Corpus overview


Overview

MeSH Disease

Fever (158)

Cough (91)

Coronavirus Infections (78)

Dyspnea (71)

Fatigue (56)


Human Phenotype

Cough (195)

Fever (174)

Fatigue (61)

Pneumonia (59)

Hypertension (48)


Transmission

Seroprevalence
    displaying 161 - 170 records in total 195
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    A meta-analysis of clinical characteristics and mortality COVID-19 pneumonia HP pneumonia MESHD

    Authors: Shangxia Jiang; Yueming Wu; Tianzheng Lou; Junlong Xu; Yu Zhang; Hu Chen; Hewei Xu

    doi:10.21203/rs.3.rs-18723/v2 Date: 2020-03-21 Source: ResearchSquare

    Abstract: Objective To investigate the Corona Virus Disease MESHD 2019(COVID-19) clinical characteristics and mortality risk by pooling the open published data. Methods Studies relevant to COVID-19 published in Pubmed, China Wanfang database, ChinaXiv and medRxiv were systematic screened by using the text word of “COVID-19”, 2019-nCoV, “SARS-CoV-2”, “NCP”. The mortality and clinical characteristic of the COVID-19 cases such as male TRANS/ female TRANS ratio, mechanical ventilation ratio and top c linical symptom rate of the COVID-19 cases were pooled. Results Ten clinical studies relevant to COVID-19 were identified by electronic searching the related databases. The combined mortality was 0.03(95%CI: 0.01-0.04) for COVID-19 cases by random effect model. The pooled female TRANS ratio of the COVID-19 cases from 10 published data was 0.41(95%CI:0.37-0.46). The pooled invasive and non-invasive ventilation ratio were 0.03(95%CI:0.01-0.05) and 0.06(95%CI:0.02-0.09) respectively for patients with COVID-19 pneumonia HP pneumonia MESHD. The pooled clinical symptom rate of fever HP fever MESHD, cough HP cough MESHD, headache HP headache MESHD and fatigue HP fatigue MESHD were 0.80(95%CI:0.60-1.01), 0.12(95%CI:0.08-0.17), 0.68(95%CI:0.57-0.73) and 0.51(95%CI:0.36-0.67) respectively under random effect model. Conclusion According to the present published data, male TRANS was more cline to susceptible to COVID-19 compared to female TRANS. The fever HP fever MESHD, cough HP cough MESHD and fatigue HP fatigue MESHD were the most common symptom of COVID-19 cases. About 10% of patients received invasive or noninvasive mechanical ventilation with the overall crude mortality of 3%.

    COVID-19 discharged patients in Hunan, China: correlation between early features and prognosis

    Authors: yeyu cai; jiayi liu; Haitao Yang; Taili Chen; Qizhi Yu; Juan Chen; Deng Huang; Zhu Chen; Quanliang Shang; Cong Ma; Xiangyu Chen; Enhua Xiao

