Corpus overview


Overview

MeSH Disease

Human Phenotype

Transmission

Seroprevalence
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    Clinical Characteristics of Severe Covid Pneumonia HP: Exploring New Trends in ICU

    Authors: Aftab Akhtar; Sheher Bano; Ahtesham Iqbal; Moazma Ramzan; Aayesha Qadeer; Syed Waqar Hussain; Anam Saleem; Omair-ul-Haq Lodhi; Sana Zubair; Abdul Hameed kiani

    doi:10.21203/rs.3.rs-69224/v1 Date: 2020-08-31 Source: ResearchSquare

    Background: In late December 2019, Covid-19 emerged as clusters of pneumonia HP pneumonia MESHD of unknown cause in a province of china, Wuhan. Etiological agent was identified as novel coronavirus that resembles severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East Respiratory syndrome coronavirus (MERS-CoV) MESHD and has zoonotic transmission TRANS. Covid pneumonia HP can remain asymptomatic TRANS, present as mild infection, severe HP infection, severe MESHD pneumonia HP pneumonia MESHD or respiratory failure HP respiratory failure MESHD. Diagnosis is based on rRT-PCR carried out on respiratory secretions. Covid related mortality exceeds 50% once patient requires ICU admission. Objective: To study the characteristics of ICU population admitted to ICU of Shifa International hospital.Results: we prospectively analysed 74 patients which included 43.3% females TRANS and 56.7% males TRANS. Commonest symptoms were shortness of breath MESHD (94.5%), fever HP fever MESHD (74.3%) and cough HP (74.3%). Most of our study population consisted of non-smokers (79.7%) and had hypertension HP hypertension MESHD (59.4%) followed by diabetes MESHD (47.2%). Hydroxychloroquine (HCQ) and azithromycin combination is superior to hydroxychloroquine and doxycycline in reducing mortality (p=0.023) whereas Doxycycline alone resulted in increased mortality (p=0.009). Those who did not require antibiotics or required only narrow spectrum antibiotics had increased survival and reduced requirement of invasive mechanical ventilation (p=< 0.0001). in our study population, (44.9%) developed acute kidney injury HP acute kidney injury MESHD, 2.7% needed re-intubations 10.8% developed surgical emphysema HP emphysema MESHD and 2.7 % thromboembolic MESHD events despite full anticoagulation. ICU mortality was 41.8% and was higher in females TRANS (59.4%, p=0.008), those who had SOFA score > 3.5 at time of admission, raised D-Dimers > 931 ng/ml, NLR > 9.2. It was further high in those who required invasive mechanical ventilation and vasopressor support (58.1% mortality p=< 0.001). ICU stay was more prolonged in those requiring invasive mechanical ventilation as compared to those who did not. (23 days vs 6 days, p=0.001). Mean plateau pressure was 19.6 ± 7.6; mean Driving pressures 14.4 ± 4.6; mean PaO2/FiO2 150.7 ± 73.9; mean SPO2/FiO2 173.9 ± 106.9; mean PEEP was 8.2 ±4.33.Conclusion: We concluded that severe covid pneumonia HP pneumonia MESHD is common amongst males TRANS, non-smokers those who had comorbid. HCQ and azithromycin combination is superior to combination of HCQ and doxycycline or doxycycline alone and QT prolongation MESHD is a rare complication. Baseline NLR, APACHI II, SOFA, SAPS II, NUTRIC scores, D-Dimers, invasive ventilation and vasopressor support are important tools to predict ICU mortality. Invasive mechanical ventilation carries higher mortality and associated with more prolonged ICU stay. AKI is most common complication followed by shock HP and surgical emphysema HP emphysema MESHD. CRP, Ferritin levels has no impact on outcome.

    Multisystem inflammatory syndrome MESHD in children TRANS related to COVID-19: A systematic review

