Corpus overview


Overview

MeSH Disease

Human Phenotype

Fever (36)

Cough (28)

Pneumonia (28)

Hypertension (11)

Fatigue (11)


Transmission

Seroprevalence
    displaying 111 - 120 records in total 127
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    Dynamic profile of severe or critical COVID-19 cases

    Authors: Yang Xu

    doi:10.1101/2020.03.18.20038513 Date: 2020-03-20 Source: medRxiv

    In December 2019, a cluster of acute respiratory illness MESHD, now known as SARS-CoV-2 pneumonia MESHD pneumonia HP, occurred in Wuhan, China. World Health Organization (WHO) declared the rapidly spreading coronavirus outbreak a pandemic on March 11, 2020, acknowledging what has seemed clear for some time-the virus will likely spread to all countries on the globe. As of February 11, 2020, the Chinese Center for Disease Control and Prevention (China CDC) has officially reported that there are 2.0% (889) asymptomatic TRANS cases, 2.3% (1,023) death cases, and 80.9% mild cases among 44,672 confirmed cases TRANS. 51.4% (22,981) were male TRANS and 48.6% (21,691) were female TRANS. Lymphopenia HP Lymphopenia MESHD, in particular T lymphopenia MESHD lymphopenia HP, was common among patients with SARS-COV-2 in the observation. A notable drop in CD4 and CD8 lymphocyte counts occurred early in the course of the syndrome and was associated with adverse outcomes. The appearing a phenomenon of lymphocyte depletion ( PLD MESHD) suggested severe adverse outcomes. The outcome observed: 60% had discharged and 20% had die.

    Correlation between Fasting Blood SERO Glucose Level at Admission and Mortality in COVID-19 Patients: A Retrospective Study

    Authors: Bin Zhu; Chunguo Jiang; Xiaokai Feng; Yanfei Zheng; Jie Yang; Feng Wang; Shi Liu; Fenghua Xu; Liming Zhang; Zhigang Zhao; Ziren Tang

    doi:10.21203/rs.3.rs-18484/v2 Date: 2020-03-20 Source: ResearchSquare

    Background Coronavirus disease-19 (COVID-19) has spread rapidly, with a growing number of cases confirmed TRANS around the world. This study explores the relationship of fasting blood SERO glucose (FBG) at admission with mortality. Methods In this retrospective, single-center study, we analyzed the clinical characteristics of confirmed cases TRANS of COVID-19 in Wu Han from 29 January 2020 to 23 February 2020. Cox proportional hazard regression analysis was performed to evaluate the relationship between FBG and mortality. Results A total of 107 patients were enrolled in our study. The average age TRANS was 59.49 ± 13.33 and the FBG at admission was 7.35 ± 3.13 mmol/L. There were 16 people died of COVID-19 with an average age TRANS 68.1 ± 9.5 and the FBG was 8.94 ± 4.76 mmol/L. Regression analysis showed that there were significant association between FBG and death MESHD (HR = 1.13, 95%CI: 1.02-1.24). After adjusting for covariables, the significance still exists. In addition, our result showed that FBG > 7.0 mmol/L or diabetic mellitus MESHD can significantly increase mortality after adjusting for the age TRANS and gender TRANS. Conclusions This study suggests that FBG at admission is an effective and reliable indicator for disease prognosis in COVID-19 patients.

    Factors related to COVID-19 severity and mortality based on comparison between Henan and Zhejiang: an observational study

