Corpus overview


MeSH Disease

Human Phenotype


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    Possible silent hypoxemia HP hypoxemia MESHD in a COVID-19 patient: a case report

    Authors: Siswanto; Munawar Gani; Aditya Rifqi Fauzi; Bagus Nugroho; Denny Agustiningsih; Gunadi

    doi:10.21203/ Date: 2020-08-12 Source: ResearchSquare

    Background: It has been hypothesized that silent hypoxemia HP hypoxemia MESHD is the cause of the rapid progressive respiratory failure HP respiratory failure MESHD with severe hypoxia MESHD that occurs in some patients with COVID-19 without warning. Here, we reported one COVID-19 case with the possibility of silent hypoxemia HP hypoxemia MESHD. Case presentation: A 60-year-old male TRANS presented with complaints of cough HP that he felt starting two weeks before admission without any breathing difficulty. Complaints were accompanied by fever HP fever MESHD, runny nose and sore throat. Vital signs examination showed blood SERO pressure 130/75 mmHg, pulse 84 times per minute, normal respiratory rate (RR) of 21 times per minute, body temperature 36.5 C, and 99% oxygen saturation with oxygen via nasal cannula 3 liters per minute were recorded. On physical examination, an increase in vesicular sounds and crackles HP in both lungs were identified. Chest x-ray showed bilateral pneumonia HP pneumonia MESHD. Nasopharyngeal and oropharyngeal swab real-time polymerase chain reaction tests for COVID-19 were positive. On the third day of treatment, the patient complained of worsening of shortness of breath MESHD, but his RR was still normal with 22 times per minute. On the fifth day of treatment, the patient experienced severe shortness of breath MESHD with a RR of 38 times per minute. The patient was then intubated and his blood SERO gas analysis showed respiratory alkalosis HP respiratory alkalosis MESHD (pH 7.54, PaO2 58.9 mmHg, PaCO2 31.1 mmHg, HCO3 26.9 mEq/L, SaO2 94.7%). On the eighth day of treatment, his condition deteriorated starting in the morning, with blood SERO pressure 80/40 mmHg with norepinephrine support, pulse 109 times per minute, and 72% SpO2 with ventilator. In the afternoon, the patient experienced cardiac arrest HP cardiac arrest MESHD and underwent basic life support, then resumed strained breathing with return of spontaneous circulation. Blood SERO gas analysis showed severe respiratory acidosis HP respiratory acidosis MESHD (pH 7.07, PaO2 58.1 mmHg, PaCO2 108.9 mmHg, HCO3 32.1 mEq /L, SaO2 78.7%). Three hours later, he suffered cardiac arrest HP cardiac arrest MESHD again, but was unable to be resuscitated. The patient eventually died.Conclusions: Silent hypoxemia HP hypoxemia MESHD might be considered as an early clinical sign of deterioration of patients with COVID-19, thus, the physician may be able to intervene early and decrease its morbidity and mortality.


    Authors: Jose Luis Izquierdo; Julio Ancochea; - Savana COVID-19 Research Group; Joan B Soriano

    doi:10.1101/2020.05.22.20109959 Date: 2020-05-25 Source: medRxiv

    There remain many unknowns regarding the onset and clinical course of the ongoing COVID-19 pandemic. We used a combination of classic epidemiological methods, natural language processing (NLP), and machine learning (for predictive modeling), to analyse the electronic health records (EHRs) of patients with COVID-19. We explored the unstructured free text in the EHRs within the SESCAM Healthcare Network (Castilla La-Mancha, Spain) from the entire population with available EHRs (1,364,924 patients) from January 1st to March 29th, 2020. We extracted related clinical information upon diagnosis, progression and outcome for all COVID-19 cases, focusing in those requiring ICU admission. A total of 10,504 patients with a clinical or PCR-confirmed diagnosis of COVID-19 were identified, 52.5% males TRANS, with a mean age TRANS of 58.2 and S.D. 19.7 years. Upon admission, the most common symptoms were cough HP, fever HP fever MESHD, and dyspnoea MESHD, but all in less than half of cases. Overall, 6% of hospitalized patients required ICU admission. Using a machine-learning, data-driven algorithm we identified that a combination of age TRANS, fever HP fever MESHD, and tachypnoea was the most parsimonious predictor of ICU admission: those younger than 56 years, without tachypnoea, and temperature <39 C, (or >39 C without respiratory crackles HP), were free of ICU admission. On the contrary, COVID-19 patients aged TRANS 40 to 79 years were likely to be admitted to the ICU if they had tachypnoea and delayed their visit to the ER after being seen in primary care. Our results show that a combination of easily obtainable clinical variables ( age TRANS, fever HP fever MESHD, and tachypnoea with/without respiratory crackles HP) predicts which COVID-19 patients require ICU admission.

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MeSH Disease
Human Phenotype

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