Corpus overview


MeSH Disease

Human Phenotype

Fever (39)

Cough (31)

Pneumonia (29)

Fatigue (12)

Hypertension (11)


    displaying 101 - 110 records in total 130
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    Countrywide quarantine only mildly increased anxiety HP anxiety MESHD level during COVID-19 outbreak in China

    Authors: Wei Hu; Li Su; Juan Qiao; Jing Zhu; Yi Zhou

    doi:10.1101/2020.04.01.20041186 Date: 2020-04-04 Source: medRxiv

    In the recent outbreak of COVID-19, many countries have taken various kinds of quarantine measures to slow down the explosive spreading of COVID-19. Although these measures were proven to be successful in stopping the outbreak in China, the potential adverse effects of countrywide quarantine have not been thoroughly investigated. In this study, we performed an online survey to evaluate the psychological effects of quarantine in China using Zung Self-rating Anxiety HP Anxiety MESHD Scale in February 2020 when the outbreak was nearly peaked in China. Along with the anxiety HP anxiety MESHD scores, limited personal information such as age TRANS, gender TRANS, region, education, occupation and specifically, the type and duration of quarantine were collected for analysis. For a total number of 992 valid questionnaires, clinical significance of anxiety HP anxiety MESHD symptoms was observed in 9.58% respondents according to clinical diagnostic standards in China. Statistical results showed population with different age TRANS, education level, health status and personnel category responded differently. Other characteristics such as gender TRANS, marital status, region, and acquaintance with suspected or confirmed cases TRANS of COVID-19 did not affect anxiety HP anxiety MESHD levels significantly. Respondents experienced different forms of quarantine showed different anxiety HP anxiety MESHD levels. Unexpectedly, longer durations of quarantine did not lead to significant increase of anxiety HP anxiety MESHD level. Our results suggest a rather mild negative psychological influence caused by the countrywide quarantine during COVID-19 outbreak in China and provided reference for other countries and regions to battle COVID-19.

    Descriptive study of the first 63 cases of the ongoing SARS-CoV-2 outbreak at the transportation hub city Xuzhou in China

    Authors: Liang Wang; Jiawei Yan; Zhanzhong Liu; Jianye Yang; Yangguang Du; Michael J. Wise; Mingqiu Wu; Xiangyu Xi; Xiao Zhang; Bing Gu

    doi:10.21203/ Date: 2020-04-04 Source: ResearchSquare

    A novel coronavirus (SARS-CoV-2) outbreak from Wuhan, China has, as of February 13, 2020, infected nearly 60,000 people in China with the death toll passing 1300. The virus is also spreading worldwide rapidly, with 490 confirmed cases TRANS in 24 countries and 1 death MESHD at current stage. Numerous studies have recently been published in terms of genome structure, transmission TRANS, infection mechanism, and drug development of the SARS-CoV-2 virus. In this study, we performed a descriptive study by focusing on the first 63 confirmed COVID-19 cases in Xuzhou, a major city and a transportation hub with 10.44 million population (National Bureau of Statistics of China, 2019) on the east coast of China. Among the 63 patients with confirmed COVID-19, the median age TRANS is 45-year-old and 49.21% are male TRANS. 23 cases (36.51%) are imported. 23 cases (36.51%) were confirmed between from January 26 to 31 while 40 cases (63.49%) from February 1 to 10. The mean period from isolation to confirmation is 4.95 days. Among the ten administrative divisions of Xuzhou city, Suining county (n=17) and Pizhou City (n=15) have the most cases while Tongshan district has none. A representative familial cluster was analysed in detail in order to get a better understanding of the transmission TRANS routes of the virus. Clinical symptoms associated with COVID-19 in 41 confirmed cases TRANS were analysed, which could provide a meaningful understanding during the initial screening of the disease. In sum, this study provides an epidemiological overview of the SARS-CoV-2 outbreak in Xuzhou, the economic hub of Huaihai Economic Zone (HEZ) and an important transportation center in China. Considering the ongoing situation of this newly emerged infection MESHD both domestically and internationally, more efforts should be required to reduce the transmission TRANS of the virus so as to avoid further casualties, economic losses, and global pandemic.Authors Liang Wang, Jiawei Yan, and Zhanzhong Liu contributed equally to this study.