    Authors: Wangquan Ji; Ruonan Liang; Peiyu Zhu; Haiyan Yang; Shuaiyin Chen; Weiguo Zhang; Yuefei Jin; Guangcai Duan

    doi:10.21203/rs.3.rs-18191/v1 Date: 2020-03-19 Source: ResearchSquare

    Background: Coronavirus Disease MESHD 2019 (COVID-19) has spread across China and the world, since outbreak at the end of 2019. Although COVID-19 is generally considered as self-limiting, some of cases develop in to fatal respiratory restress, multiple organ failure MESHD and even sudden death MESHD. According to the data released by the provincial health commissions, there are obvious regional differences in COVID-19 mortality. To explore possible factors of COVID-19 related severity and mortality in laboratory- confirmed cases TRANS from Henan and Zhejiang.Methods: We collected the public data released by the government. We analyzed and compared the possible factors, including initial symptoms, gender TRANS, age TRANS, place of residence, time interval from onset to diagnosis, epidemiological history and the grade of hospital for patient’s treatment in laboratory- confirmed cases TRANS. Student’s t-test, Chi-square (2) test, Cochran-Mantel-Haenszel (CMH) test and Mann-Whitney U rank sum test were used complied with the applicable conditions. Statistical test was performed with a level of significance α=0.05.Results: Death cases in Henan were mainly from male TRANS, elderly TRANS infected persons and those who had a history of contact with patients and underlying basic diseases. Henan had the higher proportion of cases with fever HP fever MESHD and the lower proportion of asymptomatic TRANS infection MESHD, and had higher proportions of imported male TRANS cases with a contact history, and elderly TRANS cases living in rural areas, relative to Zhejiang. The time interval of confirmed cases TRANS in rural areas of Henan was 0.8 day longer than that in Zhejiang. Hospitals grade for patients’ treatment in Henan was lower than Zhejiang.Conclusions: Our findings suggest that initial symptoms, age TRANS, place of residence, gender TRANS, the time interval from onset to diagnosis and the grade of designated hospital for patient’s treatment are possible factors behind COVID-19 related severity or mortality. This study will provide useful information for public health authorities to develop disease prevention strategies.

    Analysis of clinical characteristics and laboratory findings of 95 cases of 2019 novel coronavirus pneumonia MESHD pneumonia HP in Wuhan, China: a retrospective analysis.

    Authors: Gemin Zhang; Jie Zhang; Bowen Wang; Xionglin Zhu; Qiang Wang; Shiming Qiu

    doi:10.21203/rs.3.rs-17712/v1 Date: 2020-03-17 Source: ResearchSquare

    Background: Since December 2019, 2019 novel coronavirus pneumonia emerged MESHD in Wuhan city and rapidly spread throughout China and even the world. We sought to analyse the clinical characteristics and laboratory findings of some cases with 2019 novel coronavirus pneumonia MESHD .Methods: In this retrospective study, we extracted the data on 95 patients with laboratory-confirmed 2019 novel coronavirus pneumonia MESHD in Wuhan Xinzhou District People's Hospital from January 16th to February 25th , 2020. Cases were confirmed TRANS by real-time RT-PCR and abnormal radiologic findings. Outcomes were followed up until March 2th , 2020. Results: Higher temperature, blood SERO leukocyte count, neutrophil count, neutrophil percentage, C-reactive protein level, D-dimer level, alanine aminotransferase activity, aspartate aminotransferase activity, α - hydroxybutyrate dehydrogenase activity, lactate dehydrogenase activity and creatine kinase activity were related to severe 2019 novel coronavirus pneumonia MESHD pneumonia HP and composite endpoint, and so were lower lymphocyte count, lymphocyte percentage and total protein level. Age TRANS below 40 or above 60 years old, male TRANS, higher Creatinine level, and lower platelet count also seemed related to severe 2019 novel coronavirus pneumonia MESHD pneumonia HP and composite endpoint, however the P values were greater than 0.05, which mean under the same condition studies of larger samples are needed in the future. Conclusion: Multiple factors were related to severe 2019 novel coronavirus pneumonia MESHD pneumonia HP and composite endpoint, and more related studies are needed in the future.