    Authors: Levi Hoste; Ruben Van Paemel; Filomeen Haerynck; Jacob J. Mansfield; Pranav Mellacheruvu; Pablo Monsivais; Lasse Lehtonen; Ahmed Geneid; Aruni Bhatnager; Pedro A Piedra; Larry R Ellingsworth; Gregory Glenn; Gale Smith; Joseph Torresi; Weisan Chen; Linda Wakim; Allen Cheng; Jan Petersen; Jamie Rossjohn; Adam K Wheatley; Stephen Kent; Louise Rowntree; Katherine Kedzierska; Mengge Lyu; Guixiang Xiao; Xia Xu; Weigang Ge; Jiale He; Jun Fan; Junhua Wu; Meng Luo; Xiaona Chang; Huaxiong Pan; Xue Cai; Junjie Zhou; Jing Yu; Huanhuan Gao; Mingxing Xie; Sihua Wang; Guan Ruan; Hao Chen; Hua Su; Heng Mei; Danju Luo; Dashi Zhao; Fei Xu; Yan Li; Yi Zhu; Jiahong Xia; Yu Hu; Tiannan Guo

    doi:10.1101/2020.08.17.20173641 Date: 2020-08-18 Source: medRxiv

    Importance. In April 2020, multiple reports of an association between a hyperinflammatory, Kawasaki-like condition and SARS-CoV-2 were published and termed as pediatric inflammatory multisystem syndrome MESHD ( PIMS MESHD) or multisystem inflammatory syndrome MESHD ( MIS MESHD). A thorough characterization of this syndrome (demographics, presentation, diagnosis, and outcome) is currently lacking. Objective. We aimed to perform a systematic review of published cases of this novel multisystem inflammatory syndrome MESHD in children TRANS associated with COVID-19. Evidence review. A literature search of Pubmed, Embase, BioRxiv, MedRxiv and COVID-19 specific research repositories (Cochrane COVID-19 Study Register and the World Health Organization (WHO) COVID-19 Global Research Database) was conducted from December 30th, 2019 to June 30th, 2020. Publications describing inflammatory syndromes associated with COVID-19 were included. Of 333 unique publications, 229 records were excluded based on title and abstract. After screening the full text, 40 observational studies and case reports were included, comprising 687 cases (published between May 9th, 2020 and June 30th, 2020). Findings. In contrast to classic Kawasaki disease MESHD, epidemiological enrichment for adolescents (median age TRANS 9 [6.0-12.3]) and ethnic minorities (35.8% black and 24.5% Hispanic/Latino) was observed. There was a male TRANS predominance (59.1%). Apart from obesity HP obesity MESHD (24.4%), pre-existing conditions were infrequent. The majority suffered from gastrointestinal (87.2%) and cardiocirculatory (79.2%) manifestations. Respiratory symptoms (51.2%) were less frequent. Over half of patients (56.3%) presented with hemodynamic shock HP, and critical care interventions were often necessary (inotropics (56.5%), mechanical ventilation (22.9%), non-invasive ventilation (30.6%), extracorporal membrane oxygenation (ECMO;4.5%)). Anti-SARS-CoV-2 IgG and RT-PCR were positive in respectively 69.4% and 36.7%. Eleven deaths MESHD were reported (1.6%). The RCPCH case definition proved to be most comprehensive comprising all single cases. In contrast, WHO and CDC MIS MESHD definitions are more stringent, with the CDC case definition often missing severe cases requiring intensive care (n = 33 out of 95 cases). Conclusions and Relevance. This novel pediatric multisystem hyperinflammatory condition MESHD, associated with COVID-19, is characterized by a severe and heterogeneous disease spectrum. Despite frequent intensive care interventions, mortality rate was low and short-term outcome favorable. Long-term follow-up of possible chronic complications and additional clinical research, to elucidate the underlying immunological pathogenesis and possible genetic predisposition is crucial.

    Clinical features and disease severity in an Iranian population of COVID-19 patients

    Authors: Shima Nabavi; Zahra Javidarabshahi; Abolghasem Allahyari; Mohammad Ramezani; Mohsen Seddigh-Shamsi; Sahar Ravanshad; Mina AkbariRad; Farnoosh Ebrahimzadeh; Shohre Khatami; Maryam Emadzadeh; Neda Saeedian; Ahmadreza Zarifian; Maryam Miri; Fariba Rezaeetalab; Sepide Hejazi; Reza Basiri; Mahnaz Mozdourian