    The multicenter study of Chest HRCT imaging characteristics of 2019 Novel Coronavirus (COVID-19) Pneumonia HP

    Authors: Zhehao Lyu; Meiji Ren; Lian-Ming Wu; Yuxin Yang; Yi-Bo Lu; Li Li; Xiaoming Gong; Zhiyan Lu; Hongjun Li

    doi:10.21203/ Date: 2020-04-02 Source: ResearchSquare

    Background: In December 2019, a cluster of patients with pneumonia HP pneumonia MESHD of unknown cause was linked to a seafood wholesale market in Wuhan, China. A novel coronavirus was detected, capable of infecting humans, on 6 January 2020 and termed COVID-19. By 16 February 2020, there were 51857 confirmed cases TRANS with 2019-nCoV (COVID-19) pneumonia HP pneumonia MESHD in 25 countries. COVID-19 can also lead to acute respiratory distress syndrome MESHD respiratory distress HP syndrome ( ARDS MESHD).Methods: 149 patients with 2019 Novel Coronavirus (COVID-19) pneumonia HP pneumonia MESHD(68 males TRANS, 81 females TRANS, ages TRANS 1-89)from 6 research centers in China were diagnosed with positive 2019 Novel Coronavirus(COVID-19)nucleic acids antibodies SERO. And their high-resolution computed tomography(HRCT) imaging datas were evaluated.Results: 136/149(91.3%)patients had a clear history of exposure to Wuhan. Fever HP Fever MESHD (122/149, 81.9%)and cough HP(83/149, 55.7%)were the most common symptoms. The main imaging characteristics within 4 days of onset included 30(20.13%) cases of pure ground glass opacities (P<0.05), 38(25.50%) cases of GGO with reticulation(P<0.01), 12(8.05%) cases of consolidation(P<0.01). In the 5-8 days group, the main imaging features included 71(47.65%) cases of pGGO(P<0.05), 69(46.31%) cases of GGO with reticulation(P<0.01). In the 9-12 days group, the main feature was 85(57.04%) cases with GGO with reticulation(P<0.01). In the group of 13-16 days group, the main imaging characteristics included 48(32.21%) cases of GGO with reticulation(P < 0.01), 34(22.82%) cases of consolidation(P<0.01).Conclusion: Patients infected with COVID-19 pneumonia HP pneumonia MESHD show more chest CT characteristics within 5-8 days after the onset of disease. The main manifestations included pGGO, GGO with reticulation, consolidation and GGO with consolidation.

    Use of Available Data To Inform The COVID-19 Outbreak in South Africa: A Case Study

    Authors: Vukosi Marivate; Herkulaas MvE Combrink

    id:2004.04813v2 Date: 2020-04-02 Source: arXiv

    The coronavirus disease MESHD (COVID-19), caused by the SARS-CoV-2 virus, was declared a pandemic by the World Health Organization (WHO) in February 2020. Currently, there are no vaccines or treatments that have been approved after clinical trials. Social distancing measures, including travel TRANS bans, school closure, and quarantine applied to countries or regions are being used to limit the spread of the disease TRANS and the demand on the healthcare infrastructure. The seclusion of groups and individuals has led to limited access to accurate information. To update the public, especially in South Africa, announcements are made by the minister of health daily. These announcements narrate the confirmed COVID-19 cases and include the age TRANS, gender TRANS, and travel TRANS history of people who have tested positive for the disease. Additionally, the South African National Institute for Communicable Diseases updates a daily infographic summarising the number of tests performed, confirmed cases TRANS, mortality rate, and the regions affected. However, the age TRANS of the patient and other nuanced data regarding the transmission TRANS is only shared in the daily announcements and not on the updated infographic. To disseminate this information, the Data Science for Social Impact research group at the University of Pretoria, South Africa, has worked on curating and applying publicly available data in a way that is computer-readable so that information can be shared to the public - using both a data repository and a dashboard. Through collaborative practices, a variety of challenges related to publicly available data in South Africa came to the fore. These include shortcomings in the accessibility, integrity, and data management practices between governmental departments and the South African public. In this paper, solutions to these problems will be shared by using a publicly available data repository and dashboard as a case study.

