Corpus overview


MeSH Disease

Human Phenotype



There are no seroprevalence terms in the subcorpus

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    Covid-19 in South America: Clinical and Epidemiological Characteristics Among 381 Patients During the Early Phase of the Pandemic in Santiago, Chile

    Authors: Macarena Rodriguez; Anne Peters; Inia Perez; Maria Spencer; Mario Barbe; Lorena Porte; Thomas Weitzel; Mabel Aylwin; Pablo Vial; Rafael Araos; Jose M Munita

    doi:10.21203/ Date: 2020-08-23 Source: ResearchSquare

    Background: Understanding the characteristics of the Covid-19 pandemic in different geographical regions, ethnic and socioeconomic settings are of emerging importance. This study presents the demographic and clinical features of SARS-CoV-2 infected MESHD patients in a large private healthcare center in Santiago, Chile, during the first month of the pandemic.Methods: We analyzed the demographics, laboratory and clinical characteristics including severity and outcome of all patients diagnosed with Covid-19 during the first month of the pandemic. SARS-2-CoV infection MESHD infection was confirmed TRANS by RT-PCR in nosopharyngeal samples. The primary outcome was a composite of ICU admission or all-cause, in-hospital mortality. Clinical and laboratory parameters of hospitalized patients were analyzed regarding their association with the primary outcome. Results: From March 3 to April 4, 2020, 3679 individuals were tested for SARS-CoV-2 in our hospital. Of those, 381 had Covid-19 and were included into this analysis. Most patients (99.2%) were Chileans, 12% returning from recent travel TRANS. The median age TRANS was 39 years (IQR 31-49) and 52% were female TRANS. A total of 88 patients (23.1%) were hospitalized; 18 (3.7%) required ICU and/or died. The overall mortality was 0.7%. Increased body mass index HP (BMI) and elevated C-reactive protein (CRP) were independently associated with ICU care or death MESHD.Conclusion: During the first weeks of the pandemic in Chile, most Covid-19 patients were young, with low rates of hospitalization, ICU requirement, and fatality. BMI and CRP on admission were predictors for severity. Our data provide important information on the clinical course and outcome of Covid-19 in a Latin American setting.  

    Patient trajectories and risk factors for severe outcomes among persons hospitalized for COVID-19 in the Maryland/DC region

    Authors: Brian T Garibaldi; Jacob Fiksel; John Muschelli; Matthew L Robinson; Masoud Rouhizadeh; Paul Nagy; Josh H Gray; Harsha Malapati; Mariam Ghobadi-Krueger; Timothy M Niessen; Bo Soo Kim; Peter M Hill; M. Shafeeq Ahmed; Eric D Dobkin; Renee Blanding; Jennifer Abele; Bonnie Woods; Kenneth Harkness; David R Thiemann; Mary Grace Bowring; Aalok B. Shah; Mei Cheng Wang; Karen Bandeen-Roche; Antony Rosen; Scott L Zeger; Amita Gupta

    doi:10.1101/2020.05.24.20111864 Date: 2020-05-26 Source: medRxiv

    Background: Risk factors for poor outcomes from COVID-19 are emerging among US cohorts, but patient trajectories during hospitalization ranging from mild-moderate, severe, and death MESHD and the factors associated with these outcomes have been underexplored. Methods: We performed a cohort analysis of consecutive COVID-19 hospital admissions at 5 Johns Hopkins hospitals in the Baltimore/DC area between March 4 and April 24, 2020. Disease severity and outcomes were classified using the WHO COVID-19 disease severity ordinal scale. Cox proportional-hazards regressions were performed to assess relationships between demographics, clinical features and progression to severe disease or death MESHD. Results: 832 COVID-19 patients were hospitalized; 633 (76.1%) were discharged, 113 (13.6%) died, and 85 (10.2%) remained hospitalized. Among those discharged, 518 (82%) had mild/moderate and 116 (18%) had severe illness. Mortality was statistically significantly associated with increasing age TRANS per 10 years (adjusted hazard ratio (aHR) 1.54; 95%CI 1.28-1.84), nursing home residence (aHR 2.13, 95%CI 1.41-3.23), Charlson comorbidity index (1.13; 95% CI 1.02-1.26), respiratory rate (aHR 1.13; 95%CI 1.09-1.17), D-dimer greater than 1mg/dL (aHR 2.79; 95% 1.53-5.09), and detectable troponin (aHR 2.79; 95%CI 1.53-5.09). In patients under 60, only male TRANS sex (aHR 1.7;95%CI 1.11-2.58), increasing body mass index HP (BMI) (aHR1.25 1.14-1.37), Charlson score (aHR 1.27; 1.1-1.46) and respiratory rate (aHR 1.16; 95%CI 1.13-1.2) were associated with severe illness or death MESHD. Conclusions: A combination of demographic and clinical features on admission is strongly associated with progression to severe disease MESHD or death MESHD in a US cohort of COVID-19 patients. Younger patients have distinct risk factors for poor outcomes.

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MeSH Disease
Human Phenotype

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