Corpus overview


MeSH Disease

Human Phenotype

Fever (39)

Cough (31)

Pneumonia (29)

Fatigue (12)

Hypertension (11)


    displaying 21 - 30 records in total 130
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    Epidemiological investigation and prevention control analysis of longitudinal distribution of COVID-19 in Henan province, China

    Authors: Xianguang Yang; Xuelin Chen; Cuihong Ding; Zhibo Bai; Jingyi Zhu; Gege Sun; Guoying Yu

    doi:10.1101/2020.07.25.20161844 Date: 2020-07-27 Source: medRxiv

    Objective: To analyze the vertical distribution of six cities in Henan Province,China from January 21, 2020 to June17, 2020: Xinyang City (including Gushi County), Nanyang City (including Dengzhou City), Zhumadian City (including XincaiCounty), Zhengzhou City (including Gongyi City), Puyang City and Anyang City (including Hua County) corona virus disease 2019(COVID-19) epidemiological characteristics and local prevention and control measures.Methods: Data were collected and analyzed through the COVID-19 information published on the official websites of health commissions of Henan Province and six cities.Results: As of June 17, 2020, the cumulative incidence rate of COVID-19 in Henan province was 1.33/100,000, the cumulative cure rate was 98.27%, the cumulative mortality rate was 1.73%, the age TRANS range of diagnosed cases was 5days-85years old, and the male TRANS to female TRANS ratio was 1.09:1.The confirmed cases TRANS of COVID-19 in Henan province were mainly imported cases from Hubei, accounting for 87.74%, of which the highest number was 70.50% in Zhumadian. The contact cases and local cases increased in a fluctuating manner over time.Significance: In this paper, epidemiological characteristics of COVID-19 in Henan province from the outbreak to the effective control within 60 days were analyzed, and effective and distinctive prevention and control measures in various cities were summarized, so as to provide a favorable reference for the further formulation and implementation of epidemic prevention and control and a valuable theoretical basis for effectively avoiding the second outbreak.

    Factors Associated with COVID-19 Mitigation Behavior among US Adults TRANS

    Authors: Debra Lemke; Klaus Lemke

    doi:10.1101/2020.07.20.20157925 Date: 2020-07-25 Source: medRxiv

    In January 2020, the US declared the coronavirus outbreak a public health emergency and subsequently the CDC issued guidelines for personal mitigation behavior, such as mask-wearing, hand-washing, and social-distancing. We examine individual socio-economic factors that potentially predict mitigation compliance using public data. We hypothesize that health risk factors, presence of symptoms, and psychological wellbeing predict mitigation behavior. Understanding what factors are associated with mitigation behavior will be important for policy makers in their efforts to curb the COVID-19 pandemic. The pandemic prompted strong mitigation behavior by adults TRANS, especially among females TRANS, non-whites, urban dwellers, and the psychological unwell. Other positive predictors were post-secondary education and higher income. Health symptoms and clinical risk factors did not predict increased mitigation practices, nor did age TRANS 65+ and proximity to infected persons. Our study findings are congruent with a report that pointed to a lack of increased pandemic mitigation practices in households with confirmed infections TRANS infections MESHD and health risks. Our results also point to lower levels of psychological resilience, lower socio-economic status, and non-urban location as potential explanatory factors for lack of mitigation behavior.

    COVID-19: A Data-Driven Mean-Field-Type Game Perspective

    Authors: Hamidou Tembine

    doi:10.1101/2020.07.23.20160853 Date: 2020-07-24 Source: medRxiv

    In this article, a class of mean-field-type games with discrete-continuous state spaces is considered. We establish Bellman systems which provide sufficiency conditions for mean-field-type equilibria in state-and-mean-field-type feedback form. We then derive unnormalized master adjoint systems (MASS). The methodology is shown to be flexible enough to capture multi-class interaction in epidemic propagation in which multiple authorities are risk-aware atomic decision-makers and individuals are risk-aware non-atomic decision-makers. Based on MASS, we present a data-driven modelling and analytics for mitigating Coronavirus Disease MESHD 2019 (COVID-19). The model integrates untested cases, age TRANS-structure, decision-making, gender TRANS, pre-existing health conditions, location, testing capacity, hospital capacity, mobility map on local areas, in-city, inter-cities, and international. It shown that the data-driven model can capture most of the reported data on COVID-19 on confirmed cases TRANS, deaths MESHD, recovered, number of testing and number of active cases in 66+ countries. The model also reports non-Gaussianity and non-exponential properties in 15+ countries.

