Corpus overview


MeSH Disease

Human Phenotype



There are no seroprevalence terms in the subcorpus

    displaying 1 - 3 records in total 3
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    Immediate Effects of COVID-19 Outbreak on Psychiatric Outpatients: Posttraumatic Stress MESHD and Influencing Factors

    Authors: Burc Cagri Poyraz; Cana Aksoy Poyraz; Senol Turan; Omer Faruk Demirel; Yasin Kavla; Ersel Bulu; Irem Hacisalihoglu; Elif Burcu Ersungur; Li Shen; Dokyoon Kim; Eduardo Marquez-Garcia; Edda Sciutto; Jose Moreno-Rodriguez; Jose Omar Barreto-Rodriguez; Hazel Vazquez-Rojas; Gustavo Ivan Centeno-Saenz; Nestor Alvarado-Pena; Citlaltepetl Salinas-Lara; Carlos Sanchez-Garibay; Gabriela Hernandez-Molina; Criselda Mendoza-Milla; Andrea Dominguez; Julio Granados; Lula Mena-Hernandez; Luis Angel Perez-Buenfil; Guillermo Dominguez-Cheritt; Carlos Cabello-Gutierrez; Cesar Luna-Rivero; Jorge Salas-Hernandez; Patricio Santilla-Doherty; Justino Regalado; Angelica Hernandez-Martinez; Lorena Orozco; Ethel A. Garcia-Latorre; Carmen M. Hernandez-Cardenas; Shabaana A. Khader; Albert Zlotnik; Joaquin Zuniga

    doi:10.1101/2020.08.12.20173468 Date: 2020-08-14 Source: medRxiv

    We aimed to investigate the effects of COVID-19 outbreak and public health measures on the psychological well-being of patients with psychiatric disorders MESHD. This cross-sectional study assessed 436 outpatients recruited from a tertiary psychiatry clinic in Istanbul, Turkey, nearly one month after the government introduced strict measures of lockdown against the ongoing outbreak. Respondents completed a web-based survey on sociodemographic data, subjective sleep quality, and a range of psychiatric MESHD symptoms using the Impact of Events Scale-Revised (IES-R), and Hospital Anxiety HP Anxiety MESHD and Depression Scale (HADS). Respondents reported high frequencies of clinically significant posttraumatic stress disorder MESHD ( PTSD MESHD) (32.6%, IES-R score equal to or above 33), anxiety HP anxiety MESHD (36.4%, HADS anxiety MESHD anxiety HP score > 10), and depression MESHD (51%, HADS depression MESHD score > 10). 20.5% of respondents described that their psychological status worsened during the COVID-19 outbreak, and 12.1% of respondents described poor or very poor sleep in the prior month. Positive predictors of increased PTSD MESHD symptoms included the chronic medical diseases, knowing someone in the social vicinity diagnosed with the COVID-19 infection MESHD, job loss MESHD or being on temporary leave after the outbreak, and increased exposure time to TV or social media. In contrast, male TRANS gender TRANS, older age TRANS, higher educational attainment, and the psychiatric MESHD diagnoses of schizophrenia HP schizophrenia MESHD and (to a lesser degree) bipolar disorder MESHD were the negative predictors. Our results suggest that patients with psychiatric disorders MESHD are prone to substantial psychological distress during the COVID-19 outbreak, and various individual, behavioral, and social factors mediate this effect.

    Clozapine treatment and risk of COVID-19.

    Authors: Risha Govind; Daniela Fonesca de Freitas; Megan R Pritchard; Richard D Hayes; James H MacCabe

