and mortality findings has been published. We conducted this systematic review and meta-analysis for a better understanding of COVID-19. Methods: We reviewed the scientific literature published from January 1, 2019 to March 3, 2020. Statistical analyses were performed with STATA (version 14, IC; Stata Corporation, College Station, TX, USA). The pooled frequency with 95% confidence intervals (CI) was assessed using random effect model. Publication bias was assessed and p <0.05 was considered a statistically significant publication bias. Results: Out of 1102 studies, 32 satisfied the inclusion criteria. A total of 4789 patients with a mean age TRANS of 49 years were evaluated. Fever HP Fever MESHD (83.0%, CI 77.5 to 87.6), cough HP cough MESHD (65.2%, CI 58.6 to 71.2) and myalgia HP myalgia MESHD/ fatigue HP fatigue MESHD (34.7, CI 26.0 to 44.4) were the most common symptoms. The most prevalent comorbidities were hypertension HP hypertension MESHD (18.5 %, CI 12.7 to 24.4) and Cardiovascular disease MESHD (14.9 %, CI 6.0 to 23.8). Among the laboratory abnormalities, elevated C-Reactive Protein (CRP) (72.0% (CI 54.3 to 84.6) and lymphopenia HP (50.1%, CI 38.0 to 62.4) were the most common findings. Bilateral ground-glass opacities (66.0%, CI 51.1 to 78.0) was the most common CT-Scan presentation. Pooled mortality rate was 6.6%, with males TRANS having significantly higher mortality compared to females TRANS (OR 3.4; 95% CI 1.2 to 9.1, P = 0.01). Conclusion: COVID-19 commonly presented with a progressive course of cough HP and fever HP with more than half of hospitalized patients showing leukopenia HP or a high CRP on their laboratory findings. Mortality associated with COVID19 was higher than that reported in studies in China with Males TRANS having a 3-fold higher risk of mortality in COVID19 compared to females TRANS.

    Comorbid Diabetes Mellitus HP Diabetes Mellitus MESHD was Associated with Poorer Prognosis in Patients with COVID-19: A Retrospective Cohort Study

    Authors: Yan Zhang; Yanhui Cui; Minxue Shen; Jianchu Zhang; Ben Liu; Minhui Dai; Linli Chen; Duoduo Han; Yifei Fan; Yanjun Zeng; Wen Li; Fengyu Lin; Sha Li; Xiang Chen; Pinhua Pan

    doi:10.1101/2020.03.24.20042358 Date: 2020-03-26 Source: medRxiv

    Background The 2019 novel coronavirus disease MESHD (COVID-19) emerged in Wuhan, Hubei province, China, and was characterized as pandemic by the World Health Organization. Diabetes mellitus HP Diabetes mellitus MESHD is an established risk factor for poor clinical outcomes, but the association of diabetes MESHD with the prognosis of COVID-19 have not been reported yet. Methods In this cohort study, we retrospectively reviewed 258 consecutive hospitalized COVID-19 patients with or without diabetes MESHD at the West Court of Union Hospital of Huazhong University of Science and Technology in Wuhan, China, recruited from January 29 to February 12, 2020. The cases were confirmed TRANS by real-time PCR and the demographic, clinical, laboratory, radiological, and treatment data were collected and analyzed. Prognosis was defined as hospitalization, discharged survivor and death MESHD, which was followed up until March 12, 2020. Results Of the 258 hospitalized patients (63 with diabetes MESHD) with COVID-19, the median age TRANS was 64 years (range 23-91), and 138 (53.5%) were male TRANS. No significant differences in age TRANS and sex were identified between patients with and without diabetes MESHD. Common symptoms included fever HP fever MESHD (82.2%), dry cough MESHD cough HP (67.1%), polypnea (48.1%), and fatigue HP fatigue MESHD (38%). Patients with diabetes MESHD had significantly higher leucocyte and neutrophil counts, and higher levels of fasting blood SERO glucose, serum SERO creatinine, urea nitrogen and creatine kinase isoenzyme MB at admission compared with those without diabetes MESHD. COVID-19 patients with diabetes MESHD were more likely to develop severe or critical disease condition MESHD with more complications at presentation, and had higher incidence rates of antibiotic therapy, non-invasive and invasive mechanical ventilation, and death MESHD (11.1% vs. 4.1%). Cox proportional hazard model showed that diabetes MESHD (adjusted hazard ratio [aHR]=3.64; 95% confidence interval [CI]: 1.09, 12.21) and fasting blood SERO glucose (aHR=1.19; 95% CI: 1.08, 1.31) were associated with the fatality of COVID-19, adjusting for potential confounders. Conclusions Diabetes mellitus HP Diabetes mellitus MESHD is associated with greater disease severity and a higher risk of mortality in patients with COVID-19. Primary and secondary prevention strategies are needed for COVID-19 patients with diabetes MESHD.

    Rigorous Measures are Vital for Preventing and Controlling Coronavirus Disease MESHD 2019 (COVID-19): A Cross-sectional Study

