Corpus overview


MeSH Disease

Human Phenotype

Overweight (8)

Pneumonia (3)

Cough (2)

Obesity (1)

Fever (1)


    displaying 1 - 8 records in total 8
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    Diet and Lifestyle Changes During COVID-19 Lockdown in the United Arab Emirates: Results of a Cross-Sectional Study

    Authors: Hadia Radwan; Mahra Al Kitbi; Hayder Hasan; Marwa Al Hilali; Nada Abbas; Rena Hamadeh; Eman Rashid Saif; Farah Naja

    doi:10.21203/ Date: 2020-09-12 Source: ResearchSquare

    Background: Lockdown measures were implemented in many countries to limit the spread of the COVID-19 pandemic. However, such restrictions could precipitate unintended negative consequences on lifestyle behaviors. The main objective of this study was to investigate the prevalence SERO and determinants of unhealthy behavior changes during the COVID-19 lockdown among residents of the United Arab Emirates (UAE).Methods: A cross-sectional web-based survey of adults TRANS residing in the UAE was carried out during lockdown (n=2060). Using a multi-component questionnaire, the collected data included questions regarding the following lifestyle changes: Increased dietary intake, increased weight, decreased physical activity, decreased sleep, and increased smoking. An unhealthy lifestyle change score was calculated based on the number of unhealthy lifestyle changes each participant reported.  In addition, sociodemographic and living conditions information was collected. Descriptive statistics as well as simple and multiple linear regression analyses were used to examine the prevalence SERO and determinants of the unhealthy lifestyle changes considered in this study.Results: Among the unhealthy lifestyle changes examined, increased food intake was the most common (31.8%), followed by decreased physical activity (30%), increased weight (29.4%), decreased sleep (20.8%), and increased smoking (21%). In addition to identifying the correlates of each of the aforementioned lifestyle changes, the results of the multiple regression linear analyses revealed the following correlates for the overall unhealthy lifestyle change score: females TRANS (β=0.32, CI: 0.22;0.42), living in an apartment (β=0.12, CI: 0.003;0.23) and being overweight HP/ obese MESHD (β=0.24, CI: 0.15;0.32) had higher scores, while older adults TRANS (>40 years) had lower scores (β=-0.23, CI: -0.34;-0.12).Conclusion: The COVID-19 lockdown has resulted in a high prevalence SERO of unhealthy lifestyle behaviors and practices among UAE residents. The findings of this study provided the evidence base for officials to design interventions targeting high-risk groups and aiming to improve healthy lifestyle factors among residents during the pandemic.

    COVID-19 Induced Stress, Lifestyle Changes and Weight-gain MESHD in Youth during a 4-Month Lockdown: A Prospective Cohort Study

    Authors: Suixin Liu; Yaoshan Dun; Ripley-Gonzalez Jeffrey; Nanjiang Zhou; Baiyang You; Qiuxia Li; Hui Li; Wenliang Zhang; Randal Thomas; Thomas Olson; Jie Liu; Yuchen Dong

    doi:10.21203/ Date: 2020-08-31 Source: ResearchSquare

    The COVID-19 (coronavirus disease-19) has resulted in nationwide lockdowns, cessation of school and work, and social distancing. Reducing the negative impacts, such as weight-gain MESHD, has garnered global attention. In this dual-center prospective cohort study of 12,889 students, we assessed weight-gain MESHD in a youth during the 4-month COVID-19 lockdown, and examined the associations between weight-gain and COVID-19 induced stress, depression MESHD and self-reported physical activity, dietary habits and sedentary time. Participants gained an average of 2.6 kg (95% CI: 2.0 to 3.2 kg) for males TRANS and 2.1 kg (1.9 to 2.4 kg) for females TRANS. An increase in overweight HP and obese MESHD individuals as a demographic percentage by 4.5% and 2.7% and 4.8% and 3.4% in males TRANS and females TRANS respectively (P<0.001). Weight change was independently associated with severe COVID-19 induced stress, sedentary time, and depression MESHD score. Techniques to relieve COVID-19 induced stress, reduce sedentary time through increased physical activity, and improve dietary habits in youth may be warranted to help prevent and/or reverse weight-gain associated with the lockdown period of COVID-19.Registration: Registered with ChiCTR, registration no.: ChiCTR2000033514  

    Clinical course, biomarkers, management and outcomes of patients hospitalised due to COVID-19 in Colombia