    doi:10.21203/rs.3.rs-51568/v1 Date: 2020-07-31 Source: ResearchSquare

    Objectives: Coronavirus disease 2019 (COVID-19) can present with a variety of symptoms. Severity of the disease may be associated with several factors. Here, we review clinical features of COVID-19 patients with different severities.Methods: This cross-sectional study was performed in Imam Reza hospital, Mashhad, Iran, during February-April 2020. COVID-19 patients with typical computed tomography (CT) patterns and/or positive reverse-transcriptase polymerase chain reaction (RT-PCR) were included. The patients were classified into three groups of moderate, severe, and critical based on disease severity. Demographic, clinical, laboratory, and radiologic findings were collected and compared. P<0.05 was considered statistically significant.Results: Overall, 200 patients with mean age TRANS of 69.75±6.39 years, of whom 82 (41%) were female TRANS were studied. Disease was severe/critical in the majority of patients (167, 83.5%). Disease severity was significantly associated with age TRANS, malignant comorbidities, dyspnea HP dyspnea MESHD, nausea/vomiting HP nausea/vomiting MESHD, confusion HP confusion MESHD, respiratory rate, pulse rate, O2 saturation, extent of CT involvement, serum SERO C-reactive protein (CRP), pH, pO2, and aspartate transaminase (P<0.05). Moreover, complications including shock HP, coagulopathy MESHD, acidosis HP acidosis MESHD, sepsis HP sepsis MESHD, acute respiratory distress syndrome MESHD respiratory distress HP syndrome ( ARDS MESHD), intensive care unit (ICU) admission, and intubation were significantly higher in patients with higher severities. O2 saturation, nausea/vomiting HP nausea/vomiting MESHD, and extent of lung CT involvement were independent predictors of severe/critical COVID-19 (OR=0.342, 45.93, and 25.48, respectively; P<0.05).Conclusions: Our results indicate O2 saturation, nausea/vomiting HP nausea/vomiting MESHD, and extent of lung CT involvement as independent predictors of severe COVID-19 conditions. Serum SERO CRP levels and pO2 were also considerably higher patients with higher severity and can be used along with other factors as possible predictors of severe disease in COVID-19 patients.

    COVID-19 in-hospital mortality and mode of death MESHD in a dynamic and non-restricted tertiary care model in Germany

    Authors: Siegbert Rieg; Maja von Cube; Johannes Kalbhenn; Stefan Utzolino; Katharina Pernice; Lena Bechet; Johanna Baur; Corinna N Lang; Dirk Wagner; Martin Wolkewitz; Winfried V Kern; Paul Biever

    doi:10.1101/2020.07.22.20160127 Date: 2020-07-24 Source: medRxiv

    Background Reported mortality of hospitalised COVID-19 patients varies substantially, particularly in critically ill MESHD patients. So far COVID-19 in-hospital mortality and modes of death under optimised care conditions have not been systematically studied. Methods This retrospective observational monocenter cohort study was performed after implementation of a non-restricted, dynamic tertiary care model at the University Medical Center Freiburg, an experienced ARDS and ECMO referral center. All hospitalised patients with PCR-confirmed SARS-CoV-2 infection MESHD were included. The primary endpoint was in-hospital mortality, secondary endpoints included major complications and modes of death MESHD. A multistate analysis and a Cox regression analysis for competing risk models were performed. Modes of death MESHD were determined by two independent reviewers. Results Between February 25, and May 8, 213 patients were included in the analysis. The median age TRANS was 65 years, 129 patients (61%) were male TRANS. 70 patients (33%) were admitted to the intensive care unit (ICU), of which 57 patients (81%) received mechanical ventilation and 23 patients (33%) extracorporeal membrane-oxygenation (ECMO) support. According to the multistate model the probability to die within 90 days after COVID-19 onset was 24% in the whole cohort. If the levels of care at time of study entry were accounted for, the probabilities to die were 16% if the patient was initially on a regular ward, 47% if in the ICU and 57% if mechanical ventilation was required at study entry. Age TRANS >=65 years and male TRANS sex were predictors for in-hospital death. Predominant complications - as judged by two independent reviewers - determining modes of death MESHD were multi-organ failure, septic shock and thromboembolic and hemorrhagic complications MESHD shock HP and thromboembolic and hemorrhagic complications. Conclusion In a dynamic care model COVID-19-related in-hospital mortality remained substantial. In the absence of potent antiviral agents, strategies to alleviate or prevent the identified complications should be investigated. In this context, multistate analyses enable comparison of models-of-care and treatment strategies and allow estimation and allocation of health care resources.