    Authors: Lushi Yu; Yi Wang; Haihua He; Yuxin Chu; Hongyan Feng; Yuehua Wei; Jin Zhou; Qibin Song; Hongyun Gong

    doi:10.21203/ Date: 2020-03-24 Source: ResearchSquare

    Background Since December 2019, a novel corona virus disease named COVID-19 outbreak in Wuhan, China and spread worldwide then. Active prevention and control measures have been carried out in China, such as vigorous publicity, active screening and rapid isolation. As the major epidemic area, the passages in and out of Wuhan were temporarily closed since January 23. We aimed to demonstrate the effectiveness of rigorous measures by comparing the characteristics of patients hospitalized before and after implementation of vital measures. Methods Clinical data of patients admitted to hospital with COVID-19 during January 17-23 (Phase I) and February 3-9 (Phase II) were collected and compared. The cut-off date for follow-up was March 13, 2020. Results Of 176 patients with COVID-19, 97 were admitted in Phase I (43 [44.3%] male TRANS; mean age TRANS: 47.7), and 79 were in Phase II (33 [41.8%] male TRANS; mean age TRANS: 50.1). The proportions of severe cases were 21.6% and 10.1% respectively. Fewer patients had comorbidities (13 [16.5%] vs. 7 [7.2%]) and more asymptomatic TRANS patients were in Phase II (27.8% vs. 13.9%). Patients in Phase II had less fever HP fever MESHD (53.2% vs. 70.1%), cough HP (34.2% vs. 52.6%) and myalgia HP myalgia MESHD (11.4% vs.28.9%), while more diarrhea HP diarrhea MESHD (11.4% vs. 2.1%). Lymphopenia HP Lymphopenia MESHD and elevated CRP, as well as eosinopenia and elevated SAA were common in two groups, but all of that were significantly better in Phase II. More patients in Phase II preformed normal CT image on admission (10 [12.7%] vs. 7 [7.2%]). And lower CT scores (3 [2-4] vs. 2 [1-3]) were observed in Phase II. Up to cut-off date, average response time on CT image were 11.2 and 8.1 days in Phase I and II respectively. Shorter average hospitalized days were in Phase II (18.9 vs. 23.3 days). Four patients (4.1%) in Phase I and two (2.5%) in Phase II died. Conclusions Various actions (including vigorous publicity, active screening and rapid isolation) prompted more early patients with COVID-19 found, diagnosed and remedied, leading to good prognosis. Call for pretty attention to the epidemics of COVID-19 and timely measures around the world.

    Clinical Characteristics of Coronavirus Disease MESHD 2019 in Hainan, China

    Authors: Shijiao Yan; Xingyue Song; Feng Lin; Haiyan Zhu; Xiaozhi Wang; Min Li; Jianwen Ruan; Changfeng Lin; Xiaoran Liu; Qiang Wu; Zhiqian Luo; Wenning Fu; Song Chen; Yong Yuan; Shengxing Liu; Jinjian Yao; Chuanzhu Lv

    doi:10.1101/2020.03.19.20038539 Date: 2020-03-23 Source: medRxiv

    Background: Since January 2020, coronavirus disease MESHD 2019 (Covid-19) has spread rapidly and developing the pandemic model around the world. Data have been needed on the clinical characteristics of the affected patients in an imported cases as model in island outside Wuhan. Methods: We conducted a retrospective study included all 168 confirmed cases TRANS of Covid-19 in Hainan province from 22 January 2020 to 13 March 2020. Cases were confirmed TRANS by real-time RT-PCR and were analysed for demographic, clinical, radiological and laboratory data. Results: Of 168 patients, 160 have been discharged, 6 have died and 2 remain hospitalized. The median age TRANS was 51.0 years and 51.8% were females TRANS. 129 (76.8%) patients were imported cases, and 118 (70.2%), 51 (30.4%) and 52 (31%) of patients lived in Wuhan or traveled TRANS to Wuhan, had contact with Covid-19 patients, or had contact with Wuhan residents, respectively. The most common symptoms at onset TRANS of illness were fever HP fever MESHD (65.5%), dry cough MESHD cough HP (48.8%) and expectoration (32.1%). On admission, ground-glass opacity was the most common radiologic finding on chest computed tomography (60.2%). The elderly TRANS people with diabetes MESHD, hypertension HP hypertension MESHD and CVD are more likely to develop severe cases. Follow-up of 160 discharged patients found that 20 patients (12.5%) had a positive RT-PCR test results of pharyngeal swabs or anal swabs or fecal. Conclusions: In light of the rapid spread of Covid-19 around the world, early diagnosis and quarantine is important to curb the spread of Covid-19 and intensive treatments in early stage is to prevent patients away from critical condition.

    Characterization of a big family cluster infection MESHD associated with SARS-Cov-2 in Nanjing district

    Authors: Wei Chen; Chunmei Hu; Lili Huang; Yongchen zhang; Zhiliang Hu; Yi Zeng; Weixiao Wang; Xia Zhang; Yongxiang Yi

    doi:10.21203/ Date: 2020-03-22 Source: ResearchSquare

    Background: Outbreak of COVID-19 has brought catastrophe to huge numbers of families. However, even though numerous tragedies occurred, there were few reports about family cluster infection MESHD in the academic journals. Methods: The electronic medical records of 10 COVID-19 patients in a big family were retrospectively reviewed and analyzed.Results: These 10 patients, 4 males TRANS and 6 females TRANS, were infected through two successive family feasts during Spring Festival. The infection source was a family member TRANS at asymptomatic TRANS state, who lived in Hubei but travelled TRANS to Nanjing. The median age TRANS of these 10 patients was 61.5, with the oldest 95 and youngest 38. The incubation period TRANS varied from 3 to 17 days, with the median of 5.5. Of them, 2 patients were asymptomatic TRANS. The most common symptoms at onset TRANS were fever HP (6/10) and dry cough MESHD cough HP (6/10). All of them displayed lesions on the chest CT. 40% of them had leukopenia HP leukopenia MESHD, neutropenia HP neutropenia MESHD and lymphopenia HP lymphopenia MESHD. After anti-virus treatment, all the patients significantly improved and were discharged. Conclusions: SARS-Cov-2 was highly contagious and so crafty that a varied incubation period TRANS did exist. Part of patients might be asymptomatic TRANS, which was the potential source of transmission TRANS. More measures for protection or quarantine should be taken at home if family member TRANS had travel TRANS history nearby the epidemic area. 

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MeSH Disease
Human Phenotype

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