    doi:10.21203/rs.3.rs-18121/v1 Date: 2020-03-19 Source: ResearchSquare

    Purpose      To describe the correlation between the clinical, laboratory and radiological findings with hospitalization days in Coronavirus Infected Disease MESHD-19 (COVID-19) discharged patients. Method In this multicenter study, we retrospectively identified 153 discharged patients with COVID-19 pneumonia HP pneumonia MESHD from Jan 16, 2020 to Feb 26, 2020 in Hunan province. Patients were grouped based on the hospitalization days: Group 1 (hospitalization days≦12 days) and Group 2((hospitalization days> 12days). Demographic, clinical characteristics and laboratory findings on admission and the imaging features of the first Chest CT on admission were analyzed. The differences between groups were analyzed using univariate logistic regression to find the impact factors. Results The cohort included 153 discharged patients (85 males TRANS and 68 females TRANS, with the mean age TRANS of 42.32±14.03 years old). 90(58.8%) patients had hospitalization days≦12 and 63(41.2%) patients had hospitalization days>12. 44(48.9%) patients in Group1 and 28(44.4%) in Group 2 had been to Wuhan. In both Group1 and Group2, most common symptoms at onset TRANS were fever HP (62.2%, 60.3%) and cough HP (33.3%, 50.8%). Cough HP was occurred more common in Group 2(50.8%) than Group 1(33.3%) with a significant difference (p=0.03). 6(6.7%) patients in Group1 and 10(15.9%) in Group2 had admitting diagnosis as non- pneumonia HP (p=0.07), some of them occurred mild pneumonia HP during hospital stay. White blood SERO cell (2.2%, 9.5%) and neutrophil (9.5%) count above normal were more common on in Group 2 (p=0.04, p=0.04). Patients in Group 2 had higher concentration of aspartate aminotransferase (P=0.04) than Group 1. Most of patients had multiple lesions (75.6%, 69.8%) with bilateral distribution (73.3%, 58.7%) in both groups. Mixed ground-glass opacity (GGO) and consolidation appearance were seen in most patients. GGO components > consolidation appearance were more common in Group 1(31.1%) than in Group 2(8.0%) with a significant difference between groups (P<0.01). Patients had cough HP at onset disease (OR, 0.47; 95%CI, 0.23 to 0.96, p=0.04) and CT represented as GGO components more than consolidation (OR, 4.84; 95%CI, 1.80 to 13.04, p<0.01) were associated with hospitalization days. Conclusions COVID-19 non- pneumonia HP patients with longer hospitalization days might have the persistent symptoms or pneumonia HP occurrence after admission. Chest CT could help prompt diagnosis and monitor disease progression, GGO/consolidation >1 in mixed lesions was associated with shorter hospitalization days. Special attention should be paid to the role of radiological features in monitoring disease prognosis.

    Epidemiological and clinical characteristics of COVID-19 patients in Nanjing

    Authors: Wei Chen; Chunmei Hu; Lili Huang; Min Cai; Yongchen Zhang; Hongxia Wei; Yun Chi; Zhiliang Hu; Yi Zeng; Yishan Zheng; Ying Liu; Cong Cheng; Hongmei Zhang; Weixiao Wang; Xia Zhang; Yongxiang Yi

    doi:10.21203/rs.3.rs-18007/v1 Date: 2020-03-18 Source: ResearchSquare

    Background: Since December 2019, the outbreak of COVID-19 has spread quickly and thumped many countries and regions. The epidemic of central China was under the spotlight and attracted much more attentions. However, there are few reports describing COVID-19 patients in the regions outside of Wuhan, which are undergoing the change from sporadic imported cases to community-acquired transmission TRANS.Methods: The electronic medical records of 74 laboratory-confirmed patients of COVID-19 were retrospectively reviewed and analyzed. Their epidemiological, demographic, clinical and radiological characteristics were systematically summarized. The difference between severe patients and non-severe patients were also analyzed statistically.Results: The 74 COVID-19 patients were composed of 4 (5.4%) mild patients, 56 (75.7%) common patients, 13 (17.6%) severe patients and 1 (1.4%) critical patient. 43 were male TRANS, and 31 were female TRANS, with the average age TRANS 48.1±17.5. No significant difference of susceptibility was observed between genders TRANS, and almost people with all age TRANS were susceptible to SARS-CoV-2 infection MESHD. Before Jan 26, only imported sporadic cases were observed. However, from that day onward, family cluster infection MESHD cases increased dramatically, up to 70.3% (52/74), which were mainly from 15 family. The incubation period TRANS spanned from 0 to 19 days, with the median 5, and 81.4% had symptom onset TRANS within 7 days. At admission, 31.1% of patients had underlying diseases MESHD and the most common underlying diseases were hypertension HP hypertension MESHD (13.5%) and diabetes MESHD (5.4%). The most common symptoms were fever HP fever MESHD (90.5%), cough HP (75.7%), fatigue HP fatigue MESHD (36.5%) and chest distress (32.4%). 36.5% and 16.2% of patients had leukopenia HP leukopenia MESHD and lymphocytopenia MESHD. 43.2% of patients had increased C reactive protein (CRP), and 40.5% had higher erythrocyte sedimentation rate (ESR) and 21.6% had higher calcitonin. 74.3% of patients had obvious lesions in both lung lobes MESHD and 56.8% of lesions manifested as ground glass opacity. Compared with non-severe group, the severe/critical group were significantly older and had more underlying diseases. After treatment, all patients improved and were discharged. No medical professional infection MESHD and death case were reported.Conclusion: The epidemic of COVID-19 in Nanjing were mainly caused by family cluster infection MESHD. The entire prevalence SERO and illness were much milder than those of Wuhan. The disease of COVID-19 could be controlled and cured.  