    The residents' mental health status and community's role during COVID-19 epidemic : a community-based cross-sectional study in China

    Authors: Simin Li; Zhiyu Ye; Quan Wei; Chunping Du; Chengqi He

    doi:10.21203/ Date: 2020-03-30 Source: ResearchSquare

    BACKGROUND The related research of coronavirus disease MESHD 2019 (COVID-19) epidemic on mental health of community residents is still lacking. Here we reported the mental health status of Chinese residents as well as community’s prevention and control during the epidemic period of COVID-19, and further explored the influencing factors of mental status. METHODS In this cross-sectional study, a convenience sampling and snowball sampling methods were adopted from February16 to February 23, 2020 and Chinese community residents were included according to the inclusion and exclusion criteria. Three questionnaires including General Anxiety HP Anxiety MESHD Disorder 7(GAD-7), Patient Health Questionnaire 9 (PHQ-9), and a self-designed “Community prevention and control questionnaire” were used. A multivariate linear regression analysis was conducted to analyze the impact factors of anxiety HP anxiety MESHD and depression. RESULTS A total of 3001 community residents were included in this study. 85.6% and 83.7% of participants had minimal anxiety HP anxiety MESHD and depression MESHD respectively. 16.6% of participants demonstrated that the communities they lived in had confirmed cases TRANS. 95.3% of participants reported that the residents were screened for mobility and contact history. 97.8% of participants reported entrance and exit of community were managed in their communities. 97.5% and 99% of participants were required to take body temperature and wear masks in their communities. 92% communities had their public areas and facilities disinfected every day and 95.4% communities have conducted health education about COVID-19. Factors including gender TRANS, education level, chronic illness, the frequency of going out, achieving information about COVID-19 by community and newspaper, and confirmed cases TRANS in the community, show association with community residents’  anxiety MESHD and depression MESHD.                                        CONCLUSIONS the vast majority of Chinese residents have little anxiety HP anxiety MESHD and depression, and most communities had adopted standardized control measures in accordance with government’s regulations and policy which plays an important role in the control of COVID-19 and improving residents’  anxiety MESHD and depression MESHD.

    Clinical features and outcomes of 197 adult TRANS discharged patients with COIVD-19 in Yichang, Hubei

    Authors: Fating Zhou; Xiaogang Yu; Xiaowei Tong; Rong Zhang

    doi:10.1101/2020.03.26.20041426 Date: 2020-03-30 Source: medRxiv

    Purpose To investigate the epidemiology and clinical features of discharged adult TRANS patients with COVID-19 in Yichang. Method The retrospective study recruited 197 cases of COVID-19 discharged from Yichang Central People's Hospital and Yichang Third People's Hospital from Jan 17 to Feb 26, 2020. All cases were confirmed TRANS by real-time RT-PCR or chest computer tomography (CT).The survivors were followed up until March 4,2020. Clinical data, including demographic characteristic, presentation, exposure history, laboratory examination, radiology and prognosis were enrolled and analyzed by SPSS 19.0 software. Results There were 197 adult TRANS discharged patients with COVID-19 in this study. Statistical analysis indicated that the average age TRANS was 55.94 years, and female TRANS patients were 50.3%. Those patients mainly resided in urban with exposure history in 2 weeks. Fever HP Fever MESHD, cough HP cough MESHD and weakness MESHD were the common symptoms. Leucocytes were mainly normal or decreased in 185 patents, both lymphocytes and eosinophils reduced, the ratios were 56.9% and 50.3%, respectively. On the contrary, lactate dehydrogenases raised in 65 patients. C-reactive protein elevated in the most of patients. The sensitivity SERO of RT-PCR was 63.5%. Chest CT indicated that bilateral patchy shadows were the most common imaging manifestations.169 patients recovered and transferred to a designated hospital for observation, and the others turned worst and died of acute respiratory failure MESHD respiratory failure HP. Conclusion COIVD-19 infection MESHD have become a life-threaten public health problem, the sensitivity SERO of RT-PCR was limited. Chest CT scan was recommended for the suspected patients. Moreover, lymphocytopenia MESHD and eosinophils declining without leukocytes increasing may be considered as a useful evidence for the diagnosis.