    Epidemiological, Clinical Characteristics and Outcome of Medical Staff Infected with COVID-19 in Wuhan, China: A Retrospective Case Series Analysis

    Authors: Jie Liu; Liu Ouyang; Pi Guo; Hai sheng Wu; Peng Fu; Yu liang Chen; Dan Yang; Xiao yu Han; Yu kun Cao; Osamah Alwalid; Juan Tao; Shu yi Peng; He shui Shi; Fan Yang; Chuan sheng Zheng

    doi:10.1101/2020.03.09.20033118 Date: 2020-03-13 Source: medRxiv

    Backgrounds Since December 2019, a novel coronavirus epidemic has emerged in Wuhan city, China and then rapidly spread to other areas. As of 20 Feb 2020, a total of 2,055 medical staff confirmed with coronavirus disease MESHD 2019 (COVID-19) caused by SARS-Cov-2 in China had been reported. We sought to explore the epidemiological, clinical characteristics and prognosis of novel coronavirus-infected MESHD medical staff. Methods In this retrospective study, 64 confirmed cases TRANS of novel coronavirus-infected MESHD medical staff admitted to Union Hospital, Wuhan between 16 Jan, 2020 to 15 Feb, 2020 were included. Two groups concerned were extracted from the subjects based on duration of symptoms: group 1 (<= 10 days) and group 2 (>10 days). Epidemiological and clinical data were analyzed and compared across groups. The Kaplan-Meier plot was used to inspect the change in hospital discharge rate. The Cox regression model was utilized to identify factors associated with hospital discharge. Findings The median age TRANS of medical staff included was 35 years old. 64% were female TRANS and 67% were nurses. None had an exposure to Huanan seafood wholesale market or wildlife. A small proportion of the cohort had contact with specimens (5%) as well as patients in fever HP fever MESHD clinics (8%) and isolation wards (5%). Fever HP Fever MESHD (67%) was the most common symptom, followed by cough HP (47%) and fatigue HP fatigue MESHD (34%). The median time interval between symptoms onset TRANS and admission was 8.5 days. On admission, 80% of medical staff showed abnormal IL-6 levels and 34% had lymphocytopenia MESHD. Chest CT mainly manifested as bilateral (61%), subpleural (80%) and ground-glass (52%) opacities. During the study period, no patients was transferred to intensive care unit or died, and 34 (53%) had been discharged. Higher body mass index (BMI) (HR 0.14; 95% CI 0.03-0.73), fever HP fever MESHD (HR 0.24; 95% CI 0.09-0.60) and higher levels of IL-6 on admission (HR 0.31; 95% CI 0.11-0.87) were unfavorable factors for discharge. Interpretation In this study, medical staff infected with COVID-19 have relatively milder symptoms and favorable clinical course, which may be partly due to their medical expertise, younger age TRANS and less underlying diseases. Smaller BMI, absence of fever symptoms MESHD fever HP symptoms and normal IL-6 levels on admission are favorable for discharge for medical staff. Further studies should be devoted to identifying the exact patterns of SARS-CoV-2 infection MESHD among medical staff.

    Case fatality risk of novel coronavirus diseases MESHD 2019 in China

    Authors: Xiaowei Deng; Juan Yang; Wei Wang; Xiling Wang; Jiaxin Zhou; Zhiyuan Chen; Jing Li; Yinzi Chen; Han Yan; Juanjuan Zhang; Yongli Zhang; Yan Wang; Qi Qiu; Hui Gong; Xianglin Wei; Lili Wang; Kaiyuan Sun; Peng Wu; Marco Ajelli; Benjamin J. Cowling; Cecile Viboud; Hongjie Yu