    Characterization of a big family cluster infection MESHD associated with SARS-Cov-2 in Nanjing district

    Authors: Wei Chen; Chunmei Hu; Lili Huang; Yongchen zhang; Zhiliang Hu; Yi Zeng; Weixiao Wang; Xia Zhang; Yongxiang Yi

    doi:10.21203/rs.3.rs-18077/v1 Date: 2020-03-18 Source: ResearchSquare

    Background: Outbreak of COVID-19 has brought catastrophe to huge numbers of families. However, even though numerous tragedies occurred, there were few reports about family cluster infection MESHD in the academic journals. Methods: The electronic medical records of 10 COVID-19 patients in a big family were retrospectively reviewed and analyzed. Results: These 10 patients, 4 males TRANS and 6 females TRANS, were infected through two successive family feasts during Spring Festival. The infection source was a family member TRANS at asymptomatic TRANS state, who lived in Hubei but travelled TRANS to Nanjing. The median age TRANS of these 10 patients was 61.5, with the oldest 95 and youngest 38. The incubation period TRANS varied from 3 to 17 days, with the median of 5.5. Of them, 2 patients were asymptomatic TRANS. The most common symptoms at onset TRANS were fever HP (6/10) and dry cough MESHD cough HP (6/10). All of them displayed lesions on the chest CT. 40% of them had leukopenia HP leukopenia MESHD, neutropenia HP neutropenia MESHD and lymphopenia HP lymphopenia MESHD. After anti-virus treatment, all the patients significantly improved and were discharged. Conclusions: SARS-Cov-2 was highly contagious and so crafty that a varied incubation period TRANS did exist. Part of patients might be asymptomatic TRANS, which was the potential source of transmission TRANS. More measures for protection or quarantine should be taken at home if family member TRANS had travel TRANS history nearby the epidemic area. Keywords: COVID-19, SARS-Cov-2, family cluster, asymptomatic TRANS, incubation period TRANS.

    Clinical characteristics of 2019 novel coronavirus pneumonia MESHD pneumonia HP and risk factors for severe cases: a meta-analysis involving 5,729 patients

    Authors: Zhongheng Zhang; Lin Chen; Hongying Ni; Min Yao; Casarotta Erika; Donati Abele; Carsetti Andrea; Yizhan Guo; Qing Wang