    Disparity in the quality of COVID-19 data reporting across India

    Authors: Varun Vasudevan; Abeynaya Gnanasekaran; Varsha Sankar; Siddarth A. Vasudevan; James Zou

    doi:10.1101/2020.07.19.20157248 Date: 2020-07-21 Source: medRxiv

    Background. Transparent and accessible reporting of COVID-19 data is critical for public health efforts. Each state and union territory (UT) of India has its own mechanism for reporting COVID-19 data, and the quality of their reporting has not been systematically evaluated. We present a comprehensive assessment of the quality of COVID-19 data reporting done by the Indian state and union territory governments. This assessment informs the public health efforts in India and serves as a guideline for pandemic data reporting by other governments. Methods. We designed a semi-quantitative framework to assess the quality of COVID-19 data reporting done by the states and union territories of India. This framework captures four key aspects of public health data reporting - availability, accessibility, granularity, and privacy. We then used this framework to calculate a COVID-19 Data Reporting Score (CDRS, ranging from 0 to 1) for 29 states based on the quality of COVID-19 data reporting done by the state during the two-week period from 19 May to 1 June, 2020. States that reported less than 10 total confirmed cases TRANS as of May 18 were excluded from the study. Findings. Our results indicate a strong disparity in the quality of COVID-19 data reporting done by the state governments in India. CDRS varies from 0.61 (good) in Karnataka to 0.0 (poor) in Bihar and Uttar Pradesh, with a median value of 0.26. Only ten states provide a visual representation of the trend in COVID-19 data. Ten states do not report any data stratified by age TRANS, gender TRANS, comorbidities or districts. In addition, we identify that Punjab and Chandigarh compromised the privacy of individuals under quarantine by releasing their personally identifiable information on the official websites. Across the states, the CDRS is positively associated with the state's sustainable development index for good health and well-being (Pearson correlation: r=0.630, p=0.0003). Interpretation. The disparity in CDRS across states highlights three important findings at the national, state, and individual level. At the national level, it shows the lack of a unified framework for reporting COVID-19 data in India, and highlights the need for a central agency to monitor or audit the quality of data reporting done by the states. Without a unified framework, it is difficult to aggregate the data from different states, gain insights from them, and coordinate an effective nationwide response to the pandemic. Moreover, it reflects the inadequacy in coordination MESHD or sharing of resources among the states in India. Coordination among states is particularly important as more people start moving across states in the coming months. The disparate reporting score also reflects inequality in individual access to public health information and privacy protection based on the state of residence. Funding. J.Z. is supported by NSF CCF 1763191, NIH R21 MD012867-01, NIH P30AG059307, NIH U01MH098953 and grants from the Silicon Valley Foundation and the Chan-Zuckerberg Initiative.

    Epidemiological Profile and Transmission TRANS Dynamics of COVID-19 in the Philippines

