Corpus overview


MeSH Disease

Human Phenotype

Fever (2)

Asthenia (2)

Dyspnea (2)

Cough (2)

Diarrhea (1)


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    Low albumin levels are associated with poorer outcomes in a case series of COVID-19 patients in Spain: a retrospective cohort study

    Authors: Roberto de la Rica; Marcio Borges; Maria Aranda; Alberto del Castillo; Antonia Socias; Antoni Payeras; Gemma Rialp; Lorenzo Socias; Lluis Masmiquel; Marta Gonzalez-Freire

    doi:10.1101/2020.05.07.20094987 Date: 2020-05-11 Source: medRxiv

    OBJECTIVE To describe the clinical characteristics and epidemiological features of severe (non-ICU) and critically patients (ICU) with COVID-19 at triage, prior hospitalization, in one of the main hospitals in The Balearic Islands health care system. DESIGN Retrospective observational study SETTING Son Llatzer University Hospital in Palma de Mallorca MESHD (Spain) PARTICIPANTS Among a cohort of 52 hospitalized patients as of 31 March 2020, 48 with complete demographic information and severe acute respiratory syndrome coronavirus 2 MESHD (SARS-CoV-2) positive test, were analyzed. Data were collected between March 15th, 2020, and March 31th 2020, inclusive of these dates. MAIN OUTCOMES Clinical, vital signs and routine laboratory outcomes at the time of hospitalization, including symptoms reported prior to hospitalization. Demographics and baseline comorbidities were also collected. Mortality was reported at the end of the study. RESULTS 48 patients (27 non-ICU and 21 ICU) resident in Mallorca, Spain (mean age TRANS, 66 years, [range, 33-88 years]; 67% males TRANS) with positive SARS-CoV-2 infection MESHD were analyzed. There were no differences in age TRANS or sex among groups (p >.05). Initial symptoms included fever HP fever MESHD (100%), coughing HP (85%), dyspnea HP dyspnea MESHD (76%), diarrhea HP diarrhea MESHD (42%) and asthenia HP asthenia MESHD (21%). The majority of patients in this case series were hospitalized because of low SpO2 (SpO2 below 90%) and presentation of bilateral pneumonia MESHD pneumonia HP (94%) at triage. ICU patients had a higher prevalence SERO of dyspnea HP dyspnea MESHD compared to non-ICU patients (95% vs 61%, p = .022). Acute respiratory syndrome MESHD ( ARDS MESHD) was presented in 100% of the ICU-patients. All the patients included in the study required oxygen therapy. ICU-patients had lymphopenia HP lymphopenia MESHD as well as hypoalbuminemia HP hypoalbuminemia MESHD. Inflammatory markers such as lactate dehydrogenase (LDH), C-reactive protein (CRP), and procalcitonin were significantly higher in ICU patients compared to non-ICU (p < .001).Lower albumin levels were associated with poor prognosis measured as longer hospital length (r= -0.472, p

    Clinical features of coronavirus disease MESHD 2019 (COVID-19) in a cohort of patients with disability due to spinal cord injury MESHD

    Authors: Angel Gil-Agudo; Miguel Rodriguez-Cola; Irena Jimenez-Velasco; Francisco Gutierrez-Henares; Elisa Lopez-Dolado; Claudia Gambarrutta-Malfatti; Eduardo Vargas-Baquero

    doi:10.1101/2020.04.20.20072918 Date: 2020-04-24 Source: medRxiv

    Study design: Cohort study of patients with spinal cord injury MESHD ( SCI MESHD) Objectives: To describe the clinical and analytical features of a Covid-19 infected cohort with SCI MESHD to contribute new knowledge for a more accurate diagnosis and to outline prevention measures. Setting: This study was conducted at the National Hospital for Paraplegics (Toledo, Spain). Methods: A cohort analysis of seven patients with SCI infected MESHD by Covid-19 was carried out. Diagnosis was confirmed with reverse transcriptase polymerase chain reaction (RT-PCR) of nasal exudate or sputum samples. Clinical, analytical and radiographic findings were registered. Results: RT-PCR detected COVID-19 infection MESHD in all patients, affecting males TRANS and people with a cervical level of injury more often (5 out 7). The average delay for diagnostic confirmation was 4 days (interquartile range, 1-10). Fever HP Fever MESHD was the most frequent symptom (6 out of 7). The second most common symptom was asthenia HP (4 out of 7), followed by dyspnea HP dyspnea MESHD, cough HP cough MESHD and expectoration (3 out of 7 for each symptom). The MEWS score for Covid-19 severity rating was classified as severe in 5 out of 7. All but one patient showed radiological alterations evident in chest X-Rays at the time of diagnosis. All patients recovered gradually. Conclusion: Our patients with SCI MESHD and Covid-19 infection MESHD exhibited fewer symptoms than the general population. Furthermore, they presented similar or greater clinical severity. The clinical evolution was not as pronounced as had been expected. This study recommends close supervision of the SCI MESHD population to detect early compatible signs and symptoms of Covid-19 infection MESHD.

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MeSH Disease
Human Phenotype

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