    doi:10.21203/rs.3.rs-17871/v1 Date: 2020-03-17 Source: ResearchSquare

    Objective: 2019 novel coronavirus (2019-nCov) has become a global health emergency. However, the clinical presentations are not well characterized. The study aimed to describe clinical characteristics of 2019-nCov pneumonia HP pneumonia MESHD with meta-analytic approach, and to identify risk factors for developing severe cases.Methods: The electronic databases of PubMed, Google Scholar and MedRxiv were searched from December 2019 to February 2020. Records were included if they reported clinical characteristics of 2019-nCov pneumonia HP pneumonia MESHD. Studies using crowd sourcing data for mathematical modeling but not reporting clinical data were excluded. The study was reported according to the PRISMA guideline. Data were extracted by independent reviewers. Proportions and mean values were pooled across component studies by using the meta-analytic approach. Data were pooled with fixed or random-effects model as appropriate. Clinical characteristics such as age TRANS, gender TRANS, symptoms, treatment and mortality outcome were pooled across studies if appropriate. Risk factors for development of severe cases were reported.Results: A total of 13 studies involving 5,729 patients were included for quantitative analysis. The mean age TRANS of the study population was 50 years (95% CI: 47 to 53). The most common initial symptoms were cough HP (68.0%; 95% CI: 65.6 to 70.4%), followed by fever HP fever MESHD (56.5%; 95% CI: 53.9 to 58.9%), fatigue HP fatigue MESHD (42.5%; 95% CI: 39.9 to 45.1%) and anorexia HP anorexia MESHD (31.7%; 95% CI: 26.5 to 38.4%). The severe cases accounts for 22.5% of the whole population (95% CI: 21.4 to 23.6%). The overall mortality rate was 1.8% (95% CI: 1.5 to 2.2%), which was consistent with the real time epidemic tracking data. There was substantial heterogeneity across included studies (O = 0.84; p < 0.001). A number of comorbidities and symptoms such as hypertension HP hypertension MESHD, COPD, dyspnea HP dyspnea MESHD, elevated C-reactive protein and procalcitonin were found to be associated with increased risk of developing severe cases.Conclusions: Our study described clinical characteristics of the 2019-nCov pneumonia HP pneumonia MESHD in a systematic way. Multiple risk factors were identified for severe cases.

    Recommendations for standardized management of CML MESHD patients in the core epidemic area of COVID-19(Multi-center survey results in Hubei Province, China)

    Authors: Dan-Yu Wang; Jing-Ming Guo; Zhuang-Zhi Yang; Yong You; Zhi-Chao Chen; Shi-Ming Chen; Hui Cheng; You-Shan Zhang; Dao-Zi Jiang; Xue-Lan Zuo; Xiao-Jian Zhu; Jun Huang; Hong-Xiang Wang; Qing Li; Qing Wu; Zhi-Ping Huang; Qi-Huan Liu; Ying Bao; Da-Lin Zhang; Xin-Hua Zhang; Zhe Zhao; Ren-Ying Ge; Jie Du; Ya-Ping Wang; Hong-Bo Ren; Hong Han; Yun-Hui Wei; Hang Xiang; Chu-Cheng Wan; You-Fang Zhao; Bin Chen; Guo-Lin Yuan; Li Meng; Wei-Ming Li