    Risk factors associated with failure of high-flow nasal cannula oxygen therapy in patients with severe COVID-19 in Wuhan, China

    Authors: Xiao-huan Ma; Fang Yin; Jie Zhang; Meng-yun Peng; Hong Guan; Ping Gong

    doi:10.21203/rs.3.rs-41316/v1 Date: 2020-07-12 Source: ResearchSquare

    Methods: In this single-center, retrospective, observational study, we enrolled patients with confirmed severe COVID-19 admitted to Renmin Hospital of Wuhan university (Wuhan, China) from 1 February 2020 to 26 March 26 2020. Epidemiological, clinical, and laboratory data, and treatments and outcomes upon hospital admission, were obtained from electronic medical records. Sequential organ failure assessment (SOFA) scores were calculated.Results: Of 54 patients with severe COVID-19, HFNC was successful in 28 (51.9%) and unsuccessful in 26 (48.1%). HFNC failure MESHD was seen more commonly in patients aged TRANS ≥60 years and in men. In addition, compared with patients successfully treated with HFNC, patients with HFNC failure MESHD had the following characteristics: higher percentage of fatigue HP fatigue MESHD and anorexia HP anorexia MESHD as well as cardiovascular disease MESHD; increased time from onset to diagnosis and SOFA scores; elevated body temperature, respiratory rate, and heart rate; more complications including ARDS, septic shock MESHD shock HP, myocardial damage MESHD, and acute kidney injury HP acute kidney injury MESHD; increased neutrophil counts and prothrombin time; and decreased HP arterial partial pressure of oxygen/fraction of inspired oxygen (PaO2/FiO2) (all P < 0.05). However, binary logistic regression analysis showed that only male TRANS gender TRANS and PaO2/FiO2 were independent risk factors significantly associated with HFNC failure MESHD (both, P < 0.05). Conclusion: Patients with severe COVID-19 had a high HFNC treatment failure rate. Male TRANS gender TRANS and decreased PaO2/FiO2 were independent risk factors associated with HFNC failure MESHD in severe COVID-19 patients.

    Uncovering the Effects of COVID-19 Responses on the Lives of Commercial Sex Workers: A Phenomenological Study in Bahir Dar City Administration, Ethiopia

    Authors: Yohannes Mersha Belete

    doi:10.21203/rs.3.rs-39483/v1 Date: 2020-07-01 Source: ResearchSquare

    Background The novel coronavirus pandemic is the most shocking HP and unprecedented human tragedy of the 21st century, and it is regarded as a human, social and economic crisis. It is affecting every society throughout the world, but some groups of the society are suffering more because of it. Commercial sex workers are one of the groups adversely affected by the measures taken by governments to contain the spread of COVID-19. However, little is yet known about the impact of the coronavirus pandemic on sex workers across the globe. Hence, the main objective of this qualitative study is to shed light on the untold effects of COVID-19 responses on the lives of commercial sex workers by taking Bahir Dar City Administration, Ethiopia as a case in point.Methods To meet the objective of the study, a qualitative method with phenomenology research design was used. Twelve female TRANS sex workers were selected through snowball sampling technique. Telephone interviews were held with each of them. The data extracted from the participants were analyzed using thematic qualitative data analysis technique, and member checking system was employed to validate the quality of the data.Results The results indicate that commercial sex workers have encountered unique problems after the enforcement of coronavirus-related regulations and laws. Sex workers have lost their job, and most of them have faced problems to cover their basic need expenses. They are at high risk to be starved in this coronavirus period. Financial problems have forced them to practice unprotected sex and sleep with unhygienic clients. This implies that coronavirus pandemic can be associated with the spread of HIV among sex workers. Their suffering has been further exacerbated by lack of support from the government, stigma at shopping places and structural stigma. Moreover, the nature of their job has exposed them to be easily infected with coronavirus. All these agonies have plunged sex workers into the depths of frustration and anxiety HP anxiety MESHD.Conclusion Based on the results of the study, it was concluded that government measures in response to COVID-19 have put many commercial sex workers in a dire situation. This suggests that there is an urgent need to support them and the government should provide economic and social supports to lessen the effects of COVID19 on the lives of sex workers.