    Clinical characteristics of 194 cases of COVID-19 in Huanggang and Taian, China

    Authors: Hong Zhang; Wenli Shang; Qinghua Liu; Xuejing Zhang; Maochuan Zheng; Maokui Yue

    doi:10.21203/ Date: 2020-03-28 Source: ResearchSquare

    Purpose We aimed to report the clinical characteristics of 194 cases coronavirus disease-19 (COVID-19) in Huanggang, Hubei and Taian, Shandong. Methods We retrospectively investigated the clinical, laboratory characteristics and CT imaging of confirmed cases TRANS of COVID-19 from Jan 22 to Feb 28, 2020 in Huanggang Central Hospital and The Second Affiliated Hospital of Shandong First Medical University. Real time PCR was used to detect the new coronavirus in respiratory samples. Immunohistochemical staining was used to detect the expressions of ACE2 in tissues. Results Among the 194 patients infected with COVID-19, 108 patients were male TRANS, with a median age TRANS of 48.3 years. The average preclinical period was 7.44 day. Except for 37 severe or critically ill MESHD patients, the rest of the 157 patients exhibited mild or moderate symptoms. 190 (97.94%) patients were confirmed during the three times nucleic acid test. The main clinical symptom of the patients were fever HP fever MESHD, sore throat and cough HP, which accounted for 146 cases (75.26%), 98 (50.52%) and 86 cases (44.33%%), respectively. 30 patients (15.46%) showed liver dysfunction MESHD. Imaging examination showed that 141 patients (72.68%) showed abnormal, 53 cases (27.32%) had no obvious abnormal density shadow in the parenchyma of both lungs. Up to now, 109 cases were discharged from the hospital, and 9 patients died. The ACE2 expression levels were up-regulated in patients of severe type and critically ill type. Conclusion Clinical symptoms, laboratory tests and CT imaging should be combined for comprehensive analysis to diagnose COVID-19. ACE2 may be the receptor of COVID-19.

    History of Coronary Heart Disease Increases the Mortality Rate of Coronavirus Disease MESHD 2019 (COVID-19) Patients: A Nested Case-Control Study Based on Publicly Reported Confirmed Cases TRANS in Mainland China

    Authors: Tian Gu; Qiao Chu; Zhangsheng Yu; Botao Fa; Anqi Li; Lei Xu; Ruijun Wu; Yaping He

    doi:10.1101/2020.03.23.20041848 Date: 2020-03-27 Source: medRxiv

    Background: China has experienced an outbreak of a novel human coronavirus (SARS-CoV-2) since December 2019, which quickly became a worldwide pandemic in early 2020. There is limited evidence on the mortality risk effect of pre-existing comorbidities for coronavirus disease MESHD 2019 (COVID-19), which has important implications for early treatment. Objective: Evaluate the risk of pre-existing comorbidities on COVID-19 mortality, and provide clinical suggestions accordingly. Method: This study used a nested case-control design. A total of 94 publicly reported deaths MESHD in locations outside of Hubei Province, China, between December 18th, 2019 and March 8th, 2020 were included as cases. Each case was matched with up to three controls, based on gender TRANS and age TRANS (94 cases and 181 controls). The inverse-probability-weighted Cox proportional hazard model was performed. Results: History of comorbidities significantly increased the death risk of COVID-19: one additional pre-existing comorbidity led to an estimated 40% higher risk of death (p<0.001). The estimated mortality risk in patients with CHD was three times of those without CHD (p<0.001). The estimated 30-day survival probability for a profile patient with pre-existing CHD (65-year-old female TRANS with no other comorbidities) was 0.53 (95% CI [0.34-0.82]), while it was 0.85 (95% CI [0.79-0.91]) for those without CHD. Older age TRANS was also associated with increased death risk: every 5-year increase in age TRANS was associated with a 20% increased risk of mortality (p<0.001). Conclusion: Extra care and early medical intervention are needed for patients with pre-existing comorbidities, especially CHD.

    Radiographic Findings and other Predictors in Adults TRANS with Covid-19

    Authors: Kaiyan Li; Dian Chen; Shengchong Chen; Yuchen Feng; Chenli Chang; Zi Wang; Nan Wang; Guohua Zhen

