Corpus overview


Overview

MeSH Disease

There are no MeSH Disease terms in the subcorpus


Human Phenotype

Transmission

Seroprevalence
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    High prevalence SERO of SARS-CoV-2 Infection Among Symptomatic Healthcare Workers in a large university tertiary hospital in São Paulo, Brazil

    Authors: Carolina Palamin Buonafine; Beatriz Nobre Monteiro Paiatto; Fabyano Leal; Samantha Matos; Camila Ohomoto Moraes; Giovanna Guazzelli Guerra; Marcus Vinicius Vidal Martuchelli; Danielle Leal Oliveira; Edison Luiz Durigon; Camila Pereira Soares; Erika Donizette Candido; Bruna Larotonda Telezynski; Marco Aurelio Safadi; Flavia Jacqueline Almeida

    doi:10.21203/rs.3.rs-42898/v1 Date: 2020-07-14 Source: ResearchSquare

    Background: Latin America became the epicenter of the COVID-19 pandemic in May 2020, mostly driven by Brazil's situation. Healthcare workers are at increased risk of SARS-CoV-2 infection, experiencing a significant burden from COVID-19. Identifying and understanding the clinical characteristics and risk factors associated with infection are of paramount importance to inform screening strategies and infection control practices in this scenario. The aims of this study were to investigate the prevalence SERO and clinical characteristics of healthcare workers with COVID-19 symptoms. Methods: Between March 21st and May 22nd, 2020 a cross-sectional study was performed in a tertiary university hospital in São Paulo. Prevalence SERO of SARS-CoV-2 infection among health care workers with COVID-19 symptoms was determined by RT-PCR testing on nasopharyngeal and oropharyngeal samples. Participants were asked to complete an electronic structured questionnaire including clinical and demographic data. Results: Overall, 125 (42.37%) of 295 symptomatic healthcare workers tested positive for SARS-CoV-2. Over the 10-week study period, positivity rates varied from 22.2% (CI 95% 15.9% - 60.3%) in the second week to 55.9% (CI 95% 43.2% - 68.6%) in the sixth week, reaching a plateau (38% - 46%) thereafter. Median (SD) age TRANS was 34.2 ( 9.9) years and 205 (69.5%) were female TRANS. We did not find significant differences in the prevalence SERO of the most commonly reported underlying medical condition among healthcare workers that tested positive or negative for SARS-CoV-2 infection. After multivariate analysis, using logistic regression, anosmia HP (OR 4.4 95% C.I. 2.21 - 8.74) and ocular pain HP (OR 1.95 C.I. 95% 1.14 - 3.33) were the only symptoms independently associated with positivity for SARS-CoV-2 infection. Follow-up information on clinical outcomes showed that 9 (7.2%) healthcare workers were hospitalized (seven were male TRANS) and 2 (1.6%) died.Conclusions: The findings of this study confirmed the high burden of SARS-CoV-2 infection among healthcare workers in the hardest hit city by the pandemic in Latin America. Anosmia HP and ocular pain HP were symptoms independently associated with COVID-19 diagnosis. In low and middle-income countries, where limited availability of tests is frequent, these findings may contribute to optimize a targeted symptom-oriented screening strategy.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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