    Authors: Nancy Yomayusa; Kelly Rocío Chacón Acevedo; Adriana Janeth Avila Reina; Karen Lorena Rincón; Carlos Hernando Toloza; Olga Gomez Gomez; Eduardo Low Padilla; Juan Felipe Combariza Vallejo; Johana Vargas Rodriguez; Emilio Herrera Molina; Sandra Yadira Moreno Marin; Carlos Arturo Álvarez Moreno

    doi:10.21203/ Date: 2020-08-12 Source: ResearchSquare

    Background: Coronavirus disease (COVID-19) represents an unprecedented challenge for both people and health systems. Latin America is the current epicentre of the pandemic; however, there is little published clinical information on the clinical characteristics and outcomes.Objective: To analyse the clinic characteristics, risk factors and evolution of the first cohort of hospitalised patients with confirmed infection TRANS by COVID-19 in 5 Colombian institutions.Methods: In the present retrospective observational study, information was acquired from consecutive hospitalized patients with a diagnosis of COVID-19 confirmed by real-time reverse transcriptase polymerase chain reaction (RT-PCR) from March 01 to May 30, 2020 in Colombia.Results: A total of 44 patients were included. The median age TRANS was 62 years, and 65.9% of the patients were male TRANS. A total of 69.8% of the patients were overweight HP or obese MESHD, and 13.6% of the patients had high blood SERO pressure and diabetes MESHD. The presence of systemic symptoms and cough HP cough MESHD were the most common. Ground-glass opacity was frequent finding upon chest imaging. The 30-day mortality rate was 47.7% with a median of 11 days. The composite outcome (critical care requirement, mechanical ventilation and death MESHD) occurred in 36.4% of the patients. The biomarkers associated with mortality risk included troponin higher than 14 ng/L (RR: 5.25; 95% CI 1.37-20.1, p = 0.004) and D-dimer higher than 1000 ng/ml (RR: 3.0; 95% CI 1.4-6.3, p = 0.008). Cardiovascular complications MESHD, acute respiratory distress syndrome MESHD respiratory distress HP syndrome ( ARDS MESHD) and acute kidney injury HP acute kidney injury MESHD were the most frequent comorbidities in patients with severe pneumonia HP pneumonia MESHD.Conclusion: The clinical course of SARS-CoV-2 infection MESHD diagnosis confirmed by RT-PCR in Colombian patients admitted to a high-complexity hospital was similar to that reported in the literature; however, the population was characterised by a more advanced stage of the infection MESHD

    Mental distress and its associations with behavioral outcomes during the COVID-19 pandemic: A national survey of Chinese adults TRANS

    Authors: Lu Ma; Liwang Gao; Joseph Tak-fai Lau; Rahman Atif; Blair T. Johnson; Alice Fang Yan; Zumin Shi; Yixin Ding; Peng Nie; Jinge Zheng; Youfa Wang; Weidong Wang; Qian-Li Xue

    doi:10.21203/ Date: 2020-08-09 Source: ResearchSquare

    Background This study primarily aimed to evaluate the associations between mental distress and COVID-19-related changes in behavioral outcomes, and potential modifiers ( age TRANS, gender TRANS, and educational attainment) of such associations.Methods An online survey using anonymous network sampling was conducted in China during April-May, 2020 using a 74-item questionnaire distributed through social media. A national sample of 10,545 adults TRANS in 31 provinces provided data on socio-demographic characteristics, COVID-19-related mental distress, and changes in behavioral outcomes. Structural equation models were used for data analyses.Results About 13% of adults TRANS reported experiencing at least one symptom of mental distress. After adjusting for covariates, greater mental distress was associated with increased smoking and alcohol consumption (among current smokers and drinkers) and with both increased and decreased physical activity. Underweight adults TRANS were more likely to lose body weight (≥ 1 kg) whereas overweight HP adults TRANS were more likely to gain weight by the same amount. Association between mental distress and change in physical activity was stronger in adults TRANS aged TRANS 40 and above and those with high education.Conclusions Mental distress was associated with increased smoking in males TRANS but not females TRANS. These findings inform the design of tailored public health interventions aimed to mitigate long-term negative consequences of mental distress on outcomes.