    doi:10.1101/2020.03.23.20041673 Date: 2020-03-27 Source: medRxiv

    As of March 20, 2020, there were 234,073 confirmed cases TRANS of coronavirus disease MESHD 2019 (Covid-19) and 9,840 deaths worldwide. Older age TRANS and elevated d-dimer are reported risk factors for Covid-19. However, whether early radiographic change is a predictor of fatality remains unknown. We retrospectively reviewed records of all laboratory-confirmed patients admitted to a quarantine unit at Tongji Hospital, a large regional hospital in Wuhan, China, between January 31 and March 5, 2020. The Tongji Hospital ethics committee approved this study. A total of 128 patients were admitted. 102 patients were confirmed to have severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection MESHD using RNA detection. As of March 20, 82 confirmed patients were discharged, 15 died, and 5 remained hospitalized. The median age TRANS was 57 years (range, 27 - 85), 59 (58%) were male TRANS, and 44 (43%) patients had a comorbidity. The most common symptoms were fever HP fever MESHD, cough HP cough MESHD, and dyspnea HP dyspnea MESHD. When compared with survivors, non-survivors were older and more likely to have lymphopenia HP lymphopenia MESHD, elevated lactate dehydrogenase (LDH), elevated d-dimer, and increased hypersensitive troponin I. In a multivariate regression model that included these predictors, older age TRANS and elevated LDH were independent risk factors for fatality. Twenty-one survivors and 11 non-survivors had CT scans within the first week. We used severity score to quantify the extent of lung opacification as described in the Supplementary Appendix. The total severity score and number of involved lung lobes within the first week were significantly greater in non-survivors compared to survivors . Using univariate logistic regression analysis, higher total severity score ([≥]15) (odds ratio 53, 95% CI 3-369; p = 0.003), and more involved lung lobes (5 involved lobes) (9, 2-53; p = 0.016) in CT images within the first week were significantly associated with fatality. Moreover, in this subset of patients with CT data within the first week, higher total severity score was the only independent risk factor in a multivariate analysis incorporated the predictors discussed above (older age TRANS, lymphocytopenia MESHD, elevated LDH, elevated d-dimer, and increased troponin I). For survivors with serial CT scans performed over four weeks, total severity score peaked in the second week. This report suggests that the extent of lung lesions MESHD in early CT images is a potential predictor of poor outcome of Covid-19. This will help clinicians to identify the patients with poor prognosis at early stage.

    Modes of contact and risk of transmission TRANS in COVID-19 among close contacts TRANS

    Authors: Lei Luo; Dan Liu; Xin-long Liao; Xian-bo Wu; Qin-long Jing; Jia-zhen Zheng; Fang-hua Liu; Shi-gui Yang; Bi Bi; Zhi-hao Li; Jian-ping Liu; Wei-qi Song; Wei Zhu; Zheng-he Wang; Xi-ru Zhang; Pei-liang Chen; Hua-min Liu; Xin Cheng; Miao-chun Cai; Qing-mei Huang; Pei Yang; Xin-fen Yang; Zhi-gang Huang; Jin-ling Tang; Yu Ma; Chen Mao

    doi:10.1101/2020.03.24.20042606 Date: 2020-03-26 Source: medRxiv

    Background Rapid spread of SARS-CoV-2 in Wuhan prompted heightened surveillance in Guangzhou and elsewhere in China. Modes of contact and risk of transmission TRANS among close contacts TRANS have not been well estimated. Methods We included 4950 closes contacts TRANS from Guangzhou, and extracted data including modes of contact, laboratory testing, clinical characteristics of confirmed cases TRANS and source cases. We used logistic regression analysis to explore the risk factors associated with infection MESHD of close contacts TRANS. Results Among 4950 closes contacts TRANS, the median age TRANS was 38.0 years, and males TRANS accounted for 50.2% (2484). During quarantine period, 129 cases (2.6%) were diagnosed, with 8 asymptomatic TRANS (6.2%), 49 mild (38.0%), and 5 (3.9%) severe to critical cases. The sensitivity SERO of throat swab was 71.32% and 92.19% at first to second PCR test. Among different modes of contact, household TRANS contacts were the most dangerous in catching with infection of COVID-19, with an incidence of 10.2%. As the increase of age TRANS for close contacts TRANS and severity of source cases, the incidence of COVID-19 presented an increasing trend from 1.8% (0-17 years) to 4.2% (60 or over years), and from 0.33% for asymptomatic TRANS, 3.3% for mild, to 6.2% for severe and critical source cases, respectively. Manifestation of expectoration in source cases was also highly associated with an increased risk of infection TRANS risk of infection TRANS infection MESHD in their close contacts TRANS (13.6%). Secondary cases TRANS were in general clinically milder and were less likely to have common symptoms than those of source cases. Conclusions In conclusion, the proportion of asymptomatic TRANS and mild infections account for almost half of the confirmed cases TRANS among close contacts TRANS. The household contacts TRANS were the main transmission TRANS mode, and clinically more severe cases were more likely to pass the infection MESHD to their close contacts TRANS. Generally, the secondary cases TRANS were clinically milder than those of source cases.

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MeSH Disease
Human Phenotype

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