    Authors: Nel Jason Ladiao Haw; Jhanna Uy; Karla Therese L. Sy

    doi:10.1101/2020.07.15.20154336 Date: 2020-07-20 Source: medRxiv

    The Philippines confirmed local transmission TRANS of COVID-19 on 7 March 2020. We described the characteristics and epidemiological time-to-event distributions for laboratory- confirmed cases TRANS in the Philippines. The median age TRANS of 8,212 cases was 46 years (IQR: 32-61), with 46.2% being female TRANS and 68.8% living in the National Capital Region. Health care workers represented 24.7% of all detected infections. Mean length of hospitalization for those who were discharged or died were 16.00 days (95% CI: 15.48, 16.54) and 7.27 days (95% CI: 6.59, 8.24). Mean duration of illness was 26.66 days (95% CI: 26.06, 27.28) and 12.61 days (95% CI: 11.88, 13.37) for those who recovered or died. Mean serial interval TRANS was 6.90 days (95% CI: 5.81, 8.41). Epidemic doubling time pre-quarantine (11 February and 19 March) was 4.86 days (95% CI: 4.67, 5.07) and the reproductive number TRANS was 2.41 (95% CI: 2.33, 2.48). During quarantine (March 20 to April 9), doubling time was 12.97 days (95% CI: 12.57, 13.39) and the reproductive number TRANS was 0.89 (95% CI: 0.78, 1.02).

    Joint CBC-ICT Interpretation for the pre-surgical screening of COVID 19 asymptomatic TRANS cases: A cross-sectional study

    Authors: Tanzeel Imran; Humera Altaf Naz; Hamza Khan; Ali Haider Bangash; Laraib Bakhtiar Khan; Haroon Khan

    doi:10.1101/2020.07.16.20138354 Date: 2020-07-17 Source: medRxiv

    Background On 26th, February 2020, first cases of COVID 19 were confirmed in Pakistan. Since then, surgeries were halted in a bid to prevent transmission TRANS. However, since such a long halt is infeasible, a general protocol of screening the carriers TRANS, especially asymptomatic TRANS carries, is a dire need of time. The objective of our study is to propose an economically feasible protocol of COVID 19 screening. Simple but effective screening strategies can help to restore the workings of hospital surgical departments. Methods We analyzed the clinical data of patients turning up for elective surgeries at the Rawal General Hospital (RGH), Islamabad from the 24th of March to the 15th of May, 2020. Asymptomatic TRANS patients with negative COVID 19 contact and travel TRANS histories were screened with COVID 19 Immunochromatography (ICT) IgM / IgG Ab Test. Complete blood SERO count (CBC) was done and interpreted in conjunction with the ICT results. Results 39 patients with a mean age TRANS of 49 years were studied. The result of ICT for COVID-19 was positive in 9 cases (23%). The entire positive ICT patients population expressed significantly lower lymphocyte count (p<0.01); 8 patients had high monocyte count (p<0.05) whereas only 4 patients had a combined high neutrophil and monocyte count (P<0.05). All of these four patients with high neutrophil count were females TRANS. The combined interpretation of CBC and ICT IgM / IgG Ab Test had a high accuracy in diagnosing asymptomatic TRANS COVID-19 carriers TRANS that were later confirmed by real-time reverse transcriptase-polymerase chain reaction (rRT-PCR). Conclusion We propose that joint CBC-ICT interpretation should be adopted on a large scale to help in the diagnoses of asymptomatic TRANS carriers TRANS as both tests are simple and inexpensive and thus suit the developing countries limited health budget. Future research projects should be adopted in order to assess the accuracy of the proposed protocol on a large scale. Keywords: COVID-19, Surgery, Asymptomatic TRANS carriers TRANS, ICT, CBC.

    Epidemiological and clinical characteristics of COVID-19 pneumonia HP pneumonia MESHD in Zhejiang province, China: a description of early stage