    doi:10.1101/2020.03.04.20031005 Date: 2020-03-06 Source: medRxiv

    Objective The outbreak of novel coronavirus disease MESHD 2019 (COVID-19) imposed a substantial health burden in mainland China and remains a global epidemic threat. Our objectives are to assess the case fatality risk (CFR) among COVID-19 patients detected in mainland China, stratified by clinical category and age TRANS group. Method We collected individual information on laboratory-confirmed COVID-19 cases from publicly available official sources from December 29, 2019 to February 23, 2020. We explored the risk factors associated with mortality. We used methods accounting for right-censoring and survival analyses to estimate the CFR among detected cases. Results Of 12,863 cases reported outside Hubei, we obtained individual records for 9,651 cases, including 62 deaths MESHD and 1,449 discharged cases. The deceased were significantly older than discharged cases (median age TRANS: 77 vs 39 years, p<0.001). 58% (36/62) were male TRANS. Older age TRANS (OR 1.18 per year; 95%CI: 1.14 to 1.22), being male TRANS (OR 2.02; 95%CI: 1.02 to 4.03), and being treated in less developed economic regions (e.g., West and Northeast vs. East, OR 3.93; 95%CI: 1.74 to 8.85) were mortality risk factors. The estimated CFR was 0.89-1.24% among all cases. The fatality risk among critical patients was 2-fold higher than that among severe and critical patients, and 24-fold higher than that among moderate, severe and critical patients. Conclusions Our estimates of CFR based on laboratory- confirmed cases TRANS ascertained outside of Hubei suggest that COVID-19 is not as severe as severe acute respiratory syndrome MESHD and Middle East respiratory syndrome MESHD, but more similar to the mortality risk of 2009 H1N1 influenza pandemic in hospitalized patients. The fatality risk of COVID-19 is higher in males TRANS and increases with age TRANS. Our study improves the severity assessment of the ongoing epidemic and can inform the COVID-19 outbreak response in China and beyond.

    Clinical Features of Patients Infected with the 2019 Novel Coronavirus (COVID-19) in Shanghai, China

    Authors: Min Cao; Dandan Zhang; Youhua Wang; Yunfei Lu; Xiangdong Zhu; Ying Li; Honghao Xue; Yunxiao Lin; Min Zhang; Yiguo Sun; Zongguo Yang; Jia Shi; Yi Wang; Chang Zhou; Yidan Dong; Ping Liu; Steven M Dudek; Zhen Xiao; Hongzhou Lu; Longping Peng

    doi:10.1101/2020.03.04.20030395 Date: 2020-03-06 Source: medRxiv

    Background: Since mid-December 2019, a cluster of pneumonia HP pneumonia MESHD-like diseases caused by a novel coronavirus, now designated COVID-19 by the WHO, emerged in Wuhan city and rapidly spread throughout China. Here we identify the clinical characteristics of COVID-19 in a cohort of patients in Shanghai. Methods: Cases were confirmed TRANS by real-time RT-PCR and were analysed for demographic, clinical, laboratory and radiological features. Results: Of 198 patients, the median duration from disease onset to hospital admission was 4 days. The mean age TRANS of the patients was 50.1 years, and 51.0% patients were male TRANS. The most common symptom was fever HP fever MESHD. Less than half of the patients presented with respiratory systems including cough HP, sputum production, itchy MESHD or sore throat, shortness of breath MESHD, and chest congestion. 5.6% patients had diarrhoea MESHD. On admission, T lymphocytes were decreased in 45.8% patients. Ground glass opacity was the most common radiological finding on chest computed tomography. 9.6% were admitted to the ICU because of the development of organ dysfunction. Compared with patients not treated in ICU, patients treated in the ICU were older, had longer waiting time to admission, fever HP fever MESHD over 38.5o C, dyspnoea MESHD, reduced T lymphocytes, elevated neutrophils and organ failure MESHD. Conclusions: In this single centre cohort of COVID-19 patients, the most common symptom was fever HP fever MESHD, and the most common laboratory abnormality was decreased blood T MESHD blood SERO T cell counts. Older age TRANS, male TRANS, fever HP fever MESHD over 38.5oC, symptoms of dyspnoea MESHD, and underlying comorbidity, were the risk factors most associated with severity of disease. Key words: 2019 novel coronavirus; acute respiratory infection MESHD infection; risk TRANS infection; risk TRANS factors for disease severity

    Precautions are Needed for COVID-19 Patients with Coinfection of Common Respiratory Pathogens