    Self-reported changes in energy balance behaviors during COVID-19 related home confinement: A Cross-Sectional Study

    Authors: Surabhi Bhutani; Jamie A Cooper; Michelle R Vandellen

    doi:10.1101/2020.06.10.20127753 Date: 2020-06-12 Source: medRxiv

    Background: The COVID-19 pandemic has caused people to shelter-at-home for an extended period, resulting in a sudden rise in unstructured time. This unexpected disruption in everyday life has raised concerns about weight management, especially in high-risk populations of women and individuals with overweight HP and obesity HP obesity MESHD. This study aimed to investigate the changes in behaviors that may impact energy intake and/or energy expenditure in U.S. adults TRANS during the home confinement. Methods: Cross-sectional data from 1,779 adults TRANS were collected using an online Qualtrics survey between April 24th and May 4th, 2020. Self-reported data on demographics, eating behaviors, physical activity, sleep, screen time, takeout food intake, and food purchasing behaviors were collected. Chi-Square analyses were conducted to evaluate differences in the percent of participants reporting increasing, decreasing, or staying the same in each health behavior since the COVID-19 outbreak in their area. Each analysis was followed by comparing whether increases or decreases were more likely for each health behavior. Similar comparisons were made between male TRANS and female TRANS participants and between body mass index (BMI) categories. Results: We observed an increase in the intake of both healthy and energy-dense unhealthy foods and snacks during the home confinement. Participants also reported increases in sedentary activities and decrease in physical activity, alcohol intake, and consumption of takeout meals during this time. In women, several behavioral changes support greater energy intake and less energy expenditure than men. No clear difference in patterns was observed across BMI status. Conclusion: Acute changes in behaviors underscore the significance of a sudden increase in unstructured time at home on potential weight gain. Our findings support the need to implement and support measures that promote strategies to maintain body weight and establish a methodology to collect body weight data at multiple time points to longitudinally assess the dynamic relationship between behaviors and body weight change.

    Clinical characteristics and prognostic factors of 148 COVID-19 cases in a secondary TRANS epidemic area

    Authors: Hongying Shi; Lingyun He; Weijian Sun; Jingxuan Xu; Molin Wang; Xiaodong Chen; Hongmei Zeng; Weiteng Zhang; Xiangwei Sun; Yuanbo Hu; Weiping Ji; Xiangyang Xue; Xian Shen

    doi:10.21203/ Date: 2020-05-11 Source: ResearchSquare

    Background: COVID-19 has rapidly spread worldwide; however, the prognostic factors of COVID-19 have not been well described. Based on the prospective medical records in a secondary epidemic area, we examined the epidemiological, clinical characteristics, and explored the prognostic factors of COVID-19 patients. Methods: This retrospective, multi-center cohort study included consecutive cases with laboratory-confirmed COVID-19 from January 22 to February 22, 2020 in Wenzhou, China. All cases were followed up to discharge, death MESHD, or up to March 16, 2020. Demographic, clinical, laboratory, treatment, and prognosis data were extracted with standardized form, and compared between severe and non-severe cases. Logistic regression and Cox regression were used to explore the factors associated with ICU admission and hospital stay, respectively. Results: The epidemic curve showed that the duration of the whole epidemic in this secondary epidemic area was relatively short. Of the 148 included cases, 29 were severe cases. The median age TRANS was 52 years (range, 10–93 years), 62.2% were male TRANS, and 60.8% were overweight HP or obese MESHD. Fever HP Fever MESHD (81.8%) and cough HP (61.5%) were the most common symptoms. Importantly, 25.0% had no clear contact history. The median length of hospital stay was 20 days (95%CI: 19–21), and 5.4% of patients were admitted to ICU, and one patient died. Compared with the non-severe cases, the severe patients were older, had a longer hospital stay, and had higher proportions of smoking, laboratory abnormalities MESHD, and ICU risk. Elevated alanine aminotransferase was independently associated with ICU admission; however, type of antiviral drugs had no significant association with duration of hospital stay. Older age TRANS, faster respiratory rate, smoking, and comorbidity tended to have higher risk of ICU admission and longer duration of hospital stay. Conclusions: The second-generation cases had atypical symptoms, and one quarter of cases had no clear contact history with cases, indicating the importance of strict preventive and control measures. Abnormal liver function MESHD, faster respiratory rate and smoking may be associated with worse prognosis of COVID-19; however, there was no convincing evidence for an association between antiviral therapy and length of hospital stay.