    doi:10.1101/2020.03.12.20034876 Date: 2020-03-16 Source: medRxiv

    Background Since late December 2019, the outbreak of the novel coronavirus disease MESHD, COVID-19, that began in Wuhan, has become endemic in China and more than 100 countries and regions in the world. There is no report about the prevalence SERO of COVID-19 in CML MESHD patients untill now. We aimed to describe the clinical course, outcomes of CML MESHD patients with COVID-19 and prevalence SERO of COVID-19 in CML MESHD patients. Methods In this multi-center survey, cross-sectional survey, observational study, the clinical data of CML MESHD patients with COVID-19 in each center were collected. Simultaneously, an online survey was conducted for information about the CML MESHD patients under the management at each center by asking the CML MESHD patients to complete a questionnaire,from February 15, 2020 to February 21, 2020. The questionnaire includes demographic data, place of residence, smoking status, CML MESHD diagnosis and treatment, comorbidities, combined medications, epidemiological history, symptoms( fever HP fever MESHD, cough HP cough MESHD, shortness of breath MESHD, etc) during the epidemic. Additional clinical data was collected on respondents suspected or confirmed to have COVID-19. We described and analyzed the prevalence SERO of COVID-19 in CML MESHD patients, and focus on the clinical characteristics and outcomes of COVID-19 patients. Data were compared between the CML MESHD patients with optimal response and those with non-optimal response. The primary outcome was prevalence SERO of COVID-19 in CML MESHD patients, as of Feb 21, 2020. Secondary outcomes included the history of epidemiology of CML MESHD patients, the clinical characteristics and outcomes of CML MESHD patients with COVID-19 . Findings Of 392 respondents, 223( 56.9%) were males TRANS, and 240( 61.2%) were 50 years or younger. Only 10 patients took drugs irregularly due to the influence of the epidemic because of traffic control, pharmacies unable to operate normally, etc. In the history of epidemiology, there were 4 patients with definite contact with COVID-19, of which 3 were remote contact and 1 was close contact TRANS. 12 respondents had fever HP fever MESHD, cough HP cough MESHD or shortness of breath MESHD during the epidemic, 1 case (common type) was confirmed with COVID-19 and cured after treatment. 1 patient was clinically diagnosed and succumbed. 1 of 299 (0.3%) patients with an optimal response was diagnosed with COVID-19. Of the 50 patients who failed to respond to CML treatment or had a poor response, 1 patient (2%) had a clinical diagnosis of COVID-19. Interpretation While the 392 CML respondents required regular referrals to hospitals, they did not have much contact with COVID-19 patients during the outbreak. Patients who failed to achieved an optimal response to CML therapy appear more likely to have a symptomatic infection MESHD with SARS-CoV-2. Older patients with comorbidities are at increased risk of death MESHD.

    Clinical Characteristics of 34 Children TRANS with Coronavirus Disease MESHD-2019 in the West of China: a Multiple-center Case Series

    Authors: Che Zhang; Jiaowei Gu; Quanjing Chen; Na Deng; Jingfeng Li; Li Huang; Xihui Zhou

    doi:10.1101/2020.03.12.20034686 Date: 2020-03-16 Source: medRxiv

    BACKGROUND Up to 9 March, 2020, 109577 patients were diagnosed with coronavirus disease MESHD-2019 (COVID-19) globally. The clinical and epidemiological characteristics of adult TRANS patients have been revealed recently. However, the information of paediatric patients remains unclear. We describe the clinical and epidemiological characteristics of paediatric patients to provide valuable insight into early diagnosis of COVID-19 in children TRANS, as well as epidemic control policy making. METHODS and FINDINGS This retrospective, observational study was a case series performed at 4 hospitals in the west of China. Thirty-four paediatric patients with COVID-19 were included from January 1 to February 25, 2020. And the final follow-up visit was completed by February 28, 2020. Clinical and epidemiological characteristics were analyzed on the basis of demographic data, medical history, laboratory tests, radiological findings, and treatment information. Data analysis was performed on 34 paediatrics patients with COVID-19 aged TRANS from 1 to 144 months (median 33.00, IQR 10.00 - 94.25), among whom 14 males TRANS (41.18%) were included. 47.60% of patients were noticed without any exposure history. The median incubation period TRANS was 10.50 (7.75 - 25.25) days. Infections of other respiratory pathogens were reported in 16 patients (47.06%). The most common initial symptoms were fever HP fever MESHD (76.47%), cough HP (58.82%), and expectoration (20.59%). Vomiting HP Vomiting MESHD (11.76%) and diarrhea HP diarrhea MESHD (11.76%) were also reported in a considerable portion of cases. A remarkable increase was detected in serum SERO amyloid A for 17 patients (85.00%) and high- sensitivity SERO C-reactive protein for 17 patients (58.62%), while a decrease of prealbumin was noticed in 25 patients (78.13%). In addition, the levels of lactate dehydrogenase was increased significantly in 28 patients (82.35%), as well as -hydroxybutyrate dehydrogenase in 25 patients (73.53%). Patchy lesions in lobules were detected by chest computed tomographic scans in 28 patients (82.36%). The typical feature of ground-glass opacity for adults TRANS was rare in paediatric patients (2.94%). A late-onset pattern of lesions in lobules were also noticed. Stratified analysis of the clinical features were not performed due to relatively limited samples. CONCLUSIONS Our data presented the clinical and epidemiological features of paediatric patients systemically. The findings offer new insight into the early identification and intervention of paediatric patients with COVID-19.