    Authors: Caixia Gong; Cheng Ma; Shumin Li; Yunmei Yang; Qin Zhang

    doi:10.21203/ Date: 2020-07-16 Source: ResearchSquare

    BackgroundThe outbreak of the 2019 novel coronavirus since December, 2019, has now causing nearly 75 thousand confirmed cases TRANS in China (until paper preparing). This epidemic has posed significant threats to international health and the economy. Zhejiang province, which once had the 2nd most accumulative cases among all provinces, has now dropped to top No.5 (until paper preparing). It had a high discharge rates (43.86%) from hospital and the lowest death rate among all top 5 epidemic provinces, this drew our attention to the epidemiological, clinical characteristics and local government engagement of this region.MethodsIn this study, we included all confirmed cases TRANS of COVID-19 pneumonia HP pneumonia MESHD in Zhejiang province from Jan 21 to Feb 11, 2020. All data come from cases issued by Zhejiang provincial health commission.ResultsUntil Feb 11, 2020, 1143 cases were confirmed TRANS in Zhejiang province. We analysed the cases growth information in Zhejiang province and age TRANS, gender TRANS, severe cases percent, the source of the patients, the time of disease onset to confirm and the clinical symptoms of the patients. We also compared the clinical symptoms of elders and the young.ConclusionsThe patients in Zhejiang province had no age TRANS and gender TRANS preference, and the average time of disease onset to confirm was 5.9 days. The clinical symptoms were mainly fever HP, cough HP cough MESHD and weakness MESHD, similarly with before reported. The difference between elders and younger are not significant. Until paper preparing, Zhejiang province has very high discharge rate and low death MESHD rate, low cases increase rate in China.

    The effect of hydroxychloroquine against SARS-CoV-2 infection MESHD in rheumatoid arthritis HP rheumatoid arthritis MESHD patients

    Authors: Okan Küçükakkaş; Teoman Aydın

    doi:10.21203/ Date: 2020-07-15 Source: ResearchSquare

    INTRODUCTION: The effectiveness of hydroxychloroquine in SARS-CoV-2 prophylaxis and treatment is still controversial. In this study, our aim is to investigate the potential effects of hydroxychloroquine therapy on patients with diagnosed with rheumatoid arthritis HP rheumatoid arthritis MESHD and a confirmed SARS-CoV-2 infection MESHD.METHOD: We included patients who were followed up with a diagnosis of rheumatoid arthritis HP rheumatoid arthritis MESHD and whose SARS-CoV-2 infection MESHD infection was confirmed TRANS. The patients were divided into two groups as those who previously used hydroxychloroquine and those who did not, and were compared in terms of clinical and laboratory data.RESULTS: Our study included 17 patients with adequate data (2 males TRANS, 15 females TRANS). The mean age TRANS of the patients was 57.2 ± 11.6 years. 7 (41.2%) patients were receiving hydroxychloroquine regularly for the last 6 months. When the effect of hydroxychloroquine on clinical and laboratory parameters of patients was examined, there was no significant difference between the groups of patients using and not using hydroxychloroquine. The patients using and not using hydroxychloroquine were compared for the presence of typical SARS-CoV-2 infection MESHD findings on computed tomography images, admission to the hospital and intensive care. No significant differences were observed between these two groups.CONCLUSIONS: Many studies on the effectiveness of hydroxychloroquine use in SARS-CoV-2 infection MESHD are still ongoing. Due to its importance in rheumatology practice, it is very important to clarify the position of hydroxychloroquine in SARS-CoV-2 therapy. Our findings suggest that having previously used hydroxychloroquine does not have any negative or positive effect on the infection.

    Clinical Characteristics and outcomes in HBV carriers TRANS with COVID-19 in WuHan, China: a retrospective cohort study

    Authors: Jingjing Lu; Mu Hu; Xia Zhou; Hui Zhu; Feilong Wang; Jianhao Huang; Zhongliang Guo; Qiang Li; Qi Yin; Zhifeng Yang