    Authors: Quansheng Xing; Guoju Li; Yuhan Xing; Ting Chen; Wenjie Li; Wei Ni; Kai Deng; Ruqin Gao; Changzheng Chen; Yang Gao; Qiang Li; Guiling Yu; Jianning Tong; Wei Li; Guiliang Hao; Yue Sun; Ai Zhang; Qin Wu; Zipu Li; Silin Pan

    doi:10.1101/2020.02.29.20027698 Date: 2020-03-03 Source: medRxiv

    Background: With the ongoing outbreak of Coronavirus Disease MESHD 2019 (COVID-19), infected MESHD patients within and beyond the epidemic area, Wuhan, China, showed different epidemiological and clinical characteristics. There is a paucity of data concerning coinfection with other common respiratory pathogens in COVID-19 patients outside of Wuhan. Methods: We conducted a double-centre study recruiting 68 patients with severe acute respiratory coronavirus 2 (SARS-CoV-2) infection MESHD infection confirmed TRANS by nucleic acid testing in Qingdao and Wuhan from January 17 to February 16, 2020. Indirect immunofluorescence was performed to detect the specific IgM antibody SERO against common respiratory pathogens in collected acute phase serum SERO. Results: Of the 68 patients with SARS-CoV-2 infection MESHD, 30 (44.12%) were from Qingdao. The median age TRANS of Qingdao and Wuhan patients were 50 (IQR: 37-59) and 31 (IQR: 28-38) years, respectively, and the majority of patients were female TRANS in Qingdao (60.00%) and Wuhan (55.26%). Among COVID-19 patients in Qingdao, 24 (80.00%) of them had IgM antibodies SERO against at least one respiratory pathogen, whereas only one (2.63%) of the patients in Wuhan had positive results for serum SERO IgM antibody SERO detection (P<0.0001). The most common respiratory pathogens detected in Qingdao COVID-19 patients were influenza virus A (60.00%) and influenza virus B (53.33%), followed by mycoplasma pneumoniae HP (23.33%) and legionella pneumophila MESHD (20.00%). While the pattern for coinfection in patients with community-acquired pneumonia HP pneumonia MESHD in Qingdao was quite different, with a positive rate of only 20.90%. Interpretation: We reported a large proportion of COVID-19 patients with coinfection of seasonal respiratory pathogens in Qingdao, northeast China, which differed greatly from the patients in Wuhan, central China. Precautions are needed when dealing with COVID-19 patients beyond the epidemic centre who have coinfection with other respiratory pathogens. We highly recommend adding SARS-CoV-2 to routine diagnostic testing in capable hospitals to prevent misdetection of the virus.

    Estimate the incubation period TRANS of coronavirus 2019 (COVID-19)

    Authors: Henry Han

    doi:10.1101/2020.02.24.20027474 Date: 2020-02-29 Source: medRxiv

    Motivation: Wuhan pneumonia MESHD pneumonia is an acute infectious HP infectious disease MESHD caused by the 2019 novel coronavirus (COVID-19). It is being treated as a Class A infectious disease though it was classified as Class B according to the Infectious Disease MESHD Prevention Act of China. Accurate estimation of the incubation period TRANS of the coronavirus is essential to the prevention and control. However, it remains unclear about its exact incubation period TRANS though it is believed that symptoms of COVID-19 can appear in as few as 2 days or as long as 14 or even more after exposure. The accurate incubation period TRANS calculation requires original chain-of-infection data that may not be fully available in the Wuhan regions. In this study, we aim to accurately calculate the incubation period TRANS of COVID-19 by taking advantage of the chain-of-infection data, which is well-documented and epidemiologically informative, outside the Wuhan regions. Methods: We acquired and collected officially reported COVID-19 data from 10 regions in China except for Hubei province. To achieve the accurate calculation of the incubation period TRANS, we only involved the officially confirmed cases TRANS with a clear history of exposure and time of onset. We excluded those without relevant epidemiological descriptions, working or living in Wuhan for a long time, or hard to determine the possible exposure time. We proposed a Monte Caro simulation approach to estimate the incubation of COVID-19 as well as employed nonparametric ways. We also employed manifold learning and related statistical analysis to decipher the incubation relationships between different age TRANS/ gender TRANS groups. Result: The incubation period TRANS of COVID-19 did not follow general incubation distributions such as lognormal, Weibull, and Gamma distributions. We estimated that the mean and median of its incubation were 5.84 and 5.0 days via bootstrap and proposed Monte Carlo simulations. We found that the incubation periods TRANS of the groups with age TRANS>=40 years and age TRANS<40 years demonstrated a statistically significant difference. The former group had a longer incubation period TRANS and a larger variance than the latter. It further suggested that different quarantine time should be applied to the groups for their different incubation periods TRANS. Our machine learning analysis also showed that the two groups were linearly separable. incubation of COVID-19 along with previous statistical analysis. Our results further indicated that the incubation difference between males TRANS and females TRANS did not demonstrate a statistical significance.