    Epidemiological, Clinical Characteristics and Outcome of Medical Staff Infected with COVID-19 in Wuhan, China: A Retrospective Case Series Analysis

    Authors: Jie Liu; Liu Ouyang; Pi Guo; Hai sheng Wu; Peng Fu; Yu liang Chen; Dan Yang; Xiao yu Han; Yu kun Cao; Osamah Alwalid; Juan Tao; Shu yi Peng; He shui Shi; Fan Yang; Chuan sheng Zheng

    doi:10.1101/2020.03.09.20033118 Date: 2020-03-13 Source: medRxiv

    Backgrounds Since December 2019, a novel coronavirus epidemic has emerged in Wuhan city, China and then rapidly spread to other areas. As of 20 Feb 2020, a total of 2,055 medical staff confirmed with coronavirus disease MESHD 2019 (COVID-19) caused by SARS-Cov-2 in China had been reported. We sought to explore the epidemiological, clinical characteristics and prognosis of novel coronavirus-infected MESHD medical staff. Methods In this retrospective study, 64 confirmed cases TRANS of novel coronavirus-infected MESHD medical staff admitted to Union Hospital, Wuhan between 16 Jan, 2020 to 15 Feb, 2020 were included. Two groups concerned were extracted from the subjects based on duration of symptoms: group 1 (<= 10 days) and group 2 (>10 days). Epidemiological and clinical data were analyzed and compared across groups. The Kaplan-Meier plot was used to inspect the change in hospital discharge rate. The Cox regression model was utilized to identify factors associated with hospital discharge. Findings The median age TRANS of medical staff included was 35 years old. 64% were female TRANS and 67% were nurses. None had an exposure to Huanan seafood wholesale market or wildlife. A small proportion of the cohort had contact with specimens (5%) as well as patients in fever HP fever MESHD clinics (8%) and isolation wards (5%). Fever HP Fever MESHD (67%) was the most common symptom, followed by cough HP (47%) and fatigue HP fatigue MESHD (34%). The median time interval between symptoms onset TRANS and admission was 8.5 days. On admission, 80% of medical staff showed abnormal IL-6 levels and 34% had lymphocytopenia MESHD. Chest CT mainly manifested as bilateral (61%), subpleural (80%) and ground-glass (52%) opacities. During the study period, no patients was transferred to intensive care unit or died, and 34 (53%) had been discharged. Higher body mass index (BMI) (HR 0.14; 95% CI 0.03-0.73), fever HP fever MESHD (HR 0.24; 95% CI 0.09-0.60) and higher levels of IL-6 on admission (HR 0.31; 95% CI 0.11-0.87) were unfavorable factors for discharge. Interpretation In this study, medical staff infected with COVID-19 have relatively milder symptoms and favorable clinical course, which may be partly due to their medical expertise, younger age TRANS and less underlying diseases. Smaller BMI, absence of fever symptoms MESHD fever HP symptoms and normal IL-6 levels on admission are favorable for discharge for medical staff. Further studies should be devoted to identifying the exact patterns of SARS-CoV-2 infection MESHD among medical staff.