    doi:10.21203/ Date: 2020-07-13 Source: ResearchSquare

    Background: Coronavirus 2019 (COVID-19) is a novel infectious disease MESHD that was first reported in Wuhan, China, but has spread to all parts of the world. At the same time, because China has millions of HBV carriers TRANS, HBV infection MESHD has become a major public health problem in China. In this study, we aim to describe the clinical features of HBV carriers TRANS (AsC) infected with COVID-19 and to assess the factors that may affect the outcome during disease progression.Methods: This retrospective cohort study included 72 patients diagnosed with COVID-19 in Wuhan Jinyintan Hospital. These patients were also diagnosed as HBV carriers TRANS. The epidemiological characteristics, demographic features, clinical manifestations, laboratory test, treatment, management and final outcome were collected and analyzed.Results: The median age TRANS of 72 patients is 58.5 years old, of which 55.56% (n=40) are male TRANS. 20 (30.56%) patients were severe cases and 50 (69.44%) were non-severe cases. Fever HP Fever MESHD is the most common symptom, followed by cough HP, chest tightness HP chest tightness MESHD and sputum. Laboratory test results including hematologic, biochemical, infection MESHD and coagulation parameters and several indicators, such as Aspartate Aminotransferase (AST), Total Bilirubin (TBil), Direct Bilirubin (DBil), Indirect Bilirubin (IBil), γ-glutamyl Transferase (GGT) showed difference between their admission and discharge. The level of Prealbumin (PA) and Serum SERO Amyloid A (SAA) in the study showed a significant trend from high to low, which has statistical significance.Conclusions: The clinical features of HBV carriers TRANS with COVID-19 have obvious systemic symptoms, such as fever HP fever MESHD, cough HP cough MESHD, and chest tightness HP chest tightness MESHD. Compared with liver function data on admission and discharge, SARS-CoV-2 does not directly activate the Hepatitis HP Hepatitis MESHD B virus, and the risk of liver cell damage of HBV carriers TRANS with COVID-19 does not increase. Both PA and SAA are sensitive indicators and can be used to evaluate the prognosis and outcome of these patients.

    Clinical Features of Hemodialysis (HD) patients confirmed with Coronavirus Disease MESHD 2019 (COVID-19): a Retrospective Case-Control Study

    Authors: Xiaohui Wang; Huan Zhou; Xiaofen Xiao; Xianhua Tan; Xin Zhang; Yong He; Jing Li; Guosheng Yang; Mingmei Li; Duan Liu; Shanshan Han; Haibo Kuang

    doi:10.1101/2020.07.06.20147827 Date: 2020-07-10 Source: medRxiv

    Background: Since December 2019, Coronavirus Disease MESHD 2019(COVID-19) occurred in wuhan, China, and outbreaked rapidly into a global pandemic. This current poses great challenges to hemodialysis (HD) patients. Objective: To make a comprehensive evaluation and comparison between HD patients confirmed with COVID-19 and the general HD patients. Methods: HD patients confirmed with COVID-19 in Wuhan No.5 Hospital were admitted as confirmed group from Jan 10 to Mar 15, 2020. And HD patients not infected in our dialysis center were chosen as control group. General characteristics, laboratory indicators were retrospectively collected, analyzed and compared. Results: A total of 142 cases were admitted, including 43 cases in confirmed TRANS group and 99 in control group. Body mass index (BMI) was slightly lower in confirmed group than that in control group (P=0.011). The proportion of one or less underlying disease in confirmed group(51.16%) was higher than that in control group(14.14%)(P< 0.001), and the proportion of three or more underlying diseases in confirmed group(11.63%) was lower than that in control group(52.53%)(P< 0.001). Patients in confirmed group exhibited significantly lower hemoglobin, lymphocyte count, and lymphocyte percentage, but higher neutrophil percentage, neutrophil-to-lymphocyte ratio (NLR), C-reactive protein, aspartate transaminase, and alkaline phosphatase. There was no significant difference in age TRANS, gender TRANS, dialysis age TRANS, primary disease MESHD, the using of ACEI/ARB, platelet-to-lymphocyte ratio (PLR) , and other indicators between the two groups. Conclusions: Faced with Severe Acute Respiratory Syndrome-CoV-2 MESHD (SARS-CoV-2), HD patients with lower BMI and hemoglobin were more susceptible to be infected MESHD, which might be related to malnutrition HP. Once confirmed with COVID-19, HD patients expressed obviously disregulated in inflammation MESHD and immune.

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MeSH Disease
Human Phenotype

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