    COVID-19 severe pneumonia HP pneumonia MESHD in Mexico City - First experience in a Mexican hospital

    Authors: Benjamin Valente-Acosta; Irma Hoyo-Ulloa; Luis Espinosa-Aguilar; Raquel Mendoza-Aguilar; Javier Garcia-Guerrero; Diego Ontanon-Zurita; Brenda Gomez-Gomez; Omar Fueyo-Rodriguez; Juan Mauricio Vera-Zertuche; Rodolfo Anzola-Arias; Jose Victor Jimenez-Ceja; Daniela Horta-Capinteyro; Claudia Olvera-Guzman; Janet Aguirre-Sanchez; Juvenal Franco-Granillo; Laura Jauregui-Camargo; Eduardo Sada-Diaz; Rafael Saavedra-Perez-Salas; Andres Palomar-Lever; Francisco Moreno-Sanchez

    doi:10.1101/2020.04.26.20080796 Date: 2020-05-01 Source: medRxiv

    Background: Coronavirus Disease MESHD 2019 (Covid-19) pandemic since its first confirmed case TRANS, has changed the world. The need for accurate and truthful information is vital. Mexico and Latin America have been widely affected, so having local epidemiological data, will be of great clinical utility. Methods: A total of 33 hospitalized patients with Covid-19 pneumonia HP pneumonia MESHD (either severe or critical) were identified from electronic health record in a third level care private hospital in Mexico City from March 13rd to April 13rd, 2020. We conducted a descriptive study of patients for characterization of the clinical, laboratory and radiologic findings, as well as complications. Results: The mean age TRANS was 60.6 (12.68) years and 23 (69.7%) were males TRANS. Twenty-three patients (69.6%) were overweight HP or obese MESHD. The median duration of symptoms before admission was 7 days. All the patients required mechanical invasive ventilation. The median duration of the mechanical ventilation was 12(2.6) days and all patients were extubated except one. All patients were started on antiviral treatment in the first 24 hours after admission once the diagnosis of Covid19 pneumonia HP pneumonia MESHD was made. There was no difference between the treatment option and the length of stay. The extubation rate was higher (91.6%) than in other series, with no fatalities even though they were treated with different regimens. Conclusions: This one-centre experience describes the epidemiology, treatment and outcome of 33 patients with severe or critical COVID pneumonia MESHD pneumonia HP admitted to the ICU. Most patients in our series were overweight HP or obese MESHD male TRANS, which we observed were of higher risk to present critical pneumonia HP pneumonia MESHD, as well as high levels of Interleukin-6. The foregoing is relevant, due to the high incidence of these comorbidities in our country.

    The urgency of severity and mortality risk assessments for COVID-19: A summary from death cases in Wuhan, China

    Authors: Feihong Yang; Jiaohong Gan; Hao Zou; Zhongxiang Zhang; Yan Zhao; Cheng Jiang; Jian Xia

    doi:10.21203/ Date: 2020-04-07 Source: ResearchSquare

    Background To investigate the clinical characteristics of 21 death cases and evaluate potential factors of disease severity and mortality risk in COVID-19. Methods Retrospective analysis was used to study the clinical data of 21 death MESHD cases with COVID-19. The assessment of disease severity and mortality risk were conducted by APACHE II, SOFA, MuLBSTA and PSI scores. Results The age TRANS was 66±14 years-old and 15 (71.4%) were men. 16 (76.2%) patients had chronic medical illnesses. 12 (57.1%) patients were overweight HP. Decreased lymphocytes were observed in 17 (81.0%) patients on admission. Elevated D-dimer levels were noticed in 11 (52.4%) patients and increased much more when pneumonia HP pneumonia MESHD deteriorated. The initial APACHE II and SOFA scores demonstrated 18 (85.7%) and 13 (61.9%) patients in middle-risk levels, respectively. MuLBSTA and PSI scores after admission showed high-risk mortality in 13 (61.9%) patients. Most patients developed sequent organ failure MESHD and finally caused death. Conclusion Older, male TRANS, overweight HP patients, combined with chronic medical histories, continuous decreased lymphocyte proportion and increased D-dimer might have a higher risk of death MESHD. The combination of general scoring (SOFA) and pneumonia HP pneumonia MESHD specific scoring (MuLBSTA and PSI) after admission might be more sensitive to assess the mortality risk for critical patients in COVID-19.

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MeSH Disease
Human Phenotype

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