    Clinical characteristics of 36 non-survivors with COVID-19 in Wuhan, China

    Authors: Ying Huang; Rui Yang; Ying Xu; Ping Gong

    doi:10.1101/2020.02.27.20029009 Date: 2020-02-29 Source: medRxiv

    Background Although the outbreak of Coronavirus disease MESHD 2019 (COVID-19) has caused over 2200 deaths in China, there was no study about death yet. We aimed to describe the clinical characteristics of non-survivors with COVID-19. Methods For this retrospective, single-center study, we included 36 non-survivors with COVID-19 in the Fifth Hospital of Wuhan. Cases were confirmed TRANS by real-time RT-PCR between Jan 21 and Feb 10, 2020 according to the recommended protocol. The epidemiological, demographic, clinical, laboratory, radiological and treatment data were collected and analyzed. Outcomes were followed up until Feb 14, 2020. This study was approved by the ethics commissions of the Fifth Hospital of Wuhan, with a waiver of informed consent due to a public health outbreak investigation. Results We included 36 patients who died from COVID-19. The mean age TRANS of the patients was 69.22 years (SD 9.64, range 50-90). 25(69.44%) patients were males TRANS, and 11 (30.56%) female TRANS. 26 (72.22%) patients had chronic diseases MESHD, mainly including hypertension HP hypertension MESHD, cardiovascular disease MESHD and diabetes MESHD. Patients had common clinical symptoms of fever HP fever MESHD (34 [94.44%] patients), cough HP (28 [77.78%] patients), shortness of breath MESHD (21 [58.33%] patients), and fatigue HP fatigue MESHD (17 [47.22%] patient). Chest computed tomographic scans showed that 31 (96.88%) patients had bilateral pneumonia MESHD pneumonia HP. Lymphopenia HP Lymphopenia MESHD occurred in 24 patients (70.59%), decreased albumin (30.18, [SD, 4.76]) in 25 patients (80.65%), elevated D-dimer (8.64 [IQR, 2.39-20]) in 27 patients (100%), and elevated lactate dehydrogenase (502.5 U/L [IQR, 410-629]) in 26 patients (100%). Nearly all of the patients have elevated CRP (106.3 mg/L [IQR, 60.83-225.3]), PCT (0.61 ng/ml [IQR, 0.16-2.10]) and IL-6 (100.6 pg/ml [IQR, 51.51-919.5]). Most patients received antiviral therapy and antibiotic therapy, and more than half of patients received glucocorticoid therapy (25 [69.44%]). All the patients had acute respiratory distress syndrome MESHD respiratory distress HP syndrome ( ARDS MESHD). The median time from onset to ARDS MESHD was 11 days. One (2.78%) patient presented with acute renal injury MESHD. The median time from onset to death MESHD was 17 days. Interpretation Lots of patients died from COVID-19 till now. The median survival time of these non-survivors from onset to death was about 2 weeks. Most patients were older males TRANS with comorbidities. They finally progressed to ARDS MESHD. The median time from onset to ARDS MESHD was 11 days. Gradually decreased lymphocytes and increased inflammation MESHD biomarkers were common, and need to be monitored in the routine treatment.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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