    doi:10.1101/2020.06.17.20133595 Date: 2020-06-20 Source: medRxiv

    Background Clozapine, an antipsychotic with unique efficacy in treatment resistant psychosis HP psychosis MESHD, is associated with increased susceptibility to infection, including pneumonia HP pneumonia MESHD. Aims To investigate associations between clozapine treatment and increased risk of COVID-19 in patients with schizophrenia HP schizophrenia MESHD-spectrum disorders who are receiving antipsychotic medications, using electronic health records data, in a geographically defined population in London. Method Using information from South London and Maudsley NHS Foundation Trust (SLAM) clinical records, via the Clinical Record Interactive Search system, we identified 6,309 individuals who had an ICD-10 diagnosis of schizophrenia HP schizophrenia MESHD-spectrum disorders and were taking antipsychotics at the time on the COVID-19 pandemic onset in the UK. People who were on clozapine treatment were compared with those on any other antipsychotic treatment for risk of contracting COVID-19 between 1 March and 18 May 2020. We tested associations between clozapine treatment and COVID-19 infection MESHD, adjusting for gender TRANS, age TRANS, ethnicity, BMI, smoking status, and SLAM service use. Results Of 6,309 patients, 102 tested positive for COVID-19. Individuals who were on clozapine had increased risk of COVID-19 compared with those who were on other antipsychotic medication (unadjusted HR = 2.62 (95% CI 1.73 - 3.96), which was attenuated after adjusting for potential confounders, including clinical contact (adjusted hazard ratio HR=1.76, 95% CI 1.14 - 2.72). Conclusions These findings provide support for the hypothesis that clozapine treatment is associated with an increased risk of COVID-19. Further research will be needed in other samples to confirm this association. Potential clinical implications are discussed.

    Effect of underlying comorbidities on the infection MESHD and severity of COVID-19 in South Korea

    Authors: Wonjun Ji; Kyungmin Huh; Minsun Kang; Jinwook Hong; Gi Hwan Bae; Rugyeom Lee; Yewon Na; Hyoseon Choi; SeonYeong Gong; Yoon-Hyeong Choi; Kwang-Pil Ko; Jeong-Soo Im; Jaehun Jung

    doi:10.1101/2020.05.08.20095174 Date: 2020-05-11 Source: medRxiv

    ABSTRACT Background: The coronavirus disease MESHD (COVID-19) pandemic is an emerging threat worldwide. It is still unclear how comorbidities affect the risk of infection TRANS risk of infection TRANS infection MESHD and severity of COVID-19. Methods: A nationwide retrospective case-control study of 65,149 individuals, aged TRANS 18 years or older, whose medical cost for COVID-19 testing were claimed until April 8, 2020. The diagnosis of COVID-19 and severity of COVID-19 infection were identified from the reimbursement data using diagnosis codes and based on whether respiratory support was used, respectively. Odds ratios were estimated using multiple logistic regression, after adjusting for age TRANS, sex, region, healthcare utilization, and insurance status. Results: The COVID-19 group (5,172 of 65,149) was younger and showed higher proportion of females TRANS. 5.6% (293 of 5,172) of COVID-19 cases were severe. The severe COVID-19 group had older patients and a higher male TRANS ratio than the non-severe group. Cushing syndrome MESHD (Odds ratio range (ORR) 2.059-2.358), chronic renal disease MESHD (ORR 1.292-1.604), anemia HP anemia MESHD (OR 1.132), bone marrow dysfunction MESHD (ORR 1.471-1.645), and schizophrenia HP schizophrenia MESHD (ORR 1.287-1.556) showed significant association with infection MESHD of COVID-19. In terms of severity, diabetes MESHD (OR 1.417, 95% CI 1.047-1.917), hypertension HP hypertension MESHD (OR 1.378, 95% CI 1.008-1.883), heart failure MESHD (ORR 1.562-1.730), chronic lower respiratory disease MESHD (ORR 1.361-1.413), non-infectious lower digestive system disease (ORR 1.361-1.418), rheumatoid arthritis HP rheumatoid arthritis MESHD (ORR 1.865-1.908), substance use (ORR 2.790-2.848), and schizophrenia HP schizophrenia MESHD (ORR 3.434-3.833) were related with severe COVID-19. Conclusions: We identified several comorbidities associated with COVID-19. Health care workers should be more careful when diagnosing and treating COVID-19 when the patient has the above-mentioned comorbidities. Keywords: COVID-19, SARS-CoV-2, Comorbidity, Risk factor, Severity

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MeSH Disease
Human Phenotype

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