    Risk factors associated with failure of high-flow nasal cannula oxygen therapy in patients with severe COVID-19 in Wuhan, China

    Authors: Xiao-huan Ma; Fang Yin; Jie Zhang; Meng-yun Peng; Hong Guan; Ping Gong

    doi:10.21203/rs.3.rs-37538/v1 Date: 2020-06-22 Source: ResearchSquare

    Background Acute hypoxemic respiratory failure MESHD respiratory failure HP is prevalent in severe Coronavirus Disease MESHD 2019 (COVID-19). High-flow nasal canula (HFNC) is currently the most common ventilation strategy for COVID-19 patients with respiratory failure HP respiratory failure MESHD. This study is to analyze the risk factors associated with high-flow nasal canula (HFNC) oxygen therapy failure MESHD in patients with severe COVID-19.Methods: In this single-center, retrospective, observational study, we enrolled patients with confirmed severe COVID-19 admitted to Renmin Hospital of Wuhan university (Wuhan, China) from 1 February 2020 to 26 March 26 2020. Epidemiological, clinical, and laboratory data, and treatments and outcomes upon hospital admission, were obtained from electronic medical records. Sequential organ failure assessment (SOFA) scores were calculated.Results: Of 54 patients with severe COVID-19, HFNC was successful in 28 (51.9%) and unsuccessful in 26 (48.1%). HFNC failure MESHD was seen more commonly in patients aged TRANS ≥60 years and in men. In addition, compared with patients successfully treated with HFNC, patients with HFNC failure MESHD had the following characteristics: higher percentage of fatigue HP fatigue MESHD and anorexia HP anorexia MESHD as well as cardiovascular disease MESHD; increased time from onset to diagnosis and SOFA scores; elevated body temperature, respiratory rate, and heart rate; more complications including ARDS, septic shock MESHD shock HP, myocardial damage MESHD, and acute kidney injury HP acute kidney injury MESHD; increased neutrophil counts and prothrombin time; and decreased HP arterial partial pressure of oxygen/fraction of inspired oxygen (PaO2/FiO2) (all P < 0.05). However, binary logistic regression analysis showed that only male TRANS gender TRANS and PaO2/FiO2 were independent risk factors significantly associated with HFNC failure MESHD (both, P < 0.05). Conclusion: Patients with severe COVID-19 had a high HFNC treatment failure rate. Male TRANS gender TRANS and decreased PaO2/FiO2 were independent risk factors associated with HFNC failure MESHD in severe COVID-19 patients.

    Gender TRANS Inequality in Research Productivity During the COVID-19 Pandemic

    Authors: Ruomeng Cui; Hao Ding; Feng Zhu

    id:2006.10194v3 Date: 2020-06-17 Source: arXiv

    We study the disproportionate impact of the lockdown as a result of the COVID-19 outbreak on female TRANS and male TRANS academics' research productivity in social science. The lockdown has caused substantial disruptions to academic activities, requiring people to work from home. How this disruption affects productivity and the related gender TRANS equity is an important operations and societal question. We collect data from the largest open-access preprint repository for social science on 41,858 research preprints in 18 disciplines produced by 76,832 authors across 25 countries over a span of two years. We use a difference-in-differences approach leveraging the exogenous pandemic shock HP. Our results indicate that, in the 10 weeks after the lockdown in the United States, although the total research productivity increased by 35%, female TRANS academics' productivity dropped by 13.9% relative to that of male TRANS academics. We also show that several disciplines drive such gender TRANS inequality. Finally, we find that this intensified productivity gap is more pronounced for academics in top-ranked universities, and the effect exists in six other countries. Our work points out the fairness issue in productivity caused by the lockdown, a finding that universities will find helpful when evaluating faculty productivity. It also helps organizations realize the potential unintended consequences that can arise from telecommuting.

    Serology confirms SARS-CoV-2 infection MESHD in PCR-negative children TRANS presenting with Paediatric Inflammatory Multi-System Syndrome MESHD

    Authors: Marisol Perez-Toledo; Sian E. Faustini; Sian E. Jossi; Adrian Shields; Hari Krishnan Kanthimathinathan; Joel D. Allen; Yasunori Watanabe; Margaret Goodall; David C. Wraith; Tonny V. Veenith; Mark T. Drayson; Deepthi Jyothish; Eslam Al-Abadi; Ashish Chikermane; Steven Welch; Kavitha Masilamani; Scott Hackett; Max Crispin; Barnaby Scholefield; Adam F. Cunningham; Alex G. Richter