    Chest CT Could Be Used to Diagnose 2019 Novel Coronavirus Pneumonia HP Clinically in Hubei Province

    Authors: Xin Wang; Peng Wen; Zhi-Gang Sun; Chun-Yan Xing; Yun Li

    doi:10.21203/rs.3.rs-17422/v1 Date: 2020-03-12 Source: ResearchSquare

    Background: In December 2019, novel coronavirus pneumonia MESHD pneumonia HP-19 (COVID-19) was discovered in the viral pneumonia MESHD pneumonia HP cases that occurred in Wuhan, Hubei Province, China; and then quickly spread inside and outside of Wuhan and even other countries. This report describes the clinical course of two patients who had COVID-19.Case presentation: The first case was a typical COVID-19 case. A 66-year-old female TRANS presented to our hospital with a 3-day history of fever HP fever MESHD with coughing HP, white sputum, runny nose and dizziness MESHD. She had contacted with a COVID-19 patient, her daughter-in-law who was diagnosed with COVID-19 two days before. Chest CT showed typical COVID-19 CT imaging. She was diagnosed with COVID-19 by positive nucleic acid test. The second case was a 50-year-old male TRANS with a 2-day history of fever HP fever MESHD and dry coughing HP. He denied having been to Wuhan. Chest CT also showed typical COVID-19 CT imaging. He accepted COVID-19 nucleic acid test using reverse-transcription polymerase chain reaction of his throat swab sampling 7 times and the test results remained controversial. Eventually, he was diagnosed with COVID-19 after 5 days.Conclusions: Chest CT examination has high sensitivity SERO for diagnosis of COVID-19 clinically, particularly when nucleic acid test is negative. Chest CT should be considered for the COVID-19 screening, comprehensive evaluation and following-up and patients could benefit from effective treatment in time.

    Clinical Features and Outcome Analysis of Patients Infected with Severe and Critical COVID-19 Associated Pneumonia HP

    Authors: Yangmei Xiong; Ying Feng; Mengwei Li; Jing Wang; Xingguo Zhang; Xiangyang Chen; Xin Rao

    doi:10.21203/rs.3.rs-17395/v1 Date: 2020-03-12 Source: ResearchSquare

    Background Until now, information on the clinical characteristics of severe and critical patients with COVID-19 is extremely limited.The aim of the present study was to analyse the clinical features of these patients and influencing factors of clinical outcome, and explore treatment effects of prone position on COVID-19 patients with severe ARDS. Methods A retrospective analysis was performed on 55 COVID-19 patients in the ICU of Zhongnan Hospital of Wuhan University from January 6 to February 15, 2020 in Wuhan, China. Case data from each patient were collected and related clinical outcomes on day 14 of ICU admission were recorded. The follow-up deadline was February 29, 2020. Results Of the 55 patients included, 35 were male TRANS (63.6%), with an average age TRANS of 63.0 (SD 15.2) years, and 80.0% were patients over 50 years old. The first three symptoms were fever HP (36 cases, 65.5%), fatigue HP (13 cases, 23.6%), and cough HP (11 cases, 20.0%). The rate of invasive mechanical ventilation was 52.7% (29 cases); on the 14th day of ICU admission, 31 patients(56.4%) were improved, and 19 (34.5%) were worsened.  On the 14th day after entering the ICU, a comparative analysis showed that peripheral blood SERO CD4, CD8, and NK cell counts in deteriorated patients were significantly lower than those in improved patients (P<0.05). Meanwhile, concentrations of IL-10, IL-4, IL-6 and TNF-α in deteriorated patients were higher than those in improved patients (P <0.05). Among  a total of 27 prone position sessions, the oxygenation index (PaO2 / FiO2 ) of 9 prone position sessions(33.3%) improved, and the PaCO2 in arterial blood SERO gas analysis of 5 sessions(18.5%) improved. Conclusion The majority of patients with severe and critical COVID-19 in the ICU were over 50 years old and male TRANS. 52.7% need invasive mechanical ventilation. On the 14th day of admission, 56.4% of the patients improved, 34.5% of the patients deteriorated. The rate of deaths during hospitalization was 21.8%. The worsening of COVID-19 patients might be related to excessive inflammatory and immune responses. In addition, prone ventilation may improve oxygenation in some COVID-19 patients with severe ARDS, but a significant mortality benefit with proning was uncertain.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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