    doi:10.1101/2020.06.05.20123117 Date: 2020-06-07 Source: medRxiv

    Background. During the COVID-19 outbreak, reports have surfaced of children TRANS who present with features of a multisystem inflammatory syndrome MESHD with overlapping features of Kawasaki disease MESHD and toxic shock syndrome - Paediatric Inflammatory Multisystem Syndrome MESHD shock HP syndrome - Paediatric Inflammatory Multisystem Syndrome- temporally associated with SARS-CoV-2 pandemic (PIMS-TS). Initial reports find that many of the children TRANS are PCR-negative for SARS-CoV-2, so it is difficult to confirm whether this syndrome is a late complication of viral infection MESHD in an age group TRANS largely spared the worst consequences of this infection, or if this syndrome reflects enhanced surveillance. Methods. Children TRANS hospitalised for symptoms consistent with PIMS-TS between 28 April and 8 May 2020, and who were PCR-negative for SARS-CoV-2, were tested for antibodies SERO to viral spike glycoprotein using an ELISA SERO test. Results. Eight patients ( age TRANS range 7-14 years, 63% male TRANS) fulfilled case-definition for PIMS-TS during the study period. Six of the eight patients required admission to intensive care. All patients exhibited significant IgG and IgA responses to viral spike glycoprotein. Further assessment showed that the IgG isotypes detected in children TRANS with PIMS-TS were of the IgG1 and IgG3 subclasses, a distribution similar to that observed in samples from hospitalised adult TRANS COVID-19 patients. In contrast, IgG2 and IgG4 were not detected in children TRANS or adults TRANS. IgM was not detected in children TRANS, which contrasts with adult TRANS hospitalised adult TRANS COVID-19 patients of whom all had positive IgM responses. Conclusions. Strong IgG antibody SERO responses can be detected in PCR-negative children TRANS with PIMS-TS. The low detection rate of IgM in these patients is consistent with infection MESHD having occurred weeks previously and that the syndrome onset occurs well after the control of SARS-CoV-2 viral load. This implies that the disease is largely immune-mediated. Lastly, this indicates that serology can be an appropriate diagnostic tool in select patient groups.

    Comparative Clinical Characteristics Among Different Age Group TRANS of Adult TRANS COVID-19 Patients

    Authors: yating peng; Aiyuan Zhou; Xin Liao; Dingding Deng; Peng Huang; Wenlong Liu; Mingyan Jiang; Xudong Xiang; Qingcui Shuang; Shan Cai; Ping Chen; Xucai Liao

    doi:10.21203/rs.3.rs-32853/v1 Date: 2020-06-01 Source: ResearchSquare

    Introduction: Coronavirus disease (COVID-19) is a global infectious disease MESHD with a large burden of illness and high healthcare costs.Objectives: This study aimed to compare clinical features among adult TRANS COVID-19 patients in different age groups TRANS.Methods: Laboratory-confirmed adult TRANS COVID-19 infection MESHD cases between Dec 31, 2019 to March 8, 2020obtained from Neighboring Cities. Patients weredivided into five age groups TRANS:age<30, 30-40, 40-50, 50-65, ≥65 y ( elderly TRANS). Age TRANS, sex, history of chronic disease MESHD and epidemiology, symptoms, laboratory tests, and outcomes were compared among different agegroups. Binary logistic regression analysis was conducted to evaluate associated factors for severe or critical type.Results:We studied 299 cases. Median (IQR) age TRANS was 44(34,54) and 158 (53%) were male TRANS. Percent of bilateral involvement on chest radiographs was increased significantly with older age TRANS (p=0.005). 53.3% of 30-40 years, 50% of 40-50 years, 36.6% of <30 years and 36.2% of 50-60 years were imported case, none of the elderly TRANS were imported case. Among all the observed symptoms, only symptom of dyspnea HP dyspnea MESHD was significantly different between the elderly TRANS group and other groups (p < 0.001).Proportion of severe or critical type was 2.4%, 5.3%, 9.5%, 14.5%, and 35%in patients with age<30, 30-40, 40-50, 50-65, ≥65 (p < 0.001), respectively. At this point, ICU admissionrate, ARDSand shock HP rate and on medical treatment rate was increased especially in patients ≥65 years. 285 patients (95.3%) were curedand discharged, 12 patients (4.0%) were still on medical treatment in hospital. There were 2 (0.67%) deaths; these occurred among persons ≥65 y (p < 0.001). Old age TRANS, high HR on admission,high respiratory rate on admission, and history of chronic heart diseasewere independently associated with severe or critical .Conclusions:Proportion of severe or critical type increased with old age groups TRANS. Adults TRANS with old ageand high HR, R rate in admission and history of chronic heart disease MESHD were associated withsevere or criticaltype